Background: Studies have shown that pressure-controlled ventilation improves alveolar gas distribution. And inverse ratio ventilation has advantages of improving oxygenation in acute respiratory distress syndrome (ARD...Background: Studies have shown that pressure-controlled ventilation improves alveolar gas distribution. And inverse ratio ventilation has advantages of improving oxygenation in acute respiratory distress syndrome (ARDS) patients. However, the effects that pressure-controlled inverse ration ventilation in patients undergoes endotracheal intubation general anesthesia have not been assessed. Objective: To investigate whether pressure-controlled inverse ratio ventilation (PIV) would improve ventilatory and oxygenation parameters as well as lung function compared to conventional ventilation in patients undergoing open abdominal surgery. Interventions: In the conventional ventilation (CV) group, the ventilation strategy involved zero end-expiratory pressure and volume-controlled ventilation. In the pressure-controlled inverse ratio ventilation (PIV) group, the strategy involved P high starting at 7 cm H<sub>2</sub>O, P low starting at 4 cm H<sub>2</sub>O, T high at 4 s, T low at 2 s, and an inspiratory-to-expiratory time ratio of 2:1. The ΔP value was adjusted according to VT. Pressure levels were increased by 2 cm H<sub>2</sub>O until a maximal V<sub>T</sub> was observed. Inspired oxygen fraction (FIO<sub>2</sub>) was 1.0 and tidal volume (V<sub>T</sub>) was 6 mL/kg in both groups. Main Outcome Measures: The primary outcome is pulmonary function tests. Hemodynamic, ventilatory and oxygenation parameters were measured;visual analog scale (VAS) scores, and nausea and vomiting scores were also measured. Results: The PIV group tolerated pressure-controlled inverse ratio ventilation without significant hemodynamic instability. Mean airway pressure and static compliance were significantly higher in the PIV group than those in CV group (P P 2 h was well tolerated and improved respiratory compliance and lung function on the first postoperative day.展开更多
目的探讨反比通气在妇科腹腔镜手术中对超体重患者呼吸功能的影响。方法将80例患者按随机数字表法分为对照组与实验组,每组40例,建立CO2气腹时,实验组采用反比通气,吸呼比为2∶1,对照组吸呼比为1∶2,潮气量,呼吸频率不变,观察记录麻醉前...目的探讨反比通气在妇科腹腔镜手术中对超体重患者呼吸功能的影响。方法将80例患者按随机数字表法分为对照组与实验组,每组40例,建立CO2气腹时,实验组采用反比通气,吸呼比为2∶1,对照组吸呼比为1∶2,潮气量,呼吸频率不变,观察记录麻醉前5min(T0)、气腹开始前2min(T1)、气腹后60min(T2)及气腹解除后5min(T3)不同时刻的血流动力学指标、呼吸道压力、呼吸道压力峰值(Ppeak)、呼吸末二氧化碳分压(P ET CO2),同时测量气腹前2min,气腹后60min的动脉血气。结果反比通气能明显降低气道压峰值,提高动脉血氧分压(PaO2),但动脉血二氧化碳的分压(PaCO2)和PH与对照组比较无统计学差异(P>0.05)。结论反比通气在妇科腹腔镜手术中优于常规通气模式,能有效降低腹腔镜手术中高气道压峰值,减少并发症。展开更多
文摘Background: Studies have shown that pressure-controlled ventilation improves alveolar gas distribution. And inverse ratio ventilation has advantages of improving oxygenation in acute respiratory distress syndrome (ARDS) patients. However, the effects that pressure-controlled inverse ration ventilation in patients undergoes endotracheal intubation general anesthesia have not been assessed. Objective: To investigate whether pressure-controlled inverse ratio ventilation (PIV) would improve ventilatory and oxygenation parameters as well as lung function compared to conventional ventilation in patients undergoing open abdominal surgery. Interventions: In the conventional ventilation (CV) group, the ventilation strategy involved zero end-expiratory pressure and volume-controlled ventilation. In the pressure-controlled inverse ratio ventilation (PIV) group, the strategy involved P high starting at 7 cm H<sub>2</sub>O, P low starting at 4 cm H<sub>2</sub>O, T high at 4 s, T low at 2 s, and an inspiratory-to-expiratory time ratio of 2:1. The ΔP value was adjusted according to VT. Pressure levels were increased by 2 cm H<sub>2</sub>O until a maximal V<sub>T</sub> was observed. Inspired oxygen fraction (FIO<sub>2</sub>) was 1.0 and tidal volume (V<sub>T</sub>) was 6 mL/kg in both groups. Main Outcome Measures: The primary outcome is pulmonary function tests. Hemodynamic, ventilatory and oxygenation parameters were measured;visual analog scale (VAS) scores, and nausea and vomiting scores were also measured. Results: The PIV group tolerated pressure-controlled inverse ratio ventilation without significant hemodynamic instability. Mean airway pressure and static compliance were significantly higher in the PIV group than those in CV group (P P 2 h was well tolerated and improved respiratory compliance and lung function on the first postoperative day.
文摘目的探讨反比通气在妇科腹腔镜手术中对超体重患者呼吸功能的影响。方法将80例患者按随机数字表法分为对照组与实验组,每组40例,建立CO2气腹时,实验组采用反比通气,吸呼比为2∶1,对照组吸呼比为1∶2,潮气量,呼吸频率不变,观察记录麻醉前5min(T0)、气腹开始前2min(T1)、气腹后60min(T2)及气腹解除后5min(T3)不同时刻的血流动力学指标、呼吸道压力、呼吸道压力峰值(Ppeak)、呼吸末二氧化碳分压(P ET CO2),同时测量气腹前2min,气腹后60min的动脉血气。结果反比通气能明显降低气道压峰值,提高动脉血氧分压(PaO2),但动脉血二氧化碳的分压(PaCO2)和PH与对照组比较无统计学差异(P>0.05)。结论反比通气在妇科腹腔镜手术中优于常规通气模式,能有效降低腹腔镜手术中高气道压峰值,减少并发症。
