A significant reaction in the synthesis of biomass-based chemicals is the catalyst-based and targeted oxidation of monosaccharides into valuable sugar acids.In this study,an activated carbon supported gold catalyst wa...A significant reaction in the synthesis of biomass-based chemicals is the catalyst-based and targeted oxidation of monosaccharides into valuable sugar acids.In this study,an activated carbon supported gold catalyst was used to oxidize glucose and xylose to gluconic acid and xylonic acid under neutral condition.Optimization of reaction conditions for the catalysts was performed using both a batch reactor and a flow-through reactor.In a batch reactor,the yields of gluconic and xylonic acid reached 93%and 92%,respectively,at 90°C within 180 min.In a flow reactor,both reactions reached a similar yield at 80°C with the weight hourly space velocity of 47.1 h^(-1).The reaction kinetics were explored in the flow reactor.The oxidation of glucose and xylose to gluconic and xylonic acid followed a first-order kinetics and the turnover frequency was 0.195 and 0.161 s^(-1),respectively.The activation energy was evaluated to be 60.58 and 59.30 kJ·mol^(-1),respectively.This study presents an environmentally friendly and feasible method for the selective oxidation of monosaccharides using an activated carbon supported gold catalyst,benefiting the high-value application of carbohydrates.展开更多
The aging process of atmospheric aerosols usually leads to a mixture of inorganic salts and organic compounds of anthropogenic origin.In organic compounds,polyhydroxy organic acids are important components,however,the...The aging process of atmospheric aerosols usually leads to a mixture of inorganic salts and organic compounds of anthropogenic origin.In organic compounds,polyhydroxy organic acids are important components,however,the study on composition and hygroscopic properties of the mixture containing inorganics and polyhydroxy organic acids is scanty.In this study,gluconic acid,the proxy of polyhydroxy organic acids,is mixed with the representative nitrate(Mg(NO_(3))_(2),Ca(NO_(3))_(2))to form aerosols.ATR-FTIR and optical microscopy are employed to study the component changes and hygroscopicity as a function of relative humidity.As relative humidity fluctuates,the FTIR-ATR spectra display that the internal mixed gluconic acid(CH_(2)(CH)_(4)(OH)_(5)COOH)and nitrate can react to release acidic gases,forming relevant gluconate and further affecting the hygroscopicity.The specific presentation is particles cannot be recovered to their original size after the dehydration-hydration process and there will be some disparities in GF for mixed particles.For the gluconic acid-Ca(NO_(3))_(2)/Mg(NO_(3))_(2)mixtures with molar ratios of 1:1,higher degree of reaction resulting in the production of large amounts of gluconate should be responsible to the lower hygroscopicity compared to ZSR model.For 1:2 gluconic acid-nitrate mixed systems(with higher nitrate content),the hygroscopicity of mixtures are higher than the ZSR prediction.A possible reason could be‘salt-promoting effect’on the organic fractions of the surplus inorganic salt in the mixture.These data can improve the chemical composition list evaluation,in turn hygroscopic properties and phase state of atmospheric aerosol,and then the climate effect.展开更多
Establishing a method to detect the gluconate and lysine hydrochloride in calcium gluconate and zinc gluconate oral liquid by LC-MS.The mobile phase was acetonitrile and water (10:90),flow rate was 0.2 mL/min,and MS r...Establishing a method to detect the gluconate and lysine hydrochloride in calcium gluconate and zinc gluconate oral liquid by LC-MS.The mobile phase was acetonitrile and water (10:90),flow rate was 0.2 mL/min,and MS run in negative ion mode.The m/z of gluconic acid was 195,and m/z of lysine hydrochloride was 145.展开更多
Hydrothermal fabrication of selectively doped（Ag＋＋ Pd3＋） advanced ZnO nanomaterial has been carried out under mild pressure temperature conditions（autogeneous; 150°C）.Gluconic acid has been used as a surfa...Hydrothermal fabrication of selectively doped（Ag＋＋ Pd3＋） advanced ZnO nanomaterial has been carried out under mild pressure temperature conditions（autogeneous; 150°C）.Gluconic acid has been used as a surface modifier to effectively control the particle size and morphology of these ZnO nanoparticles. The experimental parameters were tuned to achieve optimum conditions for the synthesis of selectively doped ZnO nanomaterials with an experimental duration of 4 hr. These selectively doped ZnO nanoparticles were characterized using powder X-ray diffraction（XRD）, Fourier transform infrared spectroscopy（FT-IR）, UV–Vis spectroscopy and scanning electron microscopy（SEM）. The solar driven photocatalytic studies have been carried out for organic dyes, i.e., Procion MX-5B dye,Cibacron Brilliant Yellow dye, Indigo Carmine dye, separately and all three mixed, by using gluconic acid modified selectively doped advanced ZnO nanomaterial. The influence of catalyst, its concentration and initial dye concentration resulted in the photocatalytic efficiency of 89% under daylight.展开更多
