Traumatic brain injury is a major health concern worldwide with massive financial and social impact. Conventional treatments primarily focus on the prevention of further damage to the brain parenchyma, while failing t...Traumatic brain injury is a major health concern worldwide with massive financial and social impact. Conventional treatments primarily focus on the prevention of further damage to the brain parenchyma, while failing to address the already existent symptoms. Previous clinical studies have shown that Low Level Laser Therapy (LLLT) can significantly reduce pain and induce temporary vasodilation in capillaries, which the authors hypothesize can be used to improve the quality of life in TBI patients by treating their current symptoms, which are predominately migraine-like headaches. This case report illustrates the use of LLLT in the treatment of a patient with a TBI and the great clinical success achieved in the reduction of pain, as measured by VAS—achievable within five treatments of 10 minutes in duration.展开更多
To clarify the active components of Wuzhuyu-tang, this study analyzed dynamic changes of 10 ingredients of Wuzhuyu-tang in plasma using combination high performance liquid chromatography-mass spectrometry after oral a...To clarify the active components of Wuzhuyu-tang, this study analyzed dynamic changes of 10 ingredients of Wuzhuyu-tang in plasma using combination high performance liquid chromatography-mass spectrometry after oral administration in rats. The results showed that seven ingredients were detected in portal vein plasma after oral administration of 16.3 or 8.15 g/kg equivalent of raw material of Wuzhuyu-tang extract. The absorption rate of limonin, evodiamine, gingerol （6-Gi）, and ginsenoside-Rg1 was greater than that of isorhamnetin-3-O-β-D-glucosyl （6″→1″′）-α-L-rhamnoside, ginsenoside-Rb1 （Rb1）, and ginsenoside-Re （Re）. The time most elements were absorbed into the blood was 30 to 60 minutes after administration. Re, 6-Gi and Rb1 were metabolized faster. The results suggest that the seven ingredients described above are the active components for treating migraines.展开更多
Objective:Compared to Chinese herbal piecesherbal pieces,the quality of TCM granule is stable and controllable,it is also a convenient alternative to decocting herbs.However,whether they are as clinically effective as...Objective:Compared to Chinese herbal piecesherbal pieces,the quality of TCM granule is stable and controllable,it is also a convenient alternative to decocting herbs.However,whether they are as clinically effective as Chinese herbal piecesherbal pieces is still controversial.In this study,a systematic review and meta-analysis were performed to assess the clinical efficacy of TCM granules and Chinese herbal piecesherbal pieces.Methods:A search of online databases for eligible articles was performed,including PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Internet,WanFang,and Chongqing VIP Information,searching from the inception of these databases to 2020.The Cochrane Handbook 5.1.0 was used to independently identify the trials,extract data,and assess the risk of bias.The meta-analysis was performed via RevMan 5.3 software.Results:A total of 98 eligible articles were included.After classification and statistical analysis of the related diseases,a meta-analysis was performed on 8 types of illnesses(cold,hypertension,migraine,osteoporosis,and diseases of the digestive system,such as gastritis,gastric ulcer,colitis,epigastric pain)included in 66 randomized controlled trials to compare the clinical efficacy and adverse events of TCM granules and Chinese herbal pieces.Meta-analysis showed that compared with Chinese herbal piecesherbal pieces,TCM granules had similar effectiveness and safety in treating cold,hypertension,and osteoporosis,but a higher response rate in migraines and a better effect in reducing migraine duration and higher response rate on diseases of the digestive system.Conclusion:Compared with the traditional decoctions,TCM formula granules had the same efficacy and safety,moreover,they had higher efficacy and safety in treating migraines and digestive system diseases.展开更多
We present a 29-year-old woman with a long history of attacks of migraine with and without visual aura.She was a heavy smoker(20 cigarettes/d) and was currently taking oral contraceptives. During a typical migraine at...We present a 29-year-old woman with a long history of attacks of migraine with and without visual aura.She was a heavy smoker(20 cigarettes/d) and was currently taking oral contraceptives. During a typical migraine attack with aura, she developed dysarthria,left brachial hemiparesis and hemihypoesthesia and brief and autolimited left clonic facial movements. Four hours after onset, vascular headache and focal sensorimotor neurological deficit were the only persisting symptoms and, on seventh day, she was completely recovered. Brain magnetic resonance imaging on day 20 after onset showed a subacute ischemic lesion in the right temporo-parietal cortex compatible with cortical laminar necrosis(CLN). Extensive neurological work-up done to rule out other known causes of cerebral infarct with CLN was unrevealing. Only ten of 3.808 consecutive stroke patients included in our stroke registry over a 19-year period fulfilled the strictly defined International Headache Society criteria for migrainous stroke. The present case is the unique one in our stroke registry that presents CLN related to migrainous cerebral infarction. Migrainous infarction can result in CLN.展开更多
文摘Traumatic brain injury is a major health concern worldwide with massive financial and social impact. Conventional treatments primarily focus on the prevention of further damage to the brain parenchyma, while failing to address the already existent symptoms. Previous clinical studies have shown that Low Level Laser Therapy (LLLT) can significantly reduce pain and induce temporary vasodilation in capillaries, which the authors hypothesize can be used to improve the quality of life in TBI patients by treating their current symptoms, which are predominately migraine-like headaches. This case report illustrates the use of LLLT in the treatment of a patient with a TBI and the great clinical success achieved in the reduction of pain, as measured by VAS—achievable within five treatments of 10 minutes in duration.
