Concurrent chemoradiotherapy （CCRT） is regarded as the standard treatment for locally advanced uterine cervical cancer （LACC）, including stage Ib2-IVa disease [International Federation of Gynecology and Obstetrics...Concurrent chemoradiotherapy （CCRT） is regarded as the standard treatment for locally advanced uterine cervical cancer （LACC）, including stage Ib2-IVa disease [International Federation of Gynecology and Obstetrics （FIGO） staging]. However, approximately a third of eligible patients in previous studies died of LACC despite receiving CCRT. The therapeutic significance of CCRT alone in stage Ⅲ-IVa disease has not yet been confirmed. Effective treatment of some LACC is beyond the scope of CCRT. The objective of the present review is to highlight some challenging work aimed at overcoming this seemingly intractable disease. CCRT with increased peak concentrations of cisplatin （CDDP）, surgery following CCRT, adjuvant chemotherapy （CT） following CCRT, and neoadjuvant CT followed by CCRT are strategies expected to enhance the therapeutic efficacy of CCRT. If patients with LACC were divided into those with low-risk or high-risk systemic disease or prognoses, novel strategies should be assessed in the group with high-risk disease.展开更多
宫颈癌是严重危害女性健康的恶性肿瘤之一,手术治疗方式主要为宫颈癌根治术,手术入路包括经腹、经阴道等,手术方法主要有开腹手术、腹腔镜手术及机器人辅助腹腔镜手术等。它们历经时间考验显示出各自的优势,给临床妇科肿瘤医生更多的选...宫颈癌是严重危害女性健康的恶性肿瘤之一,手术治疗方式主要为宫颈癌根治术,手术入路包括经腹、经阴道等,手术方法主要有开腹手术、腹腔镜手术及机器人辅助腹腔镜手术等。它们历经时间考验显示出各自的优势,给临床妇科肿瘤医生更多的选择空间,特别是其中的微创手术方式更加有助于患者的快速康复。然而,2018年LACC(Laparoscopic Approach to Cervical Cancer)研究横空出世,其结论认为早期宫颈癌患者经腹手术预后优于腹腔镜手术,带来巨大的争议与讨论。本文主要回顾各类型宫颈癌根治术的发展历史,并对后LACC时代早期宫颈癌患者手术治疗方式的选择进行讨论,为临床医生提供更多借鉴依据。展开更多
Remote sensing techniques have the potential to provide information on agricultural crops quantitatively , instantaneously and above all nondestructively over large areas . Crop simulation models describe the relation...Remote sensing techniques have the potential to provide information on agricultural crops quantitatively , instantaneously and above all nondestructively over large areas . Crop simulation models describe the relationship between physiological processes in plants and environmental growing conditions. The integration between remote sensing data and crop growth simulation model is an important trend for yield estimation and prediction, since remote sensing can provide information on the actual status of the agricultural crop. In this study, a new model(Rice-SRS) was developed based mainly on ORYZA1 model and modified to accept remote sensing data as input from different sources. The model can accept three kinds of NDVI data: NOAA AVHRR(LAC)-NDVI,NOAA AVHRR(GAC)-NDVI and radiometric measurements-NDVI. The integration between NOAA AVHRR (LAC) data and simulation model as applied to Rice-SRS resulted in accurate estimates for rice yield in the Shaoxing area, reduced the estimating error to 1.027%,0.794% and (-0.787%) for early, single, and late season respectively. Utilizing NDVI data derived from NOAA AVHRR (GAC) as input in Rice-SRS can yield good estimation for rice yield with the average error (-7.43%). Testing the new model for radiometric measurements showed that the average estimation error for 10 varieties under early rice conditions was less than 1%.展开更多
Objective： The aim of this study was to investigate the role of preoperative neoadjuvant intra-arterial infusion chemotherapy （NAIC） in treating locally advanced cervical caner. Methods： Nineteen locally advanced ...Objective： The aim of this study was to investigate the role of preoperative neoadjuvant intra-arterial infusion chemotherapy （NAIC） in treating locally advanced cervical caner. Methods： Nineteen locally advanced cervical cancer （LACC） patients from November 2003 to November 2005 were analyzed retrospectively. NAIC was administrated 2 courses every 2 weeks using a combination of 30 mg/m^2 bleomycin and 50 mg/m^2 cisplatin via bilateral