There are abundant hydrothermal sedimentary structures and plant fragment fossils in the siliceous rocks from the Lincang Ge deposit. The major element compositions of these siliceous rocks are characterized by high c...There are abundant hydrothermal sedimentary structures and plant fragment fossils in the siliceous rocks from the Lincang Ge deposit. The major element compositions of these siliceous rocks are characterized by high content SiO2, low TiO2 and Al2O3concentrations, and low Al/(Al+Fe+Mn) ratios (0.010 on average). The siliceous rocks are distinctly enriched in Ge, Sb, As, W, and secondly enriched in Cs, U, Mo and Tl. Their total REE content are generally less than 1μg/g, LREE relatively concentrated, and the values of Eu anomaly and Ce anomaly vary from 0.452 to 5.141 and 0.997 to 1.174, respectively. Their NAS-normalized REE patterns are plain or left-inclined. The Oxygen isotope compositions of these siliceous rocks are similar to those of the hydrothermal siliceous sinter. The above characteristics, as well as the geological setting of the deposit, indicate these siliceous rocks formed in continental hydrothermal envi- ronment. As the interlayer or cliff of the Ge-rich coal seams, siliceous rocks tightly contacted with ore-body, and the contents of Ge in siliceous rocks vary from 5.6 to 360 μg/g (78 μg/g on aver- age). The Ge content increased in coal which close to the siliceous rocks. With the increase of Ge content, the typical trace element ratios (i.e., Ge/Ga, Nb/Ta and U/Th) and REE patterns of Ge-rich coal are more close to those of the siliceous rocks. The Ge concentrated in coal seams of the Lincang Ge deposit might be transported by the hydrothermal water, which demonstrated by the siliceous rocks, during the coal-forming processes.展开更多
Ge Gen Decoction(GGD),a Traditional Chinese Medicine prescription,is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus(IAV)infection.However,the underlying mechanis...Ge Gen Decoction(GGD),a Traditional Chinese Medicine prescription,is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus(IAV)infection.However,the underlying mechanism of GGD against IAV infection remains unclear.In this study,we found that GGD had moderate anti-IAV activity in vitro.GGD was more effective when given before the viral infection and targeted the viral attachment and replication stages rather than the internalization sta ge.In vivo,GGD treatment reduced the virus titers of lung tissue significantly and improved the survival rate,lung index,and pulmonary hist opathological changes in H1N1-infected mice.We observed the changes in several key immuno-related indexes in GGD administrated H1N1-infected mice with anti-IAV drug oseltamivir phosphate as the control.GGD treatment decreased the expression of TNF-αand improved Th1/Th2 immune balance to reduce the excessive immune response in H1N1-infected mice.Besides,the expression of the toll-like receptor 7 signaling pathway in H1N1-infected mice decreased after GGD treatment.Our results showed that GGD has anti-IAV activity and can modulate the immune system to relieve lung inflammation.展开更多
基金jointly supported by the State Key Fundamental Research Developing and Planning Program of China(Grant No.G1999043210)the National Natural Science Foundation of China(Grant No.40302018).
文摘There are abundant hydrothermal sedimentary structures and plant fragment fossils in the siliceous rocks from the Lincang Ge deposit. The major element compositions of these siliceous rocks are characterized by high content SiO2, low TiO2 and Al2O3concentrations, and low Al/(Al+Fe+Mn) ratios (0.010 on average). The siliceous rocks are distinctly enriched in Ge, Sb, As, W, and secondly enriched in Cs, U, Mo and Tl. Their total REE content are generally less than 1μg/g, LREE relatively concentrated, and the values of Eu anomaly and Ce anomaly vary from 0.452 to 5.141 and 0.997 to 1.174, respectively. Their NAS-normalized REE patterns are plain or left-inclined. The Oxygen isotope compositions of these siliceous rocks are similar to those of the hydrothermal siliceous sinter. The above characteristics, as well as the geological setting of the deposit, indicate these siliceous rocks formed in continental hydrothermal envi- ronment. As the interlayer or cliff of the Ge-rich coal seams, siliceous rocks tightly contacted with ore-body, and the contents of Ge in siliceous rocks vary from 5.6 to 360 μg/g (78 μg/g on aver- age). The Ge content increased in coal which close to the siliceous rocks. With the increase of Ge content, the typical trace element ratios (i.e., Ge/Ga, Nb/Ta and U/Th) and REE patterns of Ge-rich coal are more close to those of the siliceous rocks. The Ge concentrated in coal seams of the Lincang Ge deposit might be transported by the hydrothermal water, which demonstrated by the siliceous rocks, during the coal-forming processes.
基金supported by the Key R&D Project in Shandong Province(the Second Development of the Chinese Patent Medicine Ge Gen Decoction Granule,No.2016CYJS08A01-8)
文摘Ge Gen Decoction(GGD),a Traditional Chinese Medicine prescription,is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus(IAV)infection.However,the underlying mechanism of GGD against IAV infection remains unclear.In this study,we found that GGD had moderate anti-IAV activity in vitro.GGD was more effective when given before the viral infection and targeted the viral attachment and replication stages rather than the internalization sta ge.In vivo,GGD treatment reduced the virus titers of lung tissue significantly and improved the survival rate,lung index,and pulmonary hist opathological changes in H1N1-infected mice.We observed the changes in several key immuno-related indexes in GGD administrated H1N1-infected mice with anti-IAV drug oseltamivir phosphate as the control.GGD treatment decreased the expression of TNF-αand improved Th1/Th2 immune balance to reduce the excessive immune response in H1N1-infected mice.Besides,the expression of the toll-like receptor 7 signaling pathway in H1N1-infected mice decreased after GGD treatment.Our results showed that GGD has anti-IAV activity and can modulate the immune system to relieve lung inflammation.