基金the Scientific Research Program of Beijing Municipal Education Commission-Capital Key Research Program of Chinese Medicine and Nursing, No. 10ZYH01the Supporting Program of the "Eleventh Five-year Plan" for Science and Technology Research of China, No.2006BAI08B03
文摘To clarify the active components of Wuzhuyu-tang, this study analyzed dynamic changes of 10 ingredients of Wuzhuyu-tang in plasma using combination high performance liquid chromatography-mass spectrometry after oral administration in rats. The results showed that seven ingredients were detected in portal vein plasma after oral administration of 16.3 or 8.15 g/kg equivalent of raw material of Wuzhuyu-tang extract. The absorption rate of limonin, evodiamine, gingerol （6-Gi）, and ginsenoside-Rg1 was greater than that of isorhamnetin-3-O-β-D-glucosyl （6″→1″′）-α-L-rhamnoside, ginsenoside-Rb1 （Rb1）, and ginsenoside-Re （Re）. The time most elements were absorbed into the blood was 30 to 60 minutes after administration. Re, 6-Gi and Rb1 were metabolized faster. The results suggest that the seven ingredients described above are the active components for treating migraines.
文摘Objective:Compared to Chinese herbal piecesherbal pieces,the quality of TCM granule is stable and controllable,it is also a convenient alternative to decocting herbs.However,whether they are as clinically effective as Chinese herbal piecesherbal pieces is still controversial.In this study,a systematic review and meta-analysis were performed to assess the clinical efficacy of TCM granules and Chinese herbal piecesherbal pieces.Methods:A search of online databases for eligible articles was performed,including PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Internet,WanFang,and Chongqing VIP Information,searching from the inception of these databases to 2020.The Cochrane Handbook 5.1.0 was used to independently identify the trials,extract data,and assess the risk of bias.The meta-analysis was performed via RevMan 5.3 software.Results:A total of 98 eligible articles were included.After classification and statistical analysis of the related diseases,a meta-analysis was performed on 8 types of illnesses(cold,hypertension,migraine,osteoporosis,and diseases of the digestive system,such as gastritis,gastric ulcer,colitis,epigastric pain)included in 66 randomized controlled trials to compare the clinical efficacy and adverse events of TCM granules and Chinese herbal pieces.Meta-analysis showed that compared with Chinese herbal piecesherbal pieces,TCM granules had similar effectiveness and safety in treating cold,hypertension,and osteoporosis,but a higher response rate in migraines and a better effect in reducing migraine duration and higher response rate on diseases of the digestive system.Conclusion:Compared with the traditional decoctions,TCM formula granules had the same efficacy and safety,moreover,they had higher efficacy and safety in treating migraines and digestive system diseases.
文摘We present a 29-year-old woman with a long history of attacks of migraine with and without visual aura.She was a heavy smoker(20 cigarettes/d) and was currently taking oral contraceptives. During a typical migraine attack with aura, she developed dysarthria,left brachial hemiparesis and hemihypoesthesia and brief and autolimited left clonic facial movements. Four hours after onset, vascular headache and focal sensorimotor neurological deficit were the only persisting symptoms and, on seventh day, she was completely recovered. Brain magnetic resonance imaging on day 20 after onset showed a subacute ischemic lesion in the right temporo-parietal cortex compatible with cortical laminar necrosis(CLN). Extensive neurological work-up done to rule out other known causes of cerebral infarct with CLN was unrevealing. Only ten of 3.808 consecutive stroke patients included in our stroke registry over a 19-year period fulfilled the strictly defined International Headache Society criteria for migrainous stroke. The present case is the unique one in our stroke registry that presents CLN related to migrainous cerebral infarction. Migrainous infarction can result in CLN.
