Magnetic core shell nanoparticles are composed of a highly magnetic core material surrounded by a thin shell of desired drug, polymer or metal oxide. These magnetic core shell nanoparticles have a wide range of applic...Magnetic core shell nanoparticles are composed of a highly magnetic core material surrounded by a thin shell of desired drug, polymer or metal oxide. These magnetic core shell nanoparticles have a wide range of applications in biomedical research, more specifically in tissue imaging, drug delivery and therapeutics. The present review discusses the up-to-date knowledge on the various procedures for synthesis of magnetic core shell nanoparticles along with their applications in cancer imaging, drug delivery and hyperthermia or cancer therapeutics. Literature in this area shows that magnetic core shell nanoparticle-based imaging, drug targeting and therapy through hyperthermia can potentially be a powerful tool for the advanced diagnosis and treatment of various cancers.展开更多
Recent discoveries in the synthesis and applications of magnetic vortex nanorings/nanodiscs in theranostic applications are reviewed. First, the principles of nanomagnetism and magnetic vortex are introduced. Second, ...Recent discoveries in the synthesis and applications of magnetic vortex nanorings/nanodiscs in theranostic applications are reviewed. First, the principles of nanomagnetism and magnetic vortex are introduced. Second, methods for producing magnetic vortex nanorings/nanodiscs are presented. Finally, theranostic applications of magnetic vortex nanorings/nanodiscs are addressed.展开更多
Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging(MRI)-based temperature mapping techniques are safe compared with invasi...Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging(MRI)-based temperature mapping techniques are safe compared with invasive methods and have been applied to detect temperature changes for a variety of applications. Among these techniques, the proton resonance frequency(PRF) method is relatively advanced. With a temperature measuring experiment, the effectiveness of PRF method has been proved, because the outcome temperature curve and the real temperature curve fit well. After that, an experiment has been conducted on tumors inside rabbit legs and the result indicates that this system is able to performance hyperthermia at targets based on PRF method in temperature mapping.展开更多
Tumor-associated macrophages(TAMs)play an important role in tumor development and progression.In particular,M2 TAMs can promote tumor growth by facilitating tumor progression and malignant behaviors.Selectively target...Tumor-associated macrophages(TAMs)play an important role in tumor development and progression.In particular,M2 TAMs can promote tumor growth by facilitating tumor progression and malignant behaviors.Selectively targeted elimination of M2 TAMs to inhibit tumor progression is of great significance for cancer treatment.Iron oxide nanoparticles based magnetic hyperthermia therapy(MHT)is a classical approach to destroy tumor tissue with deep penetration depth.In this study,we developed a typical M2 macrophage-targeted peptide(M2pep)functionalized superparamagnetic iron oxide nanoparticle(SPIO)for magnetic resonance imaging(MRI)-guided MHT in an orthotopic breast cancer mouse model.The obtained multifunctional SPIO-M2pep with a hydrodynamic diameter of 20 nm showed efficient targeting capability,high transverse relaxivity(149 mM^(-1) s^(-1))and satisfactory magnetic hyperthermia performance in vitro.In vivo studies demonstrated that the SPIO-M2pep based MRI can monitor the distribution of nanoparticles in tumor and indicate the suitable timing for MHT.The M2 macrophage-targeted MHT significantly reduced the tumor volume and the population of pro-tumoral M2 TAMs in tumor.In addition,the SPIO-M2pep based MHT can remodel the tumor immune microenvironment(TIME).The multifunctional SPIO-M2pep with M2 macrophage-targeting ability,high magnetic hyperthermia efficiency,MR imaging capability and effective role in remodeling the TIME hold great potential to improve clinical cancer therapy outcomes.展开更多
目的对磁共振测温在椎体环境不同组织中测温的难点初步分析。方法在3 T Phillips磁共振仪器中,分别采集T1、T2图像,根据椎体肿瘤热疗的临床需求,结合解剖图分割出手术关心的区域;再用PRF（proton resonance frequency）和谱估计两种方...目的对磁共振测温在椎体环境不同组织中测温的难点初步分析。方法在3 T Phillips磁共振仪器中,分别采集T1、T2图像,根据椎体肿瘤热疗的临床需求,结合解剖图分割出手术关心的区域;再用PRF（proton resonance frequency）和谱估计两种方法分别对含水较多和水脂混合的组织区域进行温度测量,并以肌肉区域的温度对其余区域作场漂修正。结果在重点关注区域中,分别选取80-300个像素点,对于PRF方法,脊髓和椎间盘的温度误差平均值均〈0.2℃,温度标准差〈1.5℃;主动脉和上下腔静脉的温度误差平均值在0.9℃-1.8℃,标准差〈1.7℃;椎体部分的温度误差平均值约0.9℃,但标准差接近12℃;对于谱估计方法,在水脂混合的椎体部分,温度标准差仍〉12℃。结论磁共振测温在含水较多、均匀且流动较少的组织脊髓和椎间盘测温效果较好,在主动脉和静脉血管里的血液的温度因血液流动的干扰而难以用磁共振直接测得,椎体内由松质骨所引起的磁化率干扰会给磁共振测温带来较大偏差。展开更多
Nanomagnetism is the origin of many unique properties in magnetic nanomaterials that can be used as building blocks in information technology, spintronics, and biomedicine. Progresses in nanomagnetic principles, disti...Nanomagnetism is the origin of many unique properties in magnetic nanomaterials that can be used as building blocks in information technology, spintronics, and biomedicine. Progresses in nanomagnetic principles, distinct magnetic nanostructures, and the biomedical applications of nanomagnetism are summarized.展开更多
文摘Magnetic core shell nanoparticles are composed of a highly magnetic core material surrounded by a thin shell of desired drug, polymer or metal oxide. These magnetic core shell nanoparticles have a wide range of applications in biomedical research, more specifically in tissue imaging, drug delivery and therapeutics. The present review discusses the up-to-date knowledge on the various procedures for synthesis of magnetic core shell nanoparticles along with their applications in cancer imaging, drug delivery and hyperthermia or cancer therapeutics. Literature in this area shows that magnetic core shell nanoparticle-based imaging, drug targeting and therapy through hyperthermia can potentially be a powerful tool for the advanced diagnosis and treatment of various cancers.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.21376192 and 81571809)the Research Fund for the Doctoral Program of Higher Education of China(Grant No.20126101110017)MOE Ac RF Tier 2-MOE2011-T2-1-043 and A-Star SERC 1321202068
文摘Recent discoveries in the synthesis and applications of magnetic vortex nanorings/nanodiscs in theranostic applications are reviewed. First, the principles of nanomagnetism and magnetic vortex are introduced. Second, methods for producing magnetic vortex nanorings/nanodiscs are presented. Finally, theranostic applications of magnetic vortex nanorings/nanodiscs are addressed.
