BACKGROUND： Hypothalamus-pituitary-adrenal （HPA） axis dysfunction has been closely linked to anxiety. Previous studies have shown that Valeriana jatamansi Jones extract exhibits clear anxiolytic effects, but it is ...BACKGROUND： Hypothalamus-pituitary-adrenal （HPA） axis dysfunction has been closely linked to anxiety. Previous studies have shown that Valeriana jatamansi Jones extract exhibits clear anxiolytic effects, but it is unclear about the mechanism underlying regulation of the HPA axis dysfunction in these anxiolytic effects. OBJECTIVE： To observe the effects of Valeriana jatamansi Jones （Zhizhu Xiang） extract on HPA axis function in a rat model of anxiety, and to compare these effects with positive control estazolam. DESIGN, TIME AND SETTING： Randomized, controlled, animal experiment was performed at Chengdu University of Traditional Chinese Medicine, China, between February and September in 2006. MATERIALS： Estazolam was purchased from Shanghai Jiufu Pharmaceutical, China; Valeriana jatamansiJones was purchased from the Lotus Pond Market for Chinese Herbal Medicine in Chengdu. It consisted of iridoids and flavonoid components. METHODS： A total of 72 Sprague Dawley rats, aged 2 months, were randomly assigned to 6 groups low-, medium-, and high-dose Valerianajatamansi Jones groups intragastrically injected with 0.3, 0.6, and 0.9 g/kg per day Valerianajatamansi Jones extract, respectively; estazolam group intragastrically injected with 1.5 mg/kg per day estazolam; model and normal groups administered 5 mL physiological saline. Anxiety was established in all groups, except the normal group, through the use of elevated plus-maze test at 7 days following drug administration. MAIN OUTCOME MEASURES： Blood β-endorphin and corticosterone levels were determined using enzyme-linked immunosorbent assay following treatment with ValerianajatamansiJones extract. Expressions of HPA axis-related genes were measured by cDNA microarray. RESULTS： Blood β-endorphin and corticosterone levels were significantly greater in the model group than in the normal group. Compared with the model group, levels decreased with Valeriana jatamansi Jones extract or estazolam treatment, particularly in the low-dose Valeriana jataman展开更多
Metasurfaces consisting of subwavelength structures,so-called meta-atoms,have steadily attracted considerable attention for advanced holography due to their advantages in terms of high-resolution holographic images,la...Metasurfaces consisting of subwavelength structures,so-called meta-atoms,have steadily attracted considerable attention for advanced holography due to their advantages in terms of high-resolution holographic images,large field of view,and compact device volume.In contrast to conventional holographic displays using bulky conventional diffractive optical elements,metasurface holography enables arbitrary complex wavefront shaping with a much smaller footprint.In this review,we classify metasurface holography according to the meta-atom design methodologies,which can further expand hologram functionalities.We describe light-matter interactions,particularly in metasurface systems,using the relevant the Jones matrix to rigorously explain modulations of the amplitude,phase,and polarization of light.Six different types of metaatoms are presented,and the corresponding achievable wavefronts that form the holographic images in the far-field are also provided.Such a simple classification will give a straightforward approach to design and further realize advanced metasurface holographic devices.展开更多
股骨转子间骨折是多发于老年人的骨折，因为老年人常伴有骨质疏松，且多合并内科疾病，全身情况较差，所以股骨转子间骨折围手术期的死亡率一直较高，伤后3个月内患者的死亡率约为16．7％。近年来，常用的手术方法有动力髋螺钉（dynamic...股骨转子间骨折是多发于老年人的骨折，因为老年人常伴有骨质疏松，且多合并内科疾病，全身情况较差，所以股骨转子间骨折围手术期的死亡率一直较高，伤后3个月内患者的死亡率约为16．7％。近年来，常用的手术方法有动力髋螺钉（dynamic hip screw，DHS）内固定和人工股骨头置换术等。回顾我院自2004年1月至2008年8月采用以上两种方法治疗且获得随访的高龄股骨转子间Jones—Evens分型Ⅲ型骨折58例患者的病历资料，报告如下。展开更多
Transmission of an anisotropic metasurface is analyzed in a polar base relying on the Jones calculus, and polarization conversion from the spatial uniform polarization to the spatial nonuniform polarization is explore...Transmission of an anisotropic metasurface is analyzed in a polar base relying on the Jones calculus, and polarization conversion from the spatial uniform polarization to the spatial nonuniform polarization is explored.Simple and compact polarization converters based on rectangular holes or cross holes etched in silver film are designed, and polarization conversions from the linear and circular polarization to the radial and azimuthal polarization are realized. Numerical simulations of three designed polarization converters consisting of rectangular holes equivalent to polarizers and quarter-and half-wave plates, exhibit the perfect polarization conversion.The experiment results consistent with the simulations verify theoretic predictions. This study is helpful for designing metasurface polarization converters and expanding the application of a metasurface in polarization manipulations.展开更多
