目的观察小剂量盐酸罗哌卡因腰-硬联合麻醉对剖腹产孕妇血流动力学及麻醉质量的影响。方法 132例行择期剖宫产术产妇随机分为试验组和对照组,每组各66例。均经L2-L3腰椎间隙行蛛网膜下腔穿刺麻醉,试验组给予0.75%罗哌卡因1 m L+注射用水...目的观察小剂量盐酸罗哌卡因腰-硬联合麻醉对剖腹产孕妇血流动力学及麻醉质量的影响。方法 132例行择期剖宫产术产妇随机分为试验组和对照组,每组各66例。均经L2-L3腰椎间隙行蛛网膜下腔穿刺麻醉,试验组给予0.75%罗哌卡因1 m L+注射用水2 m L;对照组给予0.75%罗哌卡因2 m L+注射用水1 m L,观察2组心率(HR)、平均动脉压(MAP)、血氧饱和度(Sp O2)、麻醉平面固定时间、麻醉时间、肌松满意度和不良反应发生情况。结果麻醉前、麻醉15 min和手术结束后,2组HR、MAP、Sp O2差异无统计学意义(P>0.05)。胎儿分娩后对照组HR(89.3±9.7)times·min-1明显增快,MAP(97.0±10.3)mm Hg和Sp O2(95.1±0.7)%明显降低(P<0.05)。2组产妇在麻醉平面、麻醉时间及肌松满意度比较差异无统计学意义(P>0.05)。试验组产妇麻醉苏醒时间(19.27±3.19)min和自主排尿时间(18.42±2.12)h均早于对照组(P<0.05),2组新生儿娩出后1 min Apgar评分比较差异无统计学意义(P>0.05)。试验组不良反应发生率(7.58%)显著低于对照组(28.79%,P<0.05)。结论小剂量盐酸罗哌卡因腰-硬联合麻醉有助于剖宫产手术患者血流动力相对稳定,提高麻醉质量。展开更多
AIM： To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. METHODS： In this prospective study, conducted over a period of three years, 1,104 patients refe...AIM： To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. METHODS： In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus （0.5-1.5 mg/kg）. Arterial blood pressure （BP） was monitored at 3 rain intervals and heart rate and oxygen saturation （SpO2） were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure. RESULTS： A statistically significant reduction in mean arterial pressure was demonstrated （P〈0.001） when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60mmHg, was noted in only 5 patients （0.5%）. Oxygen saturation decreased from 96.5% to 94.4 % （P〈0.001）. A critical decrease in oxygen saturation （〈90%） was documented in 27 patients （2.4%）. CONCLUSION： Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effelts if carefully titrated. All the patients （and especially ASA Ⅲ group） require monitoring and care of an anesthesiologist.展开更多
文摘目的观察小剂量盐酸罗哌卡因腰-硬联合麻醉对剖腹产孕妇血流动力学及麻醉质量的影响。方法 132例行择期剖宫产术产妇随机分为试验组和对照组,每组各66例。均经L2-L3腰椎间隙行蛛网膜下腔穿刺麻醉,试验组给予0.75%罗哌卡因1 m L+注射用水2 m L;对照组给予0.75%罗哌卡因2 m L+注射用水1 m L,观察2组心率(HR)、平均动脉压(MAP)、血氧饱和度(Sp O2)、麻醉平面固定时间、麻醉时间、肌松满意度和不良反应发生情况。结果麻醉前、麻醉15 min和手术结束后,2组HR、MAP、Sp O2差异无统计学意义(P>0.05)。胎儿分娩后对照组HR(89.3±9.7)times·min-1明显增快,MAP(97.0±10.3)mm Hg和Sp O2(95.1±0.7)%明显降低(P<0.05)。2组产妇在麻醉平面、麻醉时间及肌松满意度比较差异无统计学意义(P>0.05)。试验组产妇麻醉苏醒时间(19.27±3.19)min和自主排尿时间(18.42±2.12)h均早于对照组(P<0.05),2组新生儿娩出后1 min Apgar评分比较差异无统计学意义(P>0.05)。试验组不良反应发生率(7.58%)显著低于对照组(28.79%,P<0.05)。结论小剂量盐酸罗哌卡因腰-硬联合麻醉有助于剖宫产手术患者血流动力相对稳定,提高麻醉质量。
基金Supported by "Bates" Clinic, Svetice 15, Zagreb, Croatia, in the form of grant, equipment and drugs
文摘AIM： To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. METHODS： In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus （0.5-1.5 mg/kg）. Arterial blood pressure （BP） was monitored at 3 rain intervals and heart rate and oxygen saturation （SpO2） were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure. RESULTS： A statistically significant reduction in mean arterial pressure was demonstrated （P〈0.001） when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60mmHg, was noted in only 5 patients （0.5%）. Oxygen saturation decreased from 96.5% to 94.4 % （P〈0.001）. A critical decrease in oxygen saturation （〈90%） was documented in 27 patients （2.4%）. CONCLUSION： Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effelts if carefully titrated. All the patients （and especially ASA Ⅲ group） require monitoring and care of an anesthesiologist.
