Coherent Jamming is one of the Important trends in modern radar electronic warfare. High-speed sampling of wldeband radio frequency （RF） signals and high isolatlon of two receive-transmit antennas are key technologi...Coherent Jamming is one of the Important trends in modern radar electronic warfare. High-speed sampling of wldeband radio frequency （RF） signals and high isolatlon of two receive-transmit antennas are key technologies for the realization of coherent jamming. However, these technologies present significant challenges to enginserlng application. In this paper, a novel repeater Jamming based on interrupted sampling technique is presented. For a Jammer with a receive-transmit time-sharing antenna, a radar signal is sampled with a low rate by the jammer. Then, a train of false targets will be achieved after the Jamming signal feed the matched flltar of a pulse compression radar. For the case of the Ilnser frequency modulated （LFM） pulse compression radars, mathematic principles of the interrupted.sampiing repeater jamming Is developed, and then the efficiency of the jamming is described and stated as expressions of key parameters which are also beneficial to the Jamming design for other coherent radars.展开更多
AIM： To compare the volumetric-modulated arc ther- apy （VMAT） plans with conventional sliding window intensity-modulated radiotherapy （c-IMRT） plans in esophageal cancer （EC）. METHODS： Twenty patients with EC ...AIM： To compare the volumetric-modulated arc ther- apy （VMAT） plans with conventional sliding window intensity-modulated radiotherapy （c-IMRT） plans in esophageal cancer （EC）. METHODS： Twenty patients with EC were selected, including 5 cases located in the cervical, the upper, the middle and the lower thorax, respectively. Five plans were generated with the eclipse planning sys- tem： three using c-IMRT with 5 fields （5F）, 7 fields （7F） and 9 fields （gF）, and two using VMAT with a single arc （1A） and double arcs （2A）. The treatment plans were designed to deliver a dose of 60 Gy to the plan-ning target volume （PTV） with the same constrains in a 2.0 Gy daily fraction, 5 d a week. Plans were normal- ized to 95% of the PTV that received 100% of the pre- scribed dose. We examined the dose-volume histogram parameters of PTV and the organs at risk （OAR） such as lungs, spinal cord and heart. Monitor units （MU） and normal tissue complication probability （NTCP） of OAR were also reported. RESULTS： Both c-IMRT and VMAT plans resulted in abundant dose coverage of PTV for EC of different Io- cations. The dose conformity to PTV was improved as the number of field in c-IMRT or rotating arc in VMAT was increased. The doses to PTV and OAR in VMAT plans were not statistically different in comparison with c-IMRT plans, with the following exceptions： in cervical and upper thoracic EC, the conformity index （CI） was higher in VMAT （1A 0.78 and 2A 0.8） than in c-IMRT （5F 0.62, 7F 0.66 and 9F 0.73） and homogeneity was slightly better in c-IMRT （7F 1.09 and 9F 1.07） than in VMAT （1A 1,1 and 2A 1.09）, Lung V30 was lower in VMAT （1A 12.52 and 2A 12.29） than in c-IMRT （7F 14.35 and 9F 14.81）. The humeral head doses were significantly increased in VMAT as against c-IMRT. In the middle and lower thoracic EC, CI in VMAT （1A 0.76 and 2A 0.74） was higher than in c-IMRT （5F 0.63 Gy and 7F 0.67 Gy）, and homogeneity was almost similar between VMAT and c-IMRT展开更多
Stochastic resonance system is subject to the restriction of small frequency parameter in weak signal detection,in order to solve this problem,a frequency modulated weak signal detection method based on stochastic res...Stochastic resonance system is subject to the restriction of small frequency parameter in weak signal detection,in order to solve this problem,a frequency modulated weak signal detection method based on stochastic resonance and genetic algorithm is presented in this paper. The frequency limit of stochastic resonance is eliminated by introducing carrier signal,which is multiplied with the measured signal to be injected in the stochastic resonance system,meanwhile,using genetic algorithm to optimize the carrier signal frequency,which determine the generated difference-frequency signal in the lowfrequency range,so as to achieve the stochastic resonance weak signal detection. Results showthat the proposed method is feasible and effective,which can significantly improve the output SNR of stochastic resonance,in addition,the system has the better self-adaptability,according to the operation result and output phenomenon,the unknown frequency of the signal to be measured can be obtained,so as to realize the weak signal detection of arbitrary frequency.展开更多
The traditional anomaly （TA） reference frame and its corresponding anomaly for a given data span changes with the extension of data length. In this study, the modulated annual cycle （MAC）, instead of the widely us...The traditional anomaly （TA） reference frame and its corresponding anomaly for a given data span changes with the extension of data length. In this study, the modulated annual cycle （MAC）, instead of the widely used climatological mean annual cycle, is used as an alternative reference frame for computing climate anomalies to study the multi-timescale variability of surface air temperature （SAT） in China based on homogenized daily data from 1952 to 2004. The Ensemble Empirical Mode Decomposition （EEMD） method is used to separate daily SAT into a high frequency component, a MAC component, an interannual component, and a decadal-to-trend component. The results show that the EEMD method can reflect historical events reasonably well, indicating its adaptive and temporally local characteristics. It is shown that MAC is a temporally local reference frame and will not be altered over a particular time span by an exten-sion of data length, thereby making it easier for physical interpretation. In the MAC reference frame, the low frequency component is found more suitable for studying the interannual to longer timescale variability （ILV） than a 13-month window running mean, which does not exclude the annual cycle. It is also better than other traditional versions （annual or summer or winter mean） of ILV, which contains a portion of the annual cycle. The analysis reveals that the variability of the annual cycle could be as large as the magnitude of interannual variability. The possible physical causes of different timescale variability of SAT in China are further discussed.展开更多
