Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed ...Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and noncancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis.展开更多
In this paper,106 active regions(ARs)in the visible solar hemisphere in solar cycle 24 whose maximum sunspot groups’areas were larger than 400μh were selected.The association of their flare index(Iflare),largest fla...In this paper,106 active regions(ARs)in the visible solar hemisphere in solar cycle 24 whose maximum sunspot groups’areas were larger than 400μh were selected.The association of their flare index(Iflare),largest flare magnitude(Mflare),and fastest coronal mass ejection(CME)velocity(VCME)with the vector magnetic field parameters were examined,and attempts were made to predict Iflare,Mflare,and VCME using the vector magnetograms.Iflare and Mflare were found to have a good correlation with the total photospheric free magnetic energy density(Efree),the length of the magnetic neutral line with a steep horizontal magnetic gradient(LNL),and the area with strong magnetic shear(Aψ).Iflare and Mflare were also found to have a best correlation with Efree.However,VCME displayed a moderate correlation with these three magnetic field parameters with a best correlation with Aψ.Thus,Efree and Aψappear to be the best parameters that can be used to predict Iflare(Mflare)and VCME,respectively.Hence,the multiple linear regression fit is proposed more suitable to predict Iflare and Mflare because of the stronger forecasts obtained than those by the linear fit with one magnetic field parameter for Iflare and Mflare.However,the VCME forecasts are better obtained through the linear fit with Aψ.The majority of the ARs without any CMEs never produced any flare larger than X1.0 while having a relatively lower Efree,shorter LNL,and smaller Aψ.This suggests that the larger the largest flare in an AR is,the faster the fastest CME produced by the AR will be.展开更多
The discovery by the author of real magnetic charges and true anti-electrons in the atomic structures allowed him to establish that the gravitational field (GF) in reality is the vortex electromagnetic field. Dependin...The discovery by the author of real magnetic charges and true anti-electrons in the atomic structures allowed him to establish that the gravitational field (GF) in reality is the vortex electromagnetic field. Depending on the vector conditions the gravitational fields can be either paragravitational (PGF) or ferrogravitational (FGF). Masses (atoms, nucleons, etc.) emitting PGF manifest so-called attraction to each other. In fact, this process is the pressing of atoms or nucleons to each other by the forces of gravitational “Dark energy”. Namely the gravitational “Dark energy” which is formed between the masses emitting PGF and compressing of nucleons in atomic nuclei is the main force factor determining the formation of nuclear forces. Masses that emit FGF are repelled from PGF sources, for example, from the Earth. The last gravitational manifestation, discovered by the author, this is of the effect of the gravitational levitation. The atomic shell and atomic nucleus are autonomous sources of gravitational field in atomic compositions. The gravitational fields emitted these sources, by its physical parameters, are different gravitational fields, what associated with differences in the magnitudes charges of magnetic and electric particles in their compositions. The noted differences in the parameters of the GF are of reason that in atoms the process of extrusion of foreign gravitational field from the region of given gravitational source is realized. This effect should be called the effect of intra-atomic gravitational shielding (IAGS). Within the framework of this effect the shell of the atom is a kind of gravitational “insulator” that prevents the PGF of the nucleons from leaving beyond of the atom. As result of the IAGS effect, the concentration PGF of nucleons is realized only in the region of the nucleus, which leads to an increase in nuclear forces. However, the resistance of the marked “insulator” is finite and if the critical voltage PGF on the nucleus is exceeded, the complete shielding of展开更多
Magnetic flux ropes are characterized by coherently twisted magnetic field lines,which are ubiquitous in magnetized plasmas.As the core structure of various eruptive phenomena in the solar atmosphere,flux ropes hold t...Magnetic flux ropes are characterized by coherently twisted magnetic field lines,which are ubiquitous in magnetized plasmas.As the core structure of various eruptive phenomena in the solar atmosphere,flux ropes hold the key to understanding the physical mechanisms of solar eruptions,which impact the heliosphere and planetary atmospheres.The strongest disturbances in the Earth’s space environments are often associated with large-scale flux ropes from the Sun colliding with the Earth’s magnetosphere,leading to adverse,sometimes catastrophic,space-weather effects.However,it remains elusive as to how a flux rope forms and evolves toward eruption,and how it is structured and embedded in the ambient field.The present paper addresses these important questions by reviewing current understandings of coronal flux ropes from an observer’s perspective,with an emphasis on their structures and nascent evolution toward solar eruptions,as achieved by combining observations of both remote sensing and in-situ detection with modeling and simulation.This paper highlights an initiation mechanism for coronal mass ejections(CMEs)in which plasmoids in current sheets coalesce into a’seed’flux rope whose subsequent evolution into a CME is consistent with the standard model,thereby bridging the gap between microscale and macroscale dynamics.展开更多
