Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone Ila can effectively improve brain tissue isch...Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone Ila can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone lla, 0.5 hour prior to model establishment. Results showed that Tanshinone Ila promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone Ila, compared with positive control Danshen injection.展开更多
国际抗癫痫联盟(International League Against Epilepsy,ILAE)是全球癫痫学术领域最权威的专业组织。ILAE根据人们对癫痫的最新认识,不定期对癫痫的国际分类和术语进行修订。其最早于1960年提出了国际癫痫分类;1981年确定了癫痫发作的...国际抗癫痫联盟(International League Against Epilepsy,ILAE)是全球癫痫学术领域最权威的专业组织。ILAE根据人们对癫痫的最新认识,不定期对癫痫的国际分类和术语进行修订。其最早于1960年提出了国际癫痫分类;1981年确定了癫痫发作的分类;1989年确定了癫痫和癫痫综合征的分类;2001年再次进行修订,提出了癫痫发作和癫痫诊断方案的建议。展开更多
Our previous studies indicate that phosphatidylinositol 4-kinase Ila can promote the growth of multi-malignant tumors via HER-2/PI3K and MAPK pathways. However, the molecular mechanisms of this pathway and its potenti...Our previous studies indicate that phosphatidylinositol 4-kinase Ila can promote the growth of multi-malignant tumors via HER-2/PI3K and MAPK pathways. However, the molecular mechanisms of this pathway and its potential for clinical application remain unknown. In this study, we found that PI4KIla could be an ideal combinatorial target for EGFR treatment via regulating EGFR degradation. Results showed that PI4KIla knockdown reduced EGFR protein level, and the expression of Pi4KIla shows a strong correlation with EGFR in human breast cancer tissues （r= 0.77, P 〈 0.01）. PI4KIla knockdown greatly prolonged the effects and decreased the effective dosage of AG-1478, a specific inhibitor of EGFR. In addition, it significantly enhanced AG1478-induced inhibition of tumor cell survival and strengthened the effect of the EGFR-targeting anti-cancer drug Iressa in xenograft tumor models. Mechanistically, we found that PI4KIla suppression increased EGFR ligand-independent degradation. Quantitative proteomic analysis by stable isotope labeling with amino acids in cell culture （SlLAC） and LC-MS/MS suggested that HsPg0 mediated the effect of PI4KIla on EGFR. Furthermore, we found that combined inhibition of PI4KIla and EGFR suppressed both PI3K/AKT and MAPK/ERK pathways, and resulted in downregulation of multiple oncogenes like PRDX2, FASN, MTA2, ultimately leading to suppression of tumor growth. Therefore, we conclude that combined inhibition of PI4KIla and EGFR exerts a multiple anti-tumor effect. Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIla presents a novel strategy to combat EGFR-dependent tumors.展开更多
癫痫是一大类不同病因、不同电临床表现和具有显著临床预后差异的病症/疾病。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)癫痫分类方案定义了三个诊断层次,包括癫痫发作类型、癫痫类型和癫痫综合征,并且强调必...癫痫是一大类不同病因、不同电临床表现和具有显著临床预后差异的病症/疾病。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)癫痫分类方案定义了三个诊断层次,包括癫痫发作类型、癫痫类型和癫痫综合征,并且强调必须在每个诊断层次上均需要考虑病因和共患病。展开更多
