目的探讨清热解毒箍围法对促进糖尿病大鼠感染性溃疡愈合的影响。方法将60只大鼠随机分为模型组、基础治疗组、青霉素外敷组、清热解毒箍围组4组,每组15只,各组于造模后次日给药。模型组予肌注生理盐水0.3 m L,基础治疗组予肌注青霉素...目的探讨清热解毒箍围法对促进糖尿病大鼠感染性溃疡愈合的影响。方法将60只大鼠随机分为模型组、基础治疗组、青霉素外敷组、清热解毒箍围组4组,每组15只,各组于造模后次日给药。模型组予肌注生理盐水0.3 m L,基础治疗组予肌注青霉素钠溶液0.3 m L,青霉素外敷组予基础治疗结合创面湿敷青霉素钠溶液0.9 m L,清热解毒箍围组予基础治疗结合创面周围箍围药箍围。于造模后特定时间观察创面变化、创周皮肤温度、创面面积、血清透明质酸水平。结果第3天、第7天、第14天清热解毒箍围组与模型组、基础治疗组、青霉素外敷组比较,创面温度均明显降低(P<0.01)。第3天、第7天、第14天清热解毒箍围组、青霉素外敷组与模型组比较,创面面积均明显缩小(P<0.01)。第3天、第7天、第14天清热解毒箍围组、青霉素外敷组与基础治疗组比较,创面面积均明显缩小(P<0.01)。第3天、第7天清热解毒箍围组与青霉素外敷组比较,创面面积均明显缩小(P<0.01)。血清透明质酸水平组间比较第3天、第7天、第14天、第21天清热解毒箍围组、青霉素外敷组明显高于模型组(P<0.01),清热解毒箍围组、青霉素外敷组明显高于基础治疗组(P<0.01),清热解毒箍围组明显高于青霉素外敷组(P<0.01)。各组组内不同时间血清透明质酸水平比较,第7天均明显高于第3天(P<0.01),第14天均明显高于第3天(P<0.01),第21天均明显低于第7天(P<0.01),第21天均明显低于第14天(P<0.01)。结论清热解毒箍围法对促进糖尿病大鼠感染性溃疡愈合具有较好的作用。展开更多
Gout is a metabolic bone and joint disease caused by purine metabolism disorder.The disturbance of inflammatory microenvironment caused by monosodium urate(MSU)deposition is an important pathological mechanism of gout...Gout is a metabolic bone and joint disease caused by purine metabolism disorder.The disturbance of inflammatory microenvironment caused by monosodium urate(MSU)deposition is an important pathological mechanism of gout occurrence and development.In the understanding of Traditional Chinese medicine(TCM),the interaction of"dampness","heat"and"stasis"is the main pathogenesis of gout,and the method of clearing heat and removing dampness is the main treatment method of TCM for gout.In recent years,studies have found that heat-clearing and dampness-removing method can improve the TCM symptom score of gout patients,especially in the body tiredness,dry mouth and dry throat,short yellow urine,thirsty,etc.,which are the characteristics of dampness and heat syndrome,this may be related to the fact that the TCM heat-clearing and dampness-removing method in the treatment of gout removes the appearance of dampness and heat,improves the inflammatory microenvironment of gout and restores the normal metabolic function of human body.This paper deeply explores the specific mechanism of TCM heat-clearing and dampness-removing method to improve the inflammatory microenvironment of gout,which can provide new ideas for the diagnosis and treatment of clinical gout.展开更多
Objective:To evaluate the effect of heat-clearing and detoxifying method on the macrophages polarization in patients with acute myocardial infarction with heat toxin syndrome after intervention.Methods:Sixty patients ...Objective:To evaluate the effect of heat-clearing and detoxifying method on the macrophages polarization in patients with acute myocardial infarction with heat toxin syndrome after intervention.Methods:Sixty patients with acute myocardial infarction and undergoing percutaneous coronary intervention with heat toxin syndrome were randomly divided into a control group and a test group with 30 cases each.The control group was given conventional treatment,and the test group was given Huanglian Jiedu Decoction,the representative of the method of clearing heat and detoxification,orally on the basis of the control group.The intervention time of both groups was 2 weeks.Comparing The Seattle Angina Pectoris Scale(SAQ)before and after treatment,creatine kinase(CK),creatine kinase MB isoenzyme(CKMB),high-sensitivity troponin I(hs-TnI),and Lipoprotein-associated phospholipaseA2(LPPLA_2)),the phenotype ratio of M1 and M2 macrophages,and observe the adverse reactions.Results:After treatment,the SAQ scores of the two groups of patients were improved,and the levels of CK,CK-MB,hs-TnI,and LP-PLA_2 decreased significantly.The scores of AS,AF,TS,and DP in the SAQ of the test group were all higher than those of the control group,and the hs-TnI and LP-PLA_2 were better than those of the control Group(P<0.05 or P<0.01).After treatment,the proportion of M1 type macrophages in the two groups of patients'macrophages decreased significantly(P<0.05 or P<0.01),the ratio of M2 type macrophages increased(P<0.05),and the M1/M2 ratio decreased.The ratio of M1/M2 in the test group of the control group was significantly lower than that of the control group(P<0.01).There were no obvious adverse reactions in both groups.Conclusions:The method of clearing heat and detoxifying has a definite effect on patients with acute myocardial infarction of heat toxin syndrome after interventional operation.It can reduce myocardial damage,improve myocardial function,and reduce inflammation.And it is safe for clinical treatment without any increasing risk of bleed展开更多