Trends in the frequencies of four temperature extremes （the occurrence of warm days, cold days, warm nights and cold nights） with respect to a modulated annual cycle （MAC）, and those associated exclusively with we...Trends in the frequencies of four temperature extremes （the occurrence of warm days, cold days, warm nights and cold nights） with respect to a modulated annual cycle （MAC）, and those associated exclusively with weather-intraseasonal fluctuations （WIF） in eastern China were investigated based on an updated homogenized daily maximum and minimum temperature dataset for 1960–2008. The Ensemble Empirical Mode Decomposition （EEMD） method was used to isolate the WIF, MAC, and longer-term components from the temperature series. The annual, winter and summer occurrences of warm （cold） nights were found to have increased （decreased） significantly almost everywhere, while those of warm （cold） days have increased （decreased） in northern China （north of 40°N）. However, the four temperature extremes associated exclusively with WIF for winter have decreased almost everywhere, while those for summer have decreased in the north but increased in the south. These characteristics agree with changes in the amplitude of WIF. In particular, winter WIF of maximum temperature tended to weaken almost everywhere, especially in eastern coastal areas （by 10%–20%）; summer WIF tended to intensify in southern China by 10%–20%. It is notable that in northern China, the occurrence of warm days has increased, even where that associated with WIF has decreased significantly. This suggests that the recent increasing frequency of warm extremes is due to a considerable rise in the mean temperature level, which surpasses the effect of the weakening weather fluctuations in northern China.展开更多
Zinc and Zn-Ni alloy compositionally modulated multilayer （CMM） coatings were electrodeposited on to a steel substrate by the successive deposition of zinc and Zn-Ni alloy sublayers from dual baths. The coated sampl...Zinc and Zn-Ni alloy compositionally modulated multilayer （CMM） coatings were electrodeposited on to a steel substrate by the successive deposition of zinc and Zn-Ni alloy sublayers from dual baths. The coated samples were evaluated in terms of the surface appearance, surface and cross-sectional morphologies, as well as corrosion resistance. The microstructural characteristics that were examined using the field emission gun scanning electron microscopy （FEGSEM） confirmed the layered structure, grain refinement of the zinc and Zn-Ni alloy CMM coatings, and revealed the existence of microcracks caused by the internal stress in the thick Zn-Ni alloy sublayers. The corrosion resistance that was evaluated by means of the salt spray test shows that the zinc and Zn-Ni alloy CMM coatings were more corrosion-resistant than the monolithic coatings of zinc or Zn-Ni alloy of the same thickness. The possible reasons for the better protective performance of Zn-Ni/Zn CMM coatings were given on the basis of the analysis on the micrographic features of zinc and Zn-Ni alloy CMM eoatings after the corrosion test. A probable corrosion mechanism of zinc and Zn-Ni alloy CMM coatings was also proposed.展开更多
Outcomes in patients with gastric cancer in the United States remain disappointing, with a five-year overall survival rate of approximately 23%. Given high rates of local-regional control following surgery, a strong r...Outcomes in patients with gastric cancer in the United States remain disappointing, with a five-year overall survival rate of approximately 23%. Given high rates of local-regional control following surgery, a strong rationale exists for the use of adjuvant radiation therapy. Randomized trials have shown superior local control with adjuvant radiotherapy and improved overall survival with adjuvant chemoradiation. The benefit of adjuvant chemoradiation in patients who have undergone D2 lymph node dissection by an experienced surgeon is not known, and the benefit of adjuvant radiation therapy in addition to adjuvant chemotherapy continues to be defined. In unresectable disease, chemoradiation allows long-term survival in a small number of patients and provides effective palliation. Most trials show a benefit to combined modality therapy compared to chemotherapy or radiation therapy alone. The use of pre-operative, intra-operative, 3D conformal, and intensity modulated radiation therapy in gastric cancer is promising but requires further study. The current article reviews the role of radiation therapy in the treatment of resectable and unresectable gastric carcinoma, focusing on current recommendations in the United States.展开更多
Climatic changes in the onset of spring in northern China associated with changes in the annual cycle and with a recent warming trend were quantified using a recently developed adaptive data analysis tool, the Ensembl...Climatic changes in the onset of spring in northern China associated with changes in the annual cycle and with a recent warming trend were quantified using a recently developed adaptive data analysis tool, the Ensemble Empirical Mode Decomposition. The study was based on a homogenized daily surface air temperature （SAT） dataset for the period 1955–2003. The annual cycle here is referred to as a refined modulated annual cycle （MAC）. The results show that spring at Beijing has arrived significantly earlier by about 2.98 d （10 yr）-1, of which about 1.85 d （10 yr）-1 is due to changes in the annual cycle and 1.13 d （10 yr）-1 due to the long-term warming trend. Variations in the MAC component explain about 92.5% of the total variance in the Beijing daily SAT series and could cause as much as a 20-day shift in the onset of spring from one year to another. The onset of spring has been advancing all over northern China, but more significant in the east than in the west part of the region. These differences are somehow unexplainable by the zonal pattern of the warming trend over the whole region, but can be explained by opposite changes in the spring phase of the MAC, i.e. advancing in the east while delaying in the west. In the east of northern China, the change in the spring phase of MAC explains 40%–60% of the spring onset trend and is attributable to a weakening Asian winter monsoon. The average sea level pressure in Siberia （55°–80°N, 50°–110°E）, an index of the strength of the winter monsoon, could serve as a potential short-term predictor for the onset of spring in the east of northern China.展开更多
A new method is proposed to analyze multi-component linear frequency modulated （LFM） signals, which eliminates cross terms in conventional Wigner-Ville distribution （WVD）. The approach is based on Radon transform ...A new method is proposed to analyze multi-component linear frequency modulated （LFM） signals, which eliminates cross terms in conventional Wigner-Ville distribution （WVD）. The approach is based on Radon transform and Hilbert-Huang transform （HHT）, which is a recently developed method adaptive to non-linear and non-stationary signals. The complicated signal is decomposed into several intrinsic mode functions （IMF） by the empirical mode decomposition （EMD）, which makes the consequent instantaneous frequency meaningful. After the instantaneous frequency and Hilbert spectrum are computed, multi-component LFM signals detection and parameter estimation are obtained using Radon transform on the Hilbert spectrum plane. The simulation results show its feasibility and effectiveness.展开更多
