Melasma (or chloasma) is a hyperpigmentation disorder predominantly affecting sun-exposed skin in women, and is often refractory to treatment. The objective was to evaluate the efficacy and safety of a new whitening f...Melasma (or chloasma) is a hyperpigmentation disorder predominantly affecting sun-exposed skin in women, and is often refractory to treatment. The objective was to evaluate the efficacy and safety of a new whitening formula for the treatment of chloasma. This?single centre, double-blind, placebo controlled, bilateral (split-face) comparison, was conducted on 44 Chinese subjects with chloasma during the winter season. The test formula was applied twice a day, for 12 weeks on left side of the face and a placebo formula on the right side of the face. Assessments included the use of the hemi-MASI (split-face Melasma Area Severity Index), both ultraviolet and standard photography, together with clinical evaluations of efficacy and safety at T0, T6 and T12 weeks. A significant difference between the 2-hemi-MASI was noticed after 6 and 12 weeks of treatment. This result was confirmed by the clinical evaluation of the dermatologists who recorded a significant improvement in the half-face treated with the new whitening formula compared with that treated with placebo (p = 0.003). The tolerance of the new formula was recorded as excellent by 82% of subjects and found to be cosmetically appealing. In this study, the new whitening formula containing ferulic acid, Ginkgo Biloba, lipohydroxyacid (LHA), niacinamide and thermal spring water was safe and significantly improved chloasma after a 3-month-treatment period compared with placebo.展开更多
目的:探讨Leptin对下丘脑外测区(LHA)、腹内侧核(VMH)和室旁核(PVN)的RNA含量和脂肪沉积的影响。方法:通过小鼠注射Leptin,连续注射14 d,70日龄时将动物宰杀,取LHA、VMH和PVN的组织,用荧光显微数字成像系统和Image Pro plus图像分析,测...目的:探讨Leptin对下丘脑外测区(LHA)、腹内侧核(VMH)和室旁核(PVN)的RNA含量和脂肪沉积的影响。方法:通过小鼠注射Leptin,连续注射14 d,70日龄时将动物宰杀,取LHA、VMH和PVN的组织,用荧光显微数字成像系统和Image Pro plus图像分析,测RNA。结果:Leptin引起生长期小鼠LHA和VMH的RNA含量显著增高(P<0.01、P<0.05),PVN的RNA含量降低,腹腔脂肪沉积显著减少(P<0.05)。结论:Leptin能引起LHA和VMH的功能加强,且两者都均与腹腔脂肪沉积呈负相关。展开更多
文摘Melasma (or chloasma) is a hyperpigmentation disorder predominantly affecting sun-exposed skin in women, and is often refractory to treatment. The objective was to evaluate the efficacy and safety of a new whitening formula for the treatment of chloasma. This?single centre, double-blind, placebo controlled, bilateral (split-face) comparison, was conducted on 44 Chinese subjects with chloasma during the winter season. The test formula was applied twice a day, for 12 weeks on left side of the face and a placebo formula on the right side of the face. Assessments included the use of the hemi-MASI (split-face Melasma Area Severity Index), both ultraviolet and standard photography, together with clinical evaluations of efficacy and safety at T0, T6 and T12 weeks. A significant difference between the 2-hemi-MASI was noticed after 6 and 12 weeks of treatment. This result was confirmed by the clinical evaluation of the dermatologists who recorded a significant improvement in the half-face treated with the new whitening formula compared with that treated with placebo (p = 0.003). The tolerance of the new formula was recorded as excellent by 82% of subjects and found to be cosmetically appealing. In this study, the new whitening formula containing ferulic acid, Ginkgo Biloba, lipohydroxyacid (LHA), niacinamide and thermal spring water was safe and significantly improved chloasma after a 3-month-treatment period compared with placebo.
文摘目的:探讨Leptin对下丘脑外测区(LHA)、腹内侧核(VMH)和室旁核(PVN)的RNA含量和脂肪沉积的影响。方法:通过小鼠注射Leptin,连续注射14 d,70日龄时将动物宰杀,取LHA、VMH和PVN的组织,用荧光显微数字成像系统和Image Pro plus图像分析,测RNA。结果:Leptin引起生长期小鼠LHA和VMH的RNA含量显著增高(P<0.01、P<0.05),PVN的RNA含量降低,腹腔脂肪沉积显著减少(P<0.05)。结论:Leptin能引起LHA和VMH的功能加强,且两者都均与腹腔脂肪沉积呈负相关。