A low profile dual-band multiple-input-multiple-output (MIMO) antenna system is proposed. The proposed MIMO antenna consists of two low profile unbalanced fed inverted L antennas with parasitic elements to resonate at...A low profile dual-band multiple-input-multiple-output (MIMO) antenna system is proposed. The proposed MIMO antenna consists of two low profile unbalanced fed inverted L antennas with parasitic elements to resonate at 2.45 GHz and 5 GHz. The structure is uncomplicated by locating two ultra low profile inverted L antennas on the finite conducting plane. The proposed MIMO antenna is numerically and experimentally analyzed. When the size of conducting plane is 55 mm by 55 mm and the height of antenna is 9 mm, the directive gain of 4.11 dBi and the S11 bandwidth of 5.71% are achieved for lower frequency of 2.45 GHz. At the upper frequency of 5 GHz, the directive gain of 8.22 dBi and the S11 bandwidth of 6% are obtained. The proposed antenna has good diversity gain, shown by the correlation coefficient becomes less than 0.005 at the frequency of 2.45 GHz and 5 GHz band when the distance between inverted L elements is 41 mm. A good agreement between calculated and measured results is obtained. The results show that the weak mutual coupling of the proposed antenna and this feature enables it to cover the required bandwidths for WLAN operation at the 2.4 GHz band and 5 GHz band.展开更多
2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)官方杂志《Epilepsia》在线发表了ILAE病因学和定义特别工作组关于癫痫综合征分类与定义的报告[1-2],该报告共包括了6篇文章:《癫痫综合征论文介绍》、《癫痫...2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)官方杂志《Epilepsia》在线发表了ILAE病因学和定义特别工作组关于癫痫综合征分类与定义的报告[1-2],该报告共包括了6篇文章:《癫痫综合征论文介绍》、《癫痫综合征进行分类和定义的方法及综合征列表:ILAE疾病分类和定义特别工作组的报告》、《新生儿-婴儿期起病的癫痫综合征的ILAE分类与定义:ILAE疾病分类和定义特别工作组的立场声明》。展开更多
2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)疾病分类和定义特别工作组(2017—2021)在ILAE官方杂志Epilepsia在线发表了关于癫痫综合征的定义、诊断和分类的系列文章,中国抗癫痫协会青年委员会组织人员对...2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)疾病分类和定义特别工作组(2017—2021)在ILAE官方杂志Epilepsia在线发表了关于癫痫综合征的定义、诊断和分类的系列文章,中国抗癫痫协会青年委员会组织人员对六篇文章进行了全文翻译和分篇解读。其中《可出现在各年龄段的癫痫综合征的ILAE分类与定义:ILAE疾病分类和定义特别工作组的立场声明》重点关注起病年龄既可以是儿童期(≤18岁)也可以在成年期(≥19岁)的综合征,本文对其进行解读。展开更多
2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)官方杂志Epilepsia在线发表了ILAE病因学和定义特别工作组关于癫痫综合征分类与定义的报告,该报告共包括了6篇文章。中国抗癫痫协会青年委员会组织相关人员进...2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)官方杂志Epilepsia在线发表了ILAE病因学和定义特别工作组关于癫痫综合征分类与定义的报告,该报告共包括了6篇文章。中国抗癫痫协会青年委员会组织相关人员进行了系列报告的翻译与解读。本文主要是针对《特发性全面性的癫痫综合征的ILAE分类与定义:ILAE疾病分类和定义特别工作组的立场声明》的解读。展开更多
基金supported by the National Natural Science Foundation of China,No.30973765New Century Excellent Talents Program,No. NECT-09-0013the Foundationfor Doctors,Ministry of Education,No.20113519110001
文摘Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone Ila can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone lla, 0.5 hour prior to model establishment. Results showed that Tanshinone Ila promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone Ila, compared with positive control Danshen injection.
