目的探讨超声造影在预测甲状腺乳头状癌(PTC)颈部淋巴结转移中的应用价值。方法回顾性分析64例PTC患者(共71个结节)的超声造影资料,根据术后病理结果,分为转移组(37个结节)和未转移组(34个结节),应用QLAB软件进行超声造影定量分析,绘制...目的探讨超声造影在预测甲状腺乳头状癌(PTC)颈部淋巴结转移中的应用价值。方法回顾性分析64例PTC患者(共71个结节)的超声造影资料,根据术后病理结果,分为转移组(37个结节)和未转移组(34个结节),应用QLAB软件进行超声造影定量分析,绘制PTC结节边缘区及中央区的时间-强度曲线(TIC),并获得上升时间(RT)、峰值强度(PI)、平均渡越时间(MTT)、曲线下面积(AUC)、峰值降半时间(TPH)、上升斜率(WIS)及达峰时间(TTP),分析比较两组PTC结节边缘区及中央区的超声造影灌注强度特征及定量参数差异;绘制相关参数判断PTC淋巴结转移的受试者工作特征(ROC)曲线,计算其诊断效能。结果 PTC结节多表现为不均匀低增强,达峰时结节边缘区灌注强度大于中央区;两组结节灌注强度特征比较差异均无统计学意义。转移组PTC结节边缘区PI、AUC分别为(8.39±2.19)d B、(220.69±83.56)d B s,未转移组PTC结节边缘区PI、AUC分别为(6.52±2.32)d B、(168.29±52.95)d B s,两组比较差异均有统计学意义(均P<0.01);余各参数比较差异均无统计学意义。PTC结节边缘区PI、AUC判断颈部淋巴结转移的ROC曲线下面积分别为0.733、0.708,当PTC结节边缘区PI临界值>8.04 d B、AUC临界值>202.99 d B s时,其判断颈部淋巴结转移的敏感性、特异性分别为67.6%、82.4%和64.9%、79.4%。结论 PTC结节边缘区超声造影定量参数PI、AUC对预测PTC颈部淋巴结转移具有一定的临床应用价值。展开更多
Objective： Colorectal cancer is one of the major contributors to cancer death worldwide. Lack of reliable colorectal cancer markers has hampered the management of these cancer patients. Our main purpose was to study ...Objective： Colorectal cancer is one of the major contributors to cancer death worldwide. Lack of reliable colorectal cancer markers has hampered the management of these cancer patients. Our main purpose was to study the correlation between histopathological variables of colorectal adenocarcinomas and identify histopathological markers that are of prognostic value in patients with colorectal cancer. Methods： In the present study, we examined the expression of carcinoembryonic antigen （CEA）, p53, Ki-67 and glutathion Stransferase （GST） -n by using immunohistochemical staining methods in 126 colorectal carcinoma patients and evaluated the lymph node metastasis status in these patients by histopathological examination. Results： The positive rates of CEA, p53, Ki-67 and GST-π expression in the colorectal cancer tissue specimens examined were 95.23%, 55.56%, 53.38% and 82.30%, respectively. Expression of p53 and Ki-67 was significantly correlated with the Dukes stages of the tumor, with higher levels of these proteins in Dukes＇ C and D tumors than those in Dukes＇ A and B tumors. Furthermore, the expression of p53, GST-π and Ki-67 correlated with prognosis of patients with colorectal cancer. Additionally, the expression of p53 in colorectal cancer was closely related to the expression of Ki-67 and the expression of GST-π was directly correlated with that of p53. Conclusion： The expression of CEA, p53, Ki-67 and GST-π was correlated with various clinical features of patients with colorectal cancer. The combined use of these histopathological markers appeared to be a promising tool in predicting the prognosis of patients with this type of cancer.展开更多
目的:探讨肺鳞癌组织中瞬时受体电位通道5(transient receptor potential cation channel subfamily C member 5,TrpC5)的表达及其临床意义。方法:利用免疫组织化学法检测73例肺鳞癌组织和对应的癌旁组织中TrpC5的表达,并分析其表达与...目的:探讨肺鳞癌组织中瞬时受体电位通道5(transient receptor potential cation channel subfamily C member 5,TrpC5)的表达及其临床意义。方法:利用免疫组织化学法检测73例肺鳞癌组织和对应的癌旁组织中TrpC5的表达,并分析其表达与各临床病理参数和肺鳞癌预后之间的关系。结果:TrpC5在肺鳞癌组织中阳性表达率显著高于癌旁组织(P<0.001),肺鳞癌组织中TrpC5的表达与肿瘤淋的巴结转移、TNM分期以及肺鳞癌预后密切相关(P<0.05)。结论:TrpC5在肺鳞癌中高表达,其高表达可能与肿瘤转移、肺鳞癌的不良预后相关。展开更多
