Gastric accommodation is important for the understanding of the pathophysiology in functional dyspepsia and is also relevant for symptom generation in other disorders. The term gastric accommodation has at least three...Gastric accommodation is important for the understanding of the pathophysiology in functional dyspepsia and is also relevant for symptom generation in other disorders. The term gastric accommodation has at least three different meanings： The accommodation process, the accommodation reflex, and the accommodation response. The gastric accommodation process is a complex phenomenon that describes how the size of the gastric compartment changes in response to a meal. The electronic barostat is considered the gold standard in assessing gastric accommodation. Imaging methods, including MRI, SPECT, and ultrasonography may also be used, particularly in patients who are stress-responsive, e.g. functional dyspepsia patients, as a non-invasive and less stress-inducing method is favourable. Ultrasonography satisfies these criteria as it does not by itself distort the physiological response in stress-responsive individuals.展开更多
AIM： To determine the relative potency and contribution of intestinal nutrients to net gastric accommodative relaxation and conscious perception. METHODS： In 12 healthy subjects, we randomly tested duodenal loads of...AIM： To determine the relative potency and contribution of intestinal nutrients to net gastric accommodative relaxation and conscious perception. METHODS： In 12 healthy subjects, we randomly tested duodenal loads of lipids and carbohydrates （12 mL administered in 4 rain） at various caloric concentrations （0.0125-0.8 kcal/mL） separated by 12-24 rain wash-out periods of saline infusion. Maximal gastric relaxation was induced at the end of each experiment by i.v glucagon （5 μg/kg）, as reference. The reflex gastric response was measured by a barostat, and symptom perception by a 0-6 score questionnaire. RESULTS： Upids induced a dose-response gastric relaxation with a steep and early rise. Maximal effect （179±42 mL relaxation） reached at a relatively low concentration （0.2 kcal/mL）, maximal lipid-induced relaxation was 61±6% of the glucagon effect. By contrast, duodenal infusion of carbohydrates induced weaker relaxation that became significant only at the high end of the physiological concentration range （65±14 ml with 0.8 kcal/mL）. Intestinal nutrient loads, either of lipid or carbohydrates, did not induce significant changes in perception （0.6±0.4 and 0.1±0.4 score increase for the highest concentrations, respectively）. CONCLUSION： Chyme entering the small bowel induces nutrient-spedfic gastric relaxatory reflexes by a physiologically saturable mechanism. Normally, neither the intestinal nutrient load nor the gastric accommodative response is perceived.展开更多
目的探讨触摸疗法联合渐进性肌肉放松训练对降低胃癌患者围手术期应激反应的作用.方法采用便利抽样法,选取2018年5-10月江苏省某二甲医院普外科胃癌患者120例为研究对象.根据随机数字表将其分为试验组60例和对照组60例.对照组采用常规...目的探讨触摸疗法联合渐进性肌肉放松训练对降低胃癌患者围手术期应激反应的作用.方法采用便利抽样法,选取2018年5-10月江苏省某二甲医院普外科胃癌患者120例为研究对象.根据随机数字表将其分为试验组60例和对照组60例.对照组采用常规护理方式,试验组采用触摸疗法联合渐进性肌肉放松训练.采用SAS、数字分级疼痛量表(NRS)、护理满意度问卷评估干预的效果.结果试验组患者术后24、48 h NRS评分低于对照组,差异有统计学意义(P<0.05).干预后试验组患者SAS评分低于对照组,差异有统计学意义(P<0.01).出院时试验组患者满意度高于对照组,差异有统计学意义(P<0.05).结论触摸疗法联合渐进性肌肉放松训练有助于降低胃癌患者围手术期应激反应.展开更多
文摘Gastric accommodation is important for the understanding of the pathophysiology in functional dyspepsia and is also relevant for symptom generation in other disorders. The term gastric accommodation has at least three different meanings： The accommodation process, the accommodation reflex, and the accommodation response. The gastric accommodation process is a complex phenomenon that describes how the size of the gastric compartment changes in response to a meal. The electronic barostat is considered the gold standard in assessing gastric accommodation. Imaging methods, including MRI, SPECT, and ultrasonography may also be used, particularly in patients who are stress-responsive, e.g. functional dyspepsia patients, as a non-invasive and less stress-inducing method is favourable. Ultrasonography satisfies these criteria as it does not by itself distort the physiological response in stress-responsive individuals.
基金Supported by the Spanish Ministry of Education (Direccion General de Ensenanza Superior del Ministerio de Educaci6ny Culture, BFI 2002-03413)the Instituto de Salud Carlos m, No. C03/02the National Institutes of Health, USA, No. DK 57064
文摘AIM： To determine the relative potency and contribution of intestinal nutrients to net gastric accommodative relaxation and conscious perception. METHODS： In 12 healthy subjects, we randomly tested duodenal loads of lipids and carbohydrates （12 mL administered in 4 rain） at various caloric concentrations （0.0125-0.8 kcal/mL） separated by 12-24 rain wash-out periods of saline infusion. Maximal gastric relaxation was induced at the end of each experiment by i.v glucagon （5 μg/kg）, as reference. The reflex gastric response was measured by a barostat, and symptom perception by a 0-6 score questionnaire. RESULTS： Upids induced a dose-response gastric relaxation with a steep and early rise. Maximal effect （179±42 mL relaxation） reached at a relatively low concentration （0.2 kcal/mL）, maximal lipid-induced relaxation was 61±6% of the glucagon effect. By contrast, duodenal infusion of carbohydrates induced weaker relaxation that became significant only at the high end of the physiological concentration range （65±14 ml with 0.8 kcal/mL）. Intestinal nutrient loads, either of lipid or carbohydrates, did not induce significant changes in perception （0.6±0.4 and 0.1±0.4 score increase for the highest concentrations, respectively）. CONCLUSION： Chyme entering the small bowel induces nutrient-spedfic gastric relaxatory reflexes by a physiologically saturable mechanism. Normally, neither the intestinal nutrient load nor the gastric accommodative response is perceived.
文摘目的探讨触摸疗法联合渐进性肌肉放松训练对降低胃癌患者围手术期应激反应的作用.方法采用便利抽样法,选取2018年5-10月江苏省某二甲医院普外科胃癌患者120例为研究对象.根据随机数字表将其分为试验组60例和对照组60例.对照组采用常规护理方式,试验组采用触摸疗法联合渐进性肌肉放松训练.采用SAS、数字分级疼痛量表(NRS)、护理满意度问卷评估干预的效果.结果试验组患者术后24、48 h NRS评分低于对照组,差异有统计学意义(P<0.05).干预后试验组患者SAS评分低于对照组,差异有统计学意义(P<0.01).出院时试验组患者满意度高于对照组,差异有统计学意义(P<0.05).结论触摸疗法联合渐进性肌肉放松训练有助于降低胃癌患者围手术期应激反应.
