We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese（Mn） solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our dat...We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese（Mn） solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure（6 h） to Mn did not cause severe defects of life span,development,and reproduction,similarly,no significant defect could be found in animals exposed to a low concentration of Mn（2.5 μmol/L） for 48 h.In contrast,prolonged exposure（48 h） to high Mn concentrations（75 and 200 μmol/L） resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2：：gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure（48 h） to high concentrations（75 and 200 μmol/L） of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans.展开更多
目的探讨电焊作业对作业工人神经行为功能的影响。方法采用世界卫生组织(WHO)推荐的神经行为核心测试组合(Neurobehavioural Core Test Batteries简称NCTB),对45名无急、慢性锰中毒作业工人和对照组45名工人的情感状态(Profiles of Mood...目的探讨电焊作业对作业工人神经行为功能的影响。方法采用世界卫生组织(WHO)推荐的神经行为核心测试组合(Neurobehavioural Core Test Batteries简称NCTB),对45名无急、慢性锰中毒作业工人和对照组45名工人的情感状态(Profiles of Mood States Test简称POMS)、简单视觉运动反应时、数字跨度、手提转捷度、数字译码、Benton视觉保留、目标测试Ⅱ等进行测试,并对测试结果进行比较分析。结果发现电焊作业组工人在抑郁、疲劳、精力充沛三项情感状态指标与对照组比较有明显差异(P<0.01,P<0.05);发现电焊作业组工人在简单视觉运动反应时、数字跨度、手提转捷度、数字译码、Benton视觉保留与对照组比较差异有非常显著性(P<0.01)。结论电焊作业对神经行为功能有一定影响,工龄与神经行为负效应关系不明显。展开更多
基金supported by the National Natural Science Foundation of China (No. 30771113, 30870810)the Program for New Century Excellent Talents in University
文摘We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese（Mn） solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure（6 h） to Mn did not cause severe defects of life span,development,and reproduction,similarly,no significant defect could be found in animals exposed to a low concentration of Mn（2.5 μmol/L） for 48 h.In contrast,prolonged exposure（48 h） to high Mn concentrations（75 and 200 μmol/L） resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2：：gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure（48 h） to high concentrations（75 and 200 μmol/L） of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans.
文摘目的探讨电焊作业对作业工人神经行为功能的影响。方法采用世界卫生组织(WHO)推荐的神经行为核心测试组合(Neurobehavioural Core Test Batteries简称NCTB),对45名无急、慢性锰中毒作业工人和对照组45名工人的情感状态(Profiles of Mood States Test简称POMS)、简单视觉运动反应时、数字跨度、手提转捷度、数字译码、Benton视觉保留、目标测试Ⅱ等进行测试,并对测试结果进行比较分析。结果发现电焊作业组工人在抑郁、疲劳、精力充沛三项情感状态指标与对照组比较有明显差异(P<0.01,P<0.05);发现电焊作业组工人在简单视觉运动反应时、数字跨度、手提转捷度、数字译码、Benton视觉保留与对照组比较差异有非常显著性(P<0.01)。结论电焊作业对神经行为功能有一定影响,工龄与神经行为负效应关系不明显。
