OBJECTIVE: To evaluate the clinical efficacy and safety of five phase music therapy in patients with depression after ischemic stroke.METHODS: A total of 92 patients with post-stroke depression were randomly divided i...OBJECTIVE: To evaluate the clinical efficacy and safety of five phase music therapy in patients with depression after ischemic stroke.METHODS: A total of 92 patients with post-stroke depression were randomly divided into the control group(32 cases), treatment group A(30 cases), and treatment group B(30 cases). All groups were given basic therapies for cerebral infarction. In addition,the control group was administerd 50 mg of oral sertraline hydrochloride daily, while treatment groups A and B received needling at Baihui(GV 20)plus acupoint injection at Yanglingquan(GB 34) daily; treatment group B also received music therapy derived from the five phases in Traditional ChineseMedicine theory twice daily. All treatments were administered for 5 d per treatment cycle for three cycles, with a 1 d interval between cycles. In all three groups, Hamilton's depression scale(HAMD-17)score and the activities of daily life(ADL) score were measured before and after treatment, and side effects were assessed with the treatment emergent symptom scale.RESULTS: The HAMD-17 score significantly decreased after treatment in all three groups, and the post-treatment reduction in HAMD-17 score was markedly greater in treatment group B than in treatment group A(P < 0.01). The ADL score significantly increased after treatment in all three groups,and the post-treatment increase in ADL score was significantly greater in treatment group B than in treatment group A(P < 0.01). The treatment emergent symptom scale score was highest in the control group, and lowest in group B, and significantly differed between the three groups(P < 0.01).CONCLUSION: Five phase music therapy plus acupoint needling and acupoint injection can improve the symptoms in patients with post-stroke depression.展开更多
目的:探究不同性别健康受试者针刺百会穴后脑部功能变化的差异。方法:选择20例健康受试者(男女各10例),使用14通道头颅柔性线圈,在针刺同时行3.0 T MRI静息态f MRI扫描,图像数据使用SPM12及RestPlus软件进行处理,受试者基础资料使用SPSS...目的:探究不同性别健康受试者针刺百会穴后脑部功能变化的差异。方法:选择20例健康受试者(男女各10例),使用14通道头颅柔性线圈,在针刺同时行3.0 T MRI静息态f MRI扫描,图像数据使用SPM12及RestPlus软件进行处理,受试者基础资料使用SPSS 25.0软件进行分析。结果:针刺后,男性正激活脑区集中在右侧枕下回及右侧缘上回,负激活脑区则集中在右侧小脑脚、右侧颞下回及右侧楔前叶;女性正激活脑区有右侧枕下回、右侧小脑、左侧中央后回、左侧内侧和旁扣带脑回,负激活脑区为右侧背外侧额上回。男性脑部整体Re Ho值高于女性,差异脑区集中在双侧丘脑。结论:不同性别受试者针刺百会穴后的激活脑区既有相同也有不同,男性在疼痛针感与女性比较差异无统计意义的情况下呈现了更强的对针灸的敏感性;2组受试者的认知情绪调节相关脑区均不同程度激活,提示可作用于相关脑功能区,与其治疗重症抑郁症等疾病的机制有一定相关性。展开更多
目的观察电针"百会"配"足三里"穴对肠易激综合征(IBS)模型大鼠内脏敏感性及其情绪心理行为的双重调节作用。方法采用母子分离加幼鼠醋酸灌肠法制备IBS大鼠模型,32只大鼠随机分为正常组、模型组、模型束缚组、电针组...目的观察电针"百会"配"足三里"穴对肠易激综合征(IBS)模型大鼠内脏敏感性及其情绪心理行为的双重调节作用。方法采用母子分离加幼鼠醋酸灌肠法制备IBS大鼠模型,32只大鼠随机分为正常组、模型组、模型束缚组、电针组(电针"百会"配"足三里"穴)。造模后,正常组、模型组不做处理,模型束缚组只捆绑束缚不治疗,电针组捆绑束缚并电针20 min,隔日1次,共5次。末次电针后对大鼠进行腹部回撤反射(AWR)及自主行为测试,采用反转录-聚合酶链反应(RT-PCR)方法检测大鼠丘脑中降钙基因相关肽(CGRP)m RNA的表达。结果电针后模型大鼠内脏敏感性降低,自主行为增多,丘脑中CGRP m RNA表达降低。结论电针"百会"配"足三里"穴能够有效改善IBS模型大鼠的慢性内脏痛及其情绪心理障碍。展开更多
目的:观察百会穴长留针治疗气虚血瘀型中风后认知功能障碍的疗效。方法:将符合纳入标准的70例(3例脱失)气虚血瘀型中风后认知功能障碍患者随机分为观察组(34例)和对照组(33例)。对照组采用基础治疗,包括神经内科常规治疗及西医康复治疗...目的:观察百会穴长留针治疗气虚血瘀型中风后认知功能障碍的疗效。方法:将符合纳入标准的70例(3例脱失)气虚血瘀型中风后认知功能障碍患者随机分为观察组(34例)和对照组(33例)。对照组采用基础治疗,包括神经内科常规治疗及西医康复治疗;观察组在接受与对照组相同治疗的同时加用百会穴长留针(24 h),隔日1次,每周3次,共治疗4周。疗程结束后,观察两组患者治疗前后美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)、简易精神状态检查量表(mini-mental state examination,MMSE)、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、气虚血瘀证候量表评分的变化,并比较两组的临床疗效。结果:治疗4周后,两组NIHSS评分均较治疗前降低(均P<0.01),MMSE、MoCA评分均较治疗前提高(P<0.05,P<0.01),且观察组评分优于对照组(均P<0.01)。两组治疗后气虚血瘀证候量表各项评分均较治疗前降低(均P<0.01);在气短乏力、面色白、舌苔脉象、头晕目眩方面,观察组优于对照组(均P<0.05),自汗方面组间比较差异无统计学意义(P>0.05)。观察组总有效率为94.1%(32/34),高于对照组的75.8%(25/33,P<0.05)。结论:在常规治疗基础上,百会穴长留针治疗气虚血瘀型中风后认知功能障碍安全有效。展开更多
