Shock formation due to flow compressibility and its interaction with boundary layers has adverse effects on aerodynamic characteristics, such as drag increase and flow separation. The objective of this paper is to app...Shock formation due to flow compressibility and its interaction with boundary layers has adverse effects on aerodynamic characteristics, such as drag increase and flow separation. The objective of this paper is to appraise the practicability of weakening shock waves and, hence, reducing the wave drag in transonic flight regime using a two-dimensional jagged wall and thereby to gain an appropriate jagged wall shape for future empirical study. Different shapes of the jagged wall, including rectangular, circular, and triangular shapes, were employed. The numerical method was validated by experimental and numerical studies involving transonic flow over the NACA0012 airfoil, and the results presented here closely match previous experimental and numerical results. The impact of parameters, including shape and the length-to-spacing ratio of a jagged wall, was studied on aerodynamic forces and flow field. The results revealed that applying a jagged wall method on the upper surface of an airfoil changes the shock structure significantly and disintegrates it, which in turn leads to a decrease in wave drag. It was also found that the maximum drag coefficient decrease of around 17 % occurs with a triangular shape, while the maximum increase in aerodynamic efficiency（lift-to-drag ratio）of around 10 % happens with a rectangular shape at an angle of attack of 2.26？.展开更多
In order to investigate the role of the Notch signaling pathway in skeletal muscle fibrosis after nerve injury, 60 Sprague-Dawley rats were selected and divided randomly into a control and two experimental groups. Gro...In order to investigate the role of the Notch signaling pathway in skeletal muscle fibrosis after nerve injury, 60 Sprague-Dawley rats were selected and divided randomly into a control and two experimental groups. Group A served as controls without any treatment. Rats in groups B were injected intraperitoneally with 0.2 mL PBS and those in group C were injected intraperitoneally with 0.2 mL PBS+100 ymol/L, 0.2 mL N-[N-(3,5-difluorophenacetyl)-l-alanyl]- S-phenylglycine t-butyl ester (DAPT, a gamma-secretase inhibitor that suppresses Notch signaling) respectively, on postoperative days 1, 3, 7, 10, and 14 in a model of denervation-induced skeletal muscle fibrosis by right sciatic nerve transection. Five rats from each group were euthanized on postoperative days 1, 7, 14, and 28 to collect the right gastrocnemii, and hematoxylin and eosin (HE) staining, immunohistochemistry test, real-time PCR, and Western blotting were performed to assess connective tissue hyperplasia and fibroblast density as well as expression of Notch 1, Jagged 1, and Notch downstream molecules Hes 1 and collagen I (COL I) on day 28. There was no significant difference in HE-stained fibroblast density between group B and C on postoperative day 1. However, fibroblast density was significantly higher in group B than in group C on postoperative days 7, 14, and 28. Notch 1, Jagged 1, Hes 1, and COL I proteins in the gastrocnemius were expressed at very low levels in group A but at high levels in group B. Expression levels of these proteins were significantly lower in group C than in group B (P<0.05), but they were higher in group C than in group A (P<0.05) on postoperative day 28. We are led to conclude that locking the Notch signaling pathway inhibits fibrosis progression of denervated skeletal muscle. Thus, it may be a new approach for treatment of fibrosis of denervated skeletal muscle.展开更多
文摘Shock formation due to flow compressibility and its interaction with boundary layers has adverse effects on aerodynamic characteristics, such as drag increase and flow separation. The objective of this paper is to appraise the practicability of weakening shock waves and, hence, reducing the wave drag in transonic flight regime using a two-dimensional jagged wall and thereby to gain an appropriate jagged wall shape for future empirical study. Different shapes of the jagged wall, including rectangular, circular, and triangular shapes, were employed. The numerical method was validated by experimental and numerical studies involving transonic flow over the NACA0012 airfoil, and the results presented here closely match previous experimental and numerical results. The impact of parameters, including shape and the length-to-spacing ratio of a jagged wall, was studied on aerodynamic forces and flow field. The results revealed that applying a jagged wall method on the upper surface of an airfoil changes the shock structure significantly and disintegrates it, which in turn leads to a decrease in wave drag. It was also found that the maximum drag coefficient decrease of around 17 % occurs with a triangular shape, while the maximum increase in aerodynamic efficiency（lift-to-drag ratio）of around 10 % happens with a rectangular shape at an angle of attack of 2.26？.
基金National Natural Science Foundation of China(51202095,51264010)the Department of Science & Technology of Jiangxi Province(GJJ160604,20122BAB216013,20121BBE50027,20153BCB23011,20133BBE50005,20142BDH80025)the Program for Excellent Young Talents,JXUST
文摘In order to investigate the role of the Notch signaling pathway in skeletal muscle fibrosis after nerve injury, 60 Sprague-Dawley rats were selected and divided randomly into a control and two experimental groups. Group A served as controls without any treatment. Rats in groups B were injected intraperitoneally with 0.2 mL PBS and those in group C were injected intraperitoneally with 0.2 mL PBS+100 ymol/L, 0.2 mL N-[N-(3,5-difluorophenacetyl)-l-alanyl]- S-phenylglycine t-butyl ester (DAPT, a gamma-secretase inhibitor that suppresses Notch signaling) respectively, on postoperative days 1, 3, 7, 10, and 14 in a model of denervation-induced skeletal muscle fibrosis by right sciatic nerve transection. Five rats from each group were euthanized on postoperative days 1, 7, 14, and 28 to collect the right gastrocnemii, and hematoxylin and eosin (HE) staining, immunohistochemistry test, real-time PCR, and Western blotting were performed to assess connective tissue hyperplasia and fibroblast density as well as expression of Notch 1, Jagged 1, and Notch downstream molecules Hes 1 and collagen I (COL I) on day 28. There was no significant difference in HE-stained fibroblast density between group B and C on postoperative day 1. However, fibroblast density was significantly higher in group B than in group C on postoperative days 7, 14, and 28. Notch 1, Jagged 1, Hes 1, and COL I proteins in the gastrocnemius were expressed at very low levels in group A but at high levels in group B. Expression levels of these proteins were significantly lower in group C than in group B (P<0.05), but they were higher in group C than in group A (P<0.05) on postoperative day 28. We are led to conclude that locking the Notch signaling pathway inhibits fibrosis progression of denervated skeletal muscle. Thus, it may be a new approach for treatment of fibrosis of denervated skeletal muscle.
