We develop a unique ternary Pd-Ni-P nanocatalyst for the sensitive enzyme- free electrooxidation detection of glucose under alkaline conditions. By reducing the distance between the Pd and Ni active sites in the Pd-Ni...We develop a unique ternary Pd-Ni-P nanocatalyst for the sensitive enzyme- free electrooxidation detection of glucose under alkaline conditions. By reducing the distance between the Pd and Ni active sites in the Pd-Ni-P nanoparticles （NPs） via atom engineering, the catalyst structure is transformed from Pd@Ni-P dumbbells into spherical NPs, greatly enhancing the catalyst sensitivity. The glassy carbon electrode modified with Pd-Ni-P ternary NPs, which behaves as an efficient nonenzymatic glucose sensor, offers excellent electrocatalytic performance with a high sensitivity of 1,136 μA·mM^-1·cm^-2, a short response time of 2 s, a wide linear range of 0.5 μM to 10.24 mM, a low limit of detection of 0.15 μM （signal-to-noise ratio = 3）, and good selectivity and reproducibility. Moreover, owing to its superior catalytic performance, the Pd-Ni-P modified electrode has excellent reliability for glucose detection in real samples of human serum. Our study provides a promising alternative strategy for designing and constructing high-performance multicomponent nanocatalyst-based sensors.展开更多
In this work, we report enhanced electroactivity of Co304 nanocrystals （nanocubes, NCs and truncated nano-octahedra, TNO） on the exposed {111} facets as compared to the {001} facets in relation to the surface densit...In this work, we report enhanced electroactivity of Co304 nanocrystals （nanocubes, NCs and truncated nano-octahedra, TNO） on the exposed {111} facets as compared to the {001} facets in relation to the surface density and the activity of the octahedral Com species. Transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy were em- ployed to characterize the crystal facets and materials properties. The enhanced electroactivity of {111 } crystal facets was evaluated by cyclic voltammetry and amperometric titration. Our results indicate that the {111 } facets in TNO has a better electroactivity for enzymeless glucose sensing with a decent glucose sensitivity of 32.54 μA （mmol/L）-1 cm-2.展开更多
近红外光谱的相对测量对实现人体血糖浓度的在体高精度检测具有重要意义。离体检测中常用的相似背景扣除以及双光路设计等方法不适合人体的复杂背景变化,而基于位置的参考测量方法被认为是有希望实现在体参考测量的方法之一。因此课题...近红外光谱的相对测量对实现人体血糖浓度的在体高精度检测具有重要意义。离体检测中常用的相似背景扣除以及双光路设计等方法不适合人体的复杂背景变化,而基于位置的参考测量方法被认为是有希望实现在体参考测量的方法之一。因此课题组提出差动式浮动基准参考测量方法来实现在体的相对测量。差动式浮动基准参考测量方法是一种具有普适性的参考测量方法,在实际应用中面临着径向检测距离的确定和差动检测信号中有效信号提取的问题。在差动式浮动基准参考测量方法的基础上,提出了基于NAS(net analyte signal)-VIP(variable importance in projection)-SPXY(sample set partitioning based on joint X-Y distances)-PLS(partial least square)的差动浮动基准测量方法,在离体实验中验证了该方法的可行性。结果表明经过该方法处理后,模型的均方根误差明显降低,相关系数也有了一定的提高。对该方法在人体实验中的有效性进行了研究,结果也表明该方法处理后所建模型的精密度和准确性有了明显改善。展开更多
基金This work was supported by the National Natural Science Foundation of China （Nos. 21475007, 21675009, and 21275015）. We also thank the support from the ＂Public Hatching Platform for Recruited Talents of Beijing University of Chemical Technology＂.
文摘We develop a unique ternary Pd-Ni-P nanocatalyst for the sensitive enzyme- free electrooxidation detection of glucose under alkaline conditions. By reducing the distance between the Pd and Ni active sites in the Pd-Ni-P nanoparticles （NPs） via atom engineering, the catalyst structure is transformed from Pd@Ni-P dumbbells into spherical NPs, greatly enhancing the catalyst sensitivity. The glassy carbon electrode modified with Pd-Ni-P ternary NPs, which behaves as an efficient nonenzymatic glucose sensor, offers excellent electrocatalytic performance with a high sensitivity of 1,136 μA·mM^-1·cm^-2, a short response time of 2 s, a wide linear range of 0.5 μM to 10.24 mM, a low limit of detection of 0.15 μM （signal-to-noise ratio = 3）, and good selectivity and reproducibility. Moreover, owing to its superior catalytic performance, the Pd-Ni-P modified electrode has excellent reliability for glucose detection in real samples of human serum. Our study provides a promising alternative strategy for designing and constructing high-performance multicomponent nanocatalyst-based sensors.
基金financial support from the University of Queenslandthe support of the Centre for Microscopy and Microanalysis at the University of Queensland through their facilities,and the scientific and technical assistance
文摘In this work, we report enhanced electroactivity of Co304 nanocrystals （nanocubes, NCs and truncated nano-octahedra, TNO） on the exposed {111} facets as compared to the {001} facets in relation to the surface density and the activity of the octahedral Com species. Transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy were em- ployed to characterize the crystal facets and materials properties. The enhanced electroactivity of {111 } crystal facets was evaluated by cyclic voltammetry and amperometric titration. Our results indicate that the {111 } facets in TNO has a better electroactivity for enzymeless glucose sensing with a decent glucose sensitivity of 32.54 μA （mmol/L）-1 cm-2.
文摘近红外光谱的相对测量对实现人体血糖浓度的在体高精度检测具有重要意义。离体检测中常用的相似背景扣除以及双光路设计等方法不适合人体的复杂背景变化,而基于位置的参考测量方法被认为是有希望实现在体参考测量的方法之一。因此课题组提出差动式浮动基准参考测量方法来实现在体的相对测量。差动式浮动基准参考测量方法是一种具有普适性的参考测量方法,在实际应用中面临着径向检测距离的确定和差动检测信号中有效信号提取的问题。在差动式浮动基准参考测量方法的基础上,提出了基于NAS(net analyte signal)-VIP(variable importance in projection)-SPXY(sample set partitioning based on joint X-Y distances)-PLS(partial least square)的差动浮动基准测量方法,在离体实验中验证了该方法的可行性。结果表明经过该方法处理后,模型的均方根误差明显降低,相关系数也有了一定的提高。对该方法在人体实验中的有效性进行了研究,结果也表明该方法处理后所建模型的精密度和准确性有了明显改善。
