Introduction: It is estimated that more than 330 million persons are living with HIV-infection globally and in Nigeria about 3.4 million persons are living with the infection, with an annual death rate of 180,000. Psy...Introduction: It is estimated that more than 330 million persons are living with HIV-infection globally and in Nigeria about 3.4 million persons are living with the infection, with an annual death rate of 180,000. Psychological morbidity often accompanies chronic illnesses and may be associated with substance abuse, poor health seeking behaviour and adherence to treatment program;it may worsen existing health problems and the overall quality of life. Until the burden is effectively identified, intervention cannot be planned. Until there is cure, the goal is to manage and cope effectively with HIV-infection. Little if any studies have been done in this area in the North West geopolitical zone of Nigeria, the study would help to identify high risk groups and prevent the progression and spread of the infection. Objectives: To identify HIV-infected persons with psychological morbidity, accessing HIV-clinic at Shika Hospital, Zaria, Kaduna State;and analyze their socio-demographic profile. Methodology: A cross sectional descriptive study was carried out to assess and analyze the socio-demographic characteristics of HIV-infected persons attending Shika hospital Zaria Nigeria, who screened positive for psychological morbidity. A total of 109 HIV-infected persons receiving HAART at Shika clinic, Zaria, Kaduna State, Nigeria, were administered questionnaires;the General Health Questionnaire (GHQ-12) measuring psychological morbidity and socio-demographic data. The participants ranged in age between 18 and 75 years. Results: Data were analyzed using SPSS software 15. Both descriptive and inferential Statistics were performed on the data. Results indicate a total prevalence rate of psychological morbidity of 78 percent among participants. Of this, about 16.2 percent were severely distressed, 25.1 percent moderately distressed and 36.7 percent were mildly distressed. The females were more likely to be distressed than men (65 percent vs. 35 percent of those with psychological morbidity, OR = 3.5 CI 95 percent). It was (57 per展开更多
In verifying antiretroviral efficacy of a Nigerian broad spectrum antiviral medicine (Antivirt<span style="white-space:nowrap;"><sup>®</sup></span>), the Nigerian Institute o...In verifying antiretroviral efficacy of a Nigerian broad spectrum antiviral medicine (Antivirt<span style="white-space:nowrap;"><sup>®</sup></span>), the Nigerian Institute of Medical Research certified it safe by toxicological test on laboratory animals, before commencing treatment of three HIV/AIDS patients whose viral loads varied widely (millions, hundreds of thousands and thousands). To overcome errors associated with such wide differences in subject-classes, percentages of viral load-reductions were calculated instead of comparing their viral loads. After first month of the Antivirt<span style="white-space:nowrap;"><sup>®</sup></span>-treatment, means of ranked viral loads of the patients significantly (P ≤ 0.05) increased from 10.00 ± 7.21 to 11.30 ± 5.51 (-41.03% infection-reduction rate) instead of reducing. From second month of the trial, their viral loads started to reduce, continuously, so that their infection-reduction rates have been increasing from that -41.03%, to -38.22% in the second month;23.98% in the third month;31.76% in the fourth month and 64.12% after the fifth month.展开更多