Objective: A dosimetric study was performed to evaluate the performance of volumetric modulated arc radiotherapy with RapidArc on locally advanced nasopharyngeal carcinoma (NPC). Methods: The CT scan data sets of 20 p...Objective: A dosimetric study was performed to evaluate the performance of volumetric modulated arc radiotherapy with RapidArc on locally advanced nasopharyngeal carcinoma (NPC). Methods: The CT scan data sets of 20 patients of locally advanced NPC were selected randomly. The plans were managed using volumetric modulated arc with RapidArc and fixed nine-field coplanar dynamic intensity-modulated radiotherapy (IMRT) for these patients. The dosimetry of the planning target volumes (PTV), the organs at risk (OARs) and the healthy tissue were evaluated. The dose prescription was set to 70 Gy to the primary tumor and 60 Gy to the clinical target volumes (CTV) in 33 fractions. Each fraction applied daily, five fractions per week. The monitor unit (MU) values and the delivery time were scored to evaluate the expected treatment efficiency. Results: Both techniques had reached clinical treatment’s requirement. The mean dose (Dmean), maximum dose (Dmax) and minimum dose (Dmin) in RapidArc and fixed field IMRT for PTV were 68.4±0.6 Gy, 74.8±0.9 Gy and 56.8±1.1 Gy; and 67.6±0.6 Gy, 73.8±0.4 Gy and 57.5±0.6 Gy (P<0.05), respectively. Homogeneity index was 78.85±1.29 in RapidArc and 80.34±0.54 (P<0.05) in IMRT. The conformity index (CI: 95%) was 0.78±0.01 for both techniques (P>0.05). Compared to IMRT, RapidArc allowed a reduction of Dmean to the brain stem, mandible and optic nerves of 14.1% (P<0.05), 5.6% (P<0.05) and 12.2% (P<0.05), respectively. For the healthy tissue and the whole absorbed dose, Dmean of RapidArc was reduced by 3.6% (P<0.05), and 3.7% (P<0.05), respectively. The Dmean to the parotids, the spinal cord and the lens had no statistical difference among them. The mean MU values of RapidArc and IMRT were 550 and 1,379. The mean treatment time of RapidArc and IMRT was 165 s and 447 s. Compared to IMRT, the delivery time and the MU values of RapidArc were reduced by 63% and 60%, respectively. Conclusion: For locally advanced NPC, both RapidArc and IMRT reached the clinic requirement. The target volume 展开更多
The flow field of the oil film between frictional pairs in the hydroviscous drive test rig is investigated. A three-dimensional Navier-Stokes（N-S） equation considering viscous force and inertial force rather than Re...The flow field of the oil film between frictional pairs in the hydroviscous drive test rig is investigated. A three-dimensional Navier-Stokes（N-S） equation considering viscous force and inertial force rather than Reynolds equation or modified Reynolds equation is presented to model the flow field. Pressure and temperature distribution in radial and circumferential direction under three different conditions, i.e., isothermal, that considering viscosity-temperature characteristic as well as shear thinning non-Newtonian fluid are simulated, respectively, by utilizing the commercial computational fluid dynamics（CFD） software FLUENT. The results reveal that the grooves on the driven plate make the pressure, temperature distribution present periodic variation. The oil temperature and shear rate have important effects on the flow field between frictional pairs, and the oil temperature is more important parameter. The simulation results lay a theoretical foundation for the reasonable designs ofhydroviscous drive.展开更多
AIM To analyse clinical and dosimetric results of helical tomotherapy(HT) and volumetric modulated arc therapy(VMAT) in complex adjuvant breast and nodes irradiation.METHODS Seventy-three patients were included(31 HT ...AIM To analyse clinical and dosimetric results of helical tomotherapy(HT) and volumetric modulated arc therapy(VMAT) in complex adjuvant breast and nodes irradiation.METHODS Seventy-three patients were included(31 HT and 42 VMAT). Dose were 63.8 Gy(HT) and 63.2 Gy(VMAT) in the tumour bed, 52.2 Gy in the breast, 50.4 Gy in supraclavicular nodes(SCN) and internal mammary chain(IMC) with HT and 52.2 Gy and 49.3 Gy in IMC and SCN with VMAT in 29 fractions. Margins to particle tracking velocimetry were greater in the VMAT cohort(7 mm vs 5 mm).RESULTS For the HT cohort, the coverage of clinical target volumes was as follows: Tumour bed: 99.4% ± 2.4%; breast: 98.4% ± 4.3%; SCN: 99.5% ± 1.2%; IMC:96.5% ± 13.9%. For the VMAT cohort, the coverage was as follows: Tumour bed: 99.7% ± 0.5%, breast: 99.3% ± 0.7%; SCN: 99.6% ± 1.4%; IMC: 99.3% ± 3%. For ipsilateral lung, Dmean and V20 were 13.6 ± 1.2 Gy, 21.1% ± 5%(HT) and 13.6 ± 1.4 Gy, 20.1% ± 3.2%(VMAT). Dmean and V30 of the heart were 7.4 ± 1.4 Gy, 1% ± 1%(HT) and 10.3 ± 4.2 Gy, 2.5% ± 3.9%(VMAT). For controlateral breast Dmean was 3.6 ± 0.2 Gy(HT) and 4.6 ± 0.9 Gy(VMAT). Acute skin toxicity grade 3 was 5% in the two cohorts.CONCLUSION HT and VMAT in complex adjuvant breast irradiation allow a good coverage of target volumes with an acceptable acute tolerance. A longer follow-up is needed to assess the impact of low doses to healthy tissues.展开更多
Aim: Heating by nanoparticles, which are located in the tissue to be treated, is a well-recognized method in hyperthermic oncology. Our objective is to investigate selective, nanoscopic heating without concentrating e...Aim: Heating by nanoparticles, which are located in the tissue to be treated, is a well-recognized method in hyperthermic oncology. Our objective is to investigate selective, nanoscopic heating without concentrating extra artificial nanoparticles. We have in silico calculation to study the heating of the transmembrane protein clusters (rafts) on cell-membrane. The transmembrane protein domains have significantly higher dielectric constant than their lipid neighborhood in the membrane. This difference causes a local gradient in the Specific Absorption Rate (SAR), which could be a factor of heating of the membranes locally, as well as exciting the receptors for various signal transduction in the cells. We suppose that this process determines the observed cellular effects of modulated electro-hyperthermia (mEHT, trade-name: oncothermia). Materials and Methods: In silico models with highly specialized software (Computer Simulation Technology (CST), Darmstadt, Germany) were performed visualizing the selectivity for