目的探讨多模态磁共振成像(MRI)鉴别诊断肿块型肝内胆管细胞癌(IMCC)与不典型肝脓肿(AHA)的应用价值。方法回顾性分析2021年1月至2024年4月咸阳市中心医院23例IMCC(IMCC组)和26例AHA(AHA组)患者的临床资料及MRI图像,观察两组病灶MRI平...目的探讨多模态磁共振成像(MRI)鉴别诊断肿块型肝内胆管细胞癌(IMCC)与不典型肝脓肿(AHA)的应用价值。方法回顾性分析2021年1月至2024年4月咸阳市中心医院23例IMCC(IMCC组)和26例AHA(AHA组)患者的临床资料及MRI图像,观察两组病灶MRI平扫、动态增强、扩散加权图像特征以及病灶周围伴随征象,分别测量病灶边缘实性部分及内部非囊变坏死部分的平均表观扩散系数(ADCmean)值及相对表观扩散系数(rADC)值。比较两组患者病灶MRI征象及ADC值的差异。结果IMCC多位于肝左叶(13/23),MRI增强多表现为花环状渐进性强化或片絮状不均匀强化;AHA多位于肝右叶(19/26),MRI增强多表现为环簇状持续性强化。IMCC患者与AHA患者MRI影像学特征中,环簇状持续性强化[8.70%(2/23)vs 57.69%(15/26)]、片絮状不均匀强化[34.78%(8/23)vs 7.69%(2/26)]、“强化环中断征”[43.48%(10/23)vs 11.54%(3/26)]在两组间差异具有统计学意义(P<0.05);病灶边缘ADCmean值[0.71(0.66,0.81)×10^(-3)mm^(2)/s vs 1.41(1.33,1.47)×10^(-3)mm^(2)/s]和rADC值[0.82(0.78,0.91)vs 1.33(1.28,1.50)]在两组间差异具有统计学意义(P<0.05);病灶内部ADCmean值[1.15(1.04,1.29)×10^(-3)mm^(2)/s vs 1.25(1.08,1.57)×10^(-3)mm^(2)/s]和rADC值[(1.26±0.24)vs(1.29±0.30)]在两组间差异无统计学意义(P>0.05);肝包膜凹陷、肝内胆管扩张、周围血管侵犯比例在两组间差异均具有统计学意义(P<0.05)。结论多模态MRI有助于鉴别IMCC与AHA,具有一定的临床应用价值。展开更多
Objective： Noninvasive diffusion-weighted magnetic resonance imaging （DWI） is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion...Objective： Noninvasive diffusion-weighted magnetic resonance imaging （DWI） is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion coefficient （ADC） value and apoptosis or proliferation is not clear by now. This study aimed to investigate whether DWI-ADC value could be used as an imaging marker related with pathologic indexes of tumors. Methods： A total of 3 0 Balb/c mice with HT2 9 colorectal carcinoma were subjected to DWI and histologic analysis. The percentage of ADC changes and the apoptotic and proliferating indexes were calculated at predefined time points. Kolmogorov-Smirnov distances were considered to determine whether the percentage of ADC changes, and the apoptotic and proliferating indexes were normally distributed. An independent-samples t-test was used to analyze the difference between apoptotic and proliferating indexes in the two groups. Results： There was a statistically significant difference in proliferating index between the radiotherapy and control groups （mean proliferating index： 49.27% vs. 83.09%）, and there was a statistically significant difference in apoptotic index between the two groups （mean apoptotic index： 37.7% vs. 2.71%）. A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. Pearson＇s correlation coefficient was 0.655 （P=0.015）. A significant negative correlation was found between the percentage of ADC changes of the viable tissue and ki-67 proliferation index. Pearson＇s correlation coefficient was 0.734 （P〈0.001）. Conclusions： Our results suggest that ADC proliferating indexes in colorectal carcinoma. value may be used in measurement of cell apoptotic and展开更多
文摘目的探讨多模态磁共振成像(MRI)鉴别诊断肿块型肝内胆管细胞癌(IMCC)与不典型肝脓肿(AHA)的应用价值。方法回顾性分析2021年1月至2024年4月咸阳市中心医院23例IMCC(IMCC组)和26例AHA(AHA组)患者的临床资料及MRI图像,观察两组病灶MRI平扫、动态增强、扩散加权图像特征以及病灶周围伴随征象,分别测量病灶边缘实性部分及内部非囊变坏死部分的平均表观扩散系数(ADCmean)值及相对表观扩散系数(rADC)值。比较两组患者病灶MRI征象及ADC值的差异。结果IMCC多位于肝左叶(13/23),MRI增强多表现为花环状渐进性强化或片絮状不均匀强化;AHA多位于肝右叶(19/26),MRI增强多表现为环簇状持续性强化。IMCC患者与AHA患者MRI影像学特征中,环簇状持续性强化[8.70%(2/23)vs 57.69%(15/26)]、片絮状不均匀强化[34.78%(8/23)vs 7.69%(2/26)]、“强化环中断征”[43.48%(10/23)vs 11.54%(3/26)]在两组间差异具有统计学意义(P<0.05);病灶边缘ADCmean值[0.71(0.66,0.81)×10^(-3)mm^(2)/s vs 1.41(1.33,1.47)×10^(-3)mm^(2)/s]和rADC值[0.82(0.78,0.91)vs 1.33(1.28,1.50)]在两组间差异具有统计学意义(P<0.05);病灶内部ADCmean值[1.15(1.04,1.29)×10^(-3)mm^(2)/s vs 1.25(1.08,1.57)×10^(-3)mm^(2)/s]和rADC值[(1.26±0.24)vs(1.29±0.30)]在两组间差异无统计学意义(P>0.05);肝包膜凹陷、肝内胆管扩张、周围血管侵犯比例在两组间差异均具有统计学意义(P<0.05)。结论多模态MRI有助于鉴别IMCC与AHA,具有一定的临床应用价值。
文摘Objective： Noninvasive diffusion-weighted magnetic resonance imaging （DWI） is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion coefficient （ADC） value and apoptosis or proliferation is not clear by now. This study aimed to investigate whether DWI-ADC value could be used as an imaging marker related with pathologic indexes of tumors. Methods： A total of 3 0 Balb/c mice with HT2 9 colorectal carcinoma were subjected to DWI and histologic analysis. The percentage of ADC changes and the apoptotic and proliferating indexes were calculated at predefined time points. Kolmogorov-Smirnov distances were considered to determine whether the percentage of ADC changes, and the apoptotic and proliferating indexes were normally distributed. An independent-samples t-test was used to analyze the difference between apoptotic and proliferating indexes in the two groups. Results： There was a statistically significant difference in proliferating index between the radiotherapy and control groups （mean proliferating index： 49.27% vs. 83.09%）, and there was a statistically significant difference in apoptotic index between the two groups （mean apoptotic index： 37.7% vs. 2.71%）. A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. Pearson＇s correlation coefficient was 0.655 （P=0.015）. A significant negative correlation was found between the percentage of ADC changes of the viable tissue and ki-67 proliferation index. Pearson＇s correlation coefficient was 0.734 （P〈0.001）. Conclusions： Our results suggest that ADC proliferating indexes in colorectal carcinoma. value may be used in measurement of cell apoptotic and