BACKGROUND Hand in hand with technological advancements,treatment modalities continue to grow.With the turn of the century,the internet has become the number one source of information for almost every topic.Thus,many ...BACKGROUND Hand in hand with technological advancements,treatment modalities continue to grow.With the turn of the century,the internet has become the number one source of information for almost every topic.Thus,many patients look toward the internet as their primary source of information to learn about their respective medical conditions.The American Medical Association and National Institute of Health strongly recommend that online medical information be written at the 6th to 8th-grade level to aid comprehension by patients of all literacy backgrounds.AIM To assess the readability of online information regarding Jones fracture.Our hypothesis is that the reading level of medical information published on websites far exceeds the recommended reading level of 6th-8th grade as proposed by the American Medical Associate and National Institute of Health.The result of this study can help us formulate improved recommendations for publishing more comprehensible material and,thus,eventually improve patient compliance and clinical outcomes.METHODS The exact phrase“Jones fracture”was queried on the three most common search engines,Google,Yahoo!,and Bing,on December 28,2022.As of December 2022,Google held 84%,Bing held 9%,and Yahoo!held 2%of the worldwide search engine market share.Web pages uniform resource locator from the first three pages of search results were recorded from each search engine.These web pages were classified according to academic,physician-sponsored,governmental and non-government organizations(NGO),commercial,and unspecified as per formally defined categories.Websites associated with an educational institution or medical organization were classified as academic.Websites with products for sale,corporate sponsorship,or advertisements were classified as commercial.Governmental websites or NGOs comprised those that received government subsidies or grants.Webpages that were independently owned by physicians or physician groups were respectively classed as physician sponsored.The remainder of websites tha展开更多
This work is a simulation model with the LAMMPS calculation code of an electrode based on alkali metal oxides (lithium, sodium and potassium) using the Lennard Jones potential. For a multiplicity of 8*8*8, we studied ...This work is a simulation model with the LAMMPS calculation code of an electrode based on alkali metal oxides (lithium, sodium and potassium) using the Lennard Jones potential. For a multiplicity of 8*8*8, we studied a gap-free model using molecular dynamics. Physical quantities such as volume and pressure of the Na-O and Li-O systems exhibit similar behaviors around the thermodynamic ensembles NPT and NVE. However, for the Na2O system, at a minimum temperature value, we observe a range of total energy values;in contrast, for the Li2O system, a minimum energy corresponds to a range of temperatures. Finally, for physicochemical properties, we studied the diffusion coefficient and activation energy of lithium and potassium oxides around their melting temperatures. The order of magnitude of the diffusion coefficients is given by the relation Dli-O >DNa-O for the multiplicity 8*8*8, while for the activation energy, the order is well reversed EaNa-O > EaLi-O.展开更多
Polarizers have always been an important optical component for optical engineering and have played an indispensable part of polarization imaging systems.Metasurface polarizers provide an excellent platform to achieve ...Polarizers have always been an important optical component for optical engineering and have played an indispensable part of polarization imaging systems.Metasurface polarizers provide an excellent platform to achieve miniaturization,high resolution,and low cost of polarization imaging systems.Here,we proposed freeform metasurface polarizers derived by adjoint-based inverse design of a full-Jones matrix with gradient-descent optimization.We designed multiple freeform polarizers with different filtered states of polarization(SOPs),including circular polarizers,elliptical polarizers,and linear polarizers that could cover the full Poincarésphere.Note that near-unitary polarization dichroism and the ultrahigh polarization extinction ratio(ER)reaching 50 d B were achieved for optimized circular polarizers.The multiple freeform polarizers with filtered polarization state locating at four vertices of an inscribed regular tetrahedron of the Poincarésphere are designed to form a full-Stokes parameters micropolarizer array.Our work provides a novel approach,we believe,for the design of meta-polarizers that may have potential applications in polarization imaging,polarization detection,and communication.展开更多
Metatarsal fractures are one of the most common injuries of the foot. There has been conflicting literatureon management of fifth metatarsal fractures due to inconsistency with respect to classification of these fract...Metatarsal fractures are one of the most common injuries of the foot. There has been conflicting literatureon management of fifth metatarsal fractures due to inconsistency with respect to classification of these fractures. This article provides a thorough review of fifth metatarsal fractures with examination of relevant literature to describe the management of fifth metatarsal fractures especially the proximal fracture. A description of nonoperative and operative management for fifth metatarsal fractures according to anatomical region is provided.展开更多
