Background Pediatric patients are susceptible to lung injury.Acute lung injury in children often results in high mortality.Partial liquid ventilation （PLV） has been shown to markedly improve oxygenation and reduce h...Background Pediatric patients are susceptible to lung injury.Acute lung injury in children often results in high mortality.Partial liquid ventilation （PLV） has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models.This study was designed to examine the hypothesis that PLV would attenuate the production of local and systemic tumor necrosis factor （TNF）-α in an immature piglet model of acute lung injury induced by oleic acid （OA）.Methods Twelve Chinese immature piglets were induced acute lung injury by OA.The animals were randomly assigned to two groups of six animals,（1） conventional mechanical ventilation （MV） group and （2） PLV with 10 ml/kg FC-77 group.Results Compared with MV group,the PLV group had better cardiopulmonary variables （P 〈0.05）.These variables included heart rate,mean blood pressure,blood pH,partial pressure of arterial oxygen （PaO2）,PaO2/inspired O2 fraction （FiO2） and partial pressure of arterial carbon dioxide （PaCO2）.PLV reduced TNF-α levels both in plasma and tissue compared with MV group （P 〈0.05）.Conclusion PLV provides protective effects against TNF-a response in OA-induced acute lung injury in immature piglets.展开更多
基金This study was supported by the grants from National Natural Science Foundation of China （No. 30670928 and No. 81070055）, Beijing Municipal Education Commission （No. PXM2011_014226 07 000060）, Beijing Municipal Science Committee （No. Z11110006150000） and Beijing Natural Science Foundation （No. 7122056）.We are grateful to Dr. LING Feng, Dr. LIU Ai-jun, Dr. LI Gang and Dr. XU Yu-lin for their preparation of the animals, to Dr. LIU Yang-qing and Dr. LIU De-bin for their histopathological assessment.
文摘Background Pediatric patients are susceptible to lung injury.Acute lung injury in children often results in high mortality.Partial liquid ventilation （PLV） has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models.This study was designed to examine the hypothesis that PLV would attenuate the production of local and systemic tumor necrosis factor （TNF）-α in an immature piglet model of acute lung injury induced by oleic acid （OA）.Methods Twelve Chinese immature piglets were induced acute lung injury by OA.The animals were randomly assigned to two groups of six animals,（1） conventional mechanical ventilation （MV） group and （2） PLV with 10 ml/kg FC-77 group.Results Compared with MV group,the PLV group had better cardiopulmonary variables （P 〈0.05）.These variables included heart rate,mean blood pressure,blood pH,partial pressure of arterial oxygen （PaO2）,PaO2/inspired O2 fraction （FiO2） and partial pressure of arterial carbon dioxide （PaCO2）.PLV reduced TNF-α levels both in plasma and tissue compared with MV group （P 〈0.05）.Conclusion PLV provides protective effects against TNF-a response in OA-induced acute lung injury in immature piglets.
