Chiral Mn Ⅲ (salen) (Jacobsen's catalyst) was axially immobilized onto a new type of organic polymer-inorganic hybrid materialzirconium poly(styrene-isopropenyl phosphonate)-phosphate(ZPS-IPPA) with different lin...Chiral Mn Ⅲ (salen) (Jacobsen's catalyst) was axially immobilized onto a new type of organic polymer-inorganic hybrid materialzirconium poly(styrene-isopropenyl phosphonate)-phosphate(ZPS-IPPA) with different linkage lengths and evaluated as catalysts for the epoxidation of unfunctionalized olefins. The results demonstrated that the prepared catalysts exhibited moderate to good activity and enantioselectivity in the asymmetric epoxidation of unfunctionalized olefins. Furthermore, the immobilized catalysts were relatively stable and could be conveniently separated from the reaction system by simple precipitation in hexane. Moreover, higher enantioselectivity was obtained with catalyst 2c than that of homogeneous counterpart catalyzed even after eight times. The excellent recycling of the catalyst was attributed to its structure feature of ZPS-IPPA which is different from either pure polystyrene or pure zirconium phosphates.展开更多
Jacobsen syndrome (JS) is a rare, inherited disorder, characterized by facial and skull dysmorphism, mental retardation, and platelet abnormalities. Paris-Trousseau syndrome (PTS) is a platelet function disorder that ...Jacobsen syndrome (JS) is a rare, inherited disorder, characterized by facial and skull dysmorphism, mental retardation, and platelet abnormalities. Paris-Trousseau syndrome (PTS) is a platelet function disorder that may be encountered in patients affected by JS. PTS is manifested by a mild lifelong bleeding tendency. Morphologically, the presence of large fused platelet alpha granules is characteristic. We present a case of Jacobsen syndrome in a child and highlight the typical morphologic and ultrastructure findings of platelets.展开更多
Cytosine methylation is an epigenetic modification of DNA that can affect gene expression and silence transposable element(TE)activities.In plants,cytosine methylation occurs in three distinct sequence contexts:CG,CHG...Cytosine methylation is an epigenetic modification of DNA that can affect gene expression and silence transposable element(TE)activities.In plants,cytosine methylation occurs in three distinct sequence contexts:CG,CHG,and CHH(where H=C,A,or T)(Law and Jacobsen,2010).The RNA-directed DNA methylation(RdDM)pathway catalyzes all types of de novo cytosine methylation,especially within small TEs or at the edges of large TEs.In brief,two plant-specific RNA polymerases,Pol IV and Pol V,independently synthesize relatively short single-stranded RNAs at RdDM target regions(Law and Jacobsen,2010).Pol IV transcripts are converted to double-stranded RNA by RNA-DEPENDENT RNA POLYMERASE 2.These double-stranded RNAs are processed into 24-nt small interfering RNAs(siRNAs)by DICER-LIKE 3.ARGONAUTE 4 binds these siRNAs and is targeted to RdDM target loci,with Pol V transcripts as scaffolds.Finally,DOMAINS REARRANGED METHYLTRANSFERASE 2 is recruited to RdDM target regions through an indirect interaction with ARGONAUTE 4 and catalyzes cytosine methylation.展开更多
时间:2006.7.21-23日裁判:美国全犬种审查员Janet Allen Jacobsen北美洲工作犬会远东区代表曾庆谦女土2006中国·苏州国际名犬展,让我们相聚在了素有"上有天堂,下有苏杭"之美誉的苏州城。由于这里是第一次举办这样大规模...时间:2006.7.21-23日裁判:美国全犬种审查员Janet Allen Jacobsen北美洲工作犬会远东区代表曾庆谦女土2006中国·苏州国际名犬展,让我们相聚在了素有"上有天堂,下有苏杭"之美誉的苏州城。由于这里是第一次举办这样大规模的犬展,所以很多人对此持观望态度,毕竟苏州宠物行业的整体水平比起北京、上海等城市还有一定的距离。但是。展开更多
导演:Esben Toft Jacobsen制片国家/地区:丹麦类型:奇幻、冒险上映时间:2011年2月10日片长:73分钟豆丁熊的剧情播报The Great Bear十一岁的乔纳森经常去爷爷住的地方度假。爷爷住在一片广阔的森林边上,关于这个森林有一个传说:里面居住...导演:Esben Toft Jacobsen制片国家/地区:丹麦类型:奇幻、冒险上映时间:2011年2月10日片长:73分钟豆丁熊的剧情播报The Great Bear十一岁的乔纳森经常去爷爷住的地方度假。爷爷住在一片广阔的森林边上,关于这个森林有一个传说:里面居住着巨大的神奇动物。这一年,乔纳森平静的度假生活被自己的小妹妹索菲打破了,她跟着乔纳森一起,也来到这里度假。爷爷住的地方四周都被高高的墙包围着,只有一扇小门能通向旁边的森林。刚到这里,爷爷就告诉他们,一定不可以去附近的森林。展开更多
基金grateful to Southwest University of China for financial supportthe Natural Science Foundation Project of CQ CSTS(2011jjA50003) for the financial support
文摘Chiral Mn Ⅲ (salen) (Jacobsen's catalyst) was axially immobilized onto a new type of organic polymer-inorganic hybrid materialzirconium poly(styrene-isopropenyl phosphonate)-phosphate(ZPS-IPPA) with different linkage lengths and evaluated as catalysts for the epoxidation of unfunctionalized olefins. The results demonstrated that the prepared catalysts exhibited moderate to good activity and enantioselectivity in the asymmetric epoxidation of unfunctionalized olefins. Furthermore, the immobilized catalysts were relatively stable and could be conveniently separated from the reaction system by simple precipitation in hexane. Moreover, higher enantioselectivity was obtained with catalyst 2c than that of homogeneous counterpart catalyzed even after eight times. The excellent recycling of the catalyst was attributed to its structure feature of ZPS-IPPA which is different from either pure polystyrene or pure zirconium phosphates.