The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric an...The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric and Magnetic fields. Also, every moving particle has a De Broglie wavelength determined by its mass and velocity. This paper shows that all of these properties of a particle can be derived from a single wave function equation for that particle. Wave functions for the Electron and the Positron are presented and principles are provided that can be used to calculate the wave functions of all the fundamental particles in Physics. Fundamental particles such as electrons and positrons are considered to be point particles in the Standard Model of Physics and are not considered to have a structure. This paper demonstrates that they do indeed have structure and that this structure extends into the space around the particle’s center (in fact, they have infinite extent), but with rapidly diminishing energy density with the distance from that center. The particles are formed from Electromagnetic standing waves, which are stable solutions to the Schrödinger and Classical wave equations. This stable structure therefore accounts for both the wave and particle nature of these particles. In fact, all of their properties such as mass, spin and electric charge, can be accounted for from this structure. These particle properties appear to originate from a single point at the center of the wave function structure, in the same sort of way that the Shell theorem of gravity causes the gravity of a body to appear to all originate from a central point. This paper represents the first two fully characterized fundamental particles, with a complete description of their structure and properties, built up from the underlying Electromagnetic waves that comprise these and all fundamental particles.展开更多
Erosion can influence cathode life,and is thus considered to be one of the main factors limiting the application of applied-field magnetoplasmadynamic thrusters.In this paper,erosion sites on graphite cathodes are stu...Erosion can influence cathode life,and is thus considered to be one of the main factors limiting the application of applied-field magnetoplasmadynamic thrusters.In this paper,erosion sites on graphite cathodes are studied so as to identify the influence of applied magnetic field and the ratio of propellant mass flow rate supplied from cathode and anode.The experiment results show that the application of applied magnetic field can significantly reduce the erosion rate of the cathode compared to that without magnetic field.The erosion sites on the cathode vary with the relative position of the convergent-divergent magnetic field,and are mainly distributed in the divergent part of the field.The erosion sites on the cathodes are found to be related to the propellant supply.The decreasing anode mass flow rate enlarges the range of erosion.These results are much helpful for the analysis of cathode erosion site location since they provide evidences of erosion mechanisms and point out the directions for further research.展开更多
Humic acids can promote the germination of many vegetable seeds,but the key active components remain unclear.This study utilized nutrient content,cross polarization magic angle spin ^(13)C solid magnetic resonance(CPM...Humic acids can promote the germination of many vegetable seeds,but the key active components remain unclear.This study utilized nutrient content,cross polarization magic angle spin ^(13)C solid magnetic resonance(CPMAS-^(13)C-NMR)and ultra-high performance liquid chromatography-mass spectrometry(UHPLC-MS)to characterize the chemical components of humic acids.Tomato seed germination index(GI)was determined with the goal of screening the key active components of humic acids.Humic acids had a significantly higher nutrient content,except for the total nitrogen(TN)and the total phosphorus(TP)contents.Humic acids had a higher content of O-CH_(3)/NCH,aromatic C-O and carbonyl C compared to weathered coal,with significantly lower anomeric C,aromatic C and O-alkyl C/alkyl C.There were 611 different compounds identified among the test materials using UHPLC-MS.Humic acids also had a significantly higher GI(158.0%and 153.1%)than weathered coal(85.5%).The organic matter(OM),TP and available potassium(AK)contents in humic acids were significantly positively correlated with GI,and available phosphorus(AP)was significantly negatively correlated.Among the carbon components,O-CH3/NCH,aromatic C-O and O-alkyl C/alkyl C were significantly positively correlated with GI,while anomeric C was significantly negatively correlated.Furthermore,among the top 10 positive and five negative correlation compounds,lipids and lipid-like molecules[armexifolin,boviquinone 4,3-methyladipic acid,lxocarpalactone A,monic acid,DG(20:1(11Z)/18:4(6Z,9Z,12Z,15Z)/0:0),and brassinolide]and organic acids and derivatives(N-acetylglutamic acid,8-hydroxy-5,6-octadienoic acid,acetyl-L-tyrosine,and hydroxyprolyl-methionine)in humic acids might be crucial active components for improving tomato seed germination.The results provided direct evidence for the identification of bioactive molecules of humic acids,and a scientific basis for the precise utilization of bioactive molecular components of humic acids in sustainable agricultural development.展开更多
