以α D 葡萄糖为原料经过乙酰化、溴化、硫氰酸化三步反应合成了 2, 3, 4, 6 四 O 乙酰基 β D 吡喃葡萄糖基异硫氰酸酯。用NMR对其进行了表征。考察了相转移催化剂种类及用量、反应时间、溶剂对反应的影响。得出最佳反应条件为:以苯做...以α D 葡萄糖为原料经过乙酰化、溴化、硫氰酸化三步反应合成了 2, 3, 4, 6 四 O 乙酰基 β D 吡喃葡萄糖基异硫氰酸酯。用NMR对其进行了表征。考察了相转移催化剂种类及用量、反应时间、溶剂对反应的影响。得出最佳反应条件为:以苯做溶剂,物料摩尔比为n(2, 3, 4, 6 四 O 乙酰基 α D 吡喃溴代葡萄糖)∶n(硫氰酸钾 )∶n(三乙基苄基氯化铵) =1∶2∶1,反应时间为 14h。把它用作柱前衍生试剂拆分异构体,测定了对映体过量 (ee)值,均得到了满意的结果。展开更多
The Reaction of arylatrloxythiophosphoric hydrazide 2a～2d with glycosyl isothiocyanates 3a～3d gave the corresponding aryl N-（glycosylthioureylene）-arylthiophosphoramidates 4a～4d,5a～5d,6a～6d,7a～7d.The resulted ...The Reaction of arylatrloxythiophosphoric hydrazide 2a～2d with glycosyl isothiocyanates 3a～3d gave the corresponding aryl N-（glycosylthioureylene）-arylthiophosphoramidates 4a～4d,5a～5d,6a～6d,7a～7d.The resulted compounds contained glycosylthioureylene and thiophosphoric amide fragments.The glycosyl isothiocyanates 3a～3d were prepared by the reaction of α-D-glycosyl bromides with Pb（SCN）2.The biologic activities of the representative compounds were studied.展开更多
文摘The Reaction of arylatrloxythiophosphoric hydrazide 2a～2d with glycosyl isothiocyanates 3a～3d gave the corresponding aryl N-（glycosylthioureylene）-arylthiophosphoramidates 4a～4d,5a～5d,6a～6d,7a～7d.The resulted compounds contained glycosylthioureylene and thiophosphoric amide fragments.The glycosyl isothiocyanates 3a～3d were prepared by the reaction of α-D-glycosyl bromides with Pb（SCN）2.The biologic activities of the representative compounds were studied.
基金supported by the National Natural Science Foundation of China(Grant No.20462006)Xinjiang Key Laboratory of Plant Resources & Natural Products Chemistry
