Background Transient sublethal ischemia is known as ischemic preconditioning, which enables cells and tissues to survive subsequent prolonged lethal ischemic injury. Ischemic preconditioning exerts neuroprotection thr...Background Transient sublethal ischemia is known as ischemic preconditioning, which enables cells and tissues to survive subsequent prolonged lethal ischemic injury. Ischemic preconditioning exerts neuroprotection through phosphatidylinositol 3-kinase （PI3K）/Akt pathway. Cbl-b belongs to the Casitas B-lineage lymphoma （Cbl） family, and it can regulate the cell signal transduction.The roles of ubiquitin ligase Cbl-b and PI3K/Akt pathway and the relationship between them in oxygen-glucose deprivation preconditioninq （OGDPC） in PC12 cells were investiaated in the ore.~e.nt study展开更多
Genes in the glycogen synthase kinase 3(GSK3)family are essential in regulating plant response to stressful conditions.This study employed bioinformatics to uncover the GSK3 gene family from the sunflower genome datab...Genes in the glycogen synthase kinase 3(GSK3)family are essential in regulating plant response to stressful conditions.This study employed bioinformatics to uncover the GSK3 gene family from the sunflower genome database.The expressions of GSK3 genes in different tissues and stress treatments,such as salt,drought,and cold,were assessed using transcriptome sequencing and quantitative real-time PCR(qRT-PCR).The study results revealed that the 12 GSK3 genes of sunflower,belonging to four classes(Classes I–IV),contained the GSK3 kinase domain and 11–13 exons.The majority of GSK3 genes were highly expressed in the leaf axil and flower,while their expression levels were relatively lower in the leaf.As a result of salt stress,six of the GSK3 genes(HaSK11,HaSK22,HaSK23,HaSK32,HaSK33,and HaSK41)displayed a notable increase in expression,while HaSK14 and HaSK21 experienced a significant decrease.With regard to drought stress,five of the GSK3 genes(HaSK11,HaSK13,HaSK21,HaSK22,and HaSK33)experienced a remarkable rise in expression.When exposed to cold stress,seven of the GSK3 genes(HaSK11,HaSK12,HaSK13,HaSK32,HaSK33,HaSK41,and HaSK42)showed a substantial increase,whereas HaSK21 and HaSK23 had a sharp decline.This research is of great importance in understanding the abiotic resistance mechanism of sunflowers and developing new varieties with improved stress resistance.展开更多
本文介绍一种实现多种基于工业以太网现场总线[1]的方法。基于MCU、FPGA、CPLD和FLASH实现3种基于工业以太网的现场总线:广州数控的GSK-Link,广州数控、华中数控、大连光洋等公司联合开发的NCUC-BUS,德国Beckhoff公司开发的EtherCAT(Eth...本文介绍一种实现多种基于工业以太网现场总线[1]的方法。基于MCU、FPGA、CPLD和FLASH实现3种基于工业以太网的现场总线:广州数控的GSK-Link,广州数控、华中数控、大连光洋等公司联合开发的NCUC-BUS,德国Beckhoff公司开发的EtherCAT(Ethernet for Control Automation Technology)。该方法以较低的硬件成本在数控系统、伺服装置中实现多种现场总线协议,使不同公司的数控系统、伺服装置实现互联,具有很好的市场应用前景。展开更多
In recent years,GSK3 has emerged as a key regulatory kinase in the nervous system,which is involved in diverse processes ranging from neural development to mood stabilization to neurodegeneration.In addition,it has be...In recent years,GSK3 has emerged as a key regulatory kinase in the nervous system,which is involved in diverse processes ranging from neural development to mood stabilization to neurodegeneration.In addition,it has been described as a regulator of several aspects of neural morphology such as polarization,axon growth and branching （Seira and Del Rio, 2014）.展开更多
Unmanned Aerial Vehicles(UAVs)provide a reliable and energyefficient solution for data collection from the Narrowband Internet of Things(NB-IoT)devices.However,the UAV’s deployment optimization,including locations of...Unmanned Aerial Vehicles(UAVs)provide a reliable and energyefficient solution for data collection from the Narrowband Internet of Things(NB-IoT)devices.However,the UAV’s deployment optimization,including locations of the UAV’s stop points,is a necessity to minimize the energy consumption of the UAV and the NB-IoT devices and also to conduct the data collection efficiently.In this regard,this paper proposes GainingSharing Knowledge(GSK)algorithm for optimizing the UAV’s deployment.In GSK,the number of UAV’s stop points in the three-dimensional space is encapsulated into a single individual with a fixed length representing an entire deployment.The superiority of using GSK in the tackled problem is verified by simulation in seven scenarios.It provides significant results in all seven scenarios compared with other four optimization algorithms used before with the same problem.Besides,the NB-IoT is proposed as the wireless communication technology between the UAV and IoT devices.展开更多
