目的探讨乙肝病毒(hepatitis B virus,HBV)感染患者外周血中几种细胞因子在疾病慢性化及疾病进展中的作用。方法分离HBV慢性感染者及健康人外周血,采用酶联免疫吸附法(ELISA法)检测IL-17、IL-23、TGF-β和IL-10的表达及其与乙肝患者肝...目的探讨乙肝病毒(hepatitis B virus,HBV)感染患者外周血中几种细胞因子在疾病慢性化及疾病进展中的作用。方法分离HBV慢性感染者及健康人外周血,采用酶联免疫吸附法(ELISA法)检测IL-17、IL-23、TGF-β和IL-10的表达及其与乙肝患者肝功能指标及血清中病毒载量的关系。结果乙肝患者血清中IL-17、IL-23和TGF-β与健康对照比较无明显差异,但IL-10显著增加,IL-17、IL-10与转氨酶水平正相关,TGF-β与转氨酶水平负相关,而IL-10与乙肝病毒DNA载量正相关。结论IL-17、IL-10及TGF-β与HBV感染者肝细胞的炎性损伤有关,对于乙肝患者肝纤维化及疾病进展程度具有提示意义,而IL-10具有促炎和耐受的双重作用,可以预测乙肝感染慢性化及病毒持续感染。展开更多
Interleukin-6(IL-6),a cytokine mainly produced by activated monocytes,has broad pleiotropic actions that affect the functions of a variety of lymphoid cells.The roles of IL-6 in regulating immunity to infections are c...Interleukin-6(IL-6),a cytokine mainly produced by activated monocytes,has broad pleiotropic actions that affect the functions of a variety of lymphoid cells.The roles of IL-6 in regulating immunity to infections are currently being defined.Remarkably,IL-6-mediated cellular and humoral immune responses play a crucial role in determining the outcome of viral infection.This article reviews the current knowledge on the critical role of IL-6 in hepatitis B virus(HBV)infection.As a competent intermediary,IL-6 derived from activated monocytes plays an important role in promoting lymphocytes responses that are essential for effective viral control.However,as a mediator of inflammation,IL-6 is also involved in the development of HBV-induced liver cirrhosis and exacerbating liver injury.Overall,the current data point to IL-6 as an immunoregulatory cytokine in HBV infection.Immunotherapeutic strategies aimed at optimizing the beneficial effects of IL-6 in HBV infection may prove to be an ordeal in the future,as they should foster the strengths of IL-6 while circumventing potential drawbacks.展开更多
文摘目的探讨乙肝病毒(hepatitis B virus,HBV)感染患者外周血中几种细胞因子在疾病慢性化及疾病进展中的作用。方法分离HBV慢性感染者及健康人外周血,采用酶联免疫吸附法(ELISA法)检测IL-17、IL-23、TGF-β和IL-10的表达及其与乙肝患者肝功能指标及血清中病毒载量的关系。结果乙肝患者血清中IL-17、IL-23和TGF-β与健康对照比较无明显差异,但IL-10显著增加,IL-17、IL-10与转氨酶水平正相关,TGF-β与转氨酶水平负相关,而IL-10与乙肝病毒DNA载量正相关。结论IL-17、IL-10及TGF-β与HBV感染者肝细胞的炎性损伤有关,对于乙肝患者肝纤维化及疾病进展程度具有提示意义,而IL-10具有促炎和耐受的双重作用,可以预测乙肝感染慢性化及病毒持续感染。
文摘Interleukin-6(IL-6),a cytokine mainly produced by activated monocytes,has broad pleiotropic actions that affect the functions of a variety of lymphoid cells.The roles of IL-6 in regulating immunity to infections are currently being defined.Remarkably,IL-6-mediated cellular and humoral immune responses play a crucial role in determining the outcome of viral infection.This article reviews the current knowledge on the critical role of IL-6 in hepatitis B virus(HBV)infection.As a competent intermediary,IL-6 derived from activated monocytes plays an important role in promoting lymphocytes responses that are essential for effective viral control.However,as a mediator of inflammation,IL-6 is also involved in the development of HBV-induced liver cirrhosis and exacerbating liver injury.Overall,the current data point to IL-6 as an immunoregulatory cytokine in HBV infection.Immunotherapeutic strategies aimed at optimizing the beneficial effects of IL-6 in HBV infection may prove to be an ordeal in the future,as they should foster the strengths of IL-6 while circumventing potential drawbacks.