the membrane domains. Local raft models were created to simulate the electromagnetic (EM) effect of a 13.56 MHz excitation between two perfect electrical conductor plates, simulating the equipotential conditions of the sides of the membrane in the vicinity of the raft. The simulations were performed with near-field (EQS) solver of CST. The electric field, current density, and electric loss density were monitored by the simulations. The applied material properties and parameters refer to the recent literature. Results: In silico models show ten times higher energy-absorption of the transmembrane domains than that of its lipid-membrane surrounding, and intra- and extracellular neighborhood. Depending on the size, orientation, and location of the membrane rafts, the value of SAR varies, but we use only two simplified models to see the absorption properties. Taking into account the characteristics of the EM field effects we showed that the selective energy-absorption increased further by the cell-cell interacti展开更多
The glass-forming ability and properties of Ni-based Ni-Fe-B-Si-Ta bulk metallic glasses are explored in this work. The alloy compositions are determined by using a combination of the cluster line approach, the multi-...The glass-forming ability and properties of Ni-based Ni-Fe-B-Si-Ta bulk metallic glasses are explored in this work. The alloy compositions are determined by using a combination of the cluster line approach, the multi-alloying strategy and the substitutions of similar elements. Bulk metallic glasses with diameters of 3 mm take shape at compositions formulated under the clus- ter-plus-glue-atom model [M9B]B~[(Ni1-xFex)7.71(Si0.66Ta0.34)1.29B]B0.94=(Ni1-xFex)70.5B17.7Si7.8Ta4, x=0.35–0.45, where the bracketed part is the cluster and the unbracketed part is the glue atoms. These alloys exhibit good magnetic properties. The maximum Is is found in the (Ni0.55Fe0.45)70.5B17.7Si7.8Ta4 alloy which reaches 0.51 T, with its Hc as low as 8.5 A/m. Interestingly, these alloys display dual glass transitions at (Ni0.65Fe0.35)70.5B17.7Si7.8Ta4, (Ni0.60Fe0.4)70.5B17.7Si7.8Ta4 and (Ni0.55Fe0.45)70.5B17.7- Si7.8Ta4 as unveiled by Temperature-Modulated Differential Scanning Calorimetry.展开更多
The mismatch effect induced by the radial motion of a target is analyzed for linear frequency modulated （LFM） signals. Then, a novel integrated processing scheme is proposed to re- solve the delay-Doppler coupling e...The mismatch effect induced by the radial motion of a target is analyzed for linear frequency modulated （LFM） signals. Then, a novel integrated processing scheme is proposed to re- solve the delay-Doppler coupling effect in LFM pulse compression. Therefore the range and radial velocity of the target can be si- multaneously estimated with a narrowband LFM pulse. Finally, numerical simulation results demonstrate the effectiveness and good performance of the proposed method.展开更多
To enhance the capacity of the radar-reconnaissance interception receiver recognizing linear frequency modulated (LFM) at a low signal-noise ratio, this paper presents WignerHough transform (WHT) of the LFM signal and...To enhance the capacity of the radar-reconnaissance interception receiver recognizing linear frequency modulated (LFM) at a low signal-noise ratio, this paper presents WignerHough transform (WHT) of the LFM signal and its corresponding characteristics, derives the probability density functions of the LFM signal and Gaussian white noise within WHT based on entropy (WHTE), dimension under different assumptions and puts forward a WHT algorithm based on entropy of slice to improve the capacity of detecting the LFM signal. Entropy of the WHT domain slice is adopted to assess the information size of polar radius or angle slice, which is converted into the weight factor to weight every slice. Double-deck weight is used to weaken the influences of noise and disturbance terms and WHTE treatment and signal detection procedure are also summarized. The rationality of the algorithm is demonstrated through theoretical analysis and formula derivation, the efficiency of the algorithm is verified by simulation comparison between WHT, fractional Fourier transform and periodic WHT, and it is highlighted that the WHTE algorithm has better detection accuracy and range of application against strong noise background.展开更多
Breast cancer is the most common type of malignancy in females. Advances in systemic therapies and radiotherapy(RT) provided long survival rates in breast cancer patients. RT has a major role in the management of brea...Breast cancer is the most common type of malignancy in females. Advances in systemic therapies and radiotherapy(RT) provided long survival rates in breast cancer patients. RT has a major role in the management of breast cancer. During the past 15 years several developments took place in the field of imaging and irradiation techniques, intensity modulated RT, hypofractionation and partial-breast irradiation. Currently, improvements in the RT technology allow us a subsequent decrease in the treatment-related complications such as fibrosis and long-term cardiac toxicity while improving the loco-regional control rates and cosmetic results. Thus, it is crucial that modern radiotherapy techniques should be carried out with maximum care and efficiency. Several randomized trials provided evidence for the feasibility of modern radiotherapy techniques in the management of breast cancer. However, the role of modern radiotherapy techniques in the management of breast cancer will continue to be defined by the mature results of randomized trials. Current review will provide an up-to-date evidence based data on the role of modern radiotherapy techniques in the management of breast cancer.展开更多
文摘Coherent Jamming is one of the Important trends in modern radar electronic warfare. High-speed sampling of wldeband radio frequency （RF） signals and high isolatlon of two receive-transmit antennas are key technologies for the realization of coherent jamming. However, these technologies present significant challenges to enginserlng application. In this paper, a novel repeater Jamming based on interrupted sampling technique is presented. For a Jammer with a receive-transmit time-sharing antenna, a radar signal is sampled with a low rate by the jammer. Then, a train of false targets will be achieved after the Jamming signal feed the matched flltar of a pulse compression radar. For the case of the Ilnser frequency modulated （LFM） pulse compression radars, mathematic principles of the interrupted.sampiing repeater jamming Is developed, and then the efficiency of the jamming is described and stated as expressions of key parameters which are also beneficial to the Jamming design for other coherent radars.