Multiple roles of glycogen synthase kinase-3（GSK-3）in neural tissues：GSK-3 is a serine/threonine kinase that has two isoforms encoded by two different genes,GSK-3αand GSK-3β,in mammals.GSK-3 has several sites of ...Multiple roles of glycogen synthase kinase-3（GSK-3）in neural tissues：GSK-3 is a serine/threonine kinase that has two isoforms encoded by two different genes,GSK-3αand GSK-3β,in mammals.GSK-3 has several sites of serine and tyrosine phosphorylation.展开更多
文摘Background Transient sublethal ischemia is known as ischemic preconditioning, which enables cells and tissues to survive subsequent prolonged lethal ischemic injury. Ischemic preconditioning exerts neuroprotection through phosphatidylinositol 3-kinase （PI3K）/Akt pathway. Cbl-b belongs to the Casitas B-lineage lymphoma （Cbl） family, and it can regulate the cell signal transduction.The roles of ubiquitin ligase Cbl-b and PI3K/Akt pathway and the relationship between them in oxygen-glucose deprivation preconditioninq （OGDPC） in PC12 cells were investiaated in the ore.~e.nt study
基金The National Natural Science Foundation of China(30725021,30830071,and 30921091)the National Special Key Project of China on Functional Genomics of Major Plants and Animals(2006AA10A103)
基金financed by the Anhui Provincial Central Leading Local Science and Technology Development Special Fund Project(202007d06020021)Project of Suzhou Science and Technology Bureau(2021143).
文摘Genes in the glycogen synthase kinase 3(GSK3)family are essential in regulating plant response to stressful conditions.This study employed bioinformatics to uncover the GSK3 gene family from the sunflower genome database.The expressions of GSK3 genes in different tissues and stress treatments,such as salt,drought,and cold,were assessed using transcriptome sequencing and quantitative real-time PCR(qRT-PCR).The study results revealed that the 12 GSK3 genes of sunflower,belonging to four classes(Classes I–IV),contained the GSK3 kinase domain and 11–13 exons.The majority of GSK3 genes were highly expressed in the leaf axil and flower,while their expression levels were relatively lower in the leaf.As a result of salt stress,six of the GSK3 genes(HaSK11,HaSK22,HaSK23,HaSK32,HaSK33,and HaSK41)displayed a notable increase in expression,while HaSK14 and HaSK21 experienced a significant decrease.With regard to drought stress,five of the GSK3 genes(HaSK11,HaSK13,HaSK21,HaSK22,and HaSK33)experienced a remarkable rise in expression.When exposed to cold stress,seven of the GSK3 genes(HaSK11,HaSK12,HaSK13,HaSK32,HaSK33,HaSK41,and HaSK42)showed a substantial increase,whereas HaSK21 and HaSK23 had a sharp decline.This research is of great importance in understanding the abiotic resistance mechanism of sunflowers and developing new varieties with improved stress resistance.
文摘本文介绍一种实现多种基于工业以太网现场总线[1]的方法。基于MCU、FPGA、CPLD和FLASH实现3种基于工业以太网的现场总线:广州数控的GSK-Link,广州数控、华中数控、大连光洋等公司联合开发的NCUC-BUS,德国Beckhoff公司开发的EtherCAT(Ethernet for Control Automation Technology)。该方法以较低的硬件成本在数控系统、伺服装置中实现多种现场总线协议,使不同公司的数控系统、伺服装置实现互联,具有很好的市场应用前景。
文摘In recent years,GSK3 has emerged as a key regulatory kinase in the nervous system,which is involved in diverse processes ranging from neural development to mood stabilization to neurodegeneration.In addition,it has been described as a regulator of several aspects of neural morphology such as polarization,axon growth and branching （Seira and Del Rio, 2014）.
文摘Unmanned Aerial Vehicles(UAVs)provide a reliable and energyefficient solution for data collection from the Narrowband Internet of Things(NB-IoT)devices.However,the UAV’s deployment optimization,including locations of the UAV’s stop points,is a necessity to minimize the energy consumption of the UAV and the NB-IoT devices and also to conduct the data collection efficiently.In this regard,this paper proposes GainingSharing Knowledge(GSK)algorithm for optimizing the UAV’s deployment.In GSK,the number of UAV’s stop points in the three-dimensional space is encapsulated into a single individual with a fixed length representing an entire deployment.The superiority of using GSK in the tackled problem is verified by simulation in seven scenarios.It provides significant results in all seven scenarios compared with other four optimization algorithms used before with the same problem.Besides,the NB-IoT is proposed as the wireless communication technology between the UAV and IoT devices.
文摘Multiple roles of glycogen synthase kinase-3（GSK-3）in neural tissues：GSK-3 is a serine/threonine kinase that has two isoforms encoded by two different genes,GSK-3αand GSK-3β,in mammals.GSK-3 has several sites of serine and tyrosine phosphorylation.
