In this study,we used plasma factor V activity and parameters of the thrombin generation test to discuss their diagnostic and prognostic value for disseminated intravascular coagulation (DIC) in patients with hematolo...In this study,we used plasma factor V activity and parameters of the thrombin generation test to discuss their diagnostic and prognostic value for disseminated intravascular coagulation (DIC) in patients with hematological malignancies.A total of 164 patients who were diagnosed with hematological malignancies in the Department of Hematology,Union Hospital,between Apr 2014 and Dec.2014 were enrolled in this study.There were 131 patients in the study group and 33 patients in the control group in terms of the laboratory results for DIC.The patients in the study group were divided into a DIC subgroup (n=59) and a non-DIC subgroup (n=72) based on the International Society of Thrombosis and Hemostasis (ISTH) Integral System,and they were divided into four subgroups [score ≤3 (n=35),score=4 (n=37),score=5 (n=47),and score >6 (n=12)] according to ISTH scores.Using 28-day mortality as the endpoint,the patients in the study group were divided into a survival subgroup (n=111) and a non-survival subgroup (n=20).The results showed that the plasma factor V activity was significantly weaker,and lag time and time to peak were significantly shorter in the study group than in the control group (P<0.01).The factor V activity,peak and endogenous thrombin potential (ETP) were significantly decreased in the DIC subgroup as compared with those in the non-DIC subgroup (P<0.01).Among factor V activity,lag time,peak,ETP,and ttPeak,only the factor V activity was significantly decreased in the nonsurvival subgroup compared with the survival subgroup (P<0.01).With the increase in ISTH score,the ETP and peak decreased gradually.The binary logistic regression analysis revealed that PLT,D-dimer,factor V activity and ETP had linear relationship with DIC diagnosed by ISTH Integral System.Using DIC diagnosed by ISTH Integral System as the endpoint,the area under curve (AUC) of factor V activity was found to be similar to that of blood platelet count (PLT) and prothrombin time (PT).In conclusion,factor V activity,ETP and peak had diagnostic value展开更多
生理状况下,机体的止血与抗凝作用处于动态平衡。但在妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)病理状况下,由于全身小血管痉挛和血管内皮损伤,这种平衡被打破,体现为血小板和凝血因子被激活,抗凝物质释放减少、抗纤...生理状况下,机体的止血与抗凝作用处于动态平衡。但在妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)病理状况下,由于全身小血管痉挛和血管内皮损伤,这种平衡被打破,体现为血小板和凝血因子被激活,抗凝物质释放减少、抗纤溶物质分泌增加等,最终导致血栓形成甚至引发弥散性血管内凝血(disseminated intravascular coagulation,DIC)。因此,应用便捷、高效的检测指标准确评估HDP凝血功能状态,对指导临床进行适时干预、减少孕妇并发症出现、改善孕妇与胎儿结局具有重要意义。对近年来用于评估HDP凝血功能状态的检测指标的应用进展进行简要综述,以期为HDP的血液学检查提供更多实践依据。展开更多
