In order to study their synergistic catalytic effects in toluene degradation, CuMn2O4/HTS-1(HTS-1 was a titanium silicon molecular sieve), Cu0.7Mn2Y0.3Ox/HTS-1 and Cu0.7Mn2Ce0.3Ox/HTS-1 catalysts were prepared by the ...In order to study their synergistic catalytic effects in toluene degradation, CuMn2O4/HTS-1(HTS-1 was a titanium silicon molecular sieve), Cu0.7Mn2Y0.3Ox/HTS-1 and Cu0.7Mn2Ce0.3Ox/HTS-1 catalysts were prepared by the impregnation method.The textural properties, redox properties and acidity of the catalysts were characterized by X-ray diffractometer(XRD),transmission electron microscopy(TEM), scanning electron microscopy(SEM), H2 temperature-programmed reduction(H2-TPR), X-ray photoelectron spectroscopy(XPS),frustrated total internal reflection(FT-IR), ammonium temperature-programmed desorption(NH3-TPD) and pyridine adsorption internal reflection(Py-IR) measurements.The potential roles of Lewis acid sites(activating dioxygen) were discussed, and the experimental results indicated that the most efficient route for toluene degradation over Cu0.7Mn2Ce0.3Ox/HTS-1(toluene conversion rate of 90%(T99) = 295℃) was ascribed to regulation of the synergistic effects of redox properties(activating molecular toluene) and Lewis acid sites(activating dioxygen).The Mars–Van–Krevelen(MVK) model was adopted to describe the reaction process of toluene oxidation, which gave an in-depth view into the toluene degradation over CuMn2O4/HTS-1, Cu0.7Mn2Y0.3Ox/HTS-1 and Cu0.7Mn2Ce0.3Ox/HTS-1.In addition, the synergistic effects between redox properties and Lewis acid sites were studied in detail.展开更多
Mutation of mevalonate kinase （MVK） is thought to account for most cases of hyperimmunoglobulinemia D syndrome （HIDS） with recurrent fever. However, its mechanism and the relationship between elevated serum immuno...Mutation of mevalonate kinase （MVK） is thought to account for most cases of hyperimmunoglobulinemia D syndrome （HIDS） with recurrent fever. However, its mechanism and the relationship between elevated serum immunoglobulin D （IgD） and the clinical features of HIDS are unclear. In this study, we generated by fusion PCR a vector to express high levels of chimeric secretory IgD （cslgD） specifically in the liver. We then generated seven founder lines of transgenic mice by co-microinjection, and verified them using genomic PCR and Southern blotting. We detected the expression of csIgD by reverse transcription PCR, quantitative PCR, western blotting, and enzyme-linked immunosorbent assays. We demonstrated that csIgD could be specifically and stably expressed in the liver. We used flow cytometry to show that overexpression of csIgD in the bone marrow and spleen cells had no effect on B cell development. Morphologic and anatomical observation of the transgenic mice revealed skin damage, hepatosplenomegaly, and nephromegaly in some transgenic mice; in these mice, pathological sections showed high levels of cell necrosis and protein-like sediments in the liver, spleen, and kidney. We demonstrated that the genomic insertion sites of the transgeues did not disrupt the MVK gene on mouse chromosome 5. This transgenic mouse will be useful to explore the pathogenesis of HIDS.展开更多
Methyl vinyl ketone （MVK） is a kind of high-value chemical which has been widely used in many fields. In this paper, it is formed from oxidation of levulinic acid--a hydrolysis product of biomass. Copper oxide suppo...Methyl vinyl ketone （MVK） is a kind of high-value chemical which has been widely used in many fields. In this paper, it is formed from oxidation of levulinic acid--a hydrolysis product of biomass. Copper oxide supported on cerium dioxide （CuO/CeO2） and alumina （CuO/AI203） were prepared and used for the oxidation of levulinic acid （LA）. The oxidants were characterized by means of X-ray diffraction （XRD）, H2-temperature programmed reduction （H2-TPR） and atomic force microscope （AFM） techniques. CuO/CeO2 and CuO/A1203 show a different behav- ior with respect to pure CuO. The experiments revealed that CuO/CeO2 and CuO/AI203 can oxidize LA and get methyl vinyl ketone [yield of 15.5% detected by head space-gas chromatograph-mass spectrometer （HS-GC-MS）] under mild reactive conditions, while pure CuO oxidizes LA to produce butanone （MEK）.展开更多
In this paper, the Global Satellite Mapping of Precipitation Moving Vector with Kalman filter (GSMaP_MVK) was evaluated and corrected at daily time scales with a spatial resolution of 0.1°;latitude/longitude. The...In this paper, the Global Satellite Mapping of Precipitation Moving Vector with Kalman filter (GSMaP_MVK) was evaluated and corrected at daily time scales with a spatial resolution of 0.1°;latitude/longitude. The reference data came from thirty-four rain gauges on Kyushu Island, Japan. This study focused on the GSMaP_MVK’s ability to detect heavy rainfall patterns that may lead to flooding. Statistical analysis was used to evaluate the GSMaP_MVK data both quantitatively and qualitatively. The statistical analysis included the relative bias (B), the mean error (E), the Nash-Sutcliffe coefficient (CNS), the Root Mean Square Error (RMSE) and the correlation coefficient (r). In addition, Generalized Additive Models (GAMs) were used to conduct GSMaP_MVK data correction. The results of these analyses indicate that GSMaP_MVK data have lower values than observed data and may be significantly underestimated during heavy rainfall. By applying GAM to bias correction, GSMaP_MVK’s ability to detect heavy rainfall was improved. In addition, GAM for bias correction could effectively be applied for significant underestimates of GSMaP_ MVK (i.e., bias of more than 55%). GAM is a new approach to predict rainfall amount for flood and landslide monitoring of satellite base precipitation, especially in areas where rain gauge data are limited.展开更多
基金supported by the Ministry of Education Blue Fire Program(No.CXZJH201717)Shijiazhuang Science and Technology Department(Nos.181240243A and 191240273A).
