We designed and fabricated a multilayer Laue lens （MLL） as a hard X-ray focusing device. WSi2/Si multilayers were chosen owing to their excellent optical properties and relatively sharp interface. The multilayer sam...We designed and fabricated a multilayer Laue lens （MLL） as a hard X-ray focusing device. WSi2/Si multilayers were chosen owing to their excellent optical properties and relatively sharp interface. The multilayer sample was fabricated by using direct current （DC） magnetron sputtering technology and then was sliced and thinned to form an MLL. The thickness of each layer was determined by scanning electron microscopy （SEM） image analysis with marking layers. The focusing property of the MLL was measured at Beamline 15U, Shanghai Synchrotron Facility （SSRF）. One-dimensional （1D） focusing resolutions of 92 nm are obtained at photon energy of 14 keV.展开更多
The protein–protein interaction between menin and mixed lineage leukemia(MLL)plays an important role in the development of human hepatocellular carcinogenesis(HCC)and is associated with poor prognosis of HCC patients...The protein–protein interaction between menin and mixed lineage leukemia(MLL)plays an important role in the development of human hepatocellular carcinogenesis(HCC)and is associated with poor prognosis of HCC patients.1,2 Hence,interrupting the menin-MLL interaction is an attractive strategy in cancer treatment,particularly for liver cancer.3,4 In this study,we identified complex C1 as the first rhodium(III)-based orally bioavailable selective inhibitor of the menin-MLL interaction for HCC.展开更多
In this paper, several photonic generating methods for optical triangular pulses were reviewed. Four frontier research methods for generating optical triangular pulses were introduced, these four methods are respectiv...In this paper, several photonic generating methods for optical triangular pulses were reviewed. Four frontier research methods for generating optical triangular pulses were introduced, these four methods are respectively based on the frequency-to-time conversion, using normally dispersive fiber, by single-stage dual-drive Mach-Zehnder modulator （MZM）, and using dual-parallel MZM. These four methods can be classified into two categories in terms of the optical source employed, such as mode-lock laser （MLL） and continuous-wave （CW） respectively. Compared with the methods based on MLL, those based on CW have many advantages, such as simpler structure, lower price, higher stability, more flexible and wider tunability. Besides, the method using single-stage drive MZM can generate versatile waveform optical pulses, which has better performance than the first two methods in tunable capability of both repetition rate and center wavelength. With the same driving signal applied, the optical source using the dual-parallel MZM can generate signal with higher frequency than that of using the single-stage MZM.展开更多
基金Supported by National Natural Science Foundation of China(U1432244,11375131)Major State Basic Research Development Program(2011CB922203)
文摘We designed and fabricated a multilayer Laue lens （MLL） as a hard X-ray focusing device. WSi2/Si multilayers were chosen owing to their excellent optical properties and relatively sharp interface. The multilayer sample was fabricated by using direct current （DC） magnetron sputtering technology and then was sliced and thinned to form an MLL. The thickness of each layer was determined by scanning electron microscopy （SEM） image analysis with marking layers. The focusing property of the MLL was measured at Beamline 15U, Shanghai Synchrotron Facility （SSRF）. One-dimensional （1D） focusing resolutions of 92 nm are obtained at photon energy of 14 keV.
基金supported by the Science and Technology Development Fund(Macao SAR,China)(No.0007/2020/A1,0020/2022/A1)the State Key Laboratory of Quality Research in Chinese Medicine(University of Macao)(SKL-QRCM(UM)-2020-2022)+9 种基金the University of Macao(China)(MYRG2019-00002-ICMS,MYRG2020-00017-ICMS)2022 Internal Research Grant of SKL-QRCM(University of Macao)(QRCM-IRG2022-011)the National Natural Science Foundation of China,China(No.22077109,21775131)the HKBU SKLEBA Research Grant(SKLP_2223_P03)the National Natural Science Foundation of China(No.82204482)the Guangdong Basic and Applied Basic Research Foundation(China)(No.2021A1515012520)Young Elite Scientists Sponsorship Program by CACM(China)(No.2021-QNRC2-B22)Guangzhou Basic and Applied Basic Research Foundation(China)(No.202102020203)the Fundamental Research Funds for the Central Universities(China)(No.11620355)A part of the research is supported by a trust fund for Yung-Chi Cheng's lab at Yale University.
文摘The protein–protein interaction between menin and mixed lineage leukemia(MLL)plays an important role in the development of human hepatocellular carcinogenesis(HCC)and is associated with poor prognosis of HCC patients.1,2 Hence,interrupting the menin-MLL interaction is an attractive strategy in cancer treatment,particularly for liver cancer.3,4 In this study,we identified complex C1 as the first rhodium(III)-based orally bioavailable selective inhibitor of the menin-MLL interaction for HCC.
基金This work was partly supported by the National Natural Science Foundation of China （Grant Nos. 61275076, 61177069）.
文摘In this paper, several photonic generating methods for optical triangular pulses were reviewed. Four frontier research methods for generating optical triangular pulses were introduced, these four methods are respectively based on the frequency-to-time conversion, using normally dispersive fiber, by single-stage dual-drive Mach-Zehnder modulator （MZM）, and using dual-parallel MZM. These four methods can be classified into two categories in terms of the optical source employed, such as mode-lock laser （MLL） and continuous-wave （CW） respectively. Compared with the methods based on MLL, those based on CW have many advantages, such as simpler structure, lower price, higher stability, more flexible and wider tunability. Besides, the method using single-stage drive MZM can generate versatile waveform optical pulses, which has better performance than the first two methods in tunable capability of both repetition rate and center wavelength. With the same driving signal applied, the optical source using the dual-parallel MZM can generate signal with higher frequency than that of using the single-stage MZM.
