乙型肝炎病毒(hepatitis B virus,HBV)感染后的自然病程十分复杂,受到宿主、病毒、环境等诸多因素的影响,了解HBV的生活周期对于慢性乙型肝炎(chronic hepatitis B,CHB)患者的临床分期以及相关预后非常重要,对于疾病的临床治疗也会有很...乙型肝炎病毒(hepatitis B virus,HBV)感染后的自然病程十分复杂,受到宿主、病毒、环境等诸多因素的影响,了解HBV的生活周期对于慢性乙型肝炎(chronic hepatitis B,CHB)患者的临床分期以及相关预后非常重要,对于疾病的临床治疗也会有很大帮助。文章结合最新的主流观点,探讨HBV感染的自然史以及相关的不良临床结局。展开更多
Covalently closed circular(ccc)DNA of hepatitis B virus(HBV)existed in the nuclei of HBV infected hepatocytes with a half-life time of 14.3 years in a mathmatic model.Viral protein feedback regulation in HBV life cycl...Covalently closed circular(ccc)DNA of hepatitis B virus(HBV)existed in the nuclei of HBV infected hepatocytes with a half-life time of 14.3 years in a mathmatic model.Viral protein feedback regulation in HBV life cycle to maintain vital viral replication is an important mechanism.Interleukin-6,epithelial growth factor,heme oxygenase-1,histones,and hepatocyte nuclear factors are demonstrated as the key regulators for HBV life cycle.CpG island structure and methylation status are involved in the regulation of HBV DNA replication.Nucleos(t)ide analogues are widely used in the clinical practice for the treatment of chronic hepatitis B patients,although no evidence indicating a direct inhibiton of HBV cccDNA.In the future,along with the study of HBV life cycle,new drugs including RNA interference technique,will pave the way to eliminate the HBV cccDNA from infected hepatocytes resulting final cure of chronic hepatitis B.展开更多
文摘乙型肝炎病毒(hepatitis B virus,HBV)感染后的自然病程十分复杂,受到宿主、病毒、环境等诸多因素的影响,了解HBV的生活周期对于慢性乙型肝炎(chronic hepatitis B,CHB)患者的临床分期以及相关预后非常重要,对于疾病的临床治疗也会有很大帮助。文章结合最新的主流观点,探讨HBV感染的自然史以及相关的不良临床结局。
文摘Covalently closed circular(ccc)DNA of hepatitis B virus(HBV)existed in the nuclei of HBV infected hepatocytes with a half-life time of 14.3 years in a mathmatic model.Viral protein feedback regulation in HBV life cycle to maintain vital viral replication is an important mechanism.Interleukin-6,epithelial growth factor,heme oxygenase-1,histones,and hepatocyte nuclear factors are demonstrated as the key regulators for HBV life cycle.CpG island structure and methylation status are involved in the regulation of HBV DNA replication.Nucleos(t)ide analogues are widely used in the clinical practice for the treatment of chronic hepatitis B patients,although no evidence indicating a direct inhibiton of HBV cccDNA.In the future,along with the study of HBV life cycle,new drugs including RNA interference technique,will pave the way to eliminate the HBV cccDNA from infected hepatocytes resulting final cure of chronic hepatitis B.