基金Supported by The National Natural Science Foundation of China, No. 30870738
文摘AIM： To compare the volumetric-modulated arc ther- apy （VMAT） plans with conventional sliding window intensity-modulated radiotherapy （c-IMRT） plans in esophageal cancer （EC）. METHODS： Twenty patients with EC were selected, including 5 cases located in the cervical, the upper, the middle and the lower thorax, respectively. Five plans were generated with the eclipse planning sys- tem： three using c-IMRT with 5 fields （5F）, 7 fields （7F） and 9 fields （gF）, and two using VMAT with a single arc （1A） and double arcs （2A）. The treatment plans were designed to deliver a dose of 60 Gy to the plan-ning target volume （PTV） with the same constrains in a 2.0 Gy daily fraction, 5 d a week. Plans were normal- ized to 95% of the PTV that received 100% of the pre- scribed dose. We examined the dose-volume histogram parameters of PTV and the organs at risk （OAR） such as lungs, spinal cord and heart. Monitor units （MU） and normal tissue complication probability （NTCP） of OAR were also reported. RESULTS： Both c-IMRT and VMAT plans resulted in abundant dose coverage of PTV for EC of different Io- cations. The dose conformity to PTV was improved as the number of field in c-IMRT or rotating arc in VMAT was increased. The doses to PTV and OAR in VMAT plans were not statistically different in comparison with c-IMRT plans, with the following exceptions： in cervical and upper thoracic EC, the conformity index （CI） was higher in VMAT （1A 0.78 and 2A 0.8） than in c-IMRT （5F 0.62, 7F 0.66 and 9F 0.73） and homogeneity was slightly better in c-IMRT （7F 1.09 and 9F 1.07） than in VMAT （1A 1,1 and 2A 1.09）, Lung V30 was lower in VMAT （1A 12.52 and 2A 12.29） than in c-IMRT （7F 14.35 and 9F 14.81）. The humeral head doses were significantly increased in VMAT as against c-IMRT. In the middle and lower thoracic EC, CI in VMAT （1A 0.76 and 2A 0.74） was higher than in c-IMRT （5F 0.63 Gy and 7F 0.67 Gy）, and homogeneity was almost similar between VMAT and c-IMRT
基金supported by the National Natural Science Foundation of China (Grant No. 61072133)the Production,Learning and Research Joint Innovation Program of Jiangsu Province,China (Grant Nos. BY2013007-02,SBY201120033)+2 种基金the Industrialization of Research Findings Promotion Program of Institution of Higher Education of Jiangsu Province,China (Grant No. JHB2011-15)the advantage discipline platform "information and Communication Engineering" of Jiangsu Province,Chinathe "Summit of the Six Top Talents" Program of Jiangsu Province,China
文摘Stochastic resonance system is subject to the restriction of small frequency parameter in weak signal detection,in order to solve this problem,a frequency modulated weak signal detection method based on stochastic resonance and genetic algorithm is presented in this paper. The frequency limit of stochastic resonance is eliminated by introducing carrier signal,which is multiplied with the measured signal to be injected in the stochastic resonance system,meanwhile,using genetic algorithm to optimize the carrier signal frequency,which determine the generated difference-frequency signal in the lowfrequency range,so as to achieve the stochastic resonance weak signal detection. Results showthat the proposed method is feasible and effective,which can significantly improve the output SNR of stochastic resonance,in addition,the system has the better self-adaptability,according to the operation result and output phenomenon,the unknown frequency of the signal to be measured can be obtained,so as to realize the weak signal detection of arbitrary frequency.
基金supported by Grant 2006CB400504 from the National Basic Research Program of ChinaGrant LCS-2006-03 fromthe Laboratory for Climate Studies, China MeteorologicalAdministration+1 种基金sponsored by the National Science Foundation of USA (ATM-0653136, ATM-0917743)sponsored by National Key Technologies R&D Pro-gram under Grant No. 2007BAC29B03
文摘The traditional anomaly （TA） reference frame and its corresponding anomaly for a given data span changes with the extension of data length. In this study, the modulated annual cycle （MAC）, instead of the widely used climatological mean annual cycle, is used as an alternative reference frame for computing climate anomalies to study the multi-timescale variability of surface air temperature （SAT） in China based on homogenized daily data from 1952 to 2004. The Ensemble Empirical Mode Decomposition （EEMD） method is used to separate daily SAT into a high frequency component, a MAC component, an interannual component, and a decadal-to-trend component. The results show that the EEMD method can reflect historical events reasonably well, indicating its adaptive and temporally local characteristics. It is shown that MAC is a temporally local reference frame and will not be altered over a particular time span by an exten-sion of data length, thereby making it easier for physical interpretation. In the MAC reference frame, the low frequency component is found more suitable for studying the interannual to longer timescale variability （ILV） than a 13-month window running mean, which does not exclude the annual cycle. It is also better than other traditional versions （annual or summer or winter mean） of ILV, which contains a portion of the annual cycle. The analysis reveals that the variability of the annual cycle could be as large as the magnitude of interannual variability. The possible physical causes of different timescale variability of SAT in China are further discussed.