文摘In order to study their synergistic catalytic effects in toluene degradation, CuMn2O4/HTS-1(HTS-1 was a titanium silicon molecular sieve), Cu0.7Mn2Y0.3Ox/HTS-1 and Cu0.7Mn2Ce0.3Ox/HTS-1 catalysts were prepared by the impregnation method.The textural properties, redox properties and acidity of the catalysts were characterized by X-ray diffractometer(XRD),transmission electron microscopy(TEM), scanning electron microscopy(SEM), H2 temperature-programmed reduction(H2-TPR), X-ray photoelectron spectroscopy(XPS),frustrated total internal reflection(FT-IR), ammonium temperature-programmed desorption(NH3-TPD) and pyridine adsorption internal reflection(Py-IR) measurements.The potential roles of Lewis acid sites(activating dioxygen) were discussed, and the experimental results indicated that the most efficient route for toluene degradation over Cu0.7Mn2Ce0.3Ox/HTS-1(toluene conversion rate of 90%(T99) = 295℃) was ascribed to regulation of the synergistic effects of redox properties(activating molecular toluene) and Lewis acid sites(activating dioxygen).The Mars–Van–Krevelen(MVK) model was adopted to describe the reaction process of toluene oxidation, which gave an in-depth view into the toluene degradation over CuMn2O4/HTS-1, Cu0.7Mn2Y0.3Ox/HTS-1 and Cu0.7Mn2Ce0.3Ox/HTS-1.In addition, the synergistic effects between redox properties and Lewis acid sites were studied in detail.
基金supported by the National Basic Research Program of China(Grant No.2010CB945300)
文摘Mutation of mevalonate kinase （MVK） is thought to account for most cases of hyperimmunoglobulinemia D syndrome （HIDS） with recurrent fever. However, its mechanism and the relationship between elevated serum immunoglobulin D （IgD） and the clinical features of HIDS are unclear. In this study, we generated by fusion PCR a vector to express high levels of chimeric secretory IgD （cslgD） specifically in the liver. We then generated seven founder lines of transgenic mice by co-microinjection, and verified them using genomic PCR and Southern blotting. We detected the expression of csIgD by reverse transcription PCR, quantitative PCR, western blotting, and enzyme-linked immunosorbent assays. We demonstrated that csIgD could be specifically and stably expressed in the liver. We used flow cytometry to show that overexpression of csIgD in the bone marrow and spleen cells had no effect on B cell development. Morphologic and anatomical observation of the transgenic mice revealed skin damage, hepatosplenomegaly, and nephromegaly in some transgenic mice; in these mice, pathological sections showed high levels of cell necrosis and protein-like sediments in the liver, spleen, and kidney. We demonstrated that the genomic insertion sites of the transgeues did not disrupt the MVK gene on mouse chromosome 5. This transgenic mouse will be useful to explore the pathogenesis of HIDS.
基金Project supported by the National Key Basic Research Program （No. 2010CB732201） from the Ministry of Science and Technology of China and the National Natural Science Foundation of China （Nos. U0733001, 50776035）.
文摘Methyl vinyl ketone （MVK） is a kind of high-value chemical which has been widely used in many fields. In this paper, it is formed from oxidation of levulinic acid--a hydrolysis product of biomass. Copper oxide supported on cerium dioxide （CuO/CeO2） and alumina （CuO/AI203） were prepared and used for the oxidation of levulinic acid （LA）. The oxidants were characterized by means of X-ray diffraction （XRD）, H2-temperature programmed reduction （H2-TPR） and atomic force microscope （AFM） techniques. CuO/CeO2 and CuO/A1203 show a different behav- ior with respect to pure CuO. The experiments revealed that CuO/CeO2 and CuO/AI203 can oxidize LA and get methyl vinyl ketone [yield of 15.5% detected by head space-gas chromatograph-mass spectrometer （HS-GC-MS）] under mild reactive conditions, while pure CuO oxidizes LA to produce butanone （MEK）.
文摘In this paper, the Global Satellite Mapping of Precipitation Moving Vector with Kalman filter (GSMaP_MVK) was evaluated and corrected at daily time scales with a spatial resolution of 0.1°;latitude/longitude. The reference data came from thirty-four rain gauges on Kyushu Island, Japan. This study focused on the GSMaP_MVK’s ability to detect heavy rainfall patterns that may lead to flooding. Statistical analysis was used to evaluate the GSMaP_MVK data both quantitatively and qualitatively. The statistical analysis included the relative bias (B), the mean error (E), the Nash-Sutcliffe coefficient (CNS), the Root Mean Square Error (RMSE) and the correlation coefficient (r). In addition, Generalized Additive Models (GAMs) were used to conduct GSMaP_MVK data correction. The results of these analyses indicate that GSMaP_MVK data have lower values than observed data and may be significantly underestimated during heavy rainfall. By applying GAM to bias correction, GSMaP_MVK’s ability to detect heavy rainfall was improved. In addition, GAM for bias correction could effectively be applied for significant underestimates of GSMaP_ MVK (i.e., bias of more than 55%). GAM is a new approach to predict rainfall amount for flood and landslide monitoring of satellite base precipitation, especially in areas where rain gauge data are limited.