femur artedes. The response to NAIC was assessed by pelvic examination and imaging diagnostics and histological analysis. Two weeks after NAIC radical hysterectomy with pelvic lymphadenectomy was performed. Results： Radical hysterectomy with pelvic lymphadenectomy were performed in 18 patients successfully. The mean tumor reduction rate was 73.04%. The overall clinical response rate of NAIC was 84.2% with 2 complete responses and 16 partial responses. Only 1 nonresponder. Six of 7 cases who had parametrial infiltration had a absence after chemotherapy, no significant change was observed in 1 case who followed by radiotherapy. Multivariate logistic regression analysis indicated that tumor volume prior to treatment was determining factor affecting the efficacy of NAIC in LACC. Conclusion： pre-operative NAIC inhibited the growth of LACC, minimized the size, eliminate effectively the pathologic dsk factors in the pelvic cavity, to improve the operability in cervical cancer patients with stage lib or above, considered inoperable.展开更多
Objective: To explore the efficacy of different neoadjuvant chemotherapy (NACT ) i n t h e treatment of locally advanced cervical cancer (LACC) and safety evaluation. Methods: A total of 68 patients with LACC who were...Objective: To explore the efficacy of different neoadjuvant chemotherapy (NACT ) i n t h e treatment of locally advanced cervical cancer (LACC) and safety evaluation. Methods: A total of 68 patients with LACC who were admitted in our hospital from April;2015 to August;2016 were included in the study and divided into the observation group (n=34) and the control group (n=34) according to different chemotherapy regimens. The patients in the observation group were given docetaxel and oxaliplatin (DTX+OXA);while the patients in the control group were given TAX and DDP. 21 d-treatment was regarded as one course;for 2 courses. After treatment;the patients in the two groups were given laparoscopic extensive hysterectomy;pelvic lymph node dissection;and abdominal aortic lymph node sampling. The short-term efficacy and adverse reactions in the two groups were observed. Pathological evaluation of postoperative specimens in the two groups was performed. The peripheral blood T lymphocyte subsets and NK cell in the two groups were detected and compared. Results: ORR and DCR in the observation group were 47.09% and 91.18%;respectively;while those in the control group were 44.12% and 85.29%;respectively;and the comparison between the two groups was not statistically significant. When compared with before treatment;CD4+;CD8+;and NK cell after treatment in the two groups were significantly reduced;while CD4+/CD8+ was significantly increased;but the comparison between the two groups was not statistically significant. It was proved by the postoperative pathology that the comparison of PCR;PR1;and PR2 between the two groups was not statistically significant. Meanwhile;the comparison of cervical infiltration depth;surgical incision;parametrial infiltration;and pelvic lymph node metastasis between the two groups was not statistically significant. The proportion of alopecia;gastrointestinal reaction;and renal toxicity in the observation was significantly lower than that in the control group;but the proportion of peripheral neurotoxicity展开更多
Objective:Because of the poor prognosis of lacrimal adenoid cystic carcinoma(LACC),we aimed to investigate the effects of perineural invasion(PNI)and consequent aberrations in GDNF/GFRα-1/RET protein expression on LA...Objective:Because of the poor prognosis of lacrimal adenoid cystic carcinoma(LACC),we aimed to investigate the effects of perineural invasion(PNI)and consequent aberrations in GDNF/GFRα-1/RET protein expression on LACC recurrence.Methods:Clinicopathological data for 51 histologically confirmed patients with LACC enrolled between 2001 and 2017 were retrospectively analyzed.Hematoxylin