Analysis of pesticide residue levels in juice beverages is important to ensure safe consumption and avoid global trade concerns associated to pesticide contaminations.A simple,inexpensive and effective method was deve...Analysis of pesticide residue levels in juice beverages is important to ensure safe consumption and avoid global trade concerns associated to pesticide contaminations.A simple,inexpensive and effective method was developed for the determination of organochlorine pesticides(OCPs)in bottled juice drinks using GC-MS.Sample pretreatment was performed using dispersive solid-phase microextraction(D-μ-SPE)for matrix desorption and dispersive liquid-liquid microextraction(DLLME)for analyte enrichment.In this study,an affordable and effective sorbent for the adsorption of OCPs from juice samples was synthesized from avocado seeds mixed with magnetic precursors for D-μSPE.The ground avocado seeds combined with a magnetic precursor nanocomposite were characterized using various instruments including scanning electron microscopy(SEM),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and Brunauer-Emmett-Teller(BET)analysis.The solution obtained from D-μ-SPE desorption was used as a dispersant for the subsequent DLLME,which made the combination of D-μ-SPE with DLLME much easier.The effectiveness of the method was enhanced by optimizing the influential parameters in both D-μ-SPE and DLLME.Then after,the optimal values were determined for the real sample analysis.Accordingly,there was good linear dynamic range with a coefficient of determination(r2)≥0.9989.The limit of detection and quantification were 0.02–0.69 and 0.06–2.10 ng/L respectively.The method showed high enrichment factors ranging from 96 to 313 with recoveries of 87–100%.Intraday and interday precisions were≤4%.Compared with other reported methods,this method is a one-step,simple,cheap,fast,and environmentally friendly alternative and straightforward method for adsorbing organochlorine pesticides from sample solutions.These results demonstrates the high potential of the proposed method for the extraction and cleanup of contaminants in selected juices and other related samples.展开更多
Solar active regions(ARs)are formed by the emergence of current-carrying magnetic flux tubes from below the photosphere.Although for an isolated flux tube the direct and return currents flowing along the tube should b...Solar active regions(ARs)are formed by the emergence of current-carrying magnetic flux tubes from below the photosphere.Although for an isolated flux tube the direct and return currents flowing along the tube should balance with each other,it remains controversial whether such a neutralization of currents is also maintained during the emergence process.Here we present a systematic survey of the degrees of the current neutralization in a large sample of flux-emerging ARs which appeared on the solar disk around the central meridian from 2010 to 2022.The vector magnetograms taken by Helioseismic and Magnetic Imager onboard Solar Dynamic Observatory are employed to calculate the distributions of the vertical current density at the photosphere.Focusing on the main phase of flux emergence,i.e.,the phase in which the total unsigned magnetic flux is continuously increased,we statistically examined the ratios of direct to return currents in all the ARs.Such a large-sample statistical study suggests that most of the ARs were born with currents close to neutralization.The degree of current neutralization seems to be not affected by the active-region size,the active-region growing rate,and the total unsigned current.The only correlation of significance as found is that the stronger the magnetic field nonpotentiality is,the further the AR deviates from current neutrality,which supports previous event studies that eruption-productive ARs often have non-neutralized currents.展开更多
The demand for optical glass has been rapidly increasing in various industries,where an ultra-smooth surface and form accuracy are critical for the functional elements of the applications.To meet the high surface-qual...The demand for optical glass has been rapidly increasing in various industries,where an ultra-smooth surface and form accuracy are critical for the functional elements of the applications.To meet the high surface-quality requirements,a polishing process is usually adopted to finish the optical glass surface to ensure an ultra-smooth surface and eliminate sub-surface damage.However,current ultra-precision polishing processes normally polish workpieces individually,leading to a low production efficiency and high polishing costs.Current mass-finishing methods cannot be used for optical glasses.Therefore,magnetic-field-assisted batch polishing(MABP)was proposed in this study to overcome this research gap and provide an efficient and cost-effective method for industrial use.A series of polishing experiments were conducted on typical optical components under different polishing parameters to evaluate the polishing performance of MABP on optical glasses.The results demonstrated that MABP is an efficient method to simultaneously polish multiple lenses while achieving a surface roughness,indicated by the arithmetic mean height(Sa),of 0.7 nm and maintained a sub-micrometer surface form for all the workpieces.In addition,no apparent sub-surface damage was observed,indicating the significant potential for the high-quality rapid polishing of optical glasses.The proposed method is highly competitive compared to the current optical polishing methods,which has the potential to revolutionize the polishing process for small optics.展开更多