文摘目的探讨清热解毒箍围法对促进糖尿病大鼠感染性溃疡愈合的影响。方法将60只大鼠随机分为模型组、基础治疗组、青霉素外敷组、清热解毒箍围组4组,每组15只,各组于造模后次日给药。模型组予肌注生理盐水0.3 m L,基础治疗组予肌注青霉素钠溶液0.3 m L,青霉素外敷组予基础治疗结合创面湿敷青霉素钠溶液0.9 m L,清热解毒箍围组予基础治疗结合创面周围箍围药箍围。于造模后特定时间观察创面变化、创周皮肤温度、创面面积、血清透明质酸水平。结果第3天、第7天、第14天清热解毒箍围组与模型组、基础治疗组、青霉素外敷组比较,创面温度均明显降低(P<0.01)。第3天、第7天、第14天清热解毒箍围组、青霉素外敷组与模型组比较,创面面积均明显缩小(P<0.01)。第3天、第7天、第14天清热解毒箍围组、青霉素外敷组与基础治疗组比较,创面面积均明显缩小(P<0.01)。第3天、第7天清热解毒箍围组与青霉素外敷组比较,创面面积均明显缩小(P<0.01)。血清透明质酸水平组间比较第3天、第7天、第14天、第21天清热解毒箍围组、青霉素外敷组明显高于模型组(P<0.01),清热解毒箍围组、青霉素外敷组明显高于基础治疗组(P<0.01),清热解毒箍围组明显高于青霉素外敷组(P<0.01)。各组组内不同时间血清透明质酸水平比较,第7天均明显高于第3天(P<0.01),第14天均明显高于第3天(P<0.01),第21天均明显低于第7天(P<0.01),第21天均明显低于第14天(P<0.01)。结论清热解毒箍围法对促进糖尿病大鼠感染性溃疡愈合具有较好的作用。
文摘Gout is a metabolic bone and joint disease caused by purine metabolism disorder.The disturbance of inflammatory microenvironment caused by monosodium urate(MSU)deposition is an important pathological mechanism of gout occurrence and development.In the understanding of Traditional Chinese medicine(TCM),the interaction of"dampness","heat"and"stasis"is the main pathogenesis of gout,and the method of clearing heat and removing dampness is the main treatment method of TCM for gout.In recent years,studies have found that heat-clearing and dampness-removing method can improve the TCM symptom score of gout patients,especially in the body tiredness,dry mouth and dry throat,short yellow urine,thirsty,etc.,which are the characteristics of dampness and heat syndrome,this may be related to the fact that the TCM heat-clearing and dampness-removing method in the treatment of gout removes the appearance of dampness and heat,improves the inflammatory microenvironment of gout and restores the normal metabolic function of human body.This paper deeply explores the specific mechanism of TCM heat-clearing and dampness-removing method to improve the inflammatory microenvironment of gout,which can provide new ideas for the diagnosis and treatment of clinical gout.
基金Guangdong Provincial Medical Science and Technology Research Fund Project(No.A2019507)Traditional Chinese Medicine Bureau of Guangdong Provincial Project(No.20191117)+1 种基金Science and Technology Program of Guangzhou(No.202102020927)National Administration of Traditional Chinese Medicine Clinical Research Base Business Construction Research Project(No.JDZX2015241)。
文摘Objective:To evaluate the effect of heat-clearing and detoxifying method on the macrophages polarization in patients with acute myocardial infarction with heat toxin syndrome after intervention.Methods:Sixty patients with acute myocardial infarction and undergoing percutaneous coronary intervention with heat toxin syndrome were randomly divided into a control group and a test group with 30 cases each.The control group was given conventional treatment,and the test group was given Huanglian Jiedu Decoction,the representative of the method of clearing heat and detoxification,orally on the basis of the control group.The intervention time of both groups was 2 weeks.Comparing The Seattle Angina Pectoris Scale(SAQ)before and after treatment,creatine kinase(CK),creatine kinase MB isoenzyme(CKMB),high-sensitivity troponin I(hs-TnI),and Lipoprotein-associated phospholipaseA2(LPPLA_2)),the phenotype ratio of M1 and M2 macrophages,and observe the adverse reactions.Results:After treatment,the SAQ scores of the two groups of patients were improved,and the levels of CK,CK-MB,hs-TnI,and LP-PLA_2 decreased significantly.The scores of AS,AF,TS,and DP in the SAQ of the test group were all higher than those of the control group,and the hs-TnI and LP-PLA_2 were better than those of the control Group(P<0.05 or P<0.01).After treatment,the proportion of M1 type macrophages in the two groups of patients'macrophages decreased significantly(P<0.05 or P<0.01),the ratio of M2 type macrophages increased(P<0.05),and the M1/M2 ratio decreased.The ratio of M1/M2 in the test group of the control group was significantly lower than that of the control group(P<0.01).There were no obvious adverse reactions in both groups.Conclusions:The method of clearing heat and detoxifying has a definite effect on patients with acute myocardial infarction of heat toxin syndrome after interventional operation.It can reduce myocardial damage,improve myocardial function,and reduce inflammation.And it is safe for clinical treatment without any increasing risk of bleed
