Introduction: Female hyperandrogenism is essentially manifested by hirsutism. It is present in Senegal but not yet elucidated for lack of data. This is why we proposed to study the profile of hyperandrogenism in our c...Introduction: Female hyperandrogenism is essentially manifested by hirsutism. It is present in Senegal but not yet elucidated for lack of data. This is why we proposed to study the profile of hyperandrogenism in our context. Patients and Methods: This was an observational, cross-sectional cohort study of 19 patients of reproductive age followed for hyperandrogenism at the Medical Clinic II of Abass Ndao Hospital, from November 1<sup>st</sup>, 2019 to August 31<sup>st</sup>, 2021. Results: Our cohort consisted of women with an average age of 25.3 years, single (73.7%), with a low socioeconomic level (42.1%). A family history of hirsutism was found in 31.6% of cases. The main reasons for consultation were a menstrual cycle disorder in 94.7% of cases, and hirsutism in 78.9% of cases. The latter was post-pubertal (66.7%), with a slow or progressive evolution. The physical examination revealed: hirsutism (100%) with an average modified Ferriman Gallwey score (mFG) of 8.9 ± 5.8, acne (36.8%), hyperseborrhea (57.9%), major signs of virilization (10.5%), acanthosis nigricans (47.4%) and galactorrhea (5.3%). Hormonal explorations revealed an elevation of: testosterone (31.6%), 17-hydroxyprogesterone (5.3%), dihydrotestosterone (31.6%), and prolactin (10.5%). The ovarian morphology was micropolycystic (84.2%). The etiological profile corresponded to polycystic ovarian syndrome or PCOS (68.4%), ovarian hyperthecosis (10.5%), hyperprolactinemia (10.5%), congenital adrenal hyperplasia or CAH (5.3%). Idiopathic hirsutism was found in 5.3% of cases. Conclusion: Female hyperandrogenism is a less frequent reason for consultation in endocrinology. It deserves to be further evaluated in a large-scale study focused on epidemiological, clinico-biological and etiological investigation, in order to assess its prevalence and better define its profile in our context.展开更多
Hirsutism,which is characterized by excessive growth of terminal hair in a male pattern,may result from various causes including polycystic ovary syndrome(PCOS),non-classic congenital adrenal hyperplasia,adrenal or ov...Hirsutism,which is characterized by excessive growth of terminal hair in a male pattern,may result from various causes including polycystic ovary syndrome(PCOS),non-classic congenital adrenal hyperplasia,adrenal or ovarian tumors or it may be idiopathic.Idiopathic hirsutism is currently defined as hirsutism associated with normal ovulatory function,normal serum androgen levels and normal ovarian morphology,however,the pathogenesis of idiopathic hirsutism is not clear.The androgens are the main hormones to stimulate growth of body hair,therefore,there should be any form of increased androgen effect irrespective of normal serum androgen levels in any patient with hirsutism.In accordance to this scientific truth,we have previously shown that,although within normal limits,patients with idiopathic hirsutism have relatively higher serum androgen levels(relative hyperandrogenemia)in comparison to healthy subjects which let as to think that is idiopathic hirsutism really idiopathic?In addition to relative hyperandrogenemia,we have previously shown that,in comparison to healthy subjects,women with idiopathic hirsutism demonstrated higher expression of steroid sulphatase and 17-beta hydroxysteroid dehydrogenase mRNA both in the subumbilical region and arm skin,which contributes to local androgen metabolism.Those results support the idea that,in some patients,although the adrenals or ovaries do not secrete increased amount of androgens leading to hyperandrogenemia,pilocebaceous unit locally produce increased amount of androgens leading to hirsutism without ovulatory dysfunction.Upon the demonstration of relative hyperandrogenemia and possible increase in local androgen synthesis in patients with idiopathic hirsutism,we think that idiopathic hirsutism is not idiopathic and it may be named as“normoandrogenic hirsutism”.Furthermore,it may not be a different entity but may be an early stage of hyperandrogenic disorders such as PCOS.Clinically,this can be find out by following-up patients with idiopathic hirsutism prospectiv展开更多
<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">To determine the prevalence of cutaneous disorders of PCOS and indicate the spe...<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">To determine the prevalence of cutaneous disorders of PCOS and indicate the specific cutaneous lesions that have reliable association with PCOS. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">134 female participants had met the criteria to be diagnosed as PCOS</span></span><span style="font-family:Verdana;">.</span><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">Dermatological examination regarding hirsutism, acne, androgenic alopecia and acanthosis nigricans as well as any other cutaneous manifestations and assessment of each as regards duration, distribution and scoring was done. Hormonal assay for FSH/LH was done together with ultrasound examination. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The study included 134 female participants </span></span><span style="font-family:Verdana;">who </span><span style="font-family:Verdana;">had met the criteria to be diagnosed as PCOS</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> the range of age was 18 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 35 years, with a mean (26.31 ± 4.47 years). Among the PCOS patients at least one cutaneous disorder was found in 18 patients (13.4%), two cutaneous disorders in 44 patients (32.8%), three cutaneous disorders in 47 patients (35.1%), four cutaneous disorders in 24</span><span style="font-family:""> </span><span style="font-family:Verdana;">(17.9%) and five cutaneous disorders were found in only one patient (0.7%). Statistically, there was a significant positive correlations between hirsutism, acne, acanthosis nigricans and LH/F.S.H ratio (p < 0.001), and total testosterone level (p = 0.019, p < 0.001, p < 0.001) respectively. Statistically, there was non</span><span style="font-family:Verdana;">-</sp展开更多