基金sponsored by the National Basic Research Program of China (GrantNo. 2011CB952000)the National Natural Science Foundation of China (Grant Nos. 41005039 and40810059003)+1 种基金Yan and Tu were sponsored by the National Basic Research Program of China (Grant No.2009CB421401)Wu was sponsored by the National Science Foundation of USA (ATM-0653136, ATM-0917743)
文摘Trends in the frequencies of four temperature extremes （the occurrence of warm days, cold days, warm nights and cold nights） with respect to a modulated annual cycle （MAC）, and those associated exclusively with weather-intraseasonal fluctuations （WIF） in eastern China were investigated based on an updated homogenized daily maximum and minimum temperature dataset for 1960–2008. The Ensemble Empirical Mode Decomposition （EEMD） method was used to isolate the WIF, MAC, and longer-term components from the temperature series. The annual, winter and summer occurrences of warm （cold） nights were found to have increased （decreased） significantly almost everywhere, while those of warm （cold） days have increased （decreased） in northern China （north of 40°N）. However, the four temperature extremes associated exclusively with WIF for winter have decreased almost everywhere, while those for summer have decreased in the north but increased in the south. These characteristics agree with changes in the amplitude of WIF. In particular, winter WIF of maximum temperature tended to weaken almost everywhere, especially in eastern coastal areas （by 10%–20%）; summer WIF tended to intensify in southern China by 10%–20%. It is notable that in northern China, the occurrence of warm days has increased, even where that associated with WIF has decreased significantly. This suggests that the recent increasing frequency of warm extremes is due to a considerable rise in the mean temperature level, which surpasses the effect of the weakening weather fluctuations in northern China.
文摘Zinc and Zn-Ni alloy compositionally modulated multilayer （CMM） coatings were electrodeposited on to a steel substrate by the successive deposition of zinc and Zn-Ni alloy sublayers from dual baths. The coated samples were evaluated in terms of the surface appearance, surface and cross-sectional morphologies, as well as corrosion resistance. The microstructural characteristics that were examined using the field emission gun scanning electron microscopy （FEGSEM） confirmed the layered structure, grain refinement of the zinc and Zn-Ni alloy CMM coatings, and revealed the existence of microcracks caused by the internal stress in the thick Zn-Ni alloy sublayers. The corrosion resistance that was evaluated by means of the salt spray test shows that the zinc and Zn-Ni alloy CMM coatings were more corrosion-resistant than the monolithic coatings of zinc or Zn-Ni alloy of the same thickness. The possible reasons for the better protective performance of Zn-Ni/Zn CMM coatings were given on the basis of the analysis on the micrographic features of zinc and Zn-Ni alloy CMM eoatings after the corrosion test. A probable corrosion mechanism of zinc and Zn-Ni alloy CMM coatings was also proposed.
文摘Outcomes in patients with gastric cancer in the United States remain disappointing, with a five-year overall survival rate of approximately 23%. Given high rates of local-regional control following surgery, a strong rationale exists for the use of adjuvant radiation therapy. Randomized trials have shown superior local control with adjuvant radiotherapy and improved overall survival with adjuvant chemoradiation. The benefit of adjuvant chemoradiation in patients who have undergone D2 lymph node dissection by an experienced surgeon is not known, and the benefit of adjuvant radiation therapy in addition to adjuvant chemotherapy continues to be defined. In unresectable disease, chemoradiation allows long-term survival in a small number of patients and provides effective palliation. Most trials show a benefit to combined modality therapy compared to chemotherapy or radiation therapy alone. The use of pre-operative, intra-operative, 3D conformal, and intensity modulated radiation therapy in gastric cancer is promising but requires further study. The current article reviews the role of radiation therapy in the treatment of resectable and unresectable gastric carcinoma, focusing on current recommendations in the United States.
基金Supported by Shantou University Medical College Clinical Research Enhancement Initiative,and Research and Travel Grants from the Science and Technology Key Project of Shantou City,China,2012,No.2012-165-131
文摘AIM: To establish the feasibility of simultaneous modulated accelerated radiation therapy (SMART) in esophageal cancer (EC).
基金sponsored by the National Basic Research Program of China(Grant Nos. 2011CB952000, 2006CB400504)the Na-tional Natural Science Foundation of China (Grant No.41005039)+1 种基金Wu was sponsored by the National Science Foundation of USA (ATM-0917743)Yan was sponsored by the National Basic Research Program of China(Grant No. 2009CB421401)
文摘Climatic changes in the onset of spring in northern China associated with changes in the annual cycle and with a recent warming trend were quantified using a recently developed adaptive data analysis tool, the Ensemble Empirical Mode Decomposition. The study was based on a homogenized daily surface air temperature （SAT） dataset for the period 1955–2003. The annual cycle here is referred to as a refined modulated annual cycle （MAC）. The results show that spring at Beijing has arrived significantly earlier by about 2.98 d （10 yr）-1, of which about 1.85 d （10 yr）-1 is due to changes in the annual cycle and 1.13 d （10 yr）-1 due to the long-term warming trend. Variations in the MAC component explain about 92.5% of the total variance in the Beijing daily SAT series and could cause as much as a 20-day shift in the onset of spring from one year to another. The onset of spring has been advancing all over northern China, but more significant in the east than in the west part of the region. These differences are somehow unexplainable by the zonal pattern of the warming trend over the whole region, but can be explained by opposite changes in the spring phase of the MAC, i.e. advancing in the east while delaying in the west. In the east of northern China, the change in the spring phase of MAC explains 40%–60% of the spring onset trend and is attributable to a weakening Asian winter monsoon. The average sea level pressure in Siberia （55°–80°N, 50°–110°E）, an index of the strength of the winter monsoon, could serve as a potential short-term predictor for the onset of spring in the east of northern China.
