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氧自由基在肝脏保存再灌注损伤中的作用及丹参的保护作用 被引量:37
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作者 赵浩亮 武小勇 +2 位作者 李士骏 陈孝平 裘法祖 《中华实验外科杂志》 CAS CSCD 北大核心 2000年第3期237-238,共2页
目的 探讨氧自由基在肝脏保存再灌注损伤 (hepaticpreservationreperfusioninjury ,HPRI)中的作用及丹参的保护作用。方法 建立大鼠肝脏保存再灌注模型 ,分别检测肝脏保存 0、8、1 6、2 4、32h组在不同灌注时间点组织超氧化物歧化酶 (... 目的 探讨氧自由基在肝脏保存再灌注损伤 (hepaticpreservationreperfusioninjury ,HPRI)中的作用及丹参的保护作用。方法 建立大鼠肝脏保存再灌注模型 ,分别检测肝脏保存 0、8、1 6、2 4、32h组在不同灌注时间点组织超氧化物歧化酶 (SOD)、丙二醛 (MDA)和灌注液谷草转氨酸(AST)的变化 ,并观察肝细胞形态学的改变。结果 与正常组 (保存 0h组 )比较 ,保存 1 6、2 4、32h组不同再灌注时点SOD显著降低 (P <0 .0 5) ,而MDA和AST均明显升高 (P <0 .0 5) ,肝细胞形态也发生异常改变 ;应用丹参组 ,SOD则明显升高 ,MDA和AST明显下降 ,与对照组比较 ,差异均有显著性(P <0 .0 5)。结论 氧自由基是导致HPRI的重要因素 ,丹参能清除氧自由基 。 展开更多
关键词 氧自由基 肝脏保存 再灌注损伤 丹参 hpri
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HPR1000: Advanced Pressurized Water Reactor with Active and Passive Safety 被引量:24
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作者 Ji xing Daiyong Song Yuxiang Wu 《Engineering》 SCIE EI 2016年第1期79-87,共9页
HPR1000 is an advanced nuclear power plant(NPP)with the significant feature of an active and passive safety design philosophy,developed by the China National Nuclear Corporation.On one hand,it is an evolutionary desig... HPR1000 is an advanced nuclear power plant(NPP)with the significant feature of an active and passive safety design philosophy,developed by the China National Nuclear Corporation.On one hand,it is an evolutionary design based on proven technology of the existing pressurized water reactor NPP;on the other hand,it incorporates advanced design features including a 177-fuel-assembly core loaded with CF3 fuel assemblies,active and passive safety systems,comprehensive severe accident prevention and mitigation measures,enhanced protection against external events,and improved emergency response capability.Extensive verification experiments and tests have been performed for critical innovative improvements on passive systems,the reactor core,and the main equipment.The design of HPR1000fulfills the international utility requirements for advanced light water reactors and the latest nuclear safety requirements,and addresses the safety issues relevant to the Fukushima accident.Along with its outstanding safety and economy,HPR1000 provides an excellent and practicable solution for both domestic and international nuclear power markets. 展开更多
关键词 hpri000 Active and passive safety Advanced nuclear power reactor
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