After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promisi...After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients w展开更多
Brain lateralization for language in high-functioning children with autism spectrum conditions (ASC) and sensory processing were explored as a part of a neuropsychological profile. A dichotic listening test and the Lu...Brain lateralization for language in high-functioning children with autism spectrum conditions (ASC) and sensory processing were explored as a part of a neuropsychological profile. A dichotic listening test and the Luria laterality subtest were administered to all participants (including controls) and the sensory profile test only to the ASC group. The usual right ear advantage was not exhibited by children with ASC and anomalies in auditory filtering were found. The sensory profile of 60% of the sample was characterized by hypersensitivity to auditory stimuli, hyposensitivity to vestibular information, high emotional reactions to sensory experiences, poor psychosocial coping strategies, high distractibility and inability to interpret body and facial language. Hyper-responsiveness to environmental auditory stimuli was significantly associated with impaired attention. Similarly, non-adaptive responses to sensory quotidian experiences were strongly connected to poor coping strategies. Our results, although preliminary, contribute to emphasizing the importance of including additional assessment methods such as the dichotic listening and the sensory profile questionnaire in the evaluation of cognitive profile in high-functioning children with ASC to plan an individualized psycho-educative intervention.展开更多
Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) ...Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Furthermore, we examined to what extent adults with PDD think that they exhibit ADHD symptoms. Methods: We developed an original Japanese self-report questionnaire to determine the presence or absence of 18 symptoms from the diagnostic criteria for ADHD in the DSM-IV-TR. We administered the questionnaire to 64 adults with high-functioning PDD (45 men and 19 women) and 21 adults with ADHD (10 men and 11 women), aged 18 to 59 years, with a full-scale intelligence quotient ≥75. Target patients were evaluated for ADHD by their psychiatrists. Results: Twenty-nine (45.3%) adults with PDD also had ADHD. The percentage of these adults who had over six perceived inattention symptoms from the DSM-IV-TR was 96.6%. The percentage of these adults who had over six perceived hyperactivity-impulsivity symptoms was 65.5%. Thirty-five (55.6%) adults with PDD responded that they were aware of having ADHD symptoms at the level of the relevant diagnostic criteria. Conclusions: The present study is the first to examine the frequency of objective and perceived ADHD symptoms in adults with PDD in Japan. Our results show that both objective and perceived ADHD symptoms frequently appear in a large number of adults with PDD. This suggests that it is necessary to attend to concomitant ADHD symptoms in the medical care of adults with PDD.展开更多
Objective: The present study compared results on the Wechsler Adult Intelligence Scale-Revised (WAIS-R) among adult patients with attention-deficit/hyperactivity disorder (AD/HD) and those with Asperger’s disorder (A...Objective: The present study compared results on the Wechsler Adult Intelligence Scale-Revised (WAIS-R) among adult patients with attention-deficit/hyperactivity disorder (AD/HD) and those with Asperger’s disorder (AD). Method: WAIS-R results were compared between 16 adults with AD/HD (8 men and 8 women;mean age, 33.81 years;mean full-scale IQ, 101.5) and 15 adults with AD (12 men and 3 women;mean age, 30.93 years;mean full-scale IQ, 104.6). Results: Verbal IQ was significantly higher than performance IQ in the AD group. Among various subtests, scores were the highest for similarities in the AD/HD group and for block design in the AD group. Picture completion test scores were the lowest scores obtained in both groups. A comparison of subtest scores between the AD/HD and AD groups showed scores for information to be significantly higher in the AD group than in the AD/HD group. Conclusions: Our results suggest that there are no differences in verbal IQ, performance IQ, and full-scale IQ scores (except for scores on the information subtest) among adult patients with AD/HD compared with adult patients with AD.展开更多