基金Supported by State Administration of Traditional Chinese Medicine of the People's Republic of China,State Clinical Research Base of Traditional Chinese Medicine,The Second Batch of Professional Skill Scientific and Research Special Project(No.JDZX2015127)Jiangsu Natural Science Foundation Youth Project(No.BK20171070)Nanjing Scientific Development Planned Project(No.201402057)
文摘OBJECTIVE: To evaluate the clinical efficacy and safety of five phase music therapy in patients with depression after ischemic stroke.METHODS: A total of 92 patients with post-stroke depression were randomly divided into the control group(32 cases), treatment group A(30 cases), and treatment group B(30 cases). All groups were given basic therapies for cerebral infarction. In addition,the control group was administerd 50 mg of oral sertraline hydrochloride daily, while treatment groups A and B received needling at Baihui(GV 20)plus acupoint injection at Yanglingquan(GB 34) daily; treatment group B also received music therapy derived from the five phases in Traditional ChineseMedicine theory twice daily. All treatments were administered for 5 d per treatment cycle for three cycles, with a 1 d interval between cycles. In all three groups, Hamilton's depression scale(HAMD-17)score and the activities of daily life(ADL) score were measured before and after treatment, and side effects were assessed with the treatment emergent symptom scale.RESULTS: The HAMD-17 score significantly decreased after treatment in all three groups, and the post-treatment reduction in HAMD-17 score was markedly greater in treatment group B than in treatment group A(P < 0.01). The ADL score significantly increased after treatment in all three groups,and the post-treatment increase in ADL score was significantly greater in treatment group B than in treatment group A(P < 0.01). The treatment emergent symptom scale score was highest in the control group, and lowest in group B, and significantly differed between the three groups(P < 0.01).CONCLUSION: Five phase music therapy plus acupoint needling and acupoint injection can improve the symptoms in patients with post-stroke depression.
文摘目的观察电针"百会"配"足三里"穴对肠易激综合征(IBS)模型大鼠内脏敏感性及其情绪心理行为的双重调节作用。方法采用母子分离加幼鼠醋酸灌肠法制备IBS大鼠模型,32只大鼠随机分为正常组、模型组、模型束缚组、电针组(电针"百会"配"足三里"穴)。造模后,正常组、模型组不做处理,模型束缚组只捆绑束缚不治疗,电针组捆绑束缚并电针20 min,隔日1次,共5次。末次电针后对大鼠进行腹部回撤反射(AWR)及自主行为测试,采用反转录-聚合酶链反应(RT-PCR)方法检测大鼠丘脑中降钙基因相关肽(CGRP)m RNA的表达。结果电针后模型大鼠内脏敏感性降低,自主行为增多,丘脑中CGRP m RNA表达降低。结论电针"百会"配"足三里"穴能够有效改善IBS模型大鼠的慢性内脏痛及其情绪心理障碍。
文摘目的:观察百会穴长留针治疗气虚血瘀型中风后认知功能障碍的疗效。方法:将符合纳入标准的70例(3例脱失)气虚血瘀型中风后认知功能障碍患者随机分为观察组(34例)和对照组(33例)。对照组采用基础治疗,包括神经内科常规治疗及西医康复治疗;观察组在接受与对照组相同治疗的同时加用百会穴长留针(24 h),隔日1次,每周3次,共治疗4周。疗程结束后,观察两组患者治疗前后美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)、简易精神状态检查量表(mini-mental state examination,MMSE)、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、气虚血瘀证候量表评分的变化,并比较两组的临床疗效。结果:治疗4周后,两组NIHSS评分均较治疗前降低(均P<0.01),MMSE、MoCA评分均较治疗前提高(P<0.05,P<0.01),且观察组评分优于对照组(均P<0.01)。两组治疗后气虚血瘀证候量表各项评分均较治疗前降低(均P<0.01);在气短乏力、面色白、舌苔脉象、头晕目眩方面,观察组优于对照组(均P<0.05),自汗方面组间比较差异无统计学意义(P>0.05)。观察组总有效率为94.1%(32/34),高于对照组的75.8%(25/33,P<0.05)。结论:在常规治疗基础上,百会穴长留针治疗气虚血瘀型中风后认知功能障碍安全有效。