文摘Introduction: Female hyperandrogenism is essentially manifested by hirsutism. It is present in Senegal but not yet elucidated for lack of data. This is why we proposed to study the profile of hyperandrogenism in our context. Patients and Methods: This was an observational, cross-sectional cohort study of 19 patients of reproductive age followed for hyperandrogenism at the Medical Clinic II of Abass Ndao Hospital, from November 1<sup>st</sup>, 2019 to August 31<sup>st</sup>, 2021. Results: Our cohort consisted of women with an average age of 25.3 years, single (73.7%), with a low socioeconomic level (42.1%). A family history of hirsutism was found in 31.6% of cases. The main reasons for consultation were a menstrual cycle disorder in 94.7% of cases, and hirsutism in 78.9% of cases. The latter was post-pubertal (66.7%), with a slow or progressive evolution. The physical examination revealed: hirsutism (100%) with an average modified Ferriman Gallwey score (mFG) of 8.9 ± 5.8, acne (36.8%), hyperseborrhea (57.9%), major signs of virilization (10.5%), acanthosis nigricans (47.4%) and galactorrhea (5.3%). Hormonal explorations revealed an elevation of: testosterone (31.6%), 17-hydroxyprogesterone (5.3%), dihydrotestosterone (31.6%), and prolactin (10.5%). The ovarian morphology was micropolycystic (84.2%). The etiological profile corresponded to polycystic ovarian syndrome or PCOS (68.4%), ovarian hyperthecosis (10.5%), hyperprolactinemia (10.5%), congenital adrenal hyperplasia or CAH (5.3%). Idiopathic hirsutism was found in 5.3% of cases. Conclusion: Female hyperandrogenism is a less frequent reason for consultation in endocrinology. It deserves to be further evaluated in a large-scale study focused on epidemiological, clinico-biological and etiological investigation, in order to assess its prevalence and better define its profile in our context.
文摘Hirsutism,which is characterized by excessive growth of terminal hair in a male pattern,may result from various causes including polycystic ovary syndrome(PCOS),non-classic congenital adrenal hyperplasia,adrenal or ovarian tumors or it may be idiopathic.Idiopathic hirsutism is currently defined as hirsutism associated with normal ovulatory function,normal serum androgen levels and normal ovarian morphology,however,the pathogenesis of idiopathic hirsutism is not clear.The androgens are the main hormones to stimulate growth of body hair,therefore,there should be any form of increased androgen effect irrespective of normal serum androgen levels in any patient with hirsutism.In accordance to this scientific truth,we have previously shown that,although within normal limits,patients with idiopathic hirsutism have relatively higher serum androgen levels(relative hyperandrogenemia)in comparison to healthy subjects which let as to think that is idiopathic hirsutism really idiopathic?In addition to relative hyperandrogenemia,we have previously shown that,in comparison to healthy subjects,women with idiopathic hirsutism demonstrated higher expression of steroid sulphatase and 17-beta hydroxysteroid dehydrogenase mRNA both in the subumbilical region and arm skin,which contributes to local androgen metabolism.Those results support the idea that,in some patients,although the adrenals or ovaries do not secrete increased amount of androgens leading to hyperandrogenemia,pilocebaceous unit locally produce increased amount of androgens leading to hirsutism without ovulatory dysfunction.Upon the demonstration of relative hyperandrogenemia and possible increase in local androgen synthesis in patients with idiopathic hirsutism,we think that idiopathic hirsutism is not idiopathic and it may be named as“normoandrogenic hirsutism”.Furthermore,it may not be a different entity but may be an early stage of hyperandrogenic disorders such as PCOS.Clinically,this can be find out by following-up patients with idiopathic hirsutism prospectiv
文摘<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">To determine the prevalence of cutaneous disorders of PCOS and indicate the specific cutaneous lesions that have reliable association with PCOS. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">134 female participants had met the criteria to be diagnosed as PCOS</span></span><span style="font-family:Verdana;">.</span><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">Dermatological examination regarding hirsutism, acne, androgenic alopecia and acanthosis nigricans as well as any other cutaneous manifestations and assessment of each as regards duration, distribution and scoring was done. Hormonal assay for FSH/LH was done together with ultrasound examination. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The study included 134 female participants </span></span><span style="font-family:Verdana;">who </span><span style="font-family:Verdana;">had met the criteria to be diagnosed as PCOS</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> the range of age was 18 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 35 years, with a mean (26.31 ± 4.47 years). Among the PCOS patients at least one cutaneous disorder was found in 18 patients (13.4%), two cutaneous disorders in 44 patients (32.8%), three cutaneous disorders in 47 patients (35.1%), four cutaneous disorders in 24</span><span style="font-family:""> </span><span style="font-family:Verdana;">(17.9%) and five cutaneous disorders were found in only one patient (0.7%). Statistically, there was a significant positive correlations between hirsutism, acne, acanthosis nigricans and LH/F.S.H ratio (p < 0.001), and total testosterone level (p = 0.019, p < 0.001, p < 0.001) respectively. Statistically, there was non</span><span style="font-family:Verdana;">-</sp