BACKGROUND Health-related risky behaviors generally refer to behaviors that have a negative impact on health and quality of life.Health-related risky behaviors in adolescents with high-functioning autism(HFA)have not ...BACKGROUND Health-related risky behaviors generally refer to behaviors that have a negative impact on health and quality of life.Health-related risky behaviors in adolescents with high-functioning autism(HFA)have not been well understood so far.Adolescents with HFA may have more health-related risky behaviors than neurotypical adolescents.AIM To investigate health-related risky behaviors and their risk factors with HFA.METHODS This is an observational study.Our study enrolled 110 adolescents aged 12-19-years-old meeting Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria for HFA.They were recruited from Peking University Sixth Hospital.There were also 110 age,sex and nationality matched controls enrolled who came from a public school in Beijing,China.Both groups completed the Adolescents Health-related Risky Behavior Inventory.Nonparametric tests were carried out for comparison of the Adolescents Health-related Risky Behavior Inventory scores between the two groups.Expression recognition,the Inventory of Subjective Life Quality for Child and Adolescent,Chinese Wechsler Intelligence Scale for Children,Wechsler Intelligence Scale for Adult-Chinese Revised,Theory of Mind test and Autism Spectrum Screening Questionnaire were assessed in the autism group to explore factors associated with health-related risky behaviors.Multivariate regression analysis was conducted to explore the risk factors of health-related risky behaviors in the HFA group.RESULTS The results showed that the total score of the Adolescents Health-related Risky Behavior Inventory and scores of“aggression and violence,”“suicide and selfinjury,”“health compromising behavior”and“unprotected sex”subscales in the HFA group were significantly higher than those in the control group(Z range-4.197 to-2.213,P<0.05).Among the associated factors,poor emotional experience(B=-0.268,P<0.001),depression(B=-0.321,P<0.001),low score of intelligence(B=-0.032,P=0.042),low score of Theory of Mind test(B=-1.321,P=0.003)and poor adapt展开更多
目的:探讨高功能孤独症儿童的统合型房树人(S-HTP)绘画测验特征及其社会性发展。方法:对符合美国精神障碍诊断与统计手册第4版(Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,DSM-Ⅳ)的35例高功能孤独症儿童...目的:探讨高功能孤独症儿童的统合型房树人(S-HTP)绘画测验特征及其社会性发展。方法:对符合美国精神障碍诊断与统计手册第4版(Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,DSM-Ⅳ)的35例高功能孤独症儿童和年龄、性别、智商相匹配的70例正常对照儿童进行S-HTP绘画测验,分析高功能孤独症儿童S-HTP绘画测验特征(整体评价15个项目、房屋评价9个项目、树木评价5个项目和人物评价14个项目)。结果:在S-HTP绘画测验中,高功能孤独症儿童绘画特征与正常儿童存在明显差异。在主要反映社交互动水平的整体评价中有8个项目存在差异,如孤独症患儿绘画的画面统合性强的比例明显低于正常儿童[5.7%(2/35)vs.67.1%(47/70),P<0.05];在主要反映家庭关系的房屋评价中的有4个项目存在差异,如孤独症儿童绘画中人只在房屋外面的比例明显高于正常儿童[100%(35/35)vs.85.7%(60/70),P<0.05];在主要反映无意识的自我形象的树木评价中有4个项目存在差异,如孤独症儿童树木简化的比例明显高于正常儿童[73.5%(25/35)vs.24.3%(17/70),P<0.05];在主要反映有意识的自我形象和人际关系的人物评价中有8个项目存在差异,如孤独症儿童绘画人物数目2人以上的比例明显低于正常儿童[20.0%(7/35)vs.68.6%(48/70),P<0.05]。结论:高功能孤独症儿童统合型房树人绘画测验绘画特征反映出其社会性发展落后于正常同龄儿童,主要表现在社交互动、人际关系、自我概念和家庭关系方面。展开更多
基金supported by the National Key R&D Program of China,No.2020YFC2004202(to DX).
文摘After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients w
文摘Brain lateralization for language in high-functioning children with autism spectrum conditions (ASC) and sensory processing were explored as a part of a neuropsychological profile. A dichotic listening test and the Luria laterality subtest were administered to all participants (including controls) and the sensory profile test only to the ASC group. The usual right ear advantage was not exhibited by children with ASC and anomalies in auditory filtering were found. The sensory profile of 60% of the sample was characterized by hypersensitivity to auditory stimuli, hyposensitivity to vestibular information, high emotional reactions to sensory experiences, poor psychosocial coping strategies, high distractibility and inability to interpret body and facial language. Hyper-responsiveness to environmental auditory stimuli was significantly associated with impaired attention. Similarly, non-adaptive responses to sensory quotidian experiences were strongly connected to poor coping strategies. Our results, although preliminary, contribute to emphasizing the importance of including additional assessment methods such as the dichotic listening and the sensory profile questionnaire in the evaluation of cognitive profile in high-functioning children with ASC to plan an individualized psycho-educative intervention.
文摘Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Furthermore, we examined to what extent adults with PDD think that they exhibit ADHD symptoms. Methods: We developed an original Japanese self-report questionnaire to determine the presence or absence of 18 symptoms from the diagnostic criteria for ADHD in the DSM-IV-TR. We administered the questionnaire to 64 adults with high-functioning PDD (45 men and 19 women) and 21 adults with ADHD (10 men and 11 women), aged 18 to 59 years, with a full-scale intelligence quotient ≥75. Target patients were evaluated for ADHD by their psychiatrists. Results: Twenty-nine (45.3%) adults with PDD also had ADHD. The percentage of these adults who had over six perceived inattention symptoms from the DSM-IV-TR was 96.6%. The percentage of these adults who had over six perceived hyperactivity-impulsivity symptoms was 65.5%. Thirty-five (55.6%) adults with PDD responded that they were aware of having ADHD symptoms at the level of the relevant diagnostic criteria. Conclusions: The present study is the first to examine the frequency of objective and perceived ADHD symptoms in adults with PDD in Japan. Our results show that both objective and perceived ADHD symptoms frequently appear in a large number of adults with PDD. This suggests that it is necessary to attend to concomitant ADHD symptoms in the medical care of adults with PDD.