In this paper,the authors discuss a three-dimensional problem of the semiconductor device type involved its mathematical description,numerical simulation and theoretical analysis.Two important factors,heat and magneti...In this paper,the authors discuss a three-dimensional problem of the semiconductor device type involved its mathematical description,numerical simulation and theoretical analysis.Two important factors,heat and magnetic influences are involved.The mathematical model is formulated by four nonlinear partial differential equations(PDEs),determining four major physical variables.The influences of magnetic fields are supposed to be weak,and the strength is parallel to the z-axis.The elliptic equation is treated by a block-centered method,and the law of conservation is preserved.The computational accuracy is improved one order.Other equations are convection-dominated,thus are approximated by upwind block-centered differences.Upwind difference can eliminate numerical dispersion and nonphysical oscillation.The diffusion is approximated by the block-centered difference,while the convection term is treated by upwind approximation.Furthermore,the unknowns and adjoint functions are computed at the same time.These characters play important roles in numerical computations of conductor device problems.Using the theories of priori analysis such as energy estimates,the principle of duality and mathematical inductions,an optimal estimates result is obtained.Then a composite numerical method is shown for solving this problem.展开更多
We review and summarize the applications of the Grad-Shafranov(GS) reconstruction technique to space plasma structures in the Earth's magnetosphere and in the interplanetary space. We organize our presentations fo...We review and summarize the applications of the Grad-Shafranov(GS) reconstruction technique to space plasma structures in the Earth's magnetosphere and in the interplanetary space. We organize our presentations following the branches of the "academic family tree" rooted on Prof. Bengt U. ? Sonnerup, the inventor of the GS method. Special attentions are paid to validations of the GS reconstruction results via(1) the direct validation by co-spatial in-situ measurements among multiple spacecraft, and(2) indirect validation by implications and interpretations of the physical connection between the structures reconstructed and other related processes. For the latter, the inter-comparison and interconnection between the large-scale magnetic flux ropes(i.e., Magnetic Clouds) in the solar wind and their solar source properties are presented. In addition, we also summarize various GS-type(or-like) reconstruction and an extension of the GS technique to toroidal geometry. In particular,we point to a possible advancement with added complexity of "helical symmetry" and mixed helicity, in the hope of stimulating interest in future development. We close by offering some thoughts on appreciating the scientific merit of GS reconstruction in general.展开更多
Serum biomarkers in the form of proteins （e.g. cluster of differentiation-44 （CD44）） have been demonstrated to have high clinical sensitivity and specificity for disease diagnosis and prognosis. Owing to the high ...Serum biomarkers in the form of proteins （e.g. cluster of differentiation-44 （CD44）） have been demonstrated to have high clinical sensitivity and specificity for disease diagnosis and prognosis. Owing to the high sample complexity and low molecular abundance in serum, the detection and profiling of biomarkers rely on efficient extraction by materials and devices, mostly using immunoassays via antibody-antigen recognition. Antibody-free approaches are promising and need to be developed for real-case applications in serum to address the limitations of antibody-based techniques in terms of robustness, expense, and throughput. In this work, we demonstrated a novel approach using hyaluronic acid （HA）-modified materials/devices for the extraction, detection, and profiling of serum biomarkers via ligand-protein interactions. We constructed Fe304@SiOa@HA particles with different sizes through layer-by-layer assembly and for the first time applied HA-functionalized particles in the facile extraction and sequence identification of CD44 in serum by mass spectrometry. We also first validated HA-CD44 binding through electrochemical sensing using HA- modified electrodes in both standard solutions and diluted serum samples, achieving a detection limit of -0.6 ng/mL and a linear response range from I ng/mL to 10 ~tg/mL. Furthermore, we performed profiling of HA-binding serum proteome, providing a new preliminary benchmark for the construction of future databases, and we investigated selected surface chemistries of particles for the capture of proteins in serum. Our work not only resulted in the development of a platform technology for CD44 extraction/detection and HA-binding proteome identification, but also guided the design of ligand affinity-based approaches for antibody-free analysis of serum biomarkers towards diagnostic applications.展开更多
基金Supported by Research Council of Norway,NO.70174300
文摘Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and noncancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis.