目的观察参灵草口服液对艾滋病病毒携带者HIV-RNA载量及CD4＋T细胞的作用。方法 2012年2~4月纳入HIV无症状感染者,给予参灵草口服液1支/d（200 m L/支）,连续服用6个月,观察不同时间点（入组前、口服2月、4月、6月）患者HIV-RNA载量及CD...目的观察参灵草口服液对艾滋病病毒携带者HIV-RNA载量及CD4＋T细胞的作用。方法 2012年2~4月纳入HIV无症状感染者,给予参灵草口服液1支/d（200 m L/支）,连续服用6个月,观察不同时间点（入组前、口服2月、4月、6月）患者HIV-RNA载量及CD4＋T细胞的变化。结果共纳入25例HIV无症状感染者。结果显示,口服参灵草前、后不同时间点CD4＋T细胞计数随时间延长呈逐渐上升的趋势,HIV-RNA载量未出现规律性变化。总有效率处于稳定状态,显效人数有增加的趋势。结论参灵草口服液有助于提高无症状HIV感染者的免疫力。受样本量和研究设计所限,本研究结论尚需进一步开展大样本、高质量的随机对照试验进行验证。展开更多
文摘Introduction: It is estimated that more than 330 million persons are living with HIV-infection globally and in Nigeria about 3.4 million persons are living with the infection, with an annual death rate of 180,000. Psychological morbidity often accompanies chronic illnesses and may be associated with substance abuse, poor health seeking behaviour and adherence to treatment program;it may worsen existing health problems and the overall quality of life. Until the burden is effectively identified, intervention cannot be planned. Until there is cure, the goal is to manage and cope effectively with HIV-infection. Little if any studies have been done in this area in the North West geopolitical zone of Nigeria, the study would help to identify high risk groups and prevent the progression and spread of the infection. Objectives: To identify HIV-infected persons with psychological morbidity, accessing HIV-clinic at Shika Hospital, Zaria, Kaduna State;and analyze their socio-demographic profile. Methodology: A cross sectional descriptive study was carried out to assess and analyze the socio-demographic characteristics of HIV-infected persons attending Shika hospital Zaria Nigeria, who screened positive for psychological morbidity. A total of 109 HIV-infected persons receiving HAART at Shika clinic, Zaria, Kaduna State, Nigeria, were administered questionnaires;the General Health Questionnaire (GHQ-12) measuring psychological morbidity and socio-demographic data. The participants ranged in age between 18 and 75 years. Results: Data were analyzed using SPSS software 15. Both descriptive and inferential Statistics were performed on the data. Results indicate a total prevalence rate of psychological morbidity of 78 percent among participants. Of this, about 16.2 percent were severely distressed, 25.1 percent moderately distressed and 36.7 percent were mildly distressed. The females were more likely to be distressed than men (65 percent vs. 35 percent of those with psychological morbidity, OR = 3.5 CI 95 percent). It was (57 per
文摘In verifying antiretroviral efficacy of a Nigerian broad spectrum antiviral medicine (Antivirt<span style="white-space:nowrap;"><sup>®</sup></span>), the Nigerian Institute of Medical Research certified it safe by toxicological test on laboratory animals, before commencing treatment of three HIV/AIDS patients whose viral loads varied widely (millions, hundreds of thousands and thousands). To overcome errors associated with such wide differences in subject-classes, percentages of viral load-reductions were calculated instead of comparing their viral loads. After first month of the Antivirt<span style="white-space:nowrap;"><sup>®</sup></span>-treatment, means of ranked viral loads of the patients significantly (P ≤ 0.05) increased from 10.00 ± 7.21 to 11.30 ± 5.51 (-41.03% infection-reduction rate) instead of reducing. From second month of the trial, their viral loads started to reduce, continuously, so that their infection-reduction rates have been increasing from that -41.03%, to -38.22% in the second month;23.98% in the third month;31.76% in the fourth month and 64.12% after the fifth month.
文摘目的观察参灵草口服液对艾滋病病毒携带者HIV-RNA载量及CD4＋T细胞的作用。方法 2012年2~4月纳入HIV无症状感染者,给予参灵草口服液1支/d（200 m L/支）,连续服用6个月,观察不同时间点（入组前、口服2月、4月、6月）患者HIV-RNA载量及CD4＋T细胞的变化。结果共纳入25例HIV无症状感染者。结果显示,口服参灵草前、后不同时间点CD4＋T细胞计数随时间延长呈逐渐上升的趋势,HIV-RNA载量未出现规律性变化。总有效率处于稳定状态,显效人数有增加的趋势。结论参灵草口服液有助于提高无症状HIV感染者的免疫力。受样本量和研究设计所限,本研究结论尚需进一步开展大样本、高质量的随机对照试验进行验证。
