Individuals with NGLY1 Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion....Individuals with NGLY1 Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion. This report provides the first set of laboratory-based measures characterizing the gait patterns of two individuals with NGLY1 Deficiency, using both linear and non-linear measures, during treadmill walking, and compares them to neurotypical controls. Lower limb kinematics were obtained with a camera-based motion analysis system and bilateral time normalized lower limb joint time series waveforms were developed. Linear measures of joint range of motion, stride times and peak angular velocity were obtained, and confidence intervals were used to determine if there were differences between the patients and control. Correlations between participant and control mean joint waveforms were calculated and used to evaluate the similarities between patients and controls. Non-linear measures included: joint angle-angle diagrams, phase-portrait areas, and continuous relative phase (CRP) measures. These measures were used to assess joint coordination and control features of the lower limb motion. Participants displayed high correlations with their control counterparts for the hip and knee joint waveforms, but joint motion was restricted. Peak angular velocities were also significantly less than those of the controls. Both angle-angle and phase-portrait areas were less than the controls although the general shapes of those diagrams were similar to those of the controls. The NGLY1 Deficient participants’ CRP measures displayed disrupted coordination patterns with the knee-ankle patterns displaying more disruption than the hip-knee measures. Overall, the participants displayed a functional walking pattern that differed in many quantitative ways from those of the neurotypical controls. Using both linear and non-linear measures to characterize gait provides a more comprehensive and nuanced characterization of NGLY1 展开更多
目的探究跟骨孤立性骨囊肿(solitary bone cyst,SBC)病灶范围与病理性骨折的关系,为SBC治疗提供参考。方法基于CT图像建立足踝三维有限元模型,在病灶好发区构建4种梯度球型骨缺损模型,模拟不同的SBC病灶范围,分析步态周期不同时相跟骨...目的探究跟骨孤立性骨囊肿(solitary bone cyst,SBC)病灶范围与病理性骨折的关系,为SBC治疗提供参考。方法基于CT图像建立足踝三维有限元模型,在病灶好发区构建4种梯度球型骨缺损模型,模拟不同的SBC病灶范围,分析步态周期不同时相跟骨的生物力学特征。结果在步态周期下,随着SBC范围增加,跟骨位移无明显变化,但峰值应力逐渐增大。当SBC直径超过跟骨宽度的75%时,跟骨沟和病灶下方皮质区域应力增加到正常跟骨的1.48倍和7.74倍。结论当SBC直径超过跟骨宽度的75%时,应力性骨折风险增大,可早期手术干预。跟骨沟和SBC下方骨皮质是应力集中区,可作为评估应力性骨折的重点区域。展开更多
We study the balance problem caused by forward leaning of the wearer's upper body during rehabilitation training with a lower limb rehabilitation exoskeleton. The instantaneous capture point is obtained by modelin...We study the balance problem caused by forward leaning of the wearer's upper body during rehabilitation training with a lower limb rehabilitation exoskeleton. The instantaneous capture point is obtained by modeling the human-exoskeleton system and using the capture point theory. By comparing the stability region with instantaneous capture points of different gait phases, the balancing characteristics of different gait phases and changes to the equilibrium state in the gait process are analyzed. Based on a model of the human-exoskeleton system and the condition of balance of different phases, a trajectory correction strategy is pro-posed for the instability of the human-exoskeleton system caused by forward leaning of the wearer's upper body. Finally, the reliability of the trajectory correction strategy is verified by carrying out experiments on the Zhejiang University Lower Extremity Exoskeleton. The proposed trajectory correction strategy can respond to forward leaning of the upper body in a timely manner. Additionally, in the process of the center of gravity transferred from a double-support phase to a single-support phase, the ratio of gait cycle to zero moment point transfer is reduced correspondingly, and the gait stability is improved.展开更多
文摘Individuals with NGLY1 Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion. This report provides the first set of laboratory-based measures characterizing the gait patterns of two individuals with NGLY1 Deficiency, using both linear and non-linear measures, during treadmill walking, and compares them to neurotypical controls. Lower limb kinematics were obtained with a camera-based motion analysis system and bilateral time normalized lower limb joint time series waveforms were developed. Linear measures of joint range of motion, stride times and peak angular velocity were obtained, and confidence intervals were used to determine if there were differences between the patients and control. Correlations between participant and control mean joint waveforms were calculated and used to evaluate the similarities between patients and controls. Non-linear measures included: joint angle-angle diagrams, phase-portrait areas, and continuous relative phase (CRP) measures. These measures were used to assess joint coordination and control features of the lower limb motion. Participants displayed high correlations with their control counterparts for the hip and knee joint waveforms, but joint motion was restricted. Peak angular velocities were also significantly less than those of the controls. Both angle-angle and phase-portrait areas were less than the controls although the general shapes of those diagrams were similar to those of the controls. The NGLY1 Deficient participants’ CRP measures displayed disrupted coordination patterns with the knee-ankle patterns displaying more disruption than the hip-knee measures. Overall, the participants displayed a functional walking pattern that differed in many quantitative ways from those of the neurotypical controls. Using both linear and non-linear measures to characterize gait provides a more comprehensive and nuanced characterization of NGLY1
文摘目的探究跟骨孤立性骨囊肿(solitary bone cyst,SBC)病灶范围与病理性骨折的关系,为SBC治疗提供参考。方法基于CT图像建立足踝三维有限元模型,在病灶好发区构建4种梯度球型骨缺损模型,模拟不同的SBC病灶范围,分析步态周期不同时相跟骨的生物力学特征。结果在步态周期下,随着SBC范围增加,跟骨位移无明显变化,但峰值应力逐渐增大。当SBC直径超过跟骨宽度的75%时,跟骨沟和病灶下方皮质区域应力增加到正常跟骨的1.48倍和7.74倍。结论当SBC直径超过跟骨宽度的75%时,应力性骨折风险增大,可早期手术干预。跟骨沟和SBC下方骨皮质是应力集中区,可作为评估应力性骨折的重点区域。
基金Project supported by the National Natural Science Foundation of China(No.51805469)。
文摘We study the balance problem caused by forward leaning of the wearer's upper body during rehabilitation training with a lower limb rehabilitation exoskeleton. The instantaneous capture point is obtained by modeling the human-exoskeleton system and using the capture point theory. By comparing the stability region with instantaneous capture points of different gait phases, the balancing characteristics of different gait phases and changes to the equilibrium state in the gait process are analyzed. Based on a model of the human-exoskeleton system and the condition of balance of different phases, a trajectory correction strategy is pro-posed for the instability of the human-exoskeleton system caused by forward leaning of the wearer's upper body. Finally, the reliability of the trajectory correction strategy is verified by carrying out experiments on the Zhejiang University Lower Extremity Exoskeleton. The proposed trajectory correction strategy can respond to forward leaning of the upper body in a timely manner. Additionally, in the process of the center of gravity transferred from a double-support phase to a single-support phase, the ratio of gait cycle to zero moment point transfer is reduced correspondingly, and the gait stability is improved.