文摘A new method is proposed to analyze multi-component linear frequency modulated （LFM） signals, which eliminates cross terms in conventional Wigner-Ville distribution （WVD）. The approach is based on Radon transform and Hilbert-Huang transform （HHT）, which is a recently developed method adaptive to non-linear and non-stationary signals. The complicated signal is decomposed into several intrinsic mode functions （IMF） by the empirical mode decomposition （EMD）, which makes the consequent instantaneous frequency meaningful. After the instantaneous frequency and Hilbert spectrum are computed, multi-component LFM signals detection and parameter estimation are obtained using Radon transform on the Hilbert spectrum plane. The simulation results show its feasibility and effectiveness.
文摘Objective: A dosimetric study was performed to evaluate the performance of volumetric modulated arc radiotherapy with RapidArc on locally advanced nasopharyngeal carcinoma (NPC). Methods: The CT scan data sets of 20 patients of locally advanced NPC were selected randomly. The plans were managed using volumetric modulated arc with RapidArc and fixed nine-field coplanar dynamic intensity-modulated radiotherapy (IMRT) for these patients. The dosimetry of the planning target volumes (PTV), the organs at risk (OARs) and the healthy tissue were evaluated. The dose prescription was set to 70 Gy to the primary tumor and 60 Gy to the clinical target volumes (CTV) in 33 fractions. Each fraction applied daily, five fractions per week. The monitor unit (MU) values and the delivery time were scored to evaluate the expected treatment efficiency. Results: Both techniques had reached clinical treatment’s requirement. The mean dose (Dmean), maximum dose (Dmax) and minimum dose (Dmin) in RapidArc and fixed field IMRT for PTV were 68.4±0.6 Gy, 74.8±0.9 Gy and 56.8±1.1 Gy; and 67.6±0.6 Gy, 73.8±0.4 Gy and 57.5±0.6 Gy (P<0.05), respectively. Homogeneity index was 78.85±1.29 in RapidArc and 80.34±0.54 (P<0.05) in IMRT. The conformity index (CI: 95%) was 0.78±0.01 for both techniques (P>0.05). Compared to IMRT, RapidArc allowed a reduction of Dmean to the brain stem, mandible and optic nerves of 14.1% (P<0.05), 5.6% (P<0.05) and 12.2% (P<0.05), respectively. For the healthy tissue and the whole absorbed dose, Dmean of RapidArc was reduced by 3.6% (P<0.05), and 3.7% (P<0.05), respectively. The Dmean to the parotids, the spinal cord and the lens had no statistical difference among them. The mean MU values of RapidArc and IMRT were 550 and 1,379. The mean treatment time of RapidArc and IMRT was 165 s and 447 s. Compared to IMRT, the delivery time and the MU values of RapidArc were reduced by 63% and 60%, respectively. Conclusion: For locally advanced NPC, both RapidArc and IMRT reached the clinic requirement. The target volume
基金National Natural Science Foundation of China(No.50475106)
文摘The flow field of the oil film between frictional pairs in the hydroviscous drive test rig is investigated. A three-dimensional Navier-Stokes（N-S） equation considering viscous force and inertial force rather than Reynolds equation or modified Reynolds equation is presented to model the flow field. Pressure and temperature distribution in radial and circumferential direction under three different conditions, i.e., isothermal, that considering viscosity-temperature characteristic as well as shear thinning non-Newtonian fluid are simulated, respectively, by utilizing the commercial computational fluid dynamics（CFD） software FLUENT. The results reveal that the grooves on the driven plate make the pressure, temperature distribution present periodic variation. The oil temperature and shear rate have important effects on the flow field between frictional pairs, and the oil temperature is more important parameter. The simulation results lay a theoretical foundation for the reasonable designs ofhydroviscous drive.
文摘AIM To analyse clinical and dosimetric results of helical tomotherapy(HT) and volumetric modulated arc therapy(VMAT) in complex adjuvant breast and nodes irradiation.METHODS Seventy-three patients were included(31 HT and 42 VMAT). Dose were 63.8 Gy(HT) and 63.2 Gy(VMAT) in the tumour bed, 52.2 Gy in the breast, 50.4 Gy in supraclavicular nodes(SCN) and internal mammary chain(IMC) with HT and 52.2 Gy and 49.3 Gy in IMC and SCN with VMAT in 29 fractions. Margins to particle tracking velocimetry were greater in the VMAT cohort(7 mm vs 5 mm).RESULTS For the HT cohort, the coverage of clinical target volumes was as follows: Tumour bed: 99.4% ± 2.4%; breast: 98.4% ± 4.3%; SCN: 99.5% ± 1.2%; IMC:96.5% ± 13.9%. For the VMAT cohort, the coverage was as follows: Tumour bed: 99.7% ± 0.5%, breast: 99.3% ± 0.7%; SCN: 99.6% ± 1.4%; IMC: 99.3% ± 3%. For ipsilateral lung, Dmean and V20 were 13.6 ± 1.2 Gy, 21.1% ± 5%(HT) and 13.6 ± 1.4 Gy, 20.1% ± 3.2%(VMAT). Dmean and V30 of the heart were 7.4 ± 1.4 Gy, 1% ± 1%(HT) and 10.3 ± 4.2 Gy, 2.5% ± 3.9%(VMAT). For controlateral breast Dmean was 3.6 ± 0.2 Gy(HT) and 4.6 ± 0.9 Gy(VMAT). Acute skin toxicity grade 3 was 5% in the two cohorts.CONCLUSION HT and VMAT in complex adjuvant breast irradiation allow a good coverage of target volumes with an acceptable acute tolerance. A longer follow-up is needed to assess the impact of low doses to healthy tissues.