and eosin staining was applied to assess PNI.Tissue-based immunohistochemistry(IHC)detection of GDNF,GFRα-1,and RET proteins was performed on LACC formalin-fixed,paraffin-embedded specimens.We generated semi-quantitative data of the IHC results and compared them with the clinicopathological data for the 51 patients.Results:Of the 51 patients,19(37.3%)were PNI positive.Recurrence was more common for LACC with than without PNI(73.7%vs.37.5%,P=0.01).GDNF,GFRα-1,and RET proteins were expressed in 62.7%,62.7%,and 54.9%of the 51 patients with LACC,respectively.The expression of all 3 proteins was more common in patients with than without PNI.In agreement with previous findings,PNI-associated GFRα-1 and RET positivity,as detected by IHC,remained significantly associated with recurrence,whereas GDNF expression,as detected by IHC,was not correlated with LACC recurrence.Specifically,patients with concurrent GFRα-1 and RET expression may have a high risk of PNI(89.5%positivity rate)and recurrence(84.2%positivity rate).Conclusions:PNI may contribute to LACC recurrence.The concurrent expression of GFRα-1 and RET proteins,as detected by IHC,may potentially be associated with LACC PNI and recurrence.展开更多
文摘Concurrent chemoradiotherapy （CCRT） is regarded as the standard treatment for locally advanced uterine cervical cancer （LACC）, including stage Ib2-IVa disease [International Federation of Gynecology and Obstetrics （FIGO） staging]. However, approximately a third of eligible patients in previous studies died of LACC despite receiving CCRT. The therapeutic significance of CCRT alone in stage Ⅲ-IVa disease has not yet been confirmed. Effective treatment of some LACC is beyond the scope of CCRT. The objective of the present review is to highlight some challenging work aimed at overcoming this seemingly intractable disease. CCRT with increased peak concentrations of cisplatin （CDDP）, surgery following CCRT, adjuvant chemotherapy （CT） following CCRT, and neoadjuvant CT followed by CCRT are strategies expected to enhance the therapeutic efficacy of CCRT. If patients with LACC were divided into those with low-risk or high-risk systemic disease or prognoses, novel strategies should be assessed in the group with high-risk disease.
文摘宫颈癌是严重危害女性健康的恶性肿瘤之一,手术治疗方式主要为宫颈癌根治术,手术入路包括经腹、经阴道等,手术方法主要有开腹手术、腹腔镜手术及机器人辅助腹腔镜手术等。它们历经时间考验显示出各自的优势,给临床妇科肿瘤医生更多的选择空间,特别是其中的微创手术方式更加有助于患者的快速康复。然而,2018年LACC(Laparoscopic Approach to Cervical Cancer)研究横空出世,其结论认为早期宫颈癌患者经腹手术预后优于腹腔镜手术,带来巨大的争议与讨论。本文主要回顾各类型宫颈癌根治术的发展历史,并对后LACC时代早期宫颈癌患者手术治疗方式的选择进行讨论,为临床医生提供更多借鉴依据。
文摘Remote sensing techniques have the potential to provide information on agricultural crops quantitatively , instantaneously and above all nondestructively over large areas . Crop simulation models describe the relationship between physiological processes in plants and environmental growing conditions. The integration between remote sensing data and crop growth simulation model is an important trend for yield estimation and prediction, since remote sensing can provide information on the actual status of the agricultural crop. In this study, a new model(Rice-SRS) was developed based mainly on ORYZA1 model and modified to accept remote sensing data as input from different sources. The model can accept three kinds of NDVI data: NOAA AVHRR(LAC)-NDVI,NOAA AVHRR(GAC)-NDVI and radiometric measurements-NDVI. The integration between NOAA AVHRR (LAC) data and simulation model as applied to Rice-SRS resulted in accurate estimates for rice yield in the Shaoxing area, reduced the estimating error to 1.027%,0.794% and (-0.787%) for early, single, and late season respectively. Utilizing NDVI data derived from NOAA AVHRR (GAC) as input in Rice-SRS can yield good estimation for rice yield with the average error (-7.43%). Testing the new model for radiometric measurements showed that the average estimation error for 10 varieties under early rice conditions was less than 1%.
