Tazarotene and calcipotriol are both effective in the treatment of psoriasis. An investigator- blind, bilateral comparison of 44 lesion pairs in 19 patients was conducted to evaluate the efficacy, side effects and dur...Tazarotene and calcipotriol are both effective in the treatment of psoriasis. An investigator- blind, bilateral comparison of 44 lesion pairs in 19 patients was conducted to evaluate the efficacy, side effects and duration of therapeutic effects of once- daily tazarotene 0.1% gel plus petrolatum with twice- daily calcipotriol 0.005% ointment in plaque psoriasis. It consisted of a 12- week treatment phase, followed by a 4- week post- treatment observation phase. At the end of the treatment phase, tazarotene- petrolatum was as effective as calcipotriol in both objective and subjective overall efficacy assessment. Calcipotriol had a significantly greater effect in reducing erythema than tazarotene- petrol- atum at weeks 2- 8. At week 16, tazarotene- petrolatum demonstrated a significantly better maintenance effect in all parameters. Local irritation was noted only intazarotene- petrolatum- treatedlesions. Once- dailytazarotene 0.1% gel plus petrolatum was as effective as twice- daily calcipotriol 0.005% ointment in the treatment of plaque psoriasis,but had a better maintenance effect after the cessation of therapy.展开更多
文摘Tazarotene and calcipotriol are both effective in the treatment of psoriasis. An investigator- blind, bilateral comparison of 44 lesion pairs in 19 patients was conducted to evaluate the efficacy, side effects and duration of therapeutic effects of once- daily tazarotene 0.1% gel plus petrolatum with twice- daily calcipotriol 0.005% ointment in plaque psoriasis. It consisted of a 12- week treatment phase, followed by a 4- week post- treatment observation phase. At the end of the treatment phase, tazarotene- petrolatum was as effective as calcipotriol in both objective and subjective overall efficacy assessment. Calcipotriol had a significantly greater effect in reducing erythema than tazarotene- petrol- atum at weeks 2- 8. At week 16, tazarotene- petrolatum demonstrated a significantly better maintenance effect in all parameters. Local irritation was noted only intazarotene- petrolatum- treatedlesions. Once- dailytazarotene 0.1% gel plus petrolatum was as effective as twice- daily calcipotriol 0.005% ointment in the treatment of plaque psoriasis,but had a better maintenance effect after the cessation of therapy.