Developing and exploring organic-inorganic hybrid multi-lanthanide(Ln)implanted heteropolyoxometalates(HPOMs)has bloomed into an emerging research fieId.In this article,two neoteric Dgluconic acids(H_(6)GA)concatenati...Developing and exploring organic-inorganic hybrid multi-lanthanide(Ln)implanted heteropolyoxometalates(HPOMs)has bloomed into an emerging research fieId.In this article,two neoteric Dgluconic acids(H_(6)GA)concatenating multi-Ln^(Ⅲ) implanted heteropoly tungstates K_(14)H_(10)[Ln_(4)(H_(2)O)_(4)W_(6)(H_(2)-GA)_(4) O_(12)(B-α-TeW_(9)O_(33))_(4)]·60 H_(2)O(Ln=La^(3+)(1),Pr^(3+)(2))were obtained in acidic aqueous system.Attractively,in the polyanion structure of 1 and 2,six WⅥand four LnⅢcenters are connected by four flexible H_(2)GA^(4-) ligands via carboxyl and hydroxyl groups,resulting in the heterometallic[Ln_(4)(H_(2)O)_(4)W_(6)H_(2)GA)_(4)O_(12)]^(8+)cluster and then the heterometallic cluster is surrounded by four[B-α-TeW_(9)O_(33)]^(8-)segments.Electrochemical measurements for the 1@CFMCN/GCE sensor(CFMCN=carboxylfunctionalized multiwalled carbon nanotube;GCE=glass carbon electrode)demonstrate that 1@CFMCN/GCE shows benign recognition response to detecting noradrenaline(NDA).This research expands the structural diversity of Ln-implanted HPOMs and presents an electrochemical platform of recognizing NDA in the field of biosensors.展开更多
A response surface method was used to optimize the purification and concentration of gluconic acid from fermentation broth using an integrated membrane system. Gluconobacter oxydans was used for the bioconversion of t...A response surface method was used to optimize the purification and concentration of gluconic acid from fermentation broth using an integrated membrane system. Gluconobacter oxydans was used for the bioconversion of the glucose in sugarcane juice to gluconic acid (concentration 45 g·L^-1) with a yield of 0.9 g·g^-1. The optimum operating conditions, such as trans-membrane pressure (TMP), pH, cross-flow rate (CFR) and initial gluconic acid concentration, were determined using response surface methodology. Five different types of polyamide nanofiltration membranes were screened and the best performing one was then used for downstream purification of gluconic acid in a flat sheet cross-flow membrane module. Under the optimum conditions (TMP=12 bar and CFR=400 L·h^-1), this membrane retained more than 85% of the unconverted glucose from the fermentation broth and had a gluconic acid permeation rate of 88% with a flux of 161 L·m^-2·h^-1. Using response surface methods to optimize this green nanofiltration process is an effective way of controlling the production of gluconic acid so that an efficient separation with high flux is obtained.展开更多
The phosphate solubilizing characteristics of a strain YC, which was isolated from phosphate mines (Hubei, China), were studied in National Botanical Research Institute’s phosphate (NBRIP) growth medium containing tr...The phosphate solubilizing characteristics of a strain YC, which was isolated from phosphate mines (Hubei, China), were studied in National Botanical Research Institute’s phosphate (NBRIP) growth medium containing tricalcium phosphate (TCP) as sole phosphorus (P) source. The strain YC is identified as Stenotrophomonas maltophilia (S. maltophilia) based upon the results of morphologic, physiological and biochemical characteristics and 16S rRNA sequences analysis. The results show that the strain S. maltophilia YC can solubilize TCP and release soluble P in NBRIP growth medium. A positive correlation between concentration of soluble P and population of the isolate and a negative correlation between concentration of soluble P and pH in the culture medium are observed from statistical analysis results. Moreover, gluconic acid is detected in the culture medium by HPLC analysis. It indicates that the isolate can release gluconic acid during the solubilizing experiment, which causes acidification of the culture medium and then TCP solubilization. S. maltophilia YC has a maximal TCP solubilizing capability when using maltose as carbon source and ammonium nitrate as nitrogen source, respectively, in NBRIP growth medium.展开更多