基金The Camille and Henry Dreyfus Foundation(TC-05-053)National Science Foundation(DMS-0833863,CHE-1112574,and CHE-1416598)Hirshberg Foundation for Pancreatic Cancer Research
基金the National Natural Science Foundation of China(No.30800246)the Shanghai Key Technologies R&D Program of China(No.09441900500)the Research Program of Shanghai Education Commission(No.14CXY05)
文摘Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging(MRI)-based temperature mapping techniques are safe compared with invasive methods and have been applied to detect temperature changes for a variety of applications. Among these techniques, the proton resonance frequency(PRF) method is relatively advanced. With a temperature measuring experiment, the effectiveness of PRF method has been proved, because the outcome temperature curve and the real temperature curve fit well. After that, an experiment has been conducted on tumors inside rabbit legs and the result indicates that this system is able to performance hyperthermia at targets based on PRF method in temperature mapping.
基金This work was finicially supported by the National Natural Science Foundation of China(Nos.81627806,91859121,81701763 and 81671789)the China Postdoctoral Science Foundation(No.2017M612098)+1 种基金the Anhui Provincial Natural Science Foundation(No.1808085QH249)the Fundamental Research Funds for the Central Universities(Nos.WK2100230017 and WK2100000007)。
文摘Tumor-associated macrophages(TAMs)play an important role in tumor development and progression.In particular,M2 TAMs can promote tumor growth by facilitating tumor progression and malignant behaviors.Selectively targeted elimination of M2 TAMs to inhibit tumor progression is of great significance for cancer treatment.Iron oxide nanoparticles based magnetic hyperthermia therapy(MHT)is a classical approach to destroy tumor tissue with deep penetration depth.In this study,we developed a typical M2 macrophage-targeted peptide(M2pep)functionalized superparamagnetic iron oxide nanoparticle(SPIO)for magnetic resonance imaging(MRI)-guided MHT in an orthotopic breast cancer mouse model.The obtained multifunctional SPIO-M2pep with a hydrodynamic diameter of 20 nm showed efficient targeting capability,high transverse relaxivity(149 mM^(-1) s^(-1))and satisfactory magnetic hyperthermia performance in vitro.In vivo studies demonstrated that the SPIO-M2pep based MRI can monitor the distribution of nanoparticles in tumor and indicate the suitable timing for MHT.The M2 macrophage-targeted MHT significantly reduced the tumor volume and the population of pro-tumoral M2 TAMs in tumor.In addition,the SPIO-M2pep based MHT can remodel the tumor immune microenvironment(TIME).The multifunctional SPIO-M2pep with M2 macrophage-targeting ability,high magnetic hyperthermia efficiency,MR imaging capability and effective role in remodeling the TIME hold great potential to improve clinical cancer therapy outcomes.
文摘目的对磁共振测温在椎体环境不同组织中测温的难点初步分析。方法在3 T Phillips磁共振仪器中,分别采集T1、T2图像,根据椎体肿瘤热疗的临床需求,结合解剖图分割出手术关心的区域;再用PRF（proton resonance frequency）和谱估计两种方法分别对含水较多和水脂混合的组织区域进行温度测量,并以肌肉区域的温度对其余区域作场漂修正。结果在重点关注区域中,分别选取80-300个像素点,对于PRF方法,脊髓和椎间盘的温度误差平均值均〈0.2℃,温度标准差〈1.5℃;主动脉和上下腔静脉的温度误差平均值在0.9℃-1.8℃,标准差〈1.7℃;椎体部分的温度误差平均值约0.9℃,但标准差接近12℃;对于谱估计方法,在水脂混合的椎体部分,温度标准差仍〉12℃。结论磁共振测温在含水较多、均匀且流动较少的组织脊髓和椎间盘测温效果较好,在主动脉和静脉血管里的血液的温度因血液流动的干扰而难以用磁共振直接测得,椎体内由松质骨所引起的磁化率干扰会给磁共振测温带来较大偏差。
基金Project supported by the National Basic Research Program of China(Grant No.2010CB934601)the National Natural Science Foundation of China(Grant Nos.51125001 and 51172005)+1 种基金the Natural Science Foundation of Beijing,China(Grant No.2122022)the Doctoral Program,China(Grant No.20120001110078)
文摘Nanomagnetism is the origin of many unique properties in magnetic nanomaterials that can be used as building blocks in information technology, spintronics, and biomedicine. Progresses in nanomagnetic principles, distinct magnetic nanostructures, and the biomedical applications of nanomagnetism are summarized.