基金Project of Sichuan Provincial Traditional Chinese Medicine Administration,No.200674Science Foundation of Southwest Jiaotong University,No.2006A10+1 种基金"Key New Drug Innovation" National Science and Technology Major Projects During Eleventh Five-Year Plan,No.2009ZX09103-370Chengdu Science and Technology Major Projects During Eleventh Five-Year Plan,No.09GGZD060SF-012
文摘BACKGROUND： Hypothalamus-pituitary-adrenal （HPA） axis dysfunction has been closely linked to anxiety. Previous studies have shown that Valeriana jatamansi Jones extract exhibits clear anxiolytic effects, but it is unclear about the mechanism underlying regulation of the HPA axis dysfunction in these anxiolytic effects. OBJECTIVE： To observe the effects of Valeriana jatamansi Jones （Zhizhu Xiang） extract on HPA axis function in a rat model of anxiety, and to compare these effects with positive control estazolam. DESIGN, TIME AND SETTING： Randomized, controlled, animal experiment was performed at Chengdu University of Traditional Chinese Medicine, China, between February and September in 2006. MATERIALS： Estazolam was purchased from Shanghai Jiufu Pharmaceutical, China; Valeriana jatamansiJones was purchased from the Lotus Pond Market for Chinese Herbal Medicine in Chengdu. It consisted of iridoids and flavonoid components. METHODS： A total of 72 Sprague Dawley rats, aged 2 months, were randomly assigned to 6 groups low-, medium-, and high-dose Valerianajatamansi Jones groups intragastrically injected with 0.3, 0.6, and 0.9 g/kg per day Valerianajatamansi Jones extract, respectively; estazolam group intragastrically injected with 1.5 mg/kg per day estazolam; model and normal groups administered 5 mL physiological saline. Anxiety was established in all groups, except the normal group, through the use of elevated plus-maze test at 7 days following drug administration. MAIN OUTCOME MEASURES： Blood β-endorphin and corticosterone levels were determined using enzyme-linked immunosorbent assay following treatment with ValerianajatamansiJones extract. Expressions of HPA axis-related genes were measured by cDNA microarray. RESULTS： Blood β-endorphin and corticosterone levels were significantly greater in the model group than in the normal group. Compared with the model group, levels decreased with Valeriana jatamansi Jones extract or estazolam treatment, particularly in the low-dose Valeriana jataman
基金Hyundai Motor Group,Grant/Award Number:Hyundai Motor Chung Mong-Koo fellowshipLG Display,Grant/Award Number:LGD-SNU incubation programNational Research Foundation of Korea,Grant/Award Numbers:CAMM-2019M3A6B3030637,NRF-2019R1A2C3003129,NRF-2019R1A5A8080290,NRF-2021R1C1C2004291。
文摘Metasurfaces consisting of subwavelength structures,so-called meta-atoms,have steadily attracted considerable attention for advanced holography due to their advantages in terms of high-resolution holographic images,large field of view,and compact device volume.In contrast to conventional holographic displays using bulky conventional diffractive optical elements,metasurface holography enables arbitrary complex wavefront shaping with a much smaller footprint.In this review,we classify metasurface holography according to the meta-atom design methodologies,which can further expand hologram functionalities.We describe light-matter interactions,particularly in metasurface systems,using the relevant the Jones matrix to rigorously explain modulations of the amplitude,phase,and polarization of light.Six different types of metaatoms are presented,and the corresponding achievable wavefronts that form the holographic images in the far-field are also provided.Such a simple classification will give a straightforward approach to design and further realize advanced metasurface holographic devices.
文摘股骨转子间骨折是多发于老年人的骨折，因为老年人常伴有骨质疏松，且多合并内科疾病，全身情况较差，所以股骨转子间骨折围手术期的死亡率一直较高，伤后3个月内患者的死亡率约为16．7％。近年来，常用的手术方法有动力髋螺钉（dynamic hip screw，DHS）内固定和人工股骨头置换术等。回顾我院自2004年1月至2008年8月采用以上两种方法治疗且获得随访的高龄股骨转子间Jones—Evens分型Ⅲ型骨折58例患者的病历资料，报告如下。
基金National Natural Science Foundation of China(NSFC)(10874105,11704231)Natural Science Foundation of Shandong Province of China(2015ZRB01864)
文摘Transmission of an anisotropic metasurface is analyzed in a polar base relying on the Jones calculus, and polarization conversion from the spatial uniform polarization to the spatial nonuniform polarization is explored.Simple and compact polarization converters based on rectangular holes or cross holes etched in silver film are designed, and polarization conversions from the linear and circular polarization to the radial and azimuthal polarization are realized. Numerical simulations of three designed polarization converters consisting of rectangular holes equivalent to polarizers and quarter-and half-wave plates, exhibit the perfect polarization conversion.The experiment results consistent with the simulations verify theoretic predictions. This study is helpful for designing metasurface polarization converters and expanding the application of a metasurface in polarization manipulations.