Gluconic acid and its derivatives have been widely used in the food and pharmaceutical industries. Conventional processes that involve the conversion of glucose into gluconic acid via fermentation present several tech...Gluconic acid and its derivatives have been widely used in the food and pharmaceutical industries. Conventional processes that involve the conversion of glucose into gluconic acid via fermentation present several technological shortcomings as they involve energy-intensive wastewater treatment and complex enzyme separation. Greener oxidation processes over heterogeneous metal catalysts have attracted increasing attention worldwide. Au-, Pt-and Pd-based heterogeneous catalysts have been extensively used for the chemical oxidation of glucose to gluconic acid. Bimetallic catalysts synthesized by adding either noble or inexpensive metals have also presented excellent performance for the oxidations of glucose. In particular, particle size, which has been recognized as the most important factor that affect catalytic performances, could be rationally tuned by changing the types of support and ligand as well as the synthesis conditions. In this perspective review, we summarize and critically discuss the recent advances in the structural design of mono-and bimetallic catalysts for the oxidation of glucose in aqueous media. Furthermore, the challenges of developing catalysts for the green synthesis of gluconic acid have been highlighted. This review provides alternative insights for designing effective catalytic materials for the catalytic oxidation of bio-derived oxygenates over heterogeneous catalysts.展开更多
Batch and continuous fermentation ofgluconic acid production has been studied. The kinetic parameters of the fermentation process were determined from the batch experimental data. The continuous fermentation was model...Batch and continuous fermentation ofgluconic acid production has been studied. The kinetic parameters of the fermentation process were determined from the batch experimental data. The continuous fermentation was modeled to be carried out in a stirred tank reactor. The effect of hydraulic retention time on the steady state continuous fermentation process of glucose by Aspergillus niger to produce gluconic acid was investigated. The result showed that increasing the hydraulic retention time caused the cell amount and gluconic acid concentration at the outlet stream increased but the glucose concentration at the outlet stream decreased. The steady state simulation result was useful for fermenter size determination. Dynamic behaviour of gluconic acid production through fermentation by Aspergillus niger was also studied for a fermenter with 24 h hydraulic retention time. Applying step change of inlet substrate concentration resulted in first order response of cell, substrate and product concentration with all having positive gain. On the other hand, applying step change of inlet cell concentration has resulted in positive gain for cell and product concentration and negative gain for substrate concentration with first order response for all those three parameters.展开更多
基金support from the National Key Research and Development Program of China(Grant No.2021YFC2101604)the National Natural Science Foundation of China(Grant No.22108088)the Natural Science Foundation of Guangdong,China(Grant No.2023A1515012740)。
文摘A significant reaction in the synthesis of biomass-based chemicals is the catalyst-based and targeted oxidation of monosaccharides into valuable sugar acids.In this study,an activated carbon supported gold catalyst was used to oxidize glucose and xylose to gluconic acid and xylonic acid under neutral condition.Optimization of reaction conditions for the catalysts was performed using both a batch reactor and a flow-through reactor.In a batch reactor,the yields of gluconic and xylonic acid reached 93%and 92%,respectively,at 90°C within 180 min.In a flow reactor,both reactions reached a similar yield at 80°C with the weight hourly space velocity of 47.1 h^(-1).The reaction kinetics were explored in the flow reactor.The oxidation of glucose and xylose to gluconic and xylonic acid followed a first-order kinetics and the turnover frequency was 0.195 and 0.161 s^(-1),respectively.The activation energy was evaluated to be 60.58 and 59.30 kJ·mol^(-1),respectively.This study presents an environmentally friendly and feasible method for the selective oxidation of monosaccharides using an activated carbon supported gold catalyst,benefiting the high-value application of carbohydrates.
