AIM: To prospectively evaluate the effectiveness and safety of continuous wound infiltration(CWI) for pain management after open gastrectomy. METHODS: Seventy-five adult patients with American Society of Anesthesiolog...AIM: To prospectively evaluate the effectiveness and safety of continuous wound infiltration(CWI) for pain management after open gastrectomy. METHODS: Seventy-five adult patients with American Society of Anesthesiologists(ASA) Physical Status Classification System(ASA) grade 1-3 undergoing open gastrectomy were randomized to three groups. Group 1 patients received CWI with 0.3% ropivacaine(group CWI). Group 2 patients received 0.5 mg/m L morphine intravenously by a patient-controlled analgesia pump(PCIA)(group PCIA). Group 3 patients received epidural analgesia(EA) with 0.12% ropivacaine and 20 μg/m L morphine with an infusion at 6-8 m L/h for 48 h(group EA). A standard general anesthetic technique was used for all three groups. Rescue analgesia(2 mg bolus of morphine, intravenous) was given when the visual analogue scale(VAS) score was ≥ 4. The outcomes measured over 48 h after the operation were VAS scores both at rest and during mobilization, total morphine consumption, relative side effects, and basic vital signs. Further results including time to extubation, recovery of bowel function, surgical wound healing,mean length of hospitalization after surgery, and the patient's satisfaction were also recorded.RESULTS: All three groups had similar VAS scores during the first 48 h after surgery. Group CWI and group EA, compared with group PCIA, had lower morphine consumption(P < 0.001), less postoperative nausea and vomiting(1.20 ± 0.41 vs 1.96 ± 0.67, 1.32 ± 0.56 vs 1.96 ± 0.67, respectively, P < 0.001), earlier extubation(16.56 ± 5.24 min vs 19.76 ± 5.75 min, P < 0.05, 15.48 ± 4.59 min vs 19.76 ± 5.75 min, P < 0.01), and earlier recovery of bowel function(2.96 ± 1.17 d vs 3.60 ± 1.04 d, 2.80 ± 1.38 d vs 3.60 ± 1.04 d, respectively, P < 0.05). The mean length of hospitalization after surgery was reduced in groups CWI(8.20 ± 2.58 d vs 10.08 ± 3.15 d, P < 0.05) and EA(7.96 ± 2.30 d vs 10.08 ± 3.15 d, P < 0.01) compared with group PCIA. All three groups had similar patient satisfaction and wound heal展开更多
目的观察罗哌卡因局部麻醉对甲状腺术后疼痛的影响。方法入选2013年2月至2014年2月在新疆医科大学第二附属医院择期进行甲状腺腺瘤切除术患者120例,随机分为罗哌卡因组(A组)、利多卡因组(B组)及对照组(C组)。A组于切皮前用0.5%罗哌卡因1...目的观察罗哌卡因局部麻醉对甲状腺术后疼痛的影响。方法入选2013年2月至2014年2月在新疆医科大学第二附属医院择期进行甲状腺腺瘤切除术患者120例,随机分为罗哌卡因组(A组)、利多卡因组(B组)及对照组(C组)。A组于切皮前用0.5%罗哌卡因10 m L对切口处进行局部浸润麻醉,肿瘤切除后逐层缝合前用0.5%罗哌卡因10 m L分别进行喷洒;B组用0.5%利多卡因以同样方法进行局麻及创口喷洒;C组不用局麻药。分别于术后1,4,8,12,24,48 h对3组患者进行视觉模拟评分法(VAS)评分,VAS评分>4分者,静脉注射盐酸曲马多注射液100 mg止痛并记录使用总量,同时记录3组患者术后恶心呕吐的发生率及切口愈合情况。结果术后4,8,12,24 h时,A组VAS评分低于B、C组(P<0.05);术后1 h时,A、B组VAS评分低于C组(P<0.05);术后B、C组患者用曲马多例数较A组多(P<0.05);B、C组恶心呕吐发生率较A组高(P<0.05);3组患者切口愈合情况比较差异无统计学意义(P>0.05)。结论甲状腺肿瘤手术用0.5%罗哌卡因局部麻醉,术后能产生良好镇痛作用,且无明显不良反应。展开更多