基金supported by the National Natural Science Foundation of China(Grant Nos.41327802,11573038,and 11873059)the Strategic Priority Program on Space Science,Chinese Academy of Sciences(Grant Nos.XDA15350203,and XDA15052200)the Basic Frontier Scientific Research Programs of Chinese Academy of Sciences(Grant No.ZDBS-LYSLH013)。
文摘In this paper,106 active regions(ARs)in the visible solar hemisphere in solar cycle 24 whose maximum sunspot groups’areas were larger than 400μh were selected.The association of their flare index(Iflare),largest flare magnitude(Mflare),and fastest coronal mass ejection(CME)velocity(VCME)with the vector magnetic field parameters were examined,and attempts were made to predict Iflare,Mflare,and VCME using the vector magnetograms.Iflare and Mflare were found to have a good correlation with the total photospheric free magnetic energy density(Efree),the length of the magnetic neutral line with a steep horizontal magnetic gradient(LNL),and the area with strong magnetic shear(Aψ).Iflare and Mflare were also found to have a best correlation with Efree.However,VCME displayed a moderate correlation with these three magnetic field parameters with a best correlation with Aψ.Thus,Efree and Aψappear to be the best parameters that can be used to predict Iflare(Mflare)and VCME,respectively.Hence,the multiple linear regression fit is proposed more suitable to predict Iflare and Mflare because of the stronger forecasts obtained than those by the linear fit with one magnetic field parameter for Iflare and Mflare.However,the VCME forecasts are better obtained through the linear fit with Aψ.The majority of the ARs without any CMEs never produced any flare larger than X1.0 while having a relatively lower Efree,shorter LNL,and smaller Aψ.This suggests that the larger the largest flare in an AR is,the faster the fastest CME produced by the AR will be.
文摘The discovery by the author of real magnetic charges and true anti-electrons in the atomic structures allowed him to establish that the gravitational field (GF) in reality is the vortex electromagnetic field. Depending on the vector conditions the gravitational fields can be either paragravitational (PGF) or ferrogravitational (FGF). Masses (atoms, nucleons, etc.) emitting PGF manifest so-called attraction to each other. In fact, this process is the pressing of atoms or nucleons to each other by the forces of gravitational “Dark energy”. Namely the gravitational “Dark energy” which is formed between the masses emitting PGF and compressing of nucleons in atomic nuclei is the main force factor determining the formation of nuclear forces. Masses that emit FGF are repelled from PGF sources, for example, from the Earth. The last gravitational manifestation, discovered by the author, this is of the effect of the gravitational levitation. The atomic shell and atomic nucleus are autonomous sources of gravitational field in atomic compositions. The gravitational fields emitted these sources, by its physical parameters, are different gravitational fields, what associated with differences in the magnitudes charges of magnetic and electric particles in their compositions. The noted differences in the parameters of the GF are of reason that in atoms the process of extrusion of foreign gravitational field from the region of given gravitational source is realized. This effect should be called the effect of intra-atomic gravitational shielding (IAGS). Within the framework of this effect the shell of the atom is a kind of gravitational “insulator” that prevents the PGF of the nucleons from leaving beyond of the atom. As result of the IAGS effect, the concentration PGF of nucleons is realized only in the region of the nucleus, which leads to an increase in nuclear forces. However, the resistance of the marked “insulator” is finite and if the critical voltage PGF on the nucleus is exceeded, the complete shielding of
基金supported by the National Natural Science Foundation of China(Grant Nos.41761134088,41774150,and 11925302)CAS Key Research Program(Grant No.KZZD-EW-01-4)the fundamental research funds for the central universities,and the Strategic Priority Program of the Chinese Academy of Sciences(Grant No.XDB41000000)。
文摘Magnetic flux ropes are characterized by coherently twisted magnetic field lines,which are ubiquitous in magnetized plasmas.As the core structure of various eruptive phenomena in the solar atmosphere,flux ropes hold the key to understanding the physical mechanisms of solar eruptions,which impact the heliosphere and planetary atmospheres.The strongest disturbances in the Earth’s space environments are often associated with large-scale flux ropes from the Sun colliding with the Earth’s magnetosphere,leading to adverse,sometimes catastrophic,space-weather effects.However,it remains elusive as to how a flux rope forms and evolves toward eruption,and how it is structured and embedded in the ambient field.The present paper addresses these important questions by reviewing current understandings of coronal flux ropes from an observer’s perspective,with an emphasis on their structures and nascent evolution toward solar eruptions,as achieved by combining observations of both remote sensing and in-situ detection with modeling and simulation.This paper highlights an initiation mechanism for coronal mass ejections(CMEs)in which plasmoids in current sheets coalesce into a’seed’flux rope whose subsequent evolution into a CME is consistent with the standard model,thereby bridging the gap between microscale and macroscale dynamics.
