The aim of this study was to verify if patients with Obsessive-Compulsive Disorder (OCD) adopted self-referential and non-adherent interactive modalities, during face-to-face conversation, to a higher extent as compar...The aim of this study was to verify if patients with Obsessive-Compulsive Disorder (OCD) adopted self-referential and non-adherent interactive modalities, during face-to-face conversation, to a higher extent as compared with subjects who did not have a diagnosis of OCD. For this purpose, four subjects with OCD and four age, sex and education matched Normal Controls (NC) underwent a semi-structured interview. The video-taped records have been evaluated and coded by means of the Initiative-Response Analysis system (I-R). The interview allowed us to obtain indexes of interactive strategies, namely, convergence, divergence and maintenance, which have been interpreted in the Communication Accommodation Theory (CAT) framework. Subjects with OCD, as compared with both NC and interviewers, mainly used Maintenance strategy, indicating a non-adherence to turns and an over-reliance on their own turns, thus neglecting the partners’ contribution. This kind of strategy exclusively correlated with the scores of the Y-BOCS compulsion subscale. Results are consistent with the hypothesis that communication in subjects with OCD relies on particular strategies and support the view that communication is strongly correlated with “personological” variables. This hypothesis may be incorporated (not being incompatible with) in the CAT framework.展开更多
BACKGROUND: Virological clearance, delayed progression to cirrhosis or liver cancer, and increased survival are the long-term goals of antiviral therapy in chronic hepatitis B patients. Identification of host factors ...BACKGROUND: Virological clearance, delayed progression to cirrhosis or liver cancer, and increased survival are the long-term goals of antiviral therapy in chronic hepatitis B patients. Identification of host factors correlated with therapeutic response may contribute greatly to individual treatment. This study aimed at investigating whether T29C genotype polymorphism of estrogen receptor alpha (ESR1) is associated with the initial response to interferon-alpha (IFN-alpha) therapy in chronic hepatitis B patients. METHODS: The initial responses of 100 patients to IFN-alpha therapy were evaluated and compared by classifying them into three groups according to T29C genotype polymorphism of ESR1: T/T, TIC, and C/C genotype groups. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze the genotype polymorphism in T29C. RESULTS: The frequency of initially combined response was markedly higher in both the T/T and TIC groups than in the C/C group (Z=10.326, P=0.006 and Z=26.247, P=0.000, respectively). In addition, the initial virological response was higher in the T/T and T/C groups than the C/C group (chi(2)=5.674, P=0.017 and chi(2)=4.980, P=0.026, respectively). In 78 initially HBeAg-positive patients, however, the frequency of initial e-antigen disappearance or seroconversion among the T/T, T/C, and C/C genotype groups was 34.15%, 27.78% and 15.79%, respectively, which were not significantly different. CONCLUSION. The T29C genotype polymorphism of ESR1 is associated with the initial response to IFN-alpha in patients with chronic hepatitis B, and might be a significant marker for predicting the initial response to IFN-alpha, at least in this study population. (Hepatobiliary Pancreat Dis Int 2010; 9: 275-279)展开更多
文摘The aim of this study was to verify if patients with Obsessive-Compulsive Disorder (OCD) adopted self-referential and non-adherent interactive modalities, during face-to-face conversation, to a higher extent as compared with subjects who did not have a diagnosis of OCD. For this purpose, four subjects with OCD and four age, sex and education matched Normal Controls (NC) underwent a semi-structured interview. The video-taped records have been evaluated and coded by means of the Initiative-Response Analysis system (I-R). The interview allowed us to obtain indexes of interactive strategies, namely, convergence, divergence and maintenance, which have been interpreted in the Communication Accommodation Theory (CAT) framework. Subjects with OCD, as compared with both NC and interviewers, mainly used Maintenance strategy, indicating a non-adherence to turns and an over-reliance on their own turns, thus neglecting the partners’ contribution. This kind of strategy exclusively correlated with the scores of the Y-BOCS compulsion subscale. Results are consistent with the hypothesis that communication in subjects with OCD relies on particular strategies and support the view that communication is strongly correlated with “personological” variables. This hypothesis may be incorporated (not being incompatible with) in the CAT framework.
基金supported by grants from the National Natural Science Foundation of China(No.30771907)the Foundation of Pre-973 Program Projects(No.2009CB526411)
文摘BACKGROUND: Virological clearance, delayed progression to cirrhosis or liver cancer, and increased survival are the long-term goals of antiviral therapy in chronic hepatitis B patients. Identification of host factors correlated with therapeutic response may contribute greatly to individual treatment. This study aimed at investigating whether T29C genotype polymorphism of estrogen receptor alpha (ESR1) is associated with the initial response to interferon-alpha (IFN-alpha) therapy in chronic hepatitis B patients. METHODS: The initial responses of 100 patients to IFN-alpha therapy were evaluated and compared by classifying them into three groups according to T29C genotype polymorphism of ESR1: T/T, TIC, and C/C genotype groups. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze the genotype polymorphism in T29C. RESULTS: The frequency of initially combined response was markedly higher in both the T/T and TIC groups than in the C/C group (Z=10.326, P=0.006 and Z=26.247, P=0.000, respectively). In addition, the initial virological response was higher in the T/T and T/C groups than the C/C group (chi(2)=5.674, P=0.017 and chi(2)=4.980, P=0.026, respectively). In 78 initially HBeAg-positive patients, however, the frequency of initial e-antigen disappearance or seroconversion among the T/T, T/C, and C/C genotype groups was 34.15%, 27.78% and 15.79%, respectively, which were not significantly different. CONCLUSION. The T29C genotype polymorphism of ESR1 is associated with the initial response to IFN-alpha in patients with chronic hepatitis B, and might be a significant marker for predicting the initial response to IFN-alpha, at least in this study population. (Hepatobiliary Pancreat Dis Int 2010; 9: 275-279)