基金supported by the National Natural Science Foundation of China(Nos.91644101 and 42127806)。
文摘The aging process of atmospheric aerosols usually leads to a mixture of inorganic salts and organic compounds of anthropogenic origin.In organic compounds,polyhydroxy organic acids are important components,however,the study on composition and hygroscopic properties of the mixture containing inorganics and polyhydroxy organic acids is scanty.In this study,gluconic acid,the proxy of polyhydroxy organic acids,is mixed with the representative nitrate(Mg(NO_(3))_(2),Ca(NO_(3))_(2))to form aerosols.ATR-FTIR and optical microscopy are employed to study the component changes and hygroscopicity as a function of relative humidity.As relative humidity fluctuates,the FTIR-ATR spectra display that the internal mixed gluconic acid(CH_(2)(CH)_(4)(OH)_(5)COOH)and nitrate can react to release acidic gases,forming relevant gluconate and further affecting the hygroscopicity.The specific presentation is particles cannot be recovered to their original size after the dehydration-hydration process and there will be some disparities in GF for mixed particles.For the gluconic acid-Ca(NO_(3))_(2)/Mg(NO_(3))_(2)mixtures with molar ratios of 1:1,higher degree of reaction resulting in the production of large amounts of gluconate should be responsible to the lower hygroscopicity compared to ZSR model.For 1:2 gluconic acid-nitrate mixed systems(with higher nitrate content),the hygroscopicity of mixtures are higher than the ZSR prediction.A possible reason could be‘salt-promoting effect’on the organic fractions of the surplus inorganic salt in the mixture.These data can improve the chemical composition list evaluation,in turn hygroscopic properties and phase state of atmospheric aerosol,and then the climate effect.
文摘Establishing a method to detect the gluconate and lysine hydrochloride in calcium gluconate and zinc gluconate oral liquid by LC-MS.The mobile phase was acetonitrile and water (10:90),flow rate was 0.2 mL/min,and MS run in negative ion mode.The m/z of gluconic acid was 195,and m/z of lysine hydrochloride was 145.
基金supported by University Grant Commission under University with Potential for excellence Programme (UPE), University of Mysore
文摘Hydrothermal fabrication of selectively doped（Ag＋＋ Pd3＋） advanced ZnO nanomaterial has been carried out under mild pressure temperature conditions（autogeneous; 150°C）.Gluconic acid has been used as a surface modifier to effectively control the particle size and morphology of these ZnO nanoparticles. The experimental parameters were tuned to achieve optimum conditions for the synthesis of selectively doped ZnO nanomaterials with an experimental duration of 4 hr. These selectively doped ZnO nanoparticles were characterized using powder X-ray diffraction（XRD）, Fourier transform infrared spectroscopy（FT-IR）, UV–Vis spectroscopy and scanning electron microscopy（SEM）. The solar driven photocatalytic studies have been carried out for organic dyes, i.e., Procion MX-5B dye,Cibacron Brilliant Yellow dye, Indigo Carmine dye, separately and all three mixed, by using gluconic acid modified selectively doped advanced ZnO nanomaterial. The influence of catalyst, its concentration and initial dye concentration resulted in the photocatalytic efficiency of 89% under daylight.
基金Project supported by the National Natural Science Foundation of China(21871077,21671054,21771052,22071042,22001058,22171070)the Program for Innovation Teams in Science and Technology in Universities of Henan Province(20IRTSTHN004)。
文摘Developing and exploring organic-inorganic hybrid multi-lanthanide(Ln)implanted heteropolyoxometalates(HPOMs)has bloomed into an emerging research fieId.In this article,two neoteric Dgluconic acids(H_(6)GA)concatenating multi-Ln^(Ⅲ) implanted heteropoly tungstates K_(14)H_(10)[Ln_(4)(H_(2)O)_(4)W_(6)(H_(2)-GA)_(4) O_(12)(B-α-TeW_(9)O_(33))_(4)]·60 H_(2)O(Ln=La^(3+)(1),Pr^(3+)(2))were obtained in acidic aqueous system.Attractively,in the polyanion structure of 1 and 2,six WⅥand four LnⅢcenters are connected by four flexible H_(2)GA^(4-) ligands via carboxyl and hydroxyl groups,resulting in the heterometallic[Ln_(4)(H_(2)O)_(4)W_(6)H_(2)GA)_(4)O_(12)]^(8+)cluster and then the heterometallic cluster is surrounded by four[B-α-TeW_(9)O_(33)]^(8-)segments.Electrochemical measurements for the 1@CFMCN/GCE sensor(CFMCN=carboxylfunctionalized multiwalled carbon nanotube;GCE=glass carbon electrode)demonstrate that 1@CFMCN/GCE shows benign recognition response to detecting noradrenaline(NDA).This research expands the structural diversity of Ln-implanted HPOMs and presents an electrochemical platform of recognizing NDA in the field of biosensors.
