BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly understood.Previous research suggests that implicit emotion regulation may play a central role in PD-related emot...BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly understood.Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance.However,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators.AIM To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical evaluations.The study utilized a case-control design with random sampling,selecting participants for the case group from March to December 2018.Participants performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control condition.ERP and behavioral data were recorded to compare the late positive potential(LPP)within and between the groups.RESULTS Both PD and HC groups showed longer reaction times and decreased accuracy under the affect labeling.In the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by decrease.Importantly,a significant group×condition interaction effect was observed.Simple effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC group.Furthermore,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and intensity.CONCLUSION PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative emotions.The late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.展开更多
Major depressive disorder(MDD)is characterized by emotion dysregulation.Whether implicit emotion regulation can compensate for this deficit remains unknown.In this study,we recruited 159 subjects who were healthy cont...Major depressive disorder(MDD)is characterized by emotion dysregulation.Whether implicit emotion regulation can compensate for this deficit remains unknown.In this study,we recruited 159 subjects who were healthy controls,had subclinical depression,or had MDD,and examined them under baseline,implicit,and explicit reappraisal conditions.Explicit reappraisal led to the most negative feelings and the largest parietal late positive potential(parietal LPP,an index of emotion intensity)in the MDD group compared to the other two groups;the group difference was absent under the other two conditions.MDD patients showed larger regulatory effects in the LPP during implicit than explicit reappraisal,whereas healthy controls showed a reversed pattern.Furthermore,the frontal P3,an index of voluntary cognitive control,showed larger amplitudes in explicit reappraisal compared to baseline in the healthy and subclinical groups,but not in the MDD group,while implicit reappraisal did not increase P3 across groups.These findings suggest that implicit reappraisal is beneficial for clinical depression.展开更多
Evidence suggests that explicit reappraisal has limited regulatory effects on high-intensity emotions,mainly due to the depletion of cognitive resources occupied by the high-intensity emotional stimulus itself.The imp...Evidence suggests that explicit reappraisal has limited regulatory effects on high-intensity emotions,mainly due to the depletion of cognitive resources occupied by the high-intensity emotional stimulus itself.The implicit form of reappraisal has proved to be resource-saving and therefore might be an ideal strategy to achieve the desired regulatory effect in high-intensity situations.In this study,we explored the regulatory effect of explicit and implicit reappraisal when participants encountered low-and high-intensity negative images.The subjective emotional rating indicated that both explicit and implicit reappraisal down-regulated negative experiences,irrespective of intensity.However,the amplitude of the parietal late positive potential(LPP;a neural index of experienced emotional intensity)showed that only implicit reappraisal had significant regulatory effects in the high-intensity context,though both explicit and implicit reappraisal successfully reduced the emotional neural responses elicited by low-intensity negative images.Meanwhile,implicit reappraisal led to a smaller frontal LPP amplitude(an index of cognitive cost)compared to explicit reappraisal,indicating that the implementation of implicit reappraisal consumes limited cognitive control resources.Furthermore,we found a prolonged effect of implicit emotion regulation introduced by training procedures.Taken together,these findings not only reveal that implicit reappraisal is suitable to relieve high-intensity negative experiences as well as neural responses,but also highlight the potential benefit of trained implicit regulation in clinical populations whose frontal control resources are limited.展开更多
基金Supported by The National Natural Science Foundation of China,No.81871080the Key R&D Program of Jining(Major Program),No.2023YXNS004+2 种基金the National Natural Science Foundation of China,No.81401486the Natural Science Foundation of Liaoning Province of China,No.20170540276the Medicine and Health Science Technology Development Program of Shandong Province,No.202003070713.
文摘BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly understood.Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance.However,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators.AIM To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical evaluations.The study utilized a case-control design with random sampling,selecting participants for the case group from March to December 2018.Participants performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control condition.ERP and behavioral data were recorded to compare the late positive potential(LPP)within and between the groups.RESULTS Both PD and HC groups showed longer reaction times and decreased accuracy under the affect labeling.In the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by decrease.Importantly,a significant group×condition interaction effect was observed.Simple effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC group.Furthermore,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and intensity.CONCLUSION PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative emotions.The late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.
基金supported by the National Natural Science Foundation of China(31970980 and 31920103009)the Major Project of National Social Science Foundation(20&ZD153)+1 种基金the Shenzhen-Hong Kong Institute of Brain Science(2019SHIBS0003)the Guangdong Key Project(2018B030335001).
文摘Major depressive disorder(MDD)is characterized by emotion dysregulation.Whether implicit emotion regulation can compensate for this deficit remains unknown.In this study,we recruited 159 subjects who were healthy controls,had subclinical depression,or had MDD,and examined them under baseline,implicit,and explicit reappraisal conditions.Explicit reappraisal led to the most negative feelings and the largest parietal late positive potential(parietal LPP,an index of emotion intensity)in the MDD group compared to the other two groups;the group difference was absent under the other two conditions.MDD patients showed larger regulatory effects in the LPP during implicit than explicit reappraisal,whereas healthy controls showed a reversed pattern.Furthermore,the frontal P3,an index of voluntary cognitive control,showed larger amplitudes in explicit reappraisal compared to baseline in the healthy and subclinical groups,but not in the MDD group,while implicit reappraisal did not increase P3 across groups.These findings suggest that implicit reappraisal is beneficial for clinical depression.
基金supported by the National Natural Science Foundation of China(32271102,31970980,31920103009)the Major Project of the National Social Science Foundation(20&ZD153)+1 种基金the Shenzhen-Hong Kong Institute of Brain Science(2022SHIBS0003)the Guangdong Key Project(2018B030335001).
文摘Evidence suggests that explicit reappraisal has limited regulatory effects on high-intensity emotions,mainly due to the depletion of cognitive resources occupied by the high-intensity emotional stimulus itself.The implicit form of reappraisal has proved to be resource-saving and therefore might be an ideal strategy to achieve the desired regulatory effect in high-intensity situations.In this study,we explored the regulatory effect of explicit and implicit reappraisal when participants encountered low-and high-intensity negative images.The subjective emotional rating indicated that both explicit and implicit reappraisal down-regulated negative experiences,irrespective of intensity.However,the amplitude of the parietal late positive potential(LPP;a neural index of experienced emotional intensity)showed that only implicit reappraisal had significant regulatory effects in the high-intensity context,though both explicit and implicit reappraisal successfully reduced the emotional neural responses elicited by low-intensity negative images.Meanwhile,implicit reappraisal led to a smaller frontal LPP amplitude(an index of cognitive cost)compared to explicit reappraisal,indicating that the implementation of implicit reappraisal consumes limited cognitive control resources.Furthermore,we found a prolonged effect of implicit emotion regulation introduced by training procedures.Taken together,these findings not only reveal that implicit reappraisal is suitable to relieve high-intensity negative experiences as well as neural responses,but also highlight the potential benefit of trained implicit regulation in clinical populations whose frontal control resources are limited.
