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Correlation of Various Foods Intakes and Plasma Levels of Omega Fatty Acids in Healthy Japanese Old Men
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作者 Akikazu Takada Fumiko Shimizu Shinji Koba 《Food and Nutrition Sciences》 2019年第6期578-587,共10页
Background: Trans fatty acids are considered to impair health and some ω fatty acids are protective against atherosclerosis and diabetes mellitus. Trans fatty acids are said to be formed by the partial hydrogenation ... Background: Trans fatty acids are considered to impair health and some ω fatty acids are protective against atherosclerosis and diabetes mellitus. Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. It is important how much these intaken fatty acids influence their plasma levels. Methods: Plasma levels of fatty acids including transforms of healthy old men are measured by gas chromatography and correlations between various foods intakes and plasma levels of trans fatty acids, and ω fatty acids are examined. Results: Intake of fish resulted in increase in plasma levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) but intake of meat such as beef, cow and chicken meat did not increase plasma levels of arachidonic acid (AA). Intakes of oils increased plasma levels of dihomo-g-linolenic acid significantly and AA to some extent. Conclusion: Plasma levels of EPA and DHA increased upon intakes of fish in Japanese old men. Oil intake but not meat intake increased DGLA significantly. These results may explain low incidence of cardiovascular diseases in Japanese people compared with American people whose plasma levels of DHA and EPA are lower. 展开更多
关键词 FATTY acid Trans FATTY acid Palmitoelaidic acid Elaidic acid linoelaidic acid Saturated FATTY acid UNSATURATED FATTY acid Ω FATTY acid DGLA (Dihomo-G-Linolenic acid) DHA (Docosahexanoic acid) EPA (Eicosapentaenoic acid) AA (Arachidonic acid)
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Effects of Various Foods Intakes on Plasma Levels of Trans Fatty Acids in Japanese Old Men
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作者 F. Shimizu Y. Ishii +3 位作者 M. Ogawa T. Takao S. Koba A. Takada 《Food and Nutrition Sciences》 2018年第7期797-805,共9页
Background: Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. In Japan, use of tr... Background: Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. In Japan, use of trans fatty acids in the foods is prohibited, thus trans fatty acids must come from foods or microbes in the digestive organs. Methods: Plasma levels of fatty acids including trans forms of healthy old men are measured by gas chromatography and correlations between various foods intakes and plasma levels of trans fatty acids such as palmitoelaidic, elaidic and linoelaidic acids are examined. Results: No correlations between various foods intakes and trans fatty acids were found except between intake of preference drinks such as tea or coffee and plasma levels of palmitoelaidic and linoelaidic acids. Conclusion: Since palmitoelaidic acid is cardioprotective, increase in plasma levels of palmitoelaidic acid may indicate that intakes of tea and coffee may be beneficial for heath by increasing palmitoelaidic acids. 展开更多
关键词 FATTY acid Trans FATTY acid Palmitoelaidic acid Elaidic acid linoelaidic acid Saturated FATTY acid UNSATURATED FATTY acid ω FATTY acid DHA (Docosahexanoic acid) EPA (Eicosapentanoic acid) AA (Arachidonic acid)
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反亚油酸诱导人脐静脉内皮细胞的转录组学及生物信息学分析
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作者 邱斌 刘玮 +3 位作者 刘丽娜 宗爱珍 贾敏 徐同成 《中国食品学报》 EI CAS CSCD 北大核心 2020年第1期52-58,共7页
通过转录组学及其生物信息学分析,研究反亚油酸诱导人脐静脉内皮细胞差异表达基因及相关信号转导通路,结果发现:126条基因发生显著变化,其中28条基因显著上调,98条基因显著下调。生物信息学分析结果表明:与细胞组成相关基因共54条,而涉... 通过转录组学及其生物信息学分析,研究反亚油酸诱导人脐静脉内皮细胞差异表达基因及相关信号转导通路,结果发现:126条基因发生显著变化,其中28条基因显著上调,98条基因显著下调。生物信息学分析结果表明:与细胞组成相关基因共54条,而涉及分子功能的基因共118条。本研究共富集到相关信号通路99条,其中显著变化的7条,包括萜类骨架生物合成通路、类固醇生物合成通路和肿瘤坏死通路等。根据PPI基因互作通路图,研究同时参与不同信号转导通路的靶基因,包括基质金属蛋白酶-3、FOS及肿瘤坏死受体相关因子-1等。 展开更多
关键词 反亚油酸 生物信息学 转录组学 内皮细胞
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