1文献来源研究一:Babaei M,Jansen L,Balavarca Y,et al.Neoadjuvant therapy in rectal cancer patients with clinical stageⅡtoⅢacross European countries:Variations and outcomes[J].Clin Colorectal Cancer,2018,17(1):e129-e1...1文献来源研究一:Babaei M,Jansen L,Balavarca Y,et al.Neoadjuvant therapy in rectal cancer patients with clinical stageⅡtoⅢacross European countries:Variations and outcomes[J].Clin Colorectal Cancer,2018,17(1):e129-e142.研究二:Takiyama H,Kawai K,Ishihara S,et al.Different impacts of preoperative radiotherapy and chemoradiotherapy on oncological outcomes in patients with stagesⅡandⅢlower rectal cancer:A propensity score analysis[J].Dig Surg,2018,35(3):212-219.2证据水平2b。3背景研究一:新辅助放化疗,全直肠系膜切除术(total mesorectal excision,TME),术后辅助化疗被用于局部进展期直肠癌(local advanced rectal cancer,LARC)的治疗。更好的使用直肠癌新辅助治疗的办法是,将直肠癌分为低等、中等、高等危险特征。对于LARC,术前新辅助治疗被认为可以提高手术切除的可能性,降低局部区域复发,并且潜在提高生存率。直肠癌的治疗建议来自一些指南,比如英国、欧洲其他国家、美国的指南,但各指南间却有很大差别。展开更多
Standard chemoradiotherapy(CRT) for local advanced rectal cancer(LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-y...Standard chemoradiotherapy(CRT) for local advanced rectal cancer(LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever. Computed tomography revealed rectal perforation, and he underwent emergency sigmoid colostomy. At 12 d after the surgery, the remaining CRT was completed according to the original plan. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis. We share this case as important evidence for the treatment of LARC perforation in the midst of preoperative CRT.展开更多
文摘1文献来源研究一:Babaei M,Jansen L,Balavarca Y,et al.Neoadjuvant therapy in rectal cancer patients with clinical stageⅡtoⅢacross European countries:Variations and outcomes[J].Clin Colorectal Cancer,2018,17(1):e129-e142.研究二:Takiyama H,Kawai K,Ishihara S,et al.Different impacts of preoperative radiotherapy and chemoradiotherapy on oncological outcomes in patients with stagesⅡandⅢlower rectal cancer:A propensity score analysis[J].Dig Surg,2018,35(3):212-219.2证据水平2b。3背景研究一:新辅助放化疗,全直肠系膜切除术(total mesorectal excision,TME),术后辅助化疗被用于局部进展期直肠癌(local advanced rectal cancer,LARC)的治疗。更好的使用直肠癌新辅助治疗的办法是,将直肠癌分为低等、中等、高等危险特征。对于LARC,术前新辅助治疗被认为可以提高手术切除的可能性,降低局部区域复发,并且潜在提高生存率。直肠癌的治疗建议来自一些指南,比如英国、欧洲其他国家、美国的指南,但各指南间却有很大差别。
文摘Standard chemoradiotherapy(CRT) for local advanced rectal cancer(LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever. Computed tomography revealed rectal perforation, and he underwent emergency sigmoid colostomy. At 12 d after the surgery, the remaining CRT was completed according to the original plan. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis. We share this case as important evidence for the treatment of LARC perforation in the midst of preoperative CRT.