文摘BACKGROUND Hand in hand with technological advancements,treatment modalities continue to grow.With the turn of the century,the internet has become the number one source of information for almost every topic.Thus,many patients look toward the internet as their primary source of information to learn about their respective medical conditions.The American Medical Association and National Institute of Health strongly recommend that online medical information be written at the 6th to 8th-grade level to aid comprehension by patients of all literacy backgrounds.AIM To assess the readability of online information regarding Jones fracture.Our hypothesis is that the reading level of medical information published on websites far exceeds the recommended reading level of 6th-8th grade as proposed by the American Medical Associate and National Institute of Health.The result of this study can help us formulate improved recommendations for publishing more comprehensible material and,thus,eventually improve patient compliance and clinical outcomes.METHODS The exact phrase“Jones fracture”was queried on the three most common search engines,Google,Yahoo!,and Bing,on December 28,2022.As of December 2022,Google held 84%,Bing held 9%,and Yahoo!held 2%of the worldwide search engine market share.Web pages uniform resource locator from the first three pages of search results were recorded from each search engine.These web pages were classified according to academic,physician-sponsored,governmental and non-government organizations(NGO),commercial,and unspecified as per formally defined categories.Websites associated with an educational institution or medical organization were classified as academic.Websites with products for sale,corporate sponsorship,or advertisements were classified as commercial.Governmental websites or NGOs comprised those that received government subsidies or grants.Webpages that were independently owned by physicians or physician groups were respectively classed as physician sponsored.The remainder of websites tha
文摘This work is a simulation model with the LAMMPS calculation code of an electrode based on alkali metal oxides (lithium, sodium and potassium) using the Lennard Jones potential. For a multiplicity of 8*8*8, we studied a gap-free model using molecular dynamics. Physical quantities such as volume and pressure of the Na-O and Li-O systems exhibit similar behaviors around the thermodynamic ensembles NPT and NVE. However, for the Na2O system, at a minimum temperature value, we observe a range of total energy values;in contrast, for the Li2O system, a minimum energy corresponds to a range of temperatures. Finally, for physicochemical properties, we studied the diffusion coefficient and activation energy of lithium and potassium oxides around their melting temperatures. The order of magnitude of the diffusion coefficients is given by the relation Dli-O >DNa-O for the multiplicity 8*8*8, while for the activation energy, the order is well reversed EaNa-O > EaLi-O.
基金supported by the National Key Research and Development Program of China(Nos.2022YFB3607300 and 2021YFB2802003)the National Natural Science Foundation of China(NSFC)(No.62075084)the Guangdong Basic and Applied Basic Research Foundation(No.2022B1515020004)。
文摘Polarizers have always been an important optical component for optical engineering and have played an indispensable part of polarization imaging systems.Metasurface polarizers provide an excellent platform to achieve miniaturization,high resolution,and low cost of polarization imaging systems.Here,we proposed freeform metasurface polarizers derived by adjoint-based inverse design of a full-Jones matrix with gradient-descent optimization.We designed multiple freeform polarizers with different filtered states of polarization(SOPs),including circular polarizers,elliptical polarizers,and linear polarizers that could cover the full Poincarésphere.Note that near-unitary polarization dichroism and the ultrahigh polarization extinction ratio(ER)reaching 50 d B were achieved for optimized circular polarizers.The multiple freeform polarizers with filtered polarization state locating at four vertices of an inscribed regular tetrahedron of the Poincarésphere are designed to form a full-Stokes parameters micropolarizer array.Our work provides a novel approach,we believe,for the design of meta-polarizers that may have potential applications in polarization imaging,polarization detection,and communication.
文摘Metatarsal fractures are one of the most common injuries of the foot. There has been conflicting literatureon management of fifth metatarsal fractures due to inconsistency with respect to classification of these fractures. This article provides a thorough review of fifth metatarsal fractures with examination of relevant literature to describe the management of fifth metatarsal fractures especially the proximal fracture. A description of nonoperative and operative management for fifth metatarsal fractures according to anatomical region is provided.