文摘A response surface method was used to optimize the purification and concentration of gluconic acid from fermentation broth using an integrated membrane system. Gluconobacter oxydans was used for the bioconversion of the glucose in sugarcane juice to gluconic acid (concentration 45 g·L^-1) with a yield of 0.9 g·g^-1. The optimum operating conditions, such as trans-membrane pressure (TMP), pH, cross-flow rate (CFR) and initial gluconic acid concentration, were determined using response surface methodology. Five different types of polyamide nanofiltration membranes were screened and the best performing one was then used for downstream purification of gluconic acid in a flat sheet cross-flow membrane module. Under the optimum conditions (TMP=12 bar and CFR=400 L·h^-1), this membrane retained more than 85% of the unconverted glucose from the fermentation broth and had a gluconic acid permeation rate of 88% with a flux of 161 L·m^-2·h^-1. Using response surface methods to optimize this green nanofiltration process is an effective way of controlling the production of gluconic acid so that an efficient separation with high flux is obtained.
基金Project(2004CB619201) supported by the Major State Basic Research and Development Program of ChinaProject(Z200515002) supported by the Key Project Foundation of the Education Department of Hubei Province, China+1 种基金Project(GCP200801) supported by the Open Research Fund of Key Laboratory for Green Chemical Process of Ministry of Education, ChinaProject(Q200811) supported by the Youths Science Foundation of Wuhan Institute of Technology, China
文摘The phosphate solubilizing characteristics of a strain YC, which was isolated from phosphate mines (Hubei, China), were studied in National Botanical Research Institute’s phosphate (NBRIP) growth medium containing tricalcium phosphate (TCP) as sole phosphorus (P) source. The strain YC is identified as Stenotrophomonas maltophilia (S. maltophilia) based upon the results of morphologic, physiological and biochemical characteristics and 16S rRNA sequences analysis. The results show that the strain S. maltophilia YC can solubilize TCP and release soluble P in NBRIP growth medium. A positive correlation between concentration of soluble P and population of the isolate and a negative correlation between concentration of soluble P and pH in the culture medium are observed from statistical analysis results. Moreover, gluconic acid is detected in the culture medium by HPLC analysis. It indicates that the isolate can release gluconic acid during the solubilizing experiment, which causes acidification of the culture medium and then TCP solubilization. S. maltophilia YC has a maximal TCP solubilizing capability when using maltose as carbon source and ammonium nitrate as nitrogen source, respectively, in NBRIP growth medium.
文摘Gluconic acid and its derivatives have been widely used in the food and pharmaceutical industries. Conventional processes that involve the conversion of glucose into gluconic acid via fermentation present several technological shortcomings as they involve energy-intensive wastewater treatment and complex enzyme separation. Greener oxidation processes over heterogeneous metal catalysts have attracted increasing attention worldwide. Au-, Pt-and Pd-based heterogeneous catalysts have been extensively used for the chemical oxidation of glucose to gluconic acid. Bimetallic catalysts synthesized by adding either noble or inexpensive metals have also presented excellent performance for the oxidations of glucose. In particular, particle size, which has been recognized as the most important factor that affect catalytic performances, could be rationally tuned by changing the types of support and ligand as well as the synthesis conditions. In this perspective review, we summarize and critically discuss the recent advances in the structural design of mono-and bimetallic catalysts for the oxidation of glucose in aqueous media. Furthermore, the challenges of developing catalysts for the green synthesis of gluconic acid have been highlighted. This review provides alternative insights for designing effective catalytic materials for the catalytic oxidation of bio-derived oxygenates over heterogeneous catalysts.
文摘Batch and continuous fermentation ofgluconic acid production has been studied. The kinetic parameters of the fermentation process were determined from the batch experimental data. The continuous fermentation was modeled to be carried out in a stirred tank reactor. The effect of hydraulic retention time on the steady state continuous fermentation process of glucose by Aspergillus niger to produce gluconic acid was investigated. The result showed that increasing the hydraulic retention time caused the cell amount and gluconic acid concentration at the outlet stream increased but the glucose concentration at the outlet stream decreased. The steady state simulation result was useful for fermenter size determination. Dynamic behaviour of gluconic acid production through fermentation by Aspergillus niger was also studied for a fermenter with 24 h hydraulic retention time. Applying step change of inlet substrate concentration resulted in first order response of cell, substrate and product concentration with all having positive gain. On the other hand, applying step change of inlet cell concentration has resulted in positive gain for cell and product concentration and negative gain for substrate concentration with first order response for all those three parameters.