目的回顾性分析艾滋病(acquired immunodeficiency syndrome,AIDS)病例的临床流行病学特征和皮肤性病特征,为疾病的诊断和治疗提供可靠依据。方法对我院2010年1月~2015年12月收治的85例AIDS资料进行分析,并对患者进行CD4^+、CD8^+T淋巴...目的回顾性分析艾滋病(acquired immunodeficiency syndrome,AIDS)病例的临床流行病学特征和皮肤性病特征,为疾病的诊断和治疗提供可靠依据。方法对我院2010年1月~2015年12月收治的85例AIDS资料进行分析,并对患者进行CD4^+、CD8^+T淋巴细胞计数和乙型肝炎病毒(hepatitis B virus,HBV)五项以及丙型肝炎病毒(hepatitis C virus,HCV)检测。对检测结果进行统计学分析,判定流行病学、皮肤性病学特征。结果通过对85例病例进行回顾分析得知,以腹泻、高烧等为主要特征;其中,男60例,占70.6%;女25例,占29.4%;患者年龄20~50岁;从感染途径上来看,以性传播为主,占71.8%(61/85),其中,异性间性传播51例,占60.0%;同性间性传播10例,占11.8%。检测患者感染类型有四种:单项HIV感染、合并HBV感染、合并HCV感染、合并HBV和HCV感染。四种感染类型中,男女患者差异有统计学意义(P<0.05)。结论对于HIV感染者来说,合并HCV、HBV感染情况较多,应对这类型患者采取相对应措施,提高患者预防治疗效果。且男性病发率高于女性,大多为青壮年,该病症主要传播途径为性传播,需要加强艾滋病筛查、知识宣传,便于尽早发现、尽早处理,预防病情蔓延,延长生存期限。展开更多
文摘In this study,we used plasma factor V activity and parameters of the thrombin generation test to discuss their diagnostic and prognostic value for disseminated intravascular coagulation (DIC) in patients with hematological malignancies.A total of 164 patients who were diagnosed with hematological malignancies in the Department of Hematology,Union Hospital,between Apr 2014 and Dec.2014 were enrolled in this study.There were 131 patients in the study group and 33 patients in the control group in terms of the laboratory results for DIC.The patients in the study group were divided into a DIC subgroup (n=59) and a non-DIC subgroup (n=72) based on the International Society of Thrombosis and Hemostasis (ISTH) Integral System,and they were divided into four subgroups [score ≤3 (n=35),score=4 (n=37),score=5 (n=47),and score >6 (n=12)] according to ISTH scores.Using 28-day mortality as the endpoint,the patients in the study group were divided into a survival subgroup (n=111) and a non-survival subgroup (n=20).The results showed that the plasma factor V activity was significantly weaker,and lag time and time to peak were significantly shorter in the study group than in the control group (P<0.01).The factor V activity,peak and endogenous thrombin potential (ETP) were significantly decreased in the DIC subgroup as compared with those in the non-DIC subgroup (P<0.01).Among factor V activity,lag time,peak,ETP,and ttPeak,only the factor V activity was significantly decreased in the nonsurvival subgroup compared with the survival subgroup (P<0.01).With the increase in ISTH score,the ETP and peak decreased gradually.The binary logistic regression analysis revealed that PLT,D-dimer,factor V activity and ETP had linear relationship with DIC diagnosed by ISTH Integral System.Using DIC diagnosed by ISTH Integral System as the endpoint,the area under curve (AUC) of factor V activity was found to be similar to that of blood platelet count (PLT) and prothrombin time (PT).In conclusion,factor V activity,ETP and peak had diagnostic value
文摘目的回顾性分析艾滋病(acquired immunodeficiency syndrome,AIDS)病例的临床流行病学特征和皮肤性病特征,为疾病的诊断和治疗提供可靠依据。方法对我院2010年1月~2015年12月收治的85例AIDS资料进行分析,并对患者进行CD4^+、CD8^+T淋巴细胞计数和乙型肝炎病毒(hepatitis B virus,HBV)五项以及丙型肝炎病毒(hepatitis C virus,HCV)检测。对检测结果进行统计学分析,判定流行病学、皮肤性病学特征。结果通过对85例病例进行回顾分析得知,以腹泻、高烧等为主要特征;其中,男60例,占70.6%;女25例,占29.4%;患者年龄20~50岁;从感染途径上来看,以性传播为主,占71.8%(61/85),其中,异性间性传播51例,占60.0%;同性间性传播10例,占11.8%。检测患者感染类型有四种:单项HIV感染、合并HBV感染、合并HCV感染、合并HBV和HCV感染。四种感染类型中,男女患者差异有统计学意义(P<0.05)。结论对于HIV感染者来说,合并HCV、HBV感染情况较多,应对这类型患者采取相对应措施,提高患者预防治疗效果。且男性病发率高于女性,大多为青壮年,该病症主要传播途径为性传播,需要加强艾滋病筛查、知识宣传,便于尽早发现、尽早处理,预防病情蔓延,延长生存期限。
