脑功能磁共振成像(functional magnetic resonance imaging,fMRI)能在活体人脑定位各功能脑区,研究脑的功能连接。本文基于静息态的应用模式,自局部脑区功能活动、脑区之间的功能连接及脑功能网络层面,综述了脑功能磁共振成像在脑性瘫...脑功能磁共振成像(functional magnetic resonance imaging,fMRI)能在活体人脑定位各功能脑区,研究脑的功能连接。本文基于静息态的应用模式,自局部脑区功能活动、脑区之间的功能连接及脑功能网络层面,综述了脑功能磁共振成像在脑性瘫痪患儿发病机制、诊断、治疗及预后等方面的临床研究现状。今后需要进行多学科、多方法相结合的综合研究,探索脑性瘫痪患儿特异的功能影像学标记,为疾病的早期发现、早期干预及预后判断等提供客观和直观的影像学依据。展开更多
Aphasia is an acquired language disorder that is a common consequence of stroke.The pathogenesis of the disease is not fully understood,and as a result,current treatment options are not satisfactory.Here,we used blood...Aphasia is an acquired language disorder that is a common consequence of stroke.The pathogenesis of the disease is not fully understood,and as a result,current treatment options are not satisfactory.Here,we used blood oxygenation level-dependent functional magnetic resonance imaging to evaluate the activation of bilateral cortices in patients with Broca＇s aphasia 1 to 3 months after stroke.Our results showed that language expression was associated with multiple brain regions in which the right hemisphere participated in the generation of language.The activation areas in the left hemisphere of aphasia patients were significantly smaller compared with those in healthy adults.The activation frequency,volumes,and intensity in the regions related to language,such as the left inferior frontal gyrus（Broca＇s area）,the left superior temporal gyrus,and the right inferior frontal gyrus（the mirror region of Broca＇s area）,were lower in patients compared with healthy adults.In contrast,activation in the right superior temporal gyrus,the bilateral superior parietal lobule,and the left inferior temporal gyrus was stronger in patients compared with healthy controls.These results suggest that the right inferior frontal gyrus plays a role in the recovery of language function in the subacute stage of stroke-related aphasia by increasing the engagement of related brain areas.展开更多
目的探讨甲苯中毒性脑病磁共振及其功能性成像表现。方法对3例甲苯中毒性脑病进行常规磁共振及其功能性成像检查。3例患者和7名健康女性志愿者均在3T GE MR扫描仪进行常规扫描及扩散加权成像(DWI)、扩散加权张量成像(DTI)、多体素氢质...目的探讨甲苯中毒性脑病磁共振及其功能性成像表现。方法对3例甲苯中毒性脑病进行常规磁共振及其功能性成像检查。3例患者和7名健康女性志愿者均在3T GE MR扫描仪进行常规扫描及扩散加权成像(DWI)、扩散加权张量成像(DTI)、多体素氢质子波谱成像(3D1H-MRS)及行3D动脉自旋标记(3D-PCASL)检查。图像传送至GE 4.4工作站,使用Functool软件包,分别测量包括皮层下白质、双侧外囊、双侧苍白球、双侧丘脑及双侧齿状核平均表观扩散系数(ADC)值和平均各向异性分数(FA)值。3D1H-MRS选定白质内病灶为感兴趣区进行波谱分析。测量双侧白质区、皮层灰质及基底节区平均脑血流量(CBF)值。所有测量值均进行统计学分析。结果3例在磁共振平扫均表现为弥漫性、对称性脑白质及基底节区包括外囊、苍白球、丘脑T2WI异常高信号,同时累及小脑齿状核。3例苍白球平均ADC值较对照组明显下降并且具有统计学意义(P<0.05),病例2、病例3皮层下白质、外囊、丘脑及齿状核平均ADC值较对照组下降,但没有统计学意义。平均FA值在所有病例均下降并具有统计学意义(P<0.002)。3例白质内病灶波谱分析发现NAA/Cr比值下降而Cho/Cr值上升,且具有统计学意义(P<0.001)。所有感兴趣区平均CBF在中毒性脑病组和对照组无差异。结论甲苯中毒性脑病在磁共振检查上具有一定特征性表现,功能性成像可以显示脑组织细微结构变化和生化信息,有助于了解中毒性脑病病理机制。展开更多