文摘国际抗癫痫联盟(International League Against Epilepsy,ILAE)是全球癫痫学术领域最权威的专业组织。ILAE根据人们对癫痫的最新认识,不定期对癫痫的国际分类和术语进行修订。其最早于1960年提出了国际癫痫分类;1981年确定了癫痫发作的分类;1989年确定了癫痫和癫痫综合征的分类;2001年再次进行修订,提出了癫痫发作和癫痫诊断方案的建议。
文摘Our previous studies indicate that phosphatidylinositol 4-kinase Ila can promote the growth of multi-malignant tumors via HER-2/PI3K and MAPK pathways. However, the molecular mechanisms of this pathway and its potential for clinical application remain unknown. In this study, we found that PI4KIla could be an ideal combinatorial target for EGFR treatment via regulating EGFR degradation. Results showed that PI4KIla knockdown reduced EGFR protein level, and the expression of Pi4KIla shows a strong correlation with EGFR in human breast cancer tissues （r= 0.77, P 〈 0.01）. PI4KIla knockdown greatly prolonged the effects and decreased the effective dosage of AG-1478, a specific inhibitor of EGFR. In addition, it significantly enhanced AG1478-induced inhibition of tumor cell survival and strengthened the effect of the EGFR-targeting anti-cancer drug Iressa in xenograft tumor models. Mechanistically, we found that PI4KIla suppression increased EGFR ligand-independent degradation. Quantitative proteomic analysis by stable isotope labeling with amino acids in cell culture （SlLAC） and LC-MS/MS suggested that HsPg0 mediated the effect of PI4KIla on EGFR. Furthermore, we found that combined inhibition of PI4KIla and EGFR suppressed both PI3K/AKT and MAPK/ERK pathways, and resulted in downregulation of multiple oncogenes like PRDX2, FASN, MTA2, ultimately leading to suppression of tumor growth. Therefore, we conclude that combined inhibition of PI4KIla and EGFR exerts a multiple anti-tumor effect. Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIla presents a novel strategy to combat EGFR-dependent tumors.
文摘癫痫是一大类不同病因、不同电临床表现和具有显著临床预后差异的病症/疾病。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)癫痫分类方案定义了三个诊断层次,包括癫痫发作类型、癫痫类型和癫痫综合征,并且强调必须在每个诊断层次上均需要考虑病因和共患病。
文摘A low profile dual-band multiple-input-multiple-output (MIMO) antenna system is proposed. The proposed MIMO antenna consists of two low profile unbalanced fed inverted L antennas with parasitic elements to resonate at 2.45 GHz and 5 GHz. The structure is uncomplicated by locating two ultra low profile inverted L antennas on the finite conducting plane. The proposed MIMO antenna is numerically and experimentally analyzed. When the size of conducting plane is 55 mm by 55 mm and the height of antenna is 9 mm, the directive gain of 4.11 dBi and the S11 bandwidth of 5.71% are achieved for lower frequency of 2.45 GHz. At the upper frequency of 5 GHz, the directive gain of 8.22 dBi and the S11 bandwidth of 6% are obtained. The proposed antenna has good diversity gain, shown by the correlation coefficient becomes less than 0.005 at the frequency of 2.45 GHz and 5 GHz band when the distance between inverted L elements is 41 mm. A good agreement between calculated and measured results is obtained. The results show that the weak mutual coupling of the proposed antenna and this feature enables it to cover the required bandwidths for WLAN operation at the 2.4 GHz band and 5 GHz band.
文摘2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)官方杂志《Epilepsia》在线发表了ILAE病因学和定义特别工作组关于癫痫综合征分类与定义的报告[1-2],该报告共包括了6篇文章:《癫痫综合征论文介绍》、《癫痫综合征进行分类和定义的方法及综合征列表:ILAE疾病分类和定义特别工作组的报告》、《新生儿-婴儿期起病的癫痫综合征的ILAE分类与定义:ILAE疾病分类和定义特别工作组的立场声明》。
文摘2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)疾病分类和定义特别工作组(2017—2021)在ILAE官方杂志Epilepsia在线发表了关于癫痫综合征的定义、诊断和分类的系列文章,中国抗癫痫协会青年委员会组织人员对六篇文章进行了全文翻译和分篇解读。其中《可出现在各年龄段的癫痫综合征的ILAE分类与定义:ILAE疾病分类和定义特别工作组的立场声明》重点关注起病年龄既可以是儿童期(≤18岁)也可以在成年期(≥19岁)的综合征,本文对其进行解读。
文摘2022年5月4日国际抗癫痫联盟(International league against epilepsy,ILAE)官方杂志Epilepsia在线发表了ILAE病因学和定义特别工作组关于癫痫综合征分类与定义的报告,该报告共包括了6篇文章。中国抗癫痫协会青年委员会组织相关人员进行了系列报告的翻译与解读。本文主要是针对《特发性全面性的癫痫综合征的ILAE分类与定义:ILAE疾病分类和定义特别工作组的立场声明》的解读。
