胞外pH值的下降能激活一种在体内广泛分布的特殊配体门控通道,即酸敏感离子通道(scid-sensing ion channels, ASICs)。ASICs也称作H+门控离子通道,是上皮钠离子通道/退化蛋白(ENaC/DEG)超家族一个分支。ASICs由5个功能基因编码,分别为AS...胞外pH值的下降能激活一种在体内广泛分布的特殊配体门控通道,即酸敏感离子通道(scid-sensing ion channels, ASICs)。ASICs也称作H+门控离子通道,是上皮钠离子通道/退化蛋白(ENaC/DEG)超家族一个分支。ASICs由5个功能基因编码,分别为ASIC1、ASIC2、ASIC3、ASIC4和ASIC5。迄今为止,已克隆出ASICs的7个亚单位:ASIC1a、ASIC1b、ASIC2a、ASIC2b、ASIC3、ASIC4、ASIC5,不同亚基存在分布特异性,7个亚基可以组成同聚体或异聚体酸敏感离子通道。ASIC1a是哺乳动物体内含量最为丰富的ASICs亚基,由ASIC1基因编码,广泛分布于中枢神经系统和外周感觉神经元。展开更多
Analysis of the secondary structures of mRNAs which encode mature peptides shows that the location of each codon in mRNA secondary structure has a trend, which appears to be in agreement with the conformational proper...Analysis of the secondary structures of mRNAs which encode mature peptides shows that the location of each codon in mRNA secondary structure has a trend, which appears to be in agreement with the conformational property of the corresponding amino acid to some extent. Most of the codons that encode hydrophobic amino acids are located in stable stem regions of mRNA secondary structures, and vice versa, most of the codons that encode hydrophilic amino acids are located in flexible loop regions. This result supports the recent conclusion that there may be the information transfer between the three dimensional structures of mRNA and the encoded protein.展开更多
文摘胞外pH值的下降能激活一种在体内广泛分布的特殊配体门控通道,即酸敏感离子通道(scid-sensing ion channels, ASICs)。ASICs也称作H+门控离子通道,是上皮钠离子通道/退化蛋白(ENaC/DEG)超家族一个分支。ASICs由5个功能基因编码,分别为ASIC1、ASIC2、ASIC3、ASIC4和ASIC5。迄今为止,已克隆出ASICs的7个亚单位:ASIC1a、ASIC1b、ASIC2a、ASIC2b、ASIC3、ASIC4、ASIC5,不同亚基存在分布特异性,7个亚基可以组成同聚体或异聚体酸敏感离子通道。ASIC1a是哺乳动物体内含量最为丰富的ASICs亚基,由ASIC1基因编码,广泛分布于中枢神经系统和外周感觉神经元。
文摘Analysis of the secondary structures of mRNAs which encode mature peptides shows that the location of each codon in mRNA secondary structure has a trend, which appears to be in agreement with the conformational property of the corresponding amino acid to some extent. Most of the codons that encode hydrophobic amino acids are located in stable stem regions of mRNA secondary structures, and vice versa, most of the codons that encode hydrophilic amino acids are located in flexible loop regions. This result supports the recent conclusion that there may be the information transfer between the three dimensional structures of mRNA and the encoded protein.