文摘脑功能磁共振成像(functional magnetic resonance imaging,fMRI)能在活体人脑定位各功能脑区,研究脑的功能连接。本文基于静息态的应用模式,自局部脑区功能活动、脑区之间的功能连接及脑功能网络层面,综述了脑功能磁共振成像在脑性瘫痪患儿发病机制、诊断、治疗及预后等方面的临床研究现状。今后需要进行多学科、多方法相结合的综合研究,探索脑性瘫痪患儿特异的功能影像学标记,为疾病的早期发现、早期干预及预后判断等提供客观和直观的影像学依据。
基金supported by the Natural Science Foundation of Guangdong Province of China,No.2016A030313327the Science and Technology Planning Project of Guangzhou City of China,No.201607010185+1 种基金the Science and Technology Planning Project of Guangdong Province of China,No.2016A020215226the National Natural Science Foundation of China,No.81401869
文摘Aphasia is an acquired language disorder that is a common consequence of stroke.The pathogenesis of the disease is not fully understood,and as a result,current treatment options are not satisfactory.Here,we used blood oxygenation level-dependent functional magnetic resonance imaging to evaluate the activation of bilateral cortices in patients with Broca＇s aphasia 1 to 3 months after stroke.Our results showed that language expression was associated with multiple brain regions in which the right hemisphere participated in the generation of language.The activation areas in the left hemisphere of aphasia patients were significantly smaller compared with those in healthy adults.The activation frequency,volumes,and intensity in the regions related to language,such as the left inferior frontal gyrus（Broca＇s area）,the left superior temporal gyrus,and the right inferior frontal gyrus（the mirror region of Broca＇s area）,were lower in patients compared with healthy adults.In contrast,activation in the right superior temporal gyrus,the bilateral superior parietal lobule,and the left inferior temporal gyrus was stronger in patients compared with healthy controls.These results suggest that the right inferior frontal gyrus plays a role in the recovery of language function in the subacute stage of stroke-related aphasia by increasing the engagement of related brain areas.
文摘目的探讨甲苯中毒性脑病磁共振及其功能性成像表现。方法对3例甲苯中毒性脑病进行常规磁共振及其功能性成像检查。3例患者和7名健康女性志愿者均在3T GE MR扫描仪进行常规扫描及扩散加权成像(DWI)、扩散加权张量成像(DTI)、多体素氢质子波谱成像(3D1H-MRS)及行3D动脉自旋标记(3D-PCASL)检查。图像传送至GE 4.4工作站,使用Functool软件包,分别测量包括皮层下白质、双侧外囊、双侧苍白球、双侧丘脑及双侧齿状核平均表观扩散系数(ADC)值和平均各向异性分数(FA)值。3D1H-MRS选定白质内病灶为感兴趣区进行波谱分析。测量双侧白质区、皮层灰质及基底节区平均脑血流量(CBF)值。所有测量值均进行统计学分析。结果3例在磁共振平扫均表现为弥漫性、对称性脑白质及基底节区包括外囊、苍白球、丘脑T2WI异常高信号,同时累及小脑齿状核。3例苍白球平均ADC值较对照组明显下降并且具有统计学意义(P<0.05),病例2、病例3皮层下白质、外囊、丘脑及齿状核平均ADC值较对照组下降,但没有统计学意义。平均FA值在所有病例均下降并具有统计学意义(P<0.002)。3例白质内病灶波谱分析发现NAA/Cr比值下降而Cho/Cr值上升,且具有统计学意义(P<0.001)。所有感兴趣区平均CBF在中毒性脑病组和对照组无差异。结论甲苯中毒性脑病在磁共振检查上具有一定特征性表现,功能性成像可以显示脑组织细微结构变化和生化信息,有助于了解中毒性脑病病理机制。