文摘Aim: Heating by nanoparticles, which are located in the tissue to be treated, is a well-recognized method in hyperthermic oncology. Our objective is to investigate selective, nanoscopic heating without concentrating extra artificial nanoparticles. We have in silico calculation to study the heating of the transmembrane protein clusters (rafts) on cell-membrane. The transmembrane protein domains have significantly higher dielectric constant than their lipid neighborhood in the membrane. This difference causes a local gradient in the Specific Absorption Rate (SAR), which could be a factor of heating of the membranes locally, as well as exciting the receptors for various signal transduction in the cells. We suppose that this process determines the observed cellular effects of modulated electro-hyperthermia (mEHT, trade-name: oncothermia). Materials and Methods: In silico models with highly specialized software (Computer Simulation Technology (CST), Darmstadt, Germany) were performed visualizing the selectivity for the membrane domains. Local raft models were created to simulate the electromagnetic (EM) effect of a 13.56 MHz excitation between two perfect electrical conductor plates, simulating the equipotential conditions of the sides of the membrane in the vicinity of the raft. The simulations were performed with near-field (EQS) solver of CST. The electric field, current density, and electric loss density were monitored by the simulations. The applied material properties and parameters refer to the recent literature. Results: In silico models show ten times higher energy-absorption of the transmembrane domains than that of its lipid-membrane surrounding, and intra- and extracellular neighborhood. Depending on the size, orientation, and location of the membrane rafts, the value of SAR varies, but we use only two simplified models to see the absorption properties. Taking into account the characteristics of the EM field effects we showed that the selective energy-absorption increased further by the cell-cell interacti
基金supported by the National Science Foundation of China (Grant Nos. 50631010 and 50901012)the National Basic Research Program of China (Grant Nos. 2007CB613902 and 2008CB617614)
文摘The glass-forming ability and properties of Ni-based Ni-Fe-B-Si-Ta bulk metallic glasses are explored in this work. The alloy compositions are determined by using a combination of the cluster line approach, the multi-alloying strategy and the substitutions of similar elements. Bulk metallic glasses with diameters of 3 mm take shape at compositions formulated under the clus- ter-plus-glue-atom model [M9B]B~[(Ni1-xFex)7.71(Si0.66Ta0.34)1.29B]B0.94=(Ni1-xFex)70.5B17.7Si7.8Ta4, x=0.35–0.45, where the bracketed part is the cluster and the unbracketed part is the glue atoms. These alloys exhibit good magnetic properties. The maximum Is is found in the (Ni0.55Fe0.45)70.5B17.7Si7.8Ta4 alloy which reaches 0.51 T, with its Hc as low as 8.5 A/m. Interestingly, these alloys display dual glass transitions at (Ni0.65Fe0.35)70.5B17.7Si7.8Ta4, (Ni0.60Fe0.4)70.5B17.7Si7.8Ta4 and (Ni0.55Fe0.45)70.5B17.7- Si7.8Ta4 as unveiled by Temperature-Modulated Differential Scanning Calorimetry.
基金supported by the Pre-Research Foundation of National Defence of China
文摘The mismatch effect induced by the radial motion of a target is analyzed for linear frequency modulated （LFM） signals. Then, a novel integrated processing scheme is proposed to re- solve the delay-Doppler coupling effect in LFM pulse compression. Therefore the range and radial velocity of the target can be si- multaneously estimated with a narrowband LFM pulse. Finally, numerical simulation results demonstrate the effectiveness and good performance of the proposed method.
基金supported by the Aeronautical Science Fund of China(201455960252015209619)
文摘To enhance the capacity of the radar-reconnaissance interception receiver recognizing linear frequency modulated (LFM) at a low signal-noise ratio, this paper presents WignerHough transform (WHT) of the LFM signal and its corresponding characteristics, derives the probability density functions of the LFM signal and Gaussian white noise within WHT based on entropy (WHTE), dimension under different assumptions and puts forward a WHT algorithm based on entropy of slice to improve the capacity of detecting the LFM signal. Entropy of the WHT domain slice is adopted to assess the information size of polar radius or angle slice, which is converted into the weight factor to weight every slice. Double-deck weight is used to weaken the influences of noise and disturbance terms and WHTE treatment and signal detection procedure are also summarized. The rationality of the algorithm is demonstrated through theoretical analysis and formula derivation, the efficiency of the algorithm is verified by simulation comparison between WHT, fractional Fourier transform and periodic WHT, and it is highlighted that the WHTE algorithm has better detection accuracy and range of application against strong noise background.
文摘Breast cancer is the most common type of malignancy in females. Advances in systemic therapies and radiotherapy(RT) provided long survival rates in breast cancer patients. RT has a major role in the management of breast cancer. During the past 15 years several developments took place in the field of imaging and irradiation techniques, intensity modulated RT, hypofractionation and partial-breast irradiation. Currently, improvements in the RT technology allow us a subsequent decrease in the treatment-related complications such as fibrosis and long-term cardiac toxicity while improving the loco-regional control rates and cosmetic results. Thus, it is crucial that modern radiotherapy techniques should be carried out with maximum care and efficiency. Several randomized trials provided evidence for the feasibility of modern radiotherapy techniques in the management of breast cancer. However, the role of modern radiotherapy techniques in the management of breast cancer will continue to be defined by the mature results of randomized trials. Current review will provide an up-to-date evidence based data on the role of modern radiotherapy techniques in the management of breast cancer.
