Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mech...Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mechanisms. Methods:Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto(WKY)rats were included in this study.SHRs were randomly divided into two groups to receive losartan at 30 mg/(kg·d)by oral gavage once daily for 8 weeks(SHR-L)or vehicle(0.9%saline)to act as controls(SHR-V);WKY rats receiving vehicle for 8 weeks served as normotensive controls.At the end of the experiment,rats were sacrificed and the hearts were removed.Expressions of Cx43 and nuclear factor-kappaB p65 (NF-κB p65)proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan(30 mg/(kg·d),8 weeks)on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western blot.Results:Left ventricular(LV)hypertrophy was prominent in SHRs,Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell surface.Treatment with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV myocardium.The distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan treatment.Conclu- sion:Cx43 level was upregulated in LV myocardium of SHR during early stage of hypertrophy.Angiotensin II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles,possibly through the NF-κB pathway.展开更多
Low voltage three-phase four-wire AC distribution grids may experience high neutral current,mainly caused by asymmetrical distribution of single-phase loads in three phases.High neutral current will not only increase ...Low voltage three-phase four-wire AC distribution grids may experience high neutral current,mainly caused by asymmetrical distribution of single-phase loads in three phases.High neutral current will not only increase line losses but also result in neutral potential variations.For the LV AC distribution grid established by a grid-forming inverter(e.g.,uninterruptible power supply and solid-state-transformer),it also suffers from the same neutral current issues.Therefore,this paper comparatively studies several neutral current control approaches and their impacts on grid voltage balance,which is required by grid code.Then,this paper proposes an optimal neutral current control approach,which can obtain maximum neutral current suppression with less impact on grid voltage balance.The correctness of the theoretical analysis is validated through both simulation and experimental results.展开更多
This paper analyzes the reliability of low voltage(LV)distribution system of the Sri Lankan power system.Performance of LV distribution systems where mainly domestic consumers depend on the individual components of th...This paper analyzes the reliability of low voltage(LV)distribution system of the Sri Lankan power system.Performance of LV distribution systems where mainly domestic consumers depend on the individual components of the system.Failure rates of elements of the system are calculated based on the historical data of the LV distribution system in a semi-urban area.Load point reliability indices are calculated using the analytical method.Consumer-oriented reliability parameters and energy not served,and its cost are determined.As a method of improvement of reliability,inclusion of fuses to the lateral feeders of the main feeder is proposed.Load point reliability indices,consumer-oriented reliability indices,and energy not served are calculated for the distribution system with fuses in lateral feeders.The results are compared with the reliability indices of the present system and analyzed.展开更多
文摘Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mechanisms. Methods:Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto(WKY)rats were included in this study.SHRs were randomly divided into two groups to receive losartan at 30 mg/(kg·d)by oral gavage once daily for 8 weeks(SHR-L)or vehicle(0.9%saline)to act as controls(SHR-V);WKY rats receiving vehicle for 8 weeks served as normotensive controls.At the end of the experiment,rats were sacrificed and the hearts were removed.Expressions of Cx43 and nuclear factor-kappaB p65 (NF-κB p65)proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan(30 mg/(kg·d),8 weeks)on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western blot.Results:Left ventricular(LV)hypertrophy was prominent in SHRs,Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell surface.Treatment with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV myocardium.The distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan treatment.Conclu- sion:Cx43 level was upregulated in LV myocardium of SHR during early stage of hypertrophy.Angiotensin II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles,possibly through the NF-κB pathway.
基金the National Natural Science Foundation of China(NSFC)under Grant 51767017National Science and Technology Major Project of Gansu Province under Grant 19ZD2GA003.
文摘Low voltage three-phase four-wire AC distribution grids may experience high neutral current,mainly caused by asymmetrical distribution of single-phase loads in three phases.High neutral current will not only increase line losses but also result in neutral potential variations.For the LV AC distribution grid established by a grid-forming inverter(e.g.,uninterruptible power supply and solid-state-transformer),it also suffers from the same neutral current issues.Therefore,this paper comparatively studies several neutral current control approaches and their impacts on grid voltage balance,which is required by grid code.Then,this paper proposes an optimal neutral current control approach,which can obtain maximum neutral current suppression with less impact on grid voltage balance.The correctness of the theoretical analysis is validated through both simulation and experimental results.
文摘This paper analyzes the reliability of low voltage(LV)distribution system of the Sri Lankan power system.Performance of LV distribution systems where mainly domestic consumers depend on the individual components of the system.Failure rates of elements of the system are calculated based on the historical data of the LV distribution system in a semi-urban area.Load point reliability indices are calculated using the analytical method.Consumer-oriented reliability parameters and energy not served,and its cost are determined.As a method of improvement of reliability,inclusion of fuses to the lateral feeders of the main feeder is proposed.Load point reliability indices,consumer-oriented reliability indices,and energy not served are calculated for the distribution system with fuses in lateral feeders.The results are compared with the reliability indices of the present system and analyzed.