文摘目的探讨超声造影在预测甲状腺乳头状癌(PTC)颈部淋巴结转移中的应用价值。方法回顾性分析64例PTC患者(共71个结节)的超声造影资料,根据术后病理结果,分为转移组(37个结节)和未转移组(34个结节),应用QLAB软件进行超声造影定量分析,绘制PTC结节边缘区及中央区的时间-强度曲线(TIC),并获得上升时间(RT)、峰值强度(PI)、平均渡越时间(MTT)、曲线下面积(AUC)、峰值降半时间(TPH)、上升斜率(WIS)及达峰时间(TTP),分析比较两组PTC结节边缘区及中央区的超声造影灌注强度特征及定量参数差异;绘制相关参数判断PTC淋巴结转移的受试者工作特征(ROC)曲线,计算其诊断效能。结果 PTC结节多表现为不均匀低增强,达峰时结节边缘区灌注强度大于中央区;两组结节灌注强度特征比较差异均无统计学意义。转移组PTC结节边缘区PI、AUC分别为(8.39±2.19)d B、(220.69±83.56)d B s,未转移组PTC结节边缘区PI、AUC分别为(6.52±2.32)d B、(168.29±52.95)d B s,两组比较差异均有统计学意义(均P<0.01);余各参数比较差异均无统计学意义。PTC结节边缘区PI、AUC判断颈部淋巴结转移的ROC曲线下面积分别为0.733、0.708,当PTC结节边缘区PI临界值>8.04 d B、AUC临界值>202.99 d B s时,其判断颈部淋巴结转移的敏感性、特异性分别为67.6%、82.4%和64.9%、79.4%。结论 PTC结节边缘区超声造影定量参数PI、AUC对预测PTC颈部淋巴结转移具有一定的临床应用价值。
基金supported by the Natural Sciences Basic Research Project,Education(08KJD310005)Department of Jiangsu Provincethe 5th"Six Talent-Person-Peak-Program",Jiangsu Province,ChinaThe progress main program fund of Nanjing Medical University 2007(nmu07002)
文摘Objective： Colorectal cancer is one of the major contributors to cancer death worldwide. Lack of reliable colorectal cancer markers has hampered the management of these cancer patients. Our main purpose was to study the correlation between histopathological variables of colorectal adenocarcinomas and identify histopathological markers that are of prognostic value in patients with colorectal cancer. Methods： In the present study, we examined the expression of carcinoembryonic antigen （CEA）, p53, Ki-67 and glutathion Stransferase （GST） -n by using immunohistochemical staining methods in 126 colorectal carcinoma patients and evaluated the lymph node metastasis status in these patients by histopathological examination. Results： The positive rates of CEA, p53, Ki-67 and GST-π expression in the colorectal cancer tissue specimens examined were 95.23%, 55.56%, 53.38% and 82.30%, respectively. Expression of p53 and Ki-67 was significantly correlated with the Dukes stages of the tumor, with higher levels of these proteins in Dukes＇ C and D tumors than those in Dukes＇ A and B tumors. Furthermore, the expression of p53, GST-π and Ki-67 correlated with prognosis of patients with colorectal cancer. Additionally, the expression of p53 in colorectal cancer was closely related to the expression of Ki-67 and the expression of GST-π was directly correlated with that of p53. Conclusion： The expression of CEA, p53, Ki-67 and GST-π was correlated with various clinical features of patients with colorectal cancer. The combined use of these histopathological markers appeared to be a promising tool in predicting the prognosis of patients with this type of cancer.
文摘目的:探讨肺鳞癌组织中瞬时受体电位通道5(transient receptor potential cation channel subfamily C member 5,TrpC5)的表达及其临床意义。方法:利用免疫组织化学法检测73例肺鳞癌组织和对应的癌旁组织中TrpC5的表达,并分析其表达与各临床病理参数和肺鳞癌预后之间的关系。结果:TrpC5在肺鳞癌组织中阳性表达率显著高于癌旁组织(P<0.001),肺鳞癌组织中TrpC5的表达与肿瘤淋的巴结转移、TNM分期以及肺鳞癌预后密切相关(P<0.05)。结论:TrpC5在肺鳞癌中高表达,其高表达可能与肿瘤转移、肺鳞癌的不良预后相关。