文摘Jacobsen syndrome (JS) is a rare, inherited disorder, characterized by facial and skull dysmorphism, mental retardation, and platelet abnormalities. Paris-Trousseau syndrome (PTS) is a platelet function disorder that may be encountered in patients affected by JS. PTS is manifested by a mild lifelong bleeding tendency. Morphologically, the presence of large fused platelet alpha granules is characteristic. We present a case of Jacobsen syndrome in a child and highlight the typical morphologic and ultrastructure findings of platelets.
基金This work was supported by JSPS KAKENHI(19H04873).
文摘Cytosine methylation is an epigenetic modification of DNA that can affect gene expression and silence transposable element(TE)activities.In plants,cytosine methylation occurs in three distinct sequence contexts:CG,CHG,and CHH(where H=C,A,or T)(Law and Jacobsen,2010).The RNA-directed DNA methylation(RdDM)pathway catalyzes all types of de novo cytosine methylation,especially within small TEs or at the edges of large TEs.In brief,two plant-specific RNA polymerases,Pol IV and Pol V,independently synthesize relatively short single-stranded RNAs at RdDM target regions(Law and Jacobsen,2010).Pol IV transcripts are converted to double-stranded RNA by RNA-DEPENDENT RNA POLYMERASE 2.These double-stranded RNAs are processed into 24-nt small interfering RNAs(siRNAs)by DICER-LIKE 3.ARGONAUTE 4 binds these siRNAs and is targeted to RdDM target loci,with Pol V transcripts as scaffolds.Finally,DOMAINS REARRANGED METHYLTRANSFERASE 2 is recruited to RdDM target regions through an indirect interaction with ARGONAUTE 4 and catalyzes cytosine methylation.
文摘A 2-month-old girl presented facial dimorphism,including frontal bossing,hypertelorism,a broad nasal bridge,low-set ears,hypotonia with mild spasticity,and mild thrombocytopenia.Her head circumference was 40.8 cm(75-90 percentile).There was no relevant perinatal history.
文摘时间:2006.7.21-23日裁判:美国全犬种审查员Janet Allen Jacobsen北美洲工作犬会远东区代表曾庆谦女土2006中国·苏州国际名犬展,让我们相聚在了素有"上有天堂,下有苏杭"之美誉的苏州城。由于这里是第一次举办这样大规模的犬展,所以很多人对此持观望态度,毕竟苏州宠物行业的整体水平比起北京、上海等城市还有一定的距离。但是。
文摘导演:Esben Toft Jacobsen制片国家/地区:丹麦类型:奇幻、冒险上映时间:2011年2月10日片长:73分钟豆丁熊的剧情播报The Great Bear十一岁的乔纳森经常去爷爷住的地方度假。爷爷住在一片广阔的森林边上,关于这个森林有一个传说:里面居住着巨大的神奇动物。这一年,乔纳森平静的度假生活被自己的小妹妹索菲打破了,她跟着乔纳森一起,也来到这里度假。爷爷住的地方四周都被高高的墙包围着,只有一扇小门能通向旁边的森林。刚到这里,爷爷就告诉他们,一定不可以去附近的森林。
基金supported by the Basic and Frontier Research Project of Chongqing (cstc2013jcyjA50013)Scientific and Technological Research Program of Chongqing Municipal Education Commission (KJ131504)the Innovation Team Building at Institutions of Higher Education in Chongqing (KJTD201325)~~
