国际半导体技术发展路线图(The International Technology Roadmap for Semiconductors,ITRS)自1999年第1版问世后,每偶数年份更新,每单数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测,对公司...国际半导体技术发展路线图(The International Technology Roadmap for Semiconductors,ITRS)自1999年第1版问世后,每偶数年份更新,每单数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测,对公司、研发团体和政府都有指导作用。路线图对提高各个层次上研发投资的决策质量都有重要意义。本篇是连载一。展开更多
国际半导体技术发展路线图(The International Technology Roadmap for Semiconductors,ITRS)自1999年第1版问世后,每偶数年份更新,每奇数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测,对公司...国际半导体技术发展路线图(The International Technology Roadmap for Semiconductors,ITRS)自1999年第1版问世后,每偶数年份更新,每奇数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测,对公司、研发团体和政府都有指导作用。路线图对提高各个层次上研发投资的决策质量都有重要意义。本篇是连载一。展开更多
Human adenoviruses(HAdvs)are major respiratory pathogens.Specifically,human adenovirus type 4(HAdV4)and human adenovirus type 7(HAdV7)are known for causing fever and pneumonia,with docu-mented cases of fatalities amon...Human adenoviruses(HAdvs)are major respiratory pathogens.Specifically,human adenovirus type 4(HAdV4)and human adenovirus type 7(HAdV7)are known for causing fever and pneumonia,with docu-mented cases of fatalities among the population.In recent years,HAdV4/HAdv7 has been implicated in caus-ing substantial outbreaks,leading to increased morbidity in multiple countries.Most HAdV4 and HAdV7 infections have been reported in North America,Asia,Europe,Africa,South America,Oceania,and the Middle East.Most fatalities occurred in North America(the United States)and Asia(China and Singapore).Engineered recombinant adenoviruses have played a crucial role as vaccine vectors.In this study,we con-structed a recombinant adenovirus,Ad4ITRmut-Ad7E3,and evaluated it in vitro and in vivo.We observed that the replication rate of Ad4ITRmut-Ad7E3 was lower than that of the RI-67 strain,indicating that the mutation of inverted terminal repeats(ITRs)weakened the replication ability of HAdV4.Immunization of BALB/c mice with the bivalent Ad4ITRmut-Ad7E3 vaccine strain,administered by intraperitoneal injection and oral gavage,resulted in the elicitation of neutralizing antibodies targeting HAdV4 and HAdv7.This finding not only pro-vides a novel method and technique for the efficient construction of a polyvalent recombinant adenovirus vac-cine candidate against HAdV4 and HAdv7 but also against other prevalent adenovirus serotypes such as HAdV3,HAdV11,HAdV14,and HAdv55,from various regions.展开更多
国际半导体技术发展路线图（The International Technology Roadmap for Semiconductors，ITRS）自1999年第1版问世后，每偶数年份更新，每单数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测，...国际半导体技术发展路线图（The International Technology Roadmap for Semiconductors，ITRS）自1999年第1版问世后，每偶数年份更新，每单数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测，对公司、研发团体和政府都有指导作用。路线图对提高各个层次上研发投资的决策质量都有重要意义。本篇是连载一。展开更多
文摘国际半导体技术发展路线图(The International Technology Roadmap for Semiconductors,ITRS)自1999年第1版问世后,每偶数年份更新,每单数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测,对公司、研发团体和政府都有指导作用。路线图对提高各个层次上研发投资的决策质量都有重要意义。本篇是连载一。
文摘国际半导体技术发展路线图(The International Technology Roadmap for Semiconductors,ITRS)自1999年第1版问世后,每偶数年份更新,每奇数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测,对公司、研发团体和政府都有指导作用。路线图对提高各个层次上研发投资的决策质量都有重要意义。本篇是连载一。
基金supported by grants from the National Key Research and Development Program of China(Grant No.2018YFA0900800).
文摘Human adenoviruses(HAdvs)are major respiratory pathogens.Specifically,human adenovirus type 4(HAdV4)and human adenovirus type 7(HAdV7)are known for causing fever and pneumonia,with docu-mented cases of fatalities among the population.In recent years,HAdV4/HAdv7 has been implicated in caus-ing substantial outbreaks,leading to increased morbidity in multiple countries.Most HAdV4 and HAdV7 infections have been reported in North America,Asia,Europe,Africa,South America,Oceania,and the Middle East.Most fatalities occurred in North America(the United States)and Asia(China and Singapore).Engineered recombinant adenoviruses have played a crucial role as vaccine vectors.In this study,we con-structed a recombinant adenovirus,Ad4ITRmut-Ad7E3,and evaluated it in vitro and in vivo.We observed that the replication rate of Ad4ITRmut-Ad7E3 was lower than that of the RI-67 strain,indicating that the mutation of inverted terminal repeats(ITRs)weakened the replication ability of HAdV4.Immunization of BALB/c mice with the bivalent Ad4ITRmut-Ad7E3 vaccine strain,administered by intraperitoneal injection and oral gavage,resulted in the elicitation of neutralizing antibodies targeting HAdV4 and HAdv7.This finding not only pro-vides a novel method and technique for the efficient construction of a polyvalent recombinant adenovirus vac-cine candidate against HAdV4 and HAdv7 but also against other prevalent adenovirus serotypes such as HAdV3,HAdV11,HAdV14,and HAdv55,from various regions.
文摘国际半导体技术发展路线图（The International Technology Roadmap for Semiconductors，ITRS）自1999年第1版问世后，每偶数年份更新，每单数年份进行全面修订。ITRS的目标是提供被工业界广泛认同的对未来15年内研发需求的最佳预测，对公司、研发团体和政府都有指导作用。路线图对提高各个层次上研发投资的决策质量都有重要意义。本篇是连载一。
文摘SoC是超越摩尔定律的未来瞩望。根据ITRS 2010介绍医学市场如何驱动SoC;解释新SoC设计者的设计V图。分析ISSCC 2008～2011中25例生物医学SoC,得到其发展趋势:以NMR-SoC为典型的整机SoC化、超低功耗的无限追求、植入式与贴片式的竞争、迎合BAN(body area networks)。摘取关键技术、分析技术亮点,得出其主要设计创新点包括ADC模块复用、阻抗法消除伪迹、功率调制以及光基因接口和电容阵列实现长时供电等。