文摘Objective： The aim of this study was to investigate the role of preoperative neoadjuvant intra-arterial infusion chemotherapy （NAIC） in treating locally advanced cervical caner. Methods： Nineteen locally advanced cervical cancer （LACC） patients from November 2003 to November 2005 were analyzed retrospectively. NAIC was administrated 2 courses every 2 weeks using a combination of 30 mg/m^2 bleomycin and 50 mg/m^2 cisplatin via bilateral femur artedes. The response to NAIC was assessed by pelvic examination and imaging diagnostics and histological analysis. Two weeks after NAIC radical hysterectomy with pelvic lymphadenectomy was performed. Results： Radical hysterectomy with pelvic lymphadenectomy were performed in 18 patients successfully. The mean tumor reduction rate was 73.04%. The overall clinical response rate of NAIC was 84.2% with 2 complete responses and 16 partial responses. Only 1 nonresponder. Six of 7 cases who had parametrial infiltration had a absence after chemotherapy, no significant change was observed in 1 case who followed by radiotherapy. Multivariate logistic regression analysis indicated that tumor volume prior to treatment was determining factor affecting the efficacy of NAIC in LACC. Conclusion： pre-operative NAIC inhibited the growth of LACC, minimized the size, eliminate effectively the pathologic dsk factors in the pelvic cavity, to improve the operability in cervical cancer patients with stage lib or above, considered inoperable.
文摘Objective: To explore the efficacy of different neoadjuvant chemotherapy (NACT ) i n t h e treatment of locally advanced cervical cancer (LACC) and safety evaluation. Methods: A total of 68 patients with LACC who were admitted in our hospital from April;2015 to August;2016 were included in the study and divided into the observation group (n=34) and the control group (n=34) according to different chemotherapy regimens. The patients in the observation group were given docetaxel and oxaliplatin (DTX+OXA);while the patients in the control group were given TAX and DDP. 21 d-treatment was regarded as one course;for 2 courses. After treatment;the patients in the two groups were given laparoscopic extensive hysterectomy;pelvic lymph node dissection;and abdominal aortic lymph node sampling. The short-term efficacy and adverse reactions in the two groups were observed. Pathological evaluation of postoperative specimens in the two groups was performed. The peripheral blood T lymphocyte subsets and NK cell in the two groups were detected and compared. Results: ORR and DCR in the observation group were 47.09% and 91.18%;respectively;while those in the control group were 44.12% and 85.29%;respectively;and the comparison between the two groups was not statistically significant. When compared with before treatment;CD4+;CD8+;and NK cell after treatment in the two groups were significantly reduced;while CD4+/CD8+ was significantly increased;but the comparison between the two groups was not statistically significant. It was proved by the postoperative pathology that the comparison of PCR;PR1;and PR2 between the two groups was not statistically significant. Meanwhile;the comparison of cervical infiltration depth;surgical incision;parametrial infiltration;and pelvic lymph node metastasis between the two groups was not statistically significant. The proportion of alopecia;gastrointestinal reaction;and renal toxicity in the observation was significantly lower than that in the control group;but the proportion of peripheral neurotoxicity
基金supported by the Tianjin Municipal Commission of Health and Family Planning Science Foundation Grant(Grant Nos.2015KZ100 and 2014KZ098)。
文摘Objective:Because of the poor prognosis of lacrimal adenoid cystic carcinoma(LACC),we aimed to investigate the effects of perineural invasion(PNI)and consequent aberrations in GDNF/GFRα-1/RET protein expression on LACC recurrence.Methods:Clinicopathological data for 51 histologically confirmed patients with LACC enrolled between 2001 and 2017 were retrospectively analyzed.Hematoxylin and eosin staining was applied to assess PNI.Tissue-based immunohistochemistry(IHC)detection of GDNF,GFRα-1,and RET proteins was performed on LACC formalin-fixed,paraffin-embedded specimens.We generated semi-quantitative data of the IHC results and compared them with the clinicopathological data for the 51 patients.Results:Of the 51 patients,19(37.3%)were PNI positive.Recurrence was more common for LACC with than without PNI(73.7%vs.37.5%,P=0.01).GDNF,GFRα-1,and RET proteins were expressed in 62.7%,62.7%,and 54.9%of the 51 patients with LACC,respectively.The expression of all 3 proteins was more common in patients with than without PNI.In agreement with previous findings,PNI-associated GFRα-1 and RET positivity,as detected by IHC,remained significantly associated with recurrence,whereas GDNF expression,as detected by IHC,was not correlated with LACC recurrence.Specifically,patients with concurrent GFRα-1 and RET expression may have a high risk of PNI(89.5%positivity rate)and recurrence(84.2%positivity rate).Conclusions:PNI may contribute to LACC recurrence.The concurrent expression of GFRα-1 and RET proteins,as detected by IHC,may potentially be associated with LACC PNI and recurrence.
