Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network （also known as ...Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network （also known as the MAX-MLX Network）, a highly conserved super-family of related basic-helix-loop-helix-zipper （bHLHZ） proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Here we summarize molecular and biological properties of the network modules with emphasis on functional interactions among network members. We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. Moreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the activity of the network as a whole, leading to tumor initiation, progression and maintenance.展开更多
MLX90614是一种非接触式红外测温器件,其内部采用低噪声放大器、17 b A/D转换器及功能强大的DSP处理单元,因而具有较高的温度分辨率和测量精度;该温度计测温范围为-40^+125℃,出厂前经过工厂校正,具有数字PWM和SMBus输出方式。详细介绍M...MLX90614是一种非接触式红外测温器件,其内部采用低噪声放大器、17 b A/D转换器及功能强大的DSP处理单元,因而具有较高的温度分辨率和测量精度;该温度计测温范围为-40^+125℃,出厂前经过工厂校正,具有数字PWM和SMBus输出方式。详细介绍MLX90614的原理并给出应用电路。展开更多
文摘Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network （also known as the MAX-MLX Network）, a highly conserved super-family of related basic-helix-loop-helix-zipper （bHLHZ） proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Here we summarize molecular and biological properties of the network modules with emphasis on functional interactions among network members. We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. Moreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the activity of the network as a whole, leading to tumor initiation, progression and maintenance.