文摘The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric and Magnetic fields. Also, every moving particle has a De Broglie wavelength determined by its mass and velocity. This paper shows that all of these properties of a particle can be derived from a single wave function equation for that particle. Wave functions for the Electron and the Positron are presented and principles are provided that can be used to calculate the wave functions of all the fundamental particles in Physics. Fundamental particles such as electrons and positrons are considered to be point particles in the Standard Model of Physics and are not considered to have a structure. This paper demonstrates that they do indeed have structure and that this structure extends into the space around the particle’s center (in fact, they have infinite extent), but with rapidly diminishing energy density with the distance from that center. The particles are formed from Electromagnetic standing waves, which are stable solutions to the Schrödinger and Classical wave equations. This stable structure therefore accounts for both the wave and particle nature of these particles. In fact, all of their properties such as mass, spin and electric charge, can be accounted for from this structure. These particle properties appear to originate from a single point at the center of the wave function structure, in the same sort of way that the Shell theorem of gravity causes the gravity of a body to appear to all originate from a central point. This paper represents the first two fully characterized fundamental particles, with a complete description of their structure and properties, built up from the underlying Electromagnetic waves that comprise these and all fundamental particles.
基金supported by the Fundamental Research Program(No.11872093)。
文摘Erosion can influence cathode life,and is thus considered to be one of the main factors limiting the application of applied-field magnetoplasmadynamic thrusters.In this paper,erosion sites on graphite cathodes are studied so as to identify the influence of applied magnetic field and the ratio of propellant mass flow rate supplied from cathode and anode.The experiment results show that the application of applied magnetic field can significantly reduce the erosion rate of the cathode compared to that without magnetic field.The erosion sites on the cathode vary with the relative position of the convergent-divergent magnetic field,and are mainly distributed in the divergent part of the field.The erosion sites on the cathodes are found to be related to the propellant supply.The decreasing anode mass flow rate enlarges the range of erosion.These results are much helpful for the analysis of cathode erosion site location since they provide evidences of erosion mechanisms and point out the directions for further research.
基金Supported by the National Natural Science Foundation of China(42207371)the Technological Project of Jiangsu Vocational College of Agriculture and Forestry(2021kj17)+1 种基金Yafu Technology Innovation and Service Major Project of Jiangsu Vocational College of Agriculture and Forestry(2024kj01)Key Research Projects of Jiangsu Vocational College of Agriculture and Forestry(2023kj14)。
文摘Humic acids can promote the germination of many vegetable seeds,but the key active components remain unclear.This study utilized nutrient content,cross polarization magic angle spin ^(13)C solid magnetic resonance(CPMAS-^(13)C-NMR)and ultra-high performance liquid chromatography-mass spectrometry(UHPLC-MS)to characterize the chemical components of humic acids.Tomato seed germination index(GI)was determined with the goal of screening the key active components of humic acids.Humic acids had a significantly higher nutrient content,except for the total nitrogen(TN)and the total phosphorus(TP)contents.Humic acids had a higher content of O-CH_(3)/NCH,aromatic C-O and carbonyl C compared to weathered coal,with significantly lower anomeric C,aromatic C and O-alkyl C/alkyl C.There were 611 different compounds identified among the test materials using UHPLC-MS.Humic acids also had a significantly higher GI(158.0%and 153.1%)than weathered coal(85.5%).The organic matter(OM),TP and available potassium(AK)contents in humic acids were significantly positively correlated with GI,and available phosphorus(AP)was significantly negatively correlated.Among the carbon components,O-CH3/NCH,aromatic C-O and O-alkyl C/alkyl C were significantly positively correlated with GI,while anomeric C was significantly negatively correlated.Furthermore,among the top 10 positive and five negative correlation compounds,lipids and lipid-like molecules[armexifolin,boviquinone 4,3-methyladipic acid,lxocarpalactone A,monic acid,DG(20:1(11Z)/18:4(6Z,9Z,12Z,15Z)/0:0),and brassinolide]and organic acids and derivatives(N-acetylglutamic acid,8-hydroxy-5,6-octadienoic acid,acetyl-L-tyrosine,and hydroxyprolyl-methionine)in humic acids might be crucial active components for improving tomato seed germination.The results provided direct evidence for the identification of bioactive molecules of humic acids,and a scientific basis for the precise utilization of bioactive molecular components of humic acids in sustainable agricultural development.
