Objective: To study the altering rule of coagulation function at molecular level in patients with secondary brain injury (SBI). Methods: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were studied in 32...Objective: To study the altering rule of coagulation function at molecular level in patients with secondary brain injury (SBI). Methods: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were studied in 32 patients 1, 2, 3 and 7 days after craniocerebral injury. Repeated cranial CT scans and platelet counts were made simultaneously. Same measurements were done in 30 normal adults except CT scan. Results: No obvious difference was found in age, sex and platelet count between the injured and the normal groups. TFPI/TF decreased markedly in the first week after injury in patients with SBI, but only decreased on the 7th day in the patients without obvious SBI. For the patients who developed delayed intracranial hematoma (DIH) or hematoma enlargement, TF rose only 1 and 2 days after injury, but TFPI had a tendency to rise again after a fall on the 3rd day. For those patients who developed no DIH, TF rose all the time within the 1st week. Conclusions: Decrease of TFPI/TF for a long time, especially within 3 days after injury, may be one of the most important reasons for SBI. High expression of TF for a relative short time and increase of TFPI after a fall within 3 days may be one of the important reasons for DIH or hematoma enlargement.展开更多
For effective water-based thermal management of high heat generating CPU chip,a series of numerical simulation has been conducted to study the effects of heat flux,fin height and flow rate on convective thermal perfor...For effective water-based thermal management of high heat generating CPU chip,a series of numerical simulation has been conducted to study the effects of heat flux,fin height and flow rate on convective thermal performance of the plate-fin microchannel heat sinks.The characteristics of heat transfer and flow resistance have been quantificationally discussed and JF factor is employed to evaluate the comprehensive efficiency of convective heat transfer of microchannel heat sink.Results show that the increase in fin height and flow rate of cooling water is helpful to decrease the maximum temperature of CPU chip.Large flow rate and heat flux and short fin height are benefit to improve Nusselt number Nu,but they lead to large resistance coefficient fRe simultaneously.Analysis of JF factor shows that the microchannel with short fins shows better convective thermal performance when the thermal power of the CPU chip is small.The fins should be heightened when the CPU is operating at higher thermal power.The employment of JF factor in the present work shows its pertinence and convenience in the application of design of microchannel heat sink.展开更多
文摘Objective: To study the altering rule of coagulation function at molecular level in patients with secondary brain injury (SBI). Methods: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were studied in 32 patients 1, 2, 3 and 7 days after craniocerebral injury. Repeated cranial CT scans and platelet counts were made simultaneously. Same measurements were done in 30 normal adults except CT scan. Results: No obvious difference was found in age, sex and platelet count between the injured and the normal groups. TFPI/TF decreased markedly in the first week after injury in patients with SBI, but only decreased on the 7th day in the patients without obvious SBI. For the patients who developed delayed intracranial hematoma (DIH) or hematoma enlargement, TF rose only 1 and 2 days after injury, but TFPI had a tendency to rise again after a fall on the 3rd day. For those patients who developed no DIH, TF rose all the time within the 1st week. Conclusions: Decrease of TFPI/TF for a long time, especially within 3 days after injury, may be one of the most important reasons for SBI. High expression of TF for a relative short time and increase of TFPI after a fall within 3 days may be one of the important reasons for DIH or hematoma enlargement.
基金supported by Doctoral Start-up Foundation of Dongguan University of Technology(GC300502-38)Guangdong Provincial Key Laboratory of Distributed Energy Systems(2020B1212060075)+1 种基金Natural Science Foundation of Guangdong Province(2019A1515110498,2019A1515111167,2021A1515110616)Dongguan Institute of Technology quality Engineering(201802096).
文摘For effective water-based thermal management of high heat generating CPU chip,a series of numerical simulation has been conducted to study the effects of heat flux,fin height and flow rate on convective thermal performance of the plate-fin microchannel heat sinks.The characteristics of heat transfer and flow resistance have been quantificationally discussed and JF factor is employed to evaluate the comprehensive efficiency of convective heat transfer of microchannel heat sink.Results show that the increase in fin height and flow rate of cooling water is helpful to decrease the maximum temperature of CPU chip.Large flow rate and heat flux and short fin height are benefit to improve Nusselt number Nu,but they lead to large resistance coefficient fRe simultaneously.Analysis of JF factor shows that the microchannel with short fins shows better convective thermal performance when the thermal power of the CPU chip is small.The fins should be heightened when the CPU is operating at higher thermal power.The employment of JF factor in the present work shows its pertinence and convenience in the application of design of microchannel heat sink.
