Metabonomics has recently been widely used todiscover the pathogenesis and find potential metabolic markers with high sensitivity and specificity. Furthermore, it develops new diagnosis and treatment methods, increase...Metabonomics has recently been widely used todiscover the pathogenesis and find potential metabolic markers with high sensitivity and specificity. Furthermore, it develops new diagnosis and treatment methods, increases early phase diagnosis rates of certain diseases and provides a new basis for targeted therapy. This review mainly analyzes the research progress of the metabonomics of hepatitis B virus(HBV)-related hepatic diseases, hoping to discover some potential metabolic markers for identification of HBVrelated hepatic diseases from other etiologies and for HBV-related hepatitis, liver cirrhosis and hepatocellular carcinoma. This can contribute to early discovery, diagnosis and treatment, eventually increasing the survival rate of HBV-related hepatic diseases.展开更多
乙型肝炎病毒(hepatitis B virus, HBV)感染是一个全球关注的问题,尽管疫苗的接种已经普及,但感染率仍处在高位。感染病毒后,机体开始发生急性或慢性变化,从肝炎发展到肝硬化,直至肝癌。微小RNA(microRNA, miRNA)是一种可以调节基因表...乙型肝炎病毒(hepatitis B virus, HBV)感染是一个全球关注的问题,尽管疫苗的接种已经普及,但感染率仍处在高位。感染病毒后,机体开始发生急性或慢性变化,从肝炎发展到肝硬化,直至肝癌。微小RNA(microRNA, miRNA)是一种可以调节基因表达的内源性非编码RNA,在病毒和宿主之间,miRNA是重要的调节因子。本研究对miRNA在HBV相关肝癌中的重要作用进行综述,旨为将来HBV相关肝癌的诊断、治疗和预后评估提供新的思路。展开更多
乙型肝炎病毒(hepatitis B virus,HBV)感染是肝癌的主要危险因素之一,HBV相关肝癌是全球最常见的肝癌类型。表观遗传学改变在HBV相关肝癌的进展过程中发挥重要作用。本综述主要介绍了HBV相关肝癌的表观遗传学改变,包括异常的DNA甲基化...乙型肝炎病毒(hepatitis B virus,HBV)感染是肝癌的主要危险因素之一,HBV相关肝癌是全球最常见的肝癌类型。表观遗传学改变在HBV相关肝癌的进展过程中发挥重要作用。本综述主要介绍了HBV相关肝癌的表观遗传学改变,包括异常的DNA甲基化、组蛋白修饰等。同时,本文还阐述了表观遗传学在HBV相关肝癌诊断、治疗和预后评估中的应用,以及对未来研究方向的展望。展开更多
基金Supported by Liaoning Natural Science Foundation of China,No.2013B003
文摘Metabonomics has recently been widely used todiscover the pathogenesis and find potential metabolic markers with high sensitivity and specificity. Furthermore, it develops new diagnosis and treatment methods, increases early phase diagnosis rates of certain diseases and provides a new basis for targeted therapy. This review mainly analyzes the research progress of the metabonomics of hepatitis B virus(HBV)-related hepatic diseases, hoping to discover some potential metabolic markers for identification of HBVrelated hepatic diseases from other etiologies and for HBV-related hepatitis, liver cirrhosis and hepatocellular carcinoma. This can contribute to early discovery, diagnosis and treatment, eventually increasing the survival rate of HBV-related hepatic diseases.
文摘乙型肝炎病毒(hepatitis B virus, HBV)感染是一个全球关注的问题,尽管疫苗的接种已经普及,但感染率仍处在高位。感染病毒后,机体开始发生急性或慢性变化,从肝炎发展到肝硬化,直至肝癌。微小RNA(microRNA, miRNA)是一种可以调节基因表达的内源性非编码RNA,在病毒和宿主之间,miRNA是重要的调节因子。本研究对miRNA在HBV相关肝癌中的重要作用进行综述,旨为将来HBV相关肝癌的诊断、治疗和预后评估提供新的思路。
文摘乙型肝炎病毒(hepatitis B virus,HBV)感染是肝癌的主要危险因素之一,HBV相关肝癌是全球最常见的肝癌类型。表观遗传学改变在HBV相关肝癌的进展过程中发挥重要作用。本综述主要介绍了HBV相关肝癌的表观遗传学改变,包括异常的DNA甲基化、组蛋白修饰等。同时,本文还阐述了表观遗传学在HBV相关肝癌诊断、治疗和预后评估中的应用,以及对未来研究方向的展望。