基金This work was financially supported by the College of Natural Sciences,Jimma University through the grand research project(CNS-Chem-11-2020/21-SP1).
文摘Analysis of pesticide residue levels in juice beverages is important to ensure safe consumption and avoid global trade concerns associated to pesticide contaminations.A simple,inexpensive and effective method was developed for the determination of organochlorine pesticides(OCPs)in bottled juice drinks using GC-MS.Sample pretreatment was performed using dispersive solid-phase microextraction(D-μ-SPE)for matrix desorption and dispersive liquid-liquid microextraction(DLLME)for analyte enrichment.In this study,an affordable and effective sorbent for the adsorption of OCPs from juice samples was synthesized from avocado seeds mixed with magnetic precursors for D-μSPE.The ground avocado seeds combined with a magnetic precursor nanocomposite were characterized using various instruments including scanning electron microscopy(SEM),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and Brunauer-Emmett-Teller(BET)analysis.The solution obtained from D-μ-SPE desorption was used as a dispersant for the subsequent DLLME,which made the combination of D-μ-SPE with DLLME much easier.The effectiveness of the method was enhanced by optimizing the influential parameters in both D-μ-SPE and DLLME.Then after,the optimal values were determined for the real sample analysis.Accordingly,there was good linear dynamic range with a coefficient of determination(r2)≥0.9989.The limit of detection and quantification were 0.02–0.69 and 0.06–2.10 ng/L respectively.The method showed high enrichment factors ranging from 96 to 313 with recoveries of 87–100%.Intraday and interday precisions were≤4%.Compared with other reported methods,this method is a one-step,simple,cheap,fast,and environmentally friendly alternative and straightforward method for adsorbing organochlorine pesticides from sample solutions.These results demonstrates the high potential of the proposed method for the extraction and cleanup of contaminants in selected juices and other related samples.
基金supported by the National Natural Science Foundation of China(NSFC)U2031108Yunnan Key Laboratory of Solar Physics and Space Science under the number YNSPCC202213。
文摘Solar active regions(ARs)are formed by the emergence of current-carrying magnetic flux tubes from below the photosphere.Although for an isolated flux tube the direct and return currents flowing along the tube should balance with each other,it remains controversial whether such a neutralization of currents is also maintained during the emergence process.Here we present a systematic survey of the degrees of the current neutralization in a large sample of flux-emerging ARs which appeared on the solar disk around the central meridian from 2010 to 2022.The vector magnetograms taken by Helioseismic and Magnetic Imager onboard Solar Dynamic Observatory are employed to calculate the distributions of the vertical current density at the photosphere.Focusing on the main phase of flux emergence,i.e.,the phase in which the total unsigned magnetic flux is continuously increased,we statistically examined the ratios of direct to return currents in all the ARs.Such a large-sample statistical study suggests that most of the ARs were born with currents close to neutralization.The degree of current neutralization seems to be not affected by the active-region size,the active-region growing rate,and the total unsigned current.The only correlation of significance as found is that the stronger the magnetic field nonpotentiality is,the further the AR deviates from current neutrality,which supports previous event studies that eruption-productive ARs often have non-neutralized currents.
基金study was mainly supported by grants from the Research Grants Council of the Government of the Hong Kong Special Administrative Region,China(Project No.15203620)the Research and Innovation Office of The Hong Kong Polytechnic University(Project codes:BBXN and BBX5)research studentships(project code:RH3Y).The authors would also like to express their sincere thanks for the funding support from the State Key Laboratories in Hong Kong from the Innovation and Technology Commission(ITC)of the Government of the Hong Kong Special Administrative Region(HKSAR),China.
文摘The demand for optical glass has been rapidly increasing in various industries,where an ultra-smooth surface and form accuracy are critical for the functional elements of the applications.To meet the high surface-quality requirements,a polishing process is usually adopted to finish the optical glass surface to ensure an ultra-smooth surface and eliminate sub-surface damage.However,current ultra-precision polishing processes normally polish workpieces individually,leading to a low production efficiency and high polishing costs.Current mass-finishing methods cannot be used for optical glasses.Therefore,magnetic-field-assisted batch polishing(MABP)was proposed in this study to overcome this research gap and provide an efficient and cost-effective method for industrial use.A series of polishing experiments were conducted on typical optical components under different polishing parameters to evaluate the polishing performance of MABP on optical glasses.The results demonstrated that MABP is an efficient method to simultaneously polish multiple lenses while achieving a surface roughness,indicated by the arithmetic mean height(Sa),of 0.7 nm and maintained a sub-micrometer surface form for all the workpieces.In addition,no apparent sub-surface damage was observed,indicating the significant potential for the high-quality rapid polishing of optical glasses.The proposed method is highly competitive compared to the current optical polishing methods,which has the potential to revolutionize the polishing process for small optics.
