Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis eval...Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.展开更多
Objective:To evaluate the possible anti-inflammatory effect of garden egg[Solatium aethiopieum (S.aethiopieum)]using experimentally induced inflammatory models in rals.Methods:Oedema was induced on the rat hind paw In...Objective:To evaluate the possible anti-inflammatory effect of garden egg[Solatium aethiopieum (S.aethiopieum)]using experimentally induced inflammatory models in rals.Methods:Oedema was induced on the rat hind paw In the injection of 0.1 mL undiluted fresh egg albumin(pbilogistic agent) into the subplantar surface of the rat paw.Tissue granuloma was induced in the rats by the implantation of two autoelaved cotton pellets(30 mg) under the flank o(previously shaved back of anaesthetised rats.Garden egg extract doses were administered to the rats for seven consecutive davs.On dav 8.the animals were killed and the pellets surrounded by granuloma tissue were disseeled out and dried.Results:Extracts of garden egg significanlly(P【0.05) reduced the fresh egg albumin-induced ral paw oedema and also significantly(P【0.05) reduced the granuloma tissue formation in the treated groups when compared to the control.Conclusions:This stud) shows that the fruits of garden egg(S.aethiopieum) have anti-inflammatory activity in the models studied.展开更多
Current research has revealed some links between psychological stress and cellular mutation,neoplastic proliferation and metastasis in patients with cancer.In stressful situations,the stress-related neuroendocrine med...Current research has revealed some links between psychological stress and cellular mutation,neoplastic proliferation and metastasis in patients with cancer.In stressful situations,the stress-related neuroendocrine mediators(e.g.,catecholamines,and glucocorticoids(GSs))are being secreted,via stimulation of the sympathetic nervous system(SNS),and the hypothalamic-pituitaryadrenocortical(HPA)axis.Catecholamine may affect the malignant progression,since they can regulate various cellular signaling pathways,via adrenergic receptors(ARs)that are expressed by different types of neoplastic cells.The ARs increase the proliferation and invasive potential of such cells,and change their“behavior”in the tumor microenvironment.Similarly,cortisol and its glucocorticoid receptors(GRs)can promote stress-induced malignant growth and metastasis.Maladaptation to stressful situations,often relevant to the cancer diagnosis and treatment,may accelerate tumor growth and spread(e.g.,via inflammation,angiogenesis,and migration).Studies have shown that psychological interventions can be helpful for adaptation to adverse circumstances during the therapeutic process in patients with cancer.This mini-review will address some interrelations between psychological stress and cancer.It will discuss how the receptor-mediated signaling pathways may lead to cancer initiation,propagation,and spread.In addition,it will describe a supportive role of the stress reduction strategies,for example,in patients with breast cancer(BC).展开更多
文摘Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.
文摘Objective:To evaluate the possible anti-inflammatory effect of garden egg[Solatium aethiopieum (S.aethiopieum)]using experimentally induced inflammatory models in rals.Methods:Oedema was induced on the rat hind paw In the injection of 0.1 mL undiluted fresh egg albumin(pbilogistic agent) into the subplantar surface of the rat paw.Tissue granuloma was induced in the rats by the implantation of two autoelaved cotton pellets(30 mg) under the flank o(previously shaved back of anaesthetised rats.Garden egg extract doses were administered to the rats for seven consecutive davs.On dav 8.the animals were killed and the pellets surrounded by granuloma tissue were disseeled out and dried.Results:Extracts of garden egg significanlly(P【0.05) reduced the fresh egg albumin-induced ral paw oedema and also significantly(P【0.05) reduced the granuloma tissue formation in the treated groups when compared to the control.Conclusions:This stud) shows that the fruits of garden egg(S.aethiopieum) have anti-inflammatory activity in the models studied.
文摘Current research has revealed some links between psychological stress and cellular mutation,neoplastic proliferation and metastasis in patients with cancer.In stressful situations,the stress-related neuroendocrine mediators(e.g.,catecholamines,and glucocorticoids(GSs))are being secreted,via stimulation of the sympathetic nervous system(SNS),and the hypothalamic-pituitaryadrenocortical(HPA)axis.Catecholamine may affect the malignant progression,since they can regulate various cellular signaling pathways,via adrenergic receptors(ARs)that are expressed by different types of neoplastic cells.The ARs increase the proliferation and invasive potential of such cells,and change their“behavior”in the tumor microenvironment.Similarly,cortisol and its glucocorticoid receptors(GRs)can promote stress-induced malignant growth and metastasis.Maladaptation to stressful situations,often relevant to the cancer diagnosis and treatment,may accelerate tumor growth and spread(e.g.,via inflammation,angiogenesis,and migration).Studies have shown that psychological interventions can be helpful for adaptation to adverse circumstances during the therapeutic process in patients with cancer.This mini-review will address some interrelations between psychological stress and cancer.It will discuss how the receptor-mediated signaling pathways may lead to cancer initiation,propagation,and spread.In addition,it will describe a supportive role of the stress reduction strategies,for example,in patients with breast cancer(BC).
