Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given tha...Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given that parasites resistant to piperaquine are susceptible to mefloquine.However,triple mutants have now emerged,suggesting that drug rotations may not be adequate to keep resistance at bay.There is,therefore,an urgent need for alternative treatment strategies to tackle resistance and prevent its spread.A proper understanding of all contributors to artemisinin resistance may help us identify novel strategies to keep artemisinins effective until new drugs become available for their replacement.This review highlights the role of the key players in artemisinin resistance,the current strategies to deal with it and suggests ways of protecting future antimalarial drugs from bowing to resistance as their predecessors did.展开更多
能量色散型 X 荧光光谱分析(EDXRF)是七十年代以后发展起来的一种新型的光谱分析方法,其分析特点是快速、无损、检测范围广。我所重新冶炼的 K13高温合金钢是能源、交通工业所需要的重要材料,其中镍铬钨钛铝的浓度均在1%以上(镍34%～38%...能量色散型 X 荧光光谱分析(EDXRF)是七十年代以后发展起来的一种新型的光谱分析方法,其分析特点是快速、无损、检测范围广。我所重新冶炼的 K13高温合金钢是能源、交通工业所需要的重要材料,其中镍铬钨钛铝的浓度均在1%以上(镍34%～38%,铬14%～16%,钨4%～7%,钛3%～4%,铝1.5%～2.0%)。本文在用 EDXRF展开更多
In this paper, the existence of two positive periodic solutions for a generalized delayed population model with an exploited term is established by using the continuation theorem of the coincidence degree theory.
文摘Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given that parasites resistant to piperaquine are susceptible to mefloquine.However,triple mutants have now emerged,suggesting that drug rotations may not be adequate to keep resistance at bay.There is,therefore,an urgent need for alternative treatment strategies to tackle resistance and prevent its spread.A proper understanding of all contributors to artemisinin resistance may help us identify novel strategies to keep artemisinins effective until new drugs become available for their replacement.This review highlights the role of the key players in artemisinin resistance,the current strategies to deal with it and suggests ways of protecting future antimalarial drugs from bowing to resistance as their predecessors did.
文摘能量色散型 X 荧光光谱分析(EDXRF)是七十年代以后发展起来的一种新型的光谱分析方法,其分析特点是快速、无损、检测范围广。我所重新冶炼的 K13高温合金钢是能源、交通工业所需要的重要材料,其中镍铬钨钛铝的浓度均在1%以上(镍34%～38%,铬14%～16%,钨4%～7%,钛3%～4%,铝1.5%～2.0%)。本文在用 EDXRF
基金This work was supported by the National Natural Science Foundation of China (Grant No. 10271044)
文摘In this paper, the existence of two positive periodic solutions for a generalized delayed population model with an exploited term is established by using the continuation theorem of the coincidence degree theory.