基金supported by the National Natural Science Foundation of China(Grant No.11871312)Natural Science Foundation of Shandong Province(Grant No.ZR2021MA019).
文摘In this paper,the authors discuss a three-dimensional problem of the semiconductor device type involved its mathematical description,numerical simulation and theoretical analysis.Two important factors,heat and magnetic influences are involved.The mathematical model is formulated by four nonlinear partial differential equations(PDEs),determining four major physical variables.The influences of magnetic fields are supposed to be weak,and the strength is parallel to the z-axis.The elliptic equation is treated by a block-centered method,and the law of conservation is preserved.The computational accuracy is improved one order.Other equations are convection-dominated,thus are approximated by upwind block-centered differences.Upwind difference can eliminate numerical dispersion and nonphysical oscillation.The diffusion is approximated by the block-centered difference,while the convection term is treated by upwind approximation.Furthermore,the unknowns and adjoint functions are computed at the same time.These characters play important roles in numerical computations of conductor device problems.Using the theories of priori analysis such as energy estimates,the principle of duality and mathematical inductions,an optimal estimates result is obtained.Then a composite numerical method is shown for solving this problem.
基金supported by National Aeronautics and Space Administration (NASA) and National Science Foundation (NSF) (Grants Nos. AGS-1062050, NNG04GF47G, NNG06GD41G, NNX12AF97G, NNX12AH50G, NNH13ZDA001N, and NNX14AF41G)
文摘We review and summarize the applications of the Grad-Shafranov(GS) reconstruction technique to space plasma structures in the Earth's magnetosphere and in the interplanetary space. We organize our presentations following the branches of the "academic family tree" rooted on Prof. Bengt U. ? Sonnerup, the inventor of the GS method. Special attentions are paid to validations of the GS reconstruction results via(1) the direct validation by co-spatial in-situ measurements among multiple spacecraft, and(2) indirect validation by implications and interpretations of the physical connection between the structures reconstructed and other related processes. For the latter, the inter-comparison and interconnection between the large-scale magnetic flux ropes(i.e., Magnetic Clouds) in the solar wind and their solar source properties are presented. In addition, we also summarize various GS-type(or-like) reconstruction and an extension of the GS technique to toroidal geometry. In particular,we point to a possible advancement with added complexity of "helical symmetry" and mixed helicity, in the hope of stimulating interest in future development. We close by offering some thoughts on appreciating the scientific merit of GS reconstruction in general.
文摘Serum biomarkers in the form of proteins （e.g. cluster of differentiation-44 （CD44）） have been demonstrated to have high clinical sensitivity and specificity for disease diagnosis and prognosis. Owing to the high sample complexity and low molecular abundance in serum, the detection and profiling of biomarkers rely on efficient extraction by materials and devices, mostly using immunoassays via antibody-antigen recognition. Antibody-free approaches are promising and need to be developed for real-case applications in serum to address the limitations of antibody-based techniques in terms of robustness, expense, and throughput. In this work, we demonstrated a novel approach using hyaluronic acid （HA）-modified materials/devices for the extraction, detection, and profiling of serum biomarkers via ligand-protein interactions. We constructed Fe304@SiOa@HA particles with different sizes through layer-by-layer assembly and for the first time applied HA-functionalized particles in the facile extraction and sequence identification of CD44 in serum by mass spectrometry. We also first validated HA-CD44 binding through electrochemical sensing using HA- modified electrodes in both standard solutions and diluted serum samples, achieving a detection limit of -0.6 ng/mL and a linear response range from I ng/mL to 10 ~tg/mL. Furthermore, we performed profiling of HA-binding serum proteome, providing a new preliminary benchmark for the construction of future databases, and we investigated selected surface chemistries of particles for the capture of proteins in serum. Our work not only resulted in the development of a platform technology for CD44 extraction/detection and HA-binding proteome identification, but also guided the design of ligand affinity-based approaches for antibody-free analysis of serum biomarkers towards diagnostic applications.
