By means of an equivalent invariant form of boundary conditions, the authors get the exis- tence and uniqueness of semi-global C1 solution to the mixed initial-boundary value problem for quasilinear hyperbolic systems...By means of an equivalent invariant form of boundary conditions, the authors get the exis- tence and uniqueness of semi-global C1 solution to the mixed initial-boundary value problem for quasilinear hyperbolic systems with general nonlinear boundary conditions.展开更多
Liver transplantation represents a fundamental therapeutic solution to end-stage liver disease. The need for liver allografts has extended the set of criteria for organ acceptability, increasing the risk of adverse ou...Liver transplantation represents a fundamental therapeutic solution to end-stage liver disease. The need for liver allografts has extended the set of criteria for organ acceptability, increasing the risk of adverse outcomes. Little is known about the early postoperative parameters that can be used as valid predictive indices for early graft function, retransplantation or surgical reintervention, secondary complications, long intensive care unit stay or death. In this review, we present state-of-the-art knowledge regarding the early post-transplantation tests and scores that can be applied during the first postoperative week to predict liver allograft function and patient outcome, thereby guiding the therapeutic and surgical decisions of the medical staff. Post-transplant clinical and biochemical assessment of patients through laboratory tests (platelet count, transaminase and bilirubin levels, INR, factor V, lactates, and Insulin Growth Factor 1) and scores (model for end-stage liver disease, acute physiology and chronic health evaluation, sequential organ failure assessment and model of early allograft function) have been reported to have good performance, but they only allow late evaluation of patient status and graft function, requiring days to be quantified. The indocyanine green plasma disappearance rate has long been used as a liver function assessment technique and has produced interesting, although not univocal, results when performed between the 1<sup>th</sup> and the 5<sup>th</sup> day after transplantation. The liver maximal function capacity test is a promising method of metabolic liver activity assessment, but its use is limited by economic cost and extrahepatic factors. To date, a consensual definition of early allograft dysfunction and the integration and validation of the above-mentioned techniques, through the development of numerically consistent multicentric prospective randomised trials, are necessary. The medical and surgical management of transplanted patients could be greatly improved by us展开更多
The numerical solution of Boussinesq equations is worked out as an initial-value problem to study the effect of the instabilities of flow on the initial error growth and mesoscale predictability. The development of we...The numerical solution of Boussinesq equations is worked out as an initial-value problem to study the effect of the instabilities of flow on the initial error growth and mesoscale predictability. The development of weather systems depends on different dynamic instability mechanisms according to the spatial scales of the system and the development of mesoscale systems is determined by symmetric instability. Since symmetric instability dominates among the three types of dynamic instability, it makes the prediction of the associated mesoscale systems more sensitive to initial uncertainties. This indicates that the stronger instability leads to faster initial error growth and thus limits the mesoscale predictability. Besides dynamic instability, the impact of thermodynamic instability is also explored. The evolvement of convective instability manifests as dramatic variation in small spatial scale and short temporal scale, and furthermore, it exhibits the upscale growth. Since these features determine the initial error growth, the mesoscale systems arising from convective instability are less predictable and the upscale error growth limits the predictability of larger scales. The latent heating is responsible for changing the stability of flow and subsequently influencing the error growth and the predictability.展开更多
基金the Special Funds for Major State Basic Research Projects of China.
文摘By means of an equivalent invariant form of boundary conditions, the authors get the exis- tence and uniqueness of semi-global C1 solution to the mixed initial-boundary value problem for quasilinear hyperbolic systems with general nonlinear boundary conditions.
文摘Liver transplantation represents a fundamental therapeutic solution to end-stage liver disease. The need for liver allografts has extended the set of criteria for organ acceptability, increasing the risk of adverse outcomes. Little is known about the early postoperative parameters that can be used as valid predictive indices for early graft function, retransplantation or surgical reintervention, secondary complications, long intensive care unit stay or death. In this review, we present state-of-the-art knowledge regarding the early post-transplantation tests and scores that can be applied during the first postoperative week to predict liver allograft function and patient outcome, thereby guiding the therapeutic and surgical decisions of the medical staff. Post-transplant clinical and biochemical assessment of patients through laboratory tests (platelet count, transaminase and bilirubin levels, INR, factor V, lactates, and Insulin Growth Factor 1) and scores (model for end-stage liver disease, acute physiology and chronic health evaluation, sequential organ failure assessment and model of early allograft function) have been reported to have good performance, but they only allow late evaluation of patient status and graft function, requiring days to be quantified. The indocyanine green plasma disappearance rate has long been used as a liver function assessment technique and has produced interesting, although not univocal, results when performed between the 1<sup>th</sup> and the 5<sup>th</sup> day after transplantation. The liver maximal function capacity test is a promising method of metabolic liver activity assessment, but its use is limited by economic cost and extrahepatic factors. To date, a consensual definition of early allograft dysfunction and the integration and validation of the above-mentioned techniques, through the development of numerically consistent multicentric prospective randomised trials, are necessary. The medical and surgical management of transplanted patients could be greatly improved by us
基金Project supported by the National Natural Science Foundation of China (Grant No. 40975031)the National Science Foundation for Young Scientists of China (Grant No. 41005030)
文摘The numerical solution of Boussinesq equations is worked out as an initial-value problem to study the effect of the instabilities of flow on the initial error growth and mesoscale predictability. The development of weather systems depends on different dynamic instability mechanisms according to the spatial scales of the system and the development of mesoscale systems is determined by symmetric instability. Since symmetric instability dominates among the three types of dynamic instability, it makes the prediction of the associated mesoscale systems more sensitive to initial uncertainties. This indicates that the stronger instability leads to faster initial error growth and thus limits the mesoscale predictability. Besides dynamic instability, the impact of thermodynamic instability is also explored. The evolvement of convective instability manifests as dramatic variation in small spatial scale and short temporal scale, and furthermore, it exhibits the upscale growth. Since these features determine the initial error growth, the mesoscale systems arising from convective instability are less predictable and the upscale error growth limits the predictability of larger scales. The latent heating is responsible for changing the stability of flow and subsequently influencing the error growth and the predictability.