基金Supported by Foundation of Health Department of Zhejiang ProvinceChina+3 种基金No.2011RCA207Foundation of Education Department of Zhejiang ProvinceChinaNo.Y201431914
文摘AIM: To prospectively evaluate the effectiveness and safety of continuous wound infiltration(CWI) for pain management after open gastrectomy. METHODS: Seventy-five adult patients with American Society of Anesthesiologists(ASA) Physical Status Classification System(ASA) grade 1-3 undergoing open gastrectomy were randomized to three groups. Group 1 patients received CWI with 0.3% ropivacaine(group CWI). Group 2 patients received 0.5 mg/m L morphine intravenously by a patient-controlled analgesia pump(PCIA)(group PCIA). Group 3 patients received epidural analgesia(EA) with 0.12% ropivacaine and 20 μg/m L morphine with an infusion at 6-8 m L/h for 48 h(group EA). A standard general anesthetic technique was used for all three groups. Rescue analgesia(2 mg bolus of morphine, intravenous) was given when the visual analogue scale(VAS) score was ≥ 4. The outcomes measured over 48 h after the operation were VAS scores both at rest and during mobilization, total morphine consumption, relative side effects, and basic vital signs. Further results including time to extubation, recovery of bowel function, surgical wound healing,mean length of hospitalization after surgery, and the patient's satisfaction were also recorded.RESULTS: All three groups had similar VAS scores during the first 48 h after surgery. Group CWI and group EA, compared with group PCIA, had lower morphine consumption(P < 0.001), less postoperative nausea and vomiting(1.20 ± 0.41 vs 1.96 ± 0.67, 1.32 ± 0.56 vs 1.96 ± 0.67, respectively, P < 0.001), earlier extubation(16.56 ± 5.24 min vs 19.76 ± 5.75 min, P < 0.05, 15.48 ± 4.59 min vs 19.76 ± 5.75 min, P < 0.01), and earlier recovery of bowel function(2.96 ± 1.17 d vs 3.60 ± 1.04 d, 2.80 ± 1.38 d vs 3.60 ± 1.04 d, respectively, P < 0.05). The mean length of hospitalization after surgery was reduced in groups CWI(8.20 ± 2.58 d vs 10.08 ± 3.15 d, P < 0.05) and EA(7.96 ± 2.30 d vs 10.08 ± 3.15 d, P < 0.01) compared with group PCIA. All three groups had similar patient satisfaction and wound heal
文摘目的观察罗哌卡因局部麻醉对甲状腺术后疼痛的影响。方法入选2013年2月至2014年2月在新疆医科大学第二附属医院择期进行甲状腺腺瘤切除术患者120例,随机分为罗哌卡因组(A组)、利多卡因组(B组)及对照组(C组)。A组于切皮前用0.5%罗哌卡因10 m L对切口处进行局部浸润麻醉,肿瘤切除后逐层缝合前用0.5%罗哌卡因10 m L分别进行喷洒;B组用0.5%利多卡因以同样方法进行局麻及创口喷洒;C组不用局麻药。分别于术后1,4,8,12,24,48 h对3组患者进行视觉模拟评分法(VAS)评分,VAS评分>4分者,静脉注射盐酸曲马多注射液100 mg止痛并记录使用总量,同时记录3组患者术后恶心呕吐的发生率及切口愈合情况。结果术后4,8,12,24 h时,A组VAS评分低于B、C组(P<0.05);术后1 h时,A、B组VAS评分低于C组(P<0.05);术后B、C组患者用曲马多例数较A组多(P<0.05);B、C组恶心呕吐发生率较A组高(P<0.05);3组患者切口愈合情况比较差异无统计学意义(P>0.05)。结论甲状腺肿瘤手术用0.5%罗哌卡因局部麻醉,术后能产生良好镇痛作用,且无明显不良反应。