文摘Objective: The present study compared results on the Wechsler Adult Intelligence Scale-Revised (WAIS-R) among adult patients with attention-deficit/hyperactivity disorder (AD/HD) and those with Asperger’s disorder (AD). Method: WAIS-R results were compared between 16 adults with AD/HD (8 men and 8 women;mean age, 33.81 years;mean full-scale IQ, 101.5) and 15 adults with AD (12 men and 3 women;mean age, 30.93 years;mean full-scale IQ, 104.6). Results: Verbal IQ was significantly higher than performance IQ in the AD group. Among various subtests, scores were the highest for similarities in the AD/HD group and for block design in the AD group. Picture completion test scores were the lowest scores obtained in both groups. A comparison of subtest scores between the AD/HD and AD groups showed scores for information to be significantly higher in the AD group than in the AD/HD group. Conclusions: Our results suggest that there are no differences in verbal IQ, performance IQ, and full-scale IQ scores (except for scores on the information subtest) among adult patients with AD/HD compared with adult patients with AD.
基金Supported by National Key R&D Program of China,No.2017YFC1309900Beijing Municipal Science&Technology Commission,No.Z171100001017088 and No.Z161100000116098.
文摘BACKGROUND Health-related risky behaviors generally refer to behaviors that have a negative impact on health and quality of life.Health-related risky behaviors in adolescents with high-functioning autism(HFA)have not been well understood so far.Adolescents with HFA may have more health-related risky behaviors than neurotypical adolescents.AIM To investigate health-related risky behaviors and their risk factors with HFA.METHODS This is an observational study.Our study enrolled 110 adolescents aged 12-19-years-old meeting Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria for HFA.They were recruited from Peking University Sixth Hospital.There were also 110 age,sex and nationality matched controls enrolled who came from a public school in Beijing,China.Both groups completed the Adolescents Health-related Risky Behavior Inventory.Nonparametric tests were carried out for comparison of the Adolescents Health-related Risky Behavior Inventory scores between the two groups.Expression recognition,the Inventory of Subjective Life Quality for Child and Adolescent,Chinese Wechsler Intelligence Scale for Children,Wechsler Intelligence Scale for Adult-Chinese Revised,Theory of Mind test and Autism Spectrum Screening Questionnaire were assessed in the autism group to explore factors associated with health-related risky behaviors.Multivariate regression analysis was conducted to explore the risk factors of health-related risky behaviors in the HFA group.RESULTS The results showed that the total score of the Adolescents Health-related Risky Behavior Inventory and scores of“aggression and violence,”“suicide and selfinjury,”“health compromising behavior”and“unprotected sex”subscales in the HFA group were significantly higher than those in the control group(Z range-4.197 to-2.213,P<0.05).Among the associated factors,poor emotional experience(B=-0.268,P<0.001),depression(B=-0.321,P<0.001),low score of intelligence(B=-0.032,P=0.042),low score of Theory of Mind test(B=-1.321,P=0.003)and poor adapt
文摘目的:探讨高功能孤独症儿童的统合型房树人(S-HTP)绘画测验特征及其社会性发展。方法:对符合美国精神障碍诊断与统计手册第4版(Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,DSM-Ⅳ)的35例高功能孤独症儿童和年龄、性别、智商相匹配的70例正常对照儿童进行S-HTP绘画测验,分析高功能孤独症儿童S-HTP绘画测验特征(整体评价15个项目、房屋评价9个项目、树木评价5个项目和人物评价14个项目)。结果:在S-HTP绘画测验中,高功能孤独症儿童绘画特征与正常儿童存在明显差异。在主要反映社交互动水平的整体评价中有8个项目存在差异,如孤独症患儿绘画的画面统合性强的比例明显低于正常儿童[5.7%(2/35)vs.67.1%(47/70),P<0.05];在主要反映家庭关系的房屋评价中的有4个项目存在差异,如孤独症儿童绘画中人只在房屋外面的比例明显高于正常儿童[100%(35/35)vs.85.7%(60/70),P<0.05];在主要反映无意识的自我形象的树木评价中有4个项目存在差异,如孤独症儿童树木简化的比例明显高于正常儿童[73.5%(25/35)vs.24.3%(17/70),P<0.05];在主要反映有意识的自我形象和人际关系的人物评价中有8个项目存在差异,如孤独症儿童绘画人物数目2人以上的比例明显低于正常儿童[20.0%(7/35)vs.68.6%(48/70),P<0.05]。结论:高功能孤独症儿童统合型房树人绘画测验绘画特征反映出其社会性发展落后于正常同龄儿童,主要表现在社交互动、人际关系、自我概念和家庭关系方面。